MAPK
Mitogen-activated protein kinases are the terminal modules of three-tier cascades, switched on by dual phosphorylation of a Thr-X-Tyr motif by MAP2Ks. The human family comprises the classical ERK1/2 (MAPK3 and MAPK1) proliferation module downstream of RAS-RAF-MEK, the stress-activated JNK1-3 and p38 alpha through delta branches that relay inflammatory and genotoxic signals, ERK5, and the atypical ERK3, ERK4 and ERK7/MAPK15 enzymes whose regulation departs from the classical modules. NLK, an evolutionarily divergent relative, modulates Wnt and Notch transcription. Substrate selectivity is enforced by docking grooves that bind D-motifs. Pharmacology is mature, with MEK inhibitors approved in oncology and p38 inhibitors extensively tested in inflammatory disease.
-
MAPK Recombinant Proteins (26)
p38 alpha/MAPK14 Protein, Human (Active, sf9, His)
0 Images
Cat. No.: HY-P73335
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: MAPK14; SAPK2A; Prev. CSBP1; Cytokine Suppressive Anti-Inflammatory Drug Binding Protein; Prev. CSBP2; Cytokine Suppressive Anti-Inflammatory Drug-Binding Protein; Prev. CSPB1; P38 Mitogen Activated Protein Kinase; Mitogen-Activated Protein Kinase P38 Alp
- Species:
- Source:
JNK1 Protein, Human (Inactive, sf9, GST)
0 Images
Cat. No.: HY-P73848
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: MAPK8; JNK-46; Prev. PRKM8; Stress-Activated Protein Kinase JNK1; SAPK1; Stress-Activated Protein Kinase JNK; JNK1; Stress-Activated Protein Kinase 1; JNK; JNK21B1/2; Stress-Activated Protein Kinase 1c; JNK1A2; C-Jun N-Terminal Kinase 1; MAPK 8; JUN N-Terminal Kinase; SAPK1C; MAP Kinase 8; Mitogen-Activated Protein Kinase 8; SAPK1c
- Species:
- Source:
MAPK1/ERK2 Protein, Human (Active, sf9, His)
0 Images
Cat. No.: HY-P75223
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: MAPK1; MAPK 2; Prev. PRKM1; ERT1; Prev. PRKM2; Mitogen-Activated Protein Kinase; ERK2; Protein Tyrosine Kinase ERK2; Extracellular Signal-Regulated Kinase 2; MAP Kinase Isoform P42; P41mapk; P42MAPK; MAPK2; MAPK 1; ERK; NS13; Mitogen-Activated Protein Kin
- Species:
- Source:
ERK1 Protein, Human (Active, GST)
0 Images
Cat. No.: HY-P701678
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: MAPK3; P44-MAPK; Prev. PRKM3; Extracellular Signal-Related Kinase 1; ERK1; Mitogen-Activated Protein Kinase; P44mapk; MAP Kinase Isoform P44; P44erk1; MAP Kinase 3; ERK-1; HS44KDAP; Extracellular Signal-Regulated Kinase 1; HUMKER1A; Microtubule-Associated
- Species:
- Source:
MAPK1/ERK2 Protein, Human (Active, Flag-His)
0 Images
Cat. No.: HY-P702735
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: MAPK1; MAPK 2; Prev. PRKM1; ERT1; Prev. PRKM2; Mitogen-Activated Protein Kinase; ERK2; Protein Tyrosine Kinase ERK2; Extracellular Signal-Regulated Kinase 2; MAP Kinase Isoform P42; P41mapk; P42MAPK; MAPK2; MAPK 1; ERK; NS13; Mitogen-Activated Protein Kin
- Species:
- Source:
MAPK8/JNK1 Protein, Human (Active, sf9, His-GST)
0 Images
Cat. No.: HY-P705996
Purity: ≥ 90%, as determined by reducing SDS-PAGE .
Synonyms: MAPK8; JNK-46; Prev. PRKM8; Stress-Activated Protein Kinase JNK1; SAPK1; Stress-Activated Protein Kinase JNK; JNK1; Stress-Activated Protein Kinase 1; JNK; JNK21B1/2; Stress-Activated Protein Kinase 1c; JNK1A2; C-Jun N-Terminal Kinase 1; MAPK 8; JUN N-Ter
- Species:
- Source:
p38 gamma/MAPK12 Protein, Human (sf9)
0 Images
Cat. No.: HY-P76532
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: MAPK12; Stress-Activated Protein Kinase 3; Prev. SAPK3; MAP Kinase 12; ERK6; MAPK 12; P38gamma; ERK-6; SAPK-3; Mitogen-Activated Protein Kinase 3; PRKM12; Mitogen-Activated Protein Kinase; Mitogen-Activated Protein Kinase P38 Gamma; ERK3; Extracellular Si
- Species:
- Source:
JNK3 Protein, Human (364a.a, His)
0 Images
Cat. No.: HY-P701790
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: MAPK10; MAP Kinase 10; Prev. PRKM10; JNK3A; JNK3; Stress Activated Protein Kinase Beta; P54bSAPK; Stress-Activated Protein Kinase JNK; P493F12; JNK3 Alpha Protein Kinase; Stress-Activated Protein Kinase JNK3; C-Jun Kinase 3; Stress-Activated Protein Kinase 1b; MAPK 10; C-Jun N-Terminal Kinase 3; SAPK1B; MAP Kinase P49 3F12; Mitogen-Activated Protein Kinase 10; SAPK1b
- Species:
- Source:
p38 delta/MAPK13 Protein, Human (Active, sf9, GST)
0 Images
Cat. No.: HY-P73334
