Cat. No.: HY-66018

Palmitoyl tripeptide-5 diTFA

Name: Palmitoyl tripeptide-5 diTFA
Brand: MedChemExpress
SKU: HY-66018
Price: 40.00 USD
Availability: InStock
Rating: 5 (1 reviews)

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Palmitoyl tripeptide-5 diTFA is a Thrombospondin I mimetic peptide. Palmitoyl tripeptide-5 diTFA specifically stimulates the synthesis of type I, III, and IV Collagen. Palmitoyl tripeptide-5 diTFA inhibits the expression of matrix metalloproteinases (MMP) through TGF-β-related signaling pathways. Palmitoyl tripeptide-5 diTFA scavenges free radicals. Palmitoyl tripeptide-5 diTFA can be used in research on skin aging.

For research use only. We do not sell to patients.

Purity : 99.64%
CAS No.: 623172-56-5
Formula: C₃₇H₆₇F₆N₅O₉
Molecular Weight:839.96

Storage:

Sealed storage, away from moisture.

Powder -80°C, 2 years , -20°C, 1 year

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Palmