SET7-IN-DC21
SET7-IN-DC21 is a selective, potent SET7 inhibitor (IC50 = 15.93 μM; KD = 18.00 μM). SET7-IN-DC21 has good selectivity for several other epigenetic targets, such as SUV39H1, G9a, NSD1, DOT1L and MOF. SET7-IN-DC21 can be used for the researches of cancer, infection, inflammation, metabolic and cardiovascular disease, such as breast cancer.
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- CAS No.: 2567886-53-5
- 화학식: C12H8O5
- 분자량:232.19
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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All Histone Methyltransferase Isoforms
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MCF7 | IC50 |
25.84 μM
Compound: DC21
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Antiproliferative activity against human MCF7 cells expresses endogenous ER by Cell Titer-Glo based luminescence assay
Antiproliferative activity against human MCF7 cells expresses endogenous ER by Cell Titer-Glo based luminescence assay
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[PMID: 32173197] |
SET7-IN-DC21 (0.5-2.5 μM, 72 h) inhibits the proliferation of MCF7 cells in a dose-dependent manner (IC50 = 25.84 μM), and has little effect on the proliferation of normal cells, including normal embryonic lung fibroblast cell line MRC-5 and umbilical vascular endothelial cell line HUV-EC-C[1].
SET7-IN-DC21 (6.25-200 μM, 72 h) can decrease the stability of ERα, which leads to a decrease in ERα protein level in the MCF7 cell line in a dose-dependent manner[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MCF7 cells, HUV-EC-C cells, MRC-5 cells
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Concentration:0.5 μM, 1 μM, 1.5 μM, 2 μM, 2.5 μM
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Incubation Time:72 h
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Result:Inhibited the proliferation of MCF7 cells in a dose-dependent manner (IC50 = 25.84 μM), and had little effect on the proliferation of normal cells, including normal embryonic lung fibroblast cell line MRC-5 and umbilical vascular endothelial cell line HUV-EC-C.
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Cell Line:MCF7 cells
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Concentration:6.25 μM, 12.5 μM, 25 μM, 50 μM, 100 μM, 200 μM
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Incubation Time:72 h
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Result:Dose-dependently reduced the protein expression level of estrogen receptor α (ERα) in MCF7 cells.
Chemical Information
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CAS No. 2567886-53-5
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분자량 232.19
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화학식 C12H8O5
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SMILES
O=C(C=C1)C(C2=CC=C(C(OC)=O)O2)=CC1=O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SET7-IN-DC21 Related Classifications
HY-133567 Related Classifications
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