Raf1 - Raf-1 proto-oncogene, serine/threonine kinase Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24703

About Raf1

Primary_assembly 4: 148,679,530-148,740,317 reverse strand.mRatBN7.2:CM026977.1

This gene has 4 transcripts (splice variants), 219 orthologues, 23 paralogues and is associated with 37 phenotypes. Biased expression in Muscle (RPKM 45.4), Heart (RPKM 314.2) and 9 other tissues.

Summary

Enables several functions, including ATP binding activity; Adenylate Cyclase activator activity; and enzyme binding activity. Involved in several processes, including MAPK cascade; protein phosphorylation; and response to hypoxia. Located in cytoplasm and plasma membrane. Biomarker of pancreatic carcinoma. Human ortholog(s) of this gene implicated in Noonan syndrome (multiple); Noonan syndrome with multiple lentigines 2; adenocarcinoma (multiple); and dilated cardiomyopathy 1NN. Orthologous to human RAF1 (Raf-1 proto-oncogene, serine/threonine kinase). [provided by Alliance of Genome Resources, Apr 2022]

Raf1 Products (1)

mRNA Protein Name
NM_012639.2 NP_036771.1 RAF proto-oncogene serine/threonine-protein kinase

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ATP binding IDA
IDA: Inferred from direct assay
16272159 RGD
enables MAP kinase kinase kinase activity IDA
IDA: Inferred from direct assay
8603510 RGD
enables MAP kinase kinase kinase activity IMP
IMP: Inferred from mutant phenotype
16508002 RGD
enables adenylate cyclase activator activity IDA
IDA: Inferred from direct assay
15385642 RGD
enables adenylate cyclase binding IPI
IPI: Inferred from physical interaction
15385642 RGD
enables mitogen-activated protein kinase kinase binding IMP
IMP: Inferred from mutant phenotype
16508002 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
10725339 RGD
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
16508002 RGD
Biological Process GO Annotation Evidence References Source
involved in MAPK cascade IDA
IDA: Inferred from direct assay
15886202 RGD
involved in MAPK cascade IMP
IMP: Inferred from mutant phenotype
17310240 RGD
involved in heart development IEP
IEP: Inferred from expression pattern
9779826 RGD
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
10648842 RGD
involved in protein phosphorylation IMP
IMP: Inferred from mutant phenotype
16508002 RGD
involved in response to hypoxia IDA
IDA: Inferred from direct assay
8603510 RGD
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
19878719 RGD
located in plasma membrane IDA
IDA: Inferred from direct assay
19878719 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Raf1 Protein Structure

RBD_CRAF

RBD_CRAF: cd17135 (54 - 130)

C1_A_C-Raf

C1_A_C-Raf: cd20870 (135 - 186)

STKc_C-Raf

STKc_C-Raf: cd14149 (355 - 637)

  • 0
  • 200
  • 400
  • 600
  • 668 a.a.
Protein Preferred Names Protein Names

RAF proto-oncogene serine/threonine-protein kinase

  • C-RAF

  • cRaf

  • murine leukemia viral (v-raf-1) oncogene homolog 1 (3611-MSV)

  • proto-oncogene c-RAF

  • v-raf-1 murine leukemia viral oncogene homolog 1

  • v-raf-leukemia viral oncogene 1

Raf1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Raf1 P11345 Arrb1 Rattus norvegicus P29066
Anti Tag CoIP
10725339
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (9)
Cat. No. 상품명 효과
Purity Rare Diseases
HY-12057 Vemurafenib 99.90% Yes
HY-10331 Regorafenib 99.97% Yes
HY-10201S Sorafenib-d3 99.57% Unkown
HY-10331A Regorafenib monohydrate 99.94% Yes
HY-N6670 Cefotetan 99.75% Unkown
HY-13308 Regorafenib Hydrochloride 99.58% Yes
HY-10201R Sorafenib (Standard) 99.71% Unkown
HY-10331B Regorafenib mesylate / Unkown
HY-10201AR Sorafenib tosylate (Standard) / Unkown

Clinical Phase

Bioactive Molecules (7)
Cat. No. 상품명 효과
Purity Phase
HY-10201S4 Sorafenib-d3 tosylate Inhibitor / Phase 4
HY-159127 HRS-4642 99.74% Phase 3
HY-114491A Rineterkib hydrochloride Inhibitor 99.81% Phase 2
HY-51424 PLX-4720 Inhibitor 99.90% Phase 1
HY-158107 BBO-8520 Inhibitor 99.90% Phase 1
HY-134813A MRTX1133 formic Inhibitor 98.23% Phase 1
HY-158107A (4R)-BBO-8520 Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (43)
Cat. No. 상품명
효과
Purity
Rare Diseases
HY-134813 MRTX1133 Inhibitor 99.97% Unkown
HY-11004 AZ 628 99.44% Unkown
HY-18832 AWL-II-38.3 Inhibitor 99.68% Unkown
HY-I0678 Regorafénib N-oxyde (M2) 98.15% Unkown
HY-W013411A Locostatin 99.88% Unkown
HY-122914 KRAS inhibitor-3 Inhibitor 99.87% Unkown
HY-P1039A R18 TFA 99.36% Unkown
HY-112440 HZX-02-059 Inhibitor 99.40% Unkown
HY-114491 Rineterkib Inhibitor 98.79% Unkown
HY-123673 MCP110 Inhibitor 99.82% Unkown
HY-15716 Kobe0065 99.93% Unkown
HY-115501 (E)-FOBISIN101 Inhibitor 95.63% Unkown
HY-117737A RRD-251 99.87% Unkown
HY-15717 Kobe2602 Inhibitor 98.20% Unkown
HY-181420A BBO-11818 99.77% Unkown
HY-10201S2 Sorafenib-13C,d3 98.35% Unkown
HY-177511 KRAS G12D-IN-30 Inhibitor 99.38% Unkown
HY-164365 PROTAC K-Ras Degrader-2 Degrader / Unkown
HY-P1039 R18 / Unkown
HY-W013411 (E/Z)-Locostatin Control 99.52% Unkown
HY-10201S1 Sorafenib-d4 99.9% Unkown
HY-10331S1 Regorafenib-13C,d3 / Unkown
HY-12057S Vemurafenib-d5 / Unkown
HY-12057S1 Vemurafenib-d7 / Unkown
HY-161760 Ferroptosis inducer-3 Inhibitor / Unkown
HY-175870A (7R)-Eras-4001 Inhibitor / Unkown
HY-179133 HDB-1 Inhibitor 98.02% Unkown
HY-181420 (S,R,S)-BBO-11818 / Unkown
HY-182749 KRAS-IN-58 Inhibitor / Unkown
HY-183674 MEK-IN-10 / Unkown
HY-E70747 MEK5 Recombinant Human Active Protein Kinase / Unkown
HY-E70765 RAF1 YDYD Recombinant Human Active Protein Kinase / Unkown
HY-I0678S Regorafénib N-oxyde-d3 (M2) / Unkown
HY-I0678S1 Regorafénib N-oxyde (M2)-13C,d3 / Unkown
HY-N13009 MO-2097 / Unkown
HY-RS11619 RAF1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS11620 Raf1 Mouse Pre-designed siRNA Set A / Unkown
HY-RS11621 Raf1 Rat Pre-designed siRNA Set A / Unkown
HY-RS12020 RNASE3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W1126467 RAS-IN-5 Inhibitor / Unkown
HY-51424S PLX-4720-d7 Inhibitor / Unkown
HY-N15264 Azaspirene Inhibitor / Unkown
HY-RS26697 Rnase2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Raf1 NCBI NCBI:5894