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Cat. No.: HY-124083

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MPT0B214

MPT0B214 is a microtubule inhibitor that strongly binds to the colchicine binding site of tubulin, preventing tubulin polymerization. MPT0B214 induces apoptosis through a mitochondrial/caspase 9 dependent pathway and shows cytotoxicity across various human tumor cell lines. MPT0B214 can be used for cancer research.

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CAS No.: 1215208-65-3
화학식: C₂₀H₂₀N₂O₅
분자량:368.38

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

MPT0B214 Chemical Structure

CAS No.: 1215208-65-3

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

All Caspase Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HT-29	IC₅₀	0.4 nM Compound: 15	Antiproliferative activity against human HT-29 cells after 72 hrs by methylene blue dye assay Antiproliferative activity against human HT-29 cells after 72 hrs by methylene blue dye assay	[PMID: 20148562]
KB	IC₅₀	0.3 nM Compound: 15	Antiproliferative activity against human KB cells after 72 hrs by methylene blue dye assay Antiproliferative activity against human KB cells after 72 hrs by methylene blue dye assay	[PMID: 20148562]
MKN-45	IC₅₀	0.3 nM Compound: 15	Antiproliferative activity against human MKN45 cells after 72 hrs by methylene blue dye assay Antiproliferative activity against human MKN45 cells after 72 hrs by methylene blue dye assay	[PMID: 20148562]
NCI-H460	IC₅₀	0.4 nM Compound: 15	Antiproliferative activity against human H460 cells after 72 hrs by methylene blue dye assay Antiproliferative activity against human H460 cells after 72 hrs by methylene blue dye assay	[PMID: 20148562]

Chemical Information

CAS No. 1215208-65-3
분자량 368.38
화학식 C₂₀H₂₀N₂O₅
SMILES

O=C(C1=CC(OC)=C(C(OC)=C1)OC)C2=NC3=CC=C(C(N)=C3C=C2)OC
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Chiang NJ, et al. A novel synthetic microtubule inhibitor, MPT0B214 exhibits antitumor activity in human tumor cells through mitochondria-dependent intrinsic pathway. PLoS One. 2013;8(3):e58953. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

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Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Biological Activity
- 제품 설명
Chemical Information
순도&문서
References

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MPT0B214

All Caspase Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

MPT0B214 Related Classifications

HY-124083 Related Classifications