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Cat. No.: HY-122241

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MT477

MT477 is a potent protein kinase C (PKC) inhibitor. MT477 induces apoptosis and necrosis. MT477 decreases the protein expression of Ras-GTP, p-Erk1/2, p-Elk1. MT477 shows antitumor activity.

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CAS No.: 328069-91-6
화학식: C₃₁H₃₀N₂O₁₂S₃
분자량:718.77

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (282 KB)

MT477 Chemical Structure

CAS No.: 328069-91-6

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

All PKC Isoforms :

In Vitro

MT477 (0.05 mM; 1, 24 h) induces apoptosis and necrosis in a time-dependent manner^[1].
MT477 (0.05 mM; 0.5, 1, 2, 4 h) decreases the protein expression of Ras-GTP, p-Erk1/2, p-Elk1 in a time-dependent manner^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

MCF-7, U87, H226, LNCaP, A549, A431 cells
Concentration:

0.001-1 mM
Incubation Time:

1 h
Result:

Showed antiproliferative activity with IC₅₀s of 0.018, 0.051, 0.013, 0.033, 0.020, 0.049 mM for MCF-7, U87, H226, LNCaP, A549, A431 cells, respectively.

Western Blot Analysis^[1]

Cell Line:

H266 cells
Concentration:

0.05 mM
Incubation Time:

0.5, 1, 2, 4 h
Result:

Decreased the protein expression of Ras-GTP, p-Erk1/2, p-Elk1 in a time-dependent manner.

Apoptosis Analysis^[1]

Cell Line:

H266 cells
Concentration:

0.05 mM
Incubation Time:

1, 24 h
Result:

Induced apoptosia with the percentage of cells underwent apoptosis after 1 h of treatment of 18.6 and after 24 h of treatment of 98%.

In Vivo

MT477 (33, 100, 1000 µg/kg; i.p.; once a day on days 1, 4, 8, 16, 18, 20) shows antitumor activity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

6-week-old male nude mice (A431 cells) ^[1]
Dosage:

33, 100, 1000 µg/kg
Administration:

I.p.; once a day on days 1, 4, 8, 16, 18, 20
Result:

Significant decreased in tumor volume of 24.5% by the third week at 1 mg/kg.

Animal Model:

6-week-old male nude mice (H226 cells) ^[1]
Dosage:

1 mg/kg
Administration:

I.p.; once a day on days 1, 4, 8, 20, 24, 28
Result:

Inhibited tumor growth by 43.6% and observed no weight loss.

Chemical Information

CAS No. 328069-91-6
분자량 718.77
화학식 C₃₁H₃₀N₂O₁₂S₃
SMILES

O=C(OC)C1=C(SC2=C(C3=C(C(OC)=CC=C3)N(C2(C)C)C(CN4C(CCC4=O)=O)=O)C15SC(C(OC)=O)=C(S5)C(OC)=O)C(OC)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (282 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Jasinski P, et al. A novel quinoline, MT477: suppresses cell signaling through Ras molecular pathway, inhibits PKC activity, and demonstrates in vivo anti-tumor activity against human carcinoma cell lines. Invest New Drugs. 2008 Jun;26(3):223-32. [Content Brief]

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

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Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Biological Activity
- 제품 설명
- In Vitro
- In Vivo
Chemical Information
순도&문서
References

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MT477

All PKC Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

MT477 Related Classifications

HY-122241 Related Classifications