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Cat. No.: HY-187059

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Piberaline

Name: Piberaline
Brand: MedChemExpress
SKU: HY-187059
Availability: PreOrder

(Synonyms: EGYT-475; Trelibet)

Piberaline (EGYT-475; Trelibet) is a psychoactive piperazine derivative with stimulant and antidepressant effects. Piberaline antagonizes Reserpine (HY-N0480)-induced dopamine depletion. Piberaline can be used for research on depression and central nervous system disorders.

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CAS No.: 39640-15-8
화학식: C₁₇H₁₉N₃O
분자량:281.36

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Piberaline Chemical Structure

CAS No.: 39640-15-8

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

제품 설명

All Dopamine Receptor Isoforms :

All 5-HT Receptor Isoforms :

In Vivo

Piberaline (EGYT-475; Trelibet) (up to 100 mg/kg; i.p.) showed no in vivo pharmacodynamic results in evaluated preclinical mouse studies^[1].
Piberaline is metabolized to produce N‑benzylpiperazine (BZP); the formed BZP can be further metabolized into 4′‑hydroxy‑BZP, 3′‑hydroxy‑BZP, 4′‑hydroxy‑3′‑methoxy‑BZP, piperazine, benzylamine and N‑benzylethylenediamine. Only 3‑4% of Piberaline is excreted into urine in the form of BZP^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 39640-15-8
분자량 281.36
화학식 C₁₇H₁₉N₃O
SMILES

O=C(C1=NC=CC=C1)N2CCN(CC=3C=CC=CC3)CC2
Synonyms

EGYT-475; Trelibet
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. D Dauzonne, et al. Synthesis and some CNS activities of new benzofuranylacryloylpiperazines,
European Journal of Medicinal Chemistry, Volume 30, Issue 1, 1995, Pages 53-59.

[2]. Nikonovich T, et al. Mechanochemical C–N Bond-Forming Reactions and Their Application in Pharmaceutical Synthesis. TalTech Press. 2024.

[3]. Staack RF, et al. Studies on the metabolism and toxicological detection of the new designer drug N-benzylpiperazine in urine using gas chromatography-mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2002 Jun 15;773(1):35-46.

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- 제품 설명
- In Vivo
Chemical Information
순도&문서
References

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Piberaline

All Dopamine Receptor Isoforms

All 5-HT Receptor Isoforms