Rabelomycin
Rabelomycin is an angucycline antibiotic and inducible nitric oxide synthase (iNOS) inhibitor with an IC50 of 63.9 μM. Rabelomycin can be used in research on bacterial infections, Alzheimer's disease, and Huntington's disease.
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- CAS No.: 28399-50-0
- 화학식: C19H14O6
- 분자량:338.31
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
All Antibiotic Isoforms
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Biological Activity
제품 설명
IC50 & Target
[1]|
iNOS 63.9 μM (IC50) |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MCF7 | IC50 |
4.28 μM
Compound: 8
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Cytotoxicity against human MCF7 cells by SRB assay
Cytotoxicity against human MCF7 cells by SRB assay
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[PMID: 23136829] |
| NCI-H460 | IC50 |
9.91 μM
Compound: 8
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Cytotoxicity against human NCI-H460 cells by SRB assay
Cytotoxicity against human NCI-H460 cells by SRB assay
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[PMID: 23136829] |
| SF-268 | IC50 |
5.54 μM
Compound: 8
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Cytotoxicity against human SF268 cells by SRB assay
Cytotoxicity against human SF268 cells by SRB assay
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[PMID: 23136829] |
In Vitro
Rabelomycin (100-10 mM; 30 minutes) dose-dependently inhibits partially purified iNOS enzyme from RAW 264.7 macrophage cell lysate with an IC50 of 63.9 μM[1].
Rabelomycin inhibits the growth of Escherichia coli ATCC 25922, Staphylococcus aureus ATCC 29213, Bacillus thuringiensis SCSIO BT01 and Bacillus subtilis SCSIO BS01, with MICs of 16 μg/mL, 1 μg/mL, 8 μg/mL and 16 μg/mL, respectively[3].
Rabelomycin inhibits the growth of SF-268, MCF-7, and NCI-H460 cells, with IC50 values of 5.54 μM, 4.28 μM, and 9.91 μM, respectively[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 28399-50-0
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분자량 338.31
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화학식 C19H14O6
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SMILES
O=C1C2=C(C[C@@](O)(C1)C)C=C(O)C(C(C3=C(O)C=CC=C34)=O)=C2C4=O
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Structure Classification
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Initial Source
Streptomyces sp.
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
[1]. Alvi KA, et al. Identification of inhibitors of inducible nitric oxide synthase from microbial extracts. J Antibiot (Tokyo). 2000;53(5):496-501. [Content Brief]
[2]. Yang K, et al. Accumulation of the angucycline antibiotic rabelomycin after disruption of an oxygenase gene in the jadomycin B biosynthetic gene cluster of Streptomyces venezuelae. Microbiology (Reading). 1996;142 ( Pt 1):123-132. [Content Brief]
[3]. Zhang W, et al. Fluostatins I-K from the South China Sea-derived micromonospora rosaria SCSIO N160. J Nat Prod. 2012 Nov 26;75(11):1937-43. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Rabelomycin Related Classifications
HY-114798 Related Classifications
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