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: MAPK13; Stress-Activated Protein Kinase 4; Prev. PRKM13; MAP Kinase 13; SAPK4; MAPK 13; P38delta; MAPK-13; Mitogen-Activated Protein Kinase P38 Delta; Mitogen-Activated Protein Kinase 13; MAP Kinase P38 Delta
- Species:
- Source:
NLK/Nemo Like Kinase Protein, Human (Active, sf9, His-GST)
p38 gamma/MAPK12 Protein, Human (sf9, His-GST)
0 Images
Cat. No.: HY-P76533
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: MAPK12; Stress-Activated Protein Kinase 3; Prev. SAPK3; MAP Kinase 12; ERK6; MAPK 12; P38gamma; ERK-6; SAPK-3; Mitogen-Activated Protein Kinase 3; PRKM12; Mitogen-Activated Protein Kinase; Mitogen-Activated Protein Kinase P38 Gamma; ERK3; Extracellular Si
- Species:
- Source:
ERK3 Protein, Human (Inactive, L290V)
0 Images
Cat. No.: HY-P701679
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: MAPK6; P97-MAPK; Prev. PRKM6; ERK-3; ERK3; Extracellular Signal-Regulated Kinase, P97; HsT17250; Protein Kinase, Mitogen-Activated 5; P97MAPK; Protein Kinase, Mitogen-Activated 6; Extracellular Signal-Regulated Kinase 3; MAP Kinase Isoform P97; MAP Kinase
- Species:
- Source:
ERK3 Protein, Human (Inactive, L290V, His)
0 Images
Cat. No.: HY-P701680
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: MAPK6; P97-MAPK; Prev. PRKM6; ERK-3; ERK3; Extracellular Signal-Regulated Kinase, P97; HsT17250; Protein Kinase, Mitogen-Activated 5; P97MAPK; Protein Kinase, Mitogen-Activated 6; Extracellular Signal-Regulated Kinase 3; MAP Kinase Isoform P97; MAP Kinase
- Species:
- Source:
P38β Protein, Human (Inactive, sf9)
0 Images
Cat. No.: HY-P701730
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: MAPK11; Mitogen-Activated Protein Kinase P38-2; Prev. PRKM11; Stress-Activated Protein Kinase 2b; P38-2; Stress-Activated Protein Kinase-2; SAPK2; Mitogen-Activated Protein Kinase; P38Beta; P38BETA2; Mitogen-Activated Protein Kinase P38 Beta; MAPK 11; MAP
- Species:
- Source:
P38β Protein, Human (Inactive, sf9, GST)
0 Images
Cat. No.: HY-P701731
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: MAPK11; Mitogen-Activated Protein Kinase P38-2; Prev. PRKM11; Stress-Activated Protein Kinase 2b; P38-2; Stress-Activated Protein Kinase-2; SAPK2; Mitogen-Activated Protein Kinase; P38Beta; P38BETA2; Mitogen-Activated Protein Kinase P38 Beta; MAPK 11; MAP
- Species:
- Source:
MAPK4 Protein, Human (sf9, His, GST)
0 Images
Cat. No.: HY-P701803
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: MAPK4; MAPK 4; Prev. PRKM4; Mitogen-Activated Protein Kinase; Erk3-Related; MAP Kinase Isoform P63; Erk4; MAP Kinase 4; Extracellular Signal-Regulated Kinase 4; P63MAPK; P63-MAPK; ERK4; Mitogen-Activated Protein Kinase 4; ERK-4
- Species:
- Source:
MAPK15 Protein, Human (Active, sf9, His-GST)
0 Images
Cat. No.: HY-P702934
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: MAPK15; MAPK 15; Mitogen-Activated Protein Kinase 15; ERK-7; ERK8; ERK-8; ERK7; Extracellular Signal Regulated Kinase 8; Extracellular Signal-Regulated Kinase 7; Extracellular Regulated Kinase 8 Delta; Extracellular Signal-Regulated Kinase 8; Mitogen-Acti
- Species:
- Source:
JNK1 Protein, Mouse (GST)
0 Images
Cat. No.: HY-P703020
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: MAPK8; JNK-46; Prev. PRKM8; Stress-Activated Protein Kinase JNK1; SAPK1; Stress-Activated Protein Kinase JNK; JNK1; Stress-Activated Protein Kinase 1; JNK; JNK21B1/2; Stress-Activated Protein Kinase 1c; JNK1A2; C-Jun N-Terminal Kinase 1; MAPK 8; JUN N-Ter
- Species:
- Source:
MAPK7 Protein, Human
0 Images
Cat. No.: HY-P703179
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: MAPK7; BMK1 Kinase; Prev. PRKM7; BMK-1; BMK1; ERK-5; ERK5; Extracellular Signal-Regulated Kinase 5; Extracellular-Signal-Regulated Kinase 5; Mitogen-Activated Protein Kinase; Big MAP Kinase 1; ERK4; MAP Kinase 7; Mitogen-Activated Protein Kinase 7; MAPK 7
- Species:
- Source:
MAPK8/JNK1 Protein, Human
0 Images
Cat. No.: HY-P705577
Synonyms: MAPK8; JNK-46; Prev. PRKM8; Stress-Activated Protein Kinase JNK1; SAPK1; Stress-Activated Protein Kinase JNK; JNK1; Stress-Activated Protein Kinase 1; JNK; JNK21B1/2; Stress-Activated Protein Kinase 1c; JNK1A2; C-Jun N-Terminal Kinase 1; MAPK 8; JUN N-Ter
- Species:
- Source:
- 1
- 2
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- 1
- 2
Capetin (28-54), human
0 Images
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
