PD-M6
Based on 1 Customer Validation
PD-M6 is a mTOR PROTAC degrader (DC50: 4.8 μM). PD-M6 promotes ubiquitination and degradation of mTOR. PD-M6 downregulates MAPKAP1 and CASTOR1, and induces Autophagy. PD-M6 inhibits the proliferation of cervical cancer, breast cancer and liver cancer cell lines. PD-M6 can be used for the research of cervical cancer, breast cancer and liver cancer.
(Pink: mTOR ligand (HY-B0795); Blue: Cereblon ligand (HY-41547); Black: linker (HY-W008296)).
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity: 98.17%
- CAS No.: 3058330-82-5
- 화학식: C30H39N9O6
- 분자량:621.69
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보관:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
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Anti-Cancer Compound Library
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Autophagy Compound Library
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Anti-Aging Compound Library
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Antioxidant Compound Library
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Oxygen Sensing Compound Library
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Glycolysis Compound Library
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Cytoskeleton Compound Library
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Anti-Breast Cancer Compound Library
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Anti-Pancreatic Cancer Compound Library
HY-L077
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Anti-Cancer Metabolism Compound Library
HY-L083
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Angiogenesis-Related Compound Library
HY-L088
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Glucose Metabolism Compound Library
HY-L092
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Anti-Liver Cancer Compound Library
HY-L101
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Pain-Related Compound Library
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PROTAC Library
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Cell Death Library
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Radioprotector Library
HY-L178
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Bioactive Compound Library
HY-L001
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High-Throughput Bioactive Compound Library
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Lactylation Compound Library
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All PROTACs Isoforms
More
Biological Activity
PD-M6 (0.001-10 μM; 4-24 h) induces dose- and time-dependent degradation of mTOR in HeLa cells, with a DC50 of 4.8 μM[1].
PD-M6 inhibits the proliferation of HeLa, MCF-7 and HepG2 cancer cells, with IC50 values of 11.3 μM, 2.58 μM and 3.23 μM, respectively[1].
PD-M6 (0.1-10 μM; 4 days) inhibits long-term colony formation of HeLa cells[1].
PD-M6 (10 μM) inhibits the migration of HeLa cells with an inhibition rate of over 50%[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HeLa cells
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Concentration:0.001-10 μM
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Incubation Time:4 h, 12 h, 24 h
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Result:Induced a dose-dependent reduction in mTOR levels, with significant degradation observed at 1 μM and maximum degradation (~90%) at 10 μM after 12 h.
Achieved a DC50 for mTOR degradation of 4.8 μM.
Reduced mTOR levels by ~50% at 4 h and ~90% at 24 h at 10 μM.
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Cell Line:HeLa cells
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Concentration:0.1-10 μM
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Incubation Time:4 days
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Result:Reduced HeLa cell colony formation in a concentration-dependent manner, with nearly 90% suppression of proliferation observed at 10 μM.
Chemical Information
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CAS No. 3058330-82-5
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Appearance Solid
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분자량 621.69
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화학식 C30H39N9O6
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Color Light yellow to yellow
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SMILES
O=C1N(C2CCC(NC2=O)=O)C(C3=CC=CC(NCCCCCCNC4=NC(N5CCOCC5)=NC(N6CCOCC6)=N4)=C13)=O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
용액&용해도
DMSO : 100 mg/mL (160.85 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.6085 mL | 8.0426 mL | 16.0852 mL | 40.2130 mL |
| 5 mM | 0.3217 mL | 1.6085 mL | 3.2170 mL | 8.0426 mL | |
| 10 mM | 0.1609 mL | 0.8043 mL | 1.6085 mL | 4.0213 mL | |
| 15 mM | 0.1072 mL | 0.5362 mL | 1.0723 mL | 2.6809 mL | |
| 20 mM | 0.0804 mL | 0.4021 mL | 0.8043 mL | 2.0106 mL | |
| 25 mM | 0.0643 mL | 0.3217 mL | 0.6434 mL | 1.6085 mL | |
| 30 mM | 0.0536 mL | 0.2681 mL | 0.5362 mL | 1.3404 mL | |
| 40 mM | 0.0402 mL | 0.2011 mL | 0.4021 mL | 1.0053 mL | |
| 50 mM | 0.0322 mL | 0.1609 mL | 0.3217 mL | 0.8043 mL | |
| 60 mM | 0.0268 mL | 0.1340 mL | 0.2681 mL | 0.6702 mL | |
| 80 mM | 0.0201 mL | 0.1005 mL | 0.2011 mL | 0.5027 mL | |
| 100 mM | 0.0161 mL | 0.0804 mL | 0.1609 mL | 0.4021 mL |
PD-M6 Related Classifications
HY-176166 Related Classifications
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