1. GPCR/G Protein
    Neuronal Signaling
  2. mGluR
  3. mGluR2 antagonist 1

mGluR2 antagonist 1 

Cat. No.: HY-133555
Handling Instructions

mGluR2 antagonist 1 is a highly potent, orally bioavailable and selective class of mGluR2 negative allosteric modulator (IC50 of 9 nM) with excellent brain permeability.

For research use only. We do not sell to patients.

mGluR2 antagonist 1 Chemical Structure

mGluR2 antagonist 1 Chemical Structure

CAS No. : 1432728-49-8

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Description

mGluR2 antagonist 1 is a highly potent, orally bioavailable and selective class of mGluR2 negative allosteric modulator (IC50 of 9 nM) with excellent brain permeability[1].

IC50 & Target[1]

mGluR2

9 nM (IC50)

In Vivo

In vivo, mGluR2 antagonist 1 (Compound 25) reverses the effect of mGluR2 agonist LY379268 in amphetamine-induced hyperlocomotion and shows good efficacy in the mouse delayed non-match to position assay at 10 mg/kg.

Molecular Weight

377.37

Formula

C₂₁H₁₆FN₃O₃

CAS No.

1432728-49-8

SMILES

NC(C1=NC2=CC(CN3C(CCC3=O)=O)=CC=C2C(C4=CC=C(F)C=C4)=C1)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

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Keywords:

mGluR2 antagonist 1mGluRMetabotropic glutamate receptorsMetabotropicglutamatereceptormGluR2CognitionAlzheimerInhibitorinhibitorinhibit

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mGluR2 antagonist 1
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