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Cat. No.: HY-170674A

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ND-L11B TFA

ND-L11B TFA is an NSD2 degrader with a K_d value of 8.77 μM, degrading the NSD2-long and RE-IIBP isoforms in multiple myeloma cells with DC₅₀ values of 1.48 μM and 0.8 μM, respectively. ND-L11B TFA reduces H3K36me2 levels and inhibits the proliferation of multiple myeloma cells. ND-L11B TFA serves as a starting point for the further development of NSD2-targeted compounds and is also a chemical knockdown tool for elucidating the multiple functions of NSD2 isoforms. ND-L11B TFA can be used for research on multiple myeloma.

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화학식: C₃₉H₅₂F₆N₁₀O₄
분자량:838.89

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (280 KB)

ND-L11B TFA Chemical Structure

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

^[1]

NSD2

8.77 μM (Kd)

All Histone Methyltransferase Isoforms :

In Vitro

Anti-cancer

ND-L11B TFA (0.09-5.0 μM; 6-48 h) simultaneously degrades both NSD2-long and RE-IIBP isoforms in KMS11 multiple myeloma cells, with DC₅₀ values of 1.48 μM and 0.80 μM, respectively, and induces time-dependent NSD2 degradation from 6 to 48 h^[1].
ND-L11B TFA (0.63-2.50 μM for KMS11 cells; 2.0-8.0 μM for 22RV1 cells) downregulates H₃K₃₆ methylation levels in KMS11 multiple myeloma cells and 22RV1 prostate cancer cells^[1].
ND-L11B TFA (12-day exposure of KMS11 cells; 8-day exposure of 293T cells) potently inhibits the proliferation of KMS11 multiple myeloma cells with an IC₅₀ of 0.90 μM, while showing very low cytotoxicity against non-malignant human embryonic kidney 293T cells (IC₅₀ > 100 μM)^[1].
ND-L11B TFA (1.25-2.50 μM; 2 days) downregulates the expression of NSD2-regulated cancer-related genes in KMS11 multiple myeloma cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

KMS11 multiple myeloma cells
Concentration:

0.09, 0.13, 0.20, 0.29, 0.44, 0.66, 0.99, 1.48, 2.22, 3.33, 5.0 μM; 5 μM (time-dependent assay)
Incubation Time:

6, 12, 24, 36, 48 h (5 μM concentration)
Result:

Induced simultaneous concentration-dependent degradation of NSD2-long and RE-IIBP isoforms, with DC₅₀ values of 1.48 μM (NSD2-long) and 0.80 μM (RE-IIBP), and a maximum degradation (D_max) of approximately 80%.
Induced time-dependent degradation of NSD2 protein over 6 to 48 hours.

Real Time qPCR^[1]

Cell Line:

KMS11 multiple myeloma cells
Concentration:

1.25, 2.50 μM
Incubation Time:

2 days
Result:

Downregulated the expression of NSD2-regulated oncogenes and cancer-related genes including JAM2, MET, PAK1, RRAS2, BACE2, CA2, IGF2BP2, and CR2.

Related Protocols :

Chemical Information

분자량 838.89
화학식 C₃₉H₅₂F₆N₁₀O₄
SMILES

O=C(NCCCCCCCCCCCN)COC1=CC(C2=NC=C(N3C[C@](CC(F)F)(N)CCC3)C(CN4C=NC5=C(N)N=CN=C45)=C2)=CC=C1F.O=C(O)C(F)(F)F
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (280 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Hu L, et al. Discovery of SET domain-binding primary alkylamine-tethered degraders for the simultaneous degradation of NSD2-long and RE-IIBP isoforms. European journal of medicinal chemistry. 2025 Feb 05;283:117179. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Other size

견적 받기

Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

ND-L11B TFA

All Histone Methyltransferase Isoforms

Biological Activity

제품 설명

IC50 & Target

In Vitro

Chemical Information

순도&문서

References

Calculators

Help & FAQs

ND-L11B TFA Related Classifications

HY-170674A Related Classifications

Bioz

Keywords

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