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PRMT5-IN-50

PRMT5-IN-50 is an orally active and selective inhibitor of PRMT5. PRMT5-IN-50 has good metabolic stability and low clearance rate in human liver microsomes. PRMT5-IN-50 inhibits SDMA/HCT116-MTAPdel and SDMA/HCT116-MTAPwt with IC50s value of 1.0, 536 nM for arginine symmetric methylation, 19, 1620 nM for anti-proliferation, respectively. PRMT5-IN-50 inhibits tumor growth in mice.

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  • CAS No.: 3002409-47-1
  • 화학식: C26H23F3N6O
  • 분자량:492.50
  • 보관:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • PRMT5-IN-50 Chemical Structure
    PRMT5-IN-50 Chemical Structure
CAS No.: 3002409-47-1
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All Histone Methyltransferase Isoforms

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  • PRMT5-IN-50 Chemical Structure
    PRMT5-IN-50 Chemical Structure
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  • PRMT5-IN-50