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Cat. No.: HY-B1370A

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(S)-Hydroxychloroquine

(Synonyms: (S)-HCQ)

2 Cited Publications

고객리뷰

Based on 2 publication(s) in Google Scholar

(S)-Hydroxychloroquine ((S)-HCQ) is the enantiomer of Hydroxychloroquine. Hydroxychloroquine, a synthetic antimalarial agent, inhibits Toll-like receptor 7/9 (TLR7/9) signaling, and shows efficiently inhibits SARS-CoV-2 infection in vitro.

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CAS No.: 137433-24-0
화학식: C₁₈H₂₆ClN₃O
분자량:335.87

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

(S)-Hydroxychloroquine Chemical Structure

CAS No.: 137433-24-0

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Biological Activity

제품 설명

(S)-Hydroxychloroquine ((S)-HCQ) is the enantiomer of Hydroxychloroquine^[1]. Hydroxychloroquine, a synthetic antimalarial agent, inhibits Toll-like receptor 7/9 (TLR7/9) signaling, and shows efficiently inhibits SARS-CoV-2 infection in vitro^[2]^[3]^[4].

IC₅₀ & Target

Plasmodium

TLR7

TLR9

All Parasite Isoforms :

All Toll-like Receptor (TLR) Isoforms :

Chemical Information

CAS No. 137433-24-0
분자량 335.87
화학식 C₁₈H₂₆ClN₃O
SMILES

CCN(CCO)CCC[C@@H](NC1=CC=NC2=CC(Cl)=CC=C12)C
Synonyms

(S)-HCQ
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (2)

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Biochem Pharmacol

Agomelatine alleviates hypoxia-induced pulmonary arterial hypertension by activating mitophagy via the SIRT1/FoxO1/ULK1 signaling pathway. [Abstract]

2026 Feb:244:117624. PMID: 41360230
J Cell Mol Med

LRP5 regulates cardiomyocyte proliferation and neonatal heart regeneration by the AKT/P21 pathway. [Abstract]

2022 May;26(10):2981-2994. PMID: 35429093

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Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Cardoso CD, et al. Enantioselective analysis of the metabolites of hydroxychloroquine and application to an in vitro metabolic study. J Pharm Biomed Anal. 2005 Apr 1;37(4):703-8. [Content Brief]

[2]. Manzo C, et al. Psychomotor Agitation Following Treatment with Hydroxychloroquine. Drug Saf Case Rep. 2017 Dec;4(1):6. [Content Brief]

[3]. Lamphier M, et al. Novel small molecule inhibitors of TLR7 and TLR9: mechanism of action and efficacy in vivo. Mol Pharmacol. 2014 Mar;85(3):429-40. [Content Brief]

[4]. Yao X, et al. In Vitro Antiviral Activity and Projection of Optimized Dosing Design of Hydroxychloroquine for the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Clin Infect Dis. 2020 Mar 9. pii: ciaa237. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

(S)-Hydroxychloroquine

2 Cited Publications

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(S)-Hydroxychloroquine

High-Throughput Bioactive Compound Library

Publications Citing Use of MedChemExpress (MCE) (S)-Hydroxychloroquine

All Parasite Isoforms

All Toll-like Receptor (TLR) Isoforms

Biological Activity

Chemical Information

Publications (2)

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References

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Help & FAQs

(S)-Hydroxychloroquine

High-Throughput Bioactive Compound Library

Publications Citing Use of MedChemExpress (MCE) (S)-Hydroxychloroquine

All Parasite Isoforms

All Toll-like Receptor (TLR) Isoforms

Biological Activity

Chemical Information

Publications (2)

순도&문서

References

Calculators

Help & FAQs

(S)-Hydroxychloroquine Related Classifications

HY-B1370A Related Classifications