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Cat. No.: HY-182486

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LEM-06

LEM-06 is an NSD2 inhibitor with a human IC₅₀ of 890 μM and 0.8 mM. LEM-06 binds to the histone-tail binding groove of NSD2-SET, inhibiting NSD2-mediated H3K36 histone methyltransferase activity and H3K36 mono-methylation. LEM-06 serves as a hit molecule for further optimization or derivation to explore NSD2 biology. LEM-06 can be used for the research of multiple myeloma.

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CAS No.: 1212675-57-4
화학식: C₂₉H₃₈N₄O₃
분자량:490.64

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

LEM-06 Chemical Structure

CAS No.: 1212675-57-4

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[1]

NSD2

890 μM (IC₅₀)

All Histone Methyltransferase Isoforms :

In Vitro

LEM-06 inhibits the H3K36 monomethylation activity of recombinant NSD2-SET protein in vitro, with an IC₅₀ value of 890 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1212675-57-4
분자량 490.64
화학식 C₂₉H₃₈N₄O₃
SMILES

O=C1N2C([C@@]3([H])CN(C4CCN(CC4)C(C)=O)C[C@@](C3)([H])C2)=CC=C1C5=C(C=CC=C5)CN6CCOCC6
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. di Luccio E, et al. Inhibition of Nuclear Receptor Binding SET Domain 2/Multiple Myeloma SET Domain by LEM-06 Implication for Epigenetic Cancer Therapies. J Cancer Prev. 2015;20(2):113-120. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Other size

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References

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LEM-06

All Histone Methyltransferase Isoforms