PRMT4-IN-1
PRMT4-IN-1 is a selective inhibitor of PRMT4 (IC50=3.2 nM). PRMT4-IN-1 inhibits MCF7 relative viability.
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- CAS No.: 3035425-70-5
- 화학식: C30H36N10O7
- 분자량:648.67
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
All Histone Methyltransferase Isoforms
More
Biological Activity
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PRMT1 0.835 μM (IC50) |
PRMT3 4.05 μM (IC50) |
PRMT4 3.2 nM (IC50) |
PRMT5 1.46 μM (IC50) |
PRMT6 1.75 μM (IC50) |
PRMT7 1.68 μM (IC50) |
PRMT8 1.95 μM (IC50) |
PRMT4-IN-1 (compound 12h) (10 μM, 50 μM, 100 μM; 24 h, 72 h) shows no effect on reduction the number of metabolically active cells[1]. PRMT4-IN-1 (50 μM; 2-8 d) decreases relative cell viability time-dependently in MCF7 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3035425-70-5
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분자량 648.67
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화학식 C30H36N10O7
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SMILES
O[C@@H]1[C@H](O)[C@@H](/C=C/CNC(NCCCCNC(NC2=CC3=C(O)C=C(C(OC)=O)C=C3C=C2)=O)=N)O[C@H]1N4C=NC5=C(N)N=CN=C45
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
[1]. Iannelli G, et al. Turning Nonselective Inhibitors of Type I Protein Arginine Methyltransferases into Potent and Selective Inhibitors of Protein Arginine Methyltransferase 4 through a Deconstruction-Reconstruction and Fragment-Growing Approach. J Med Chem. 2022 Sep 8;65(17):11574-11606. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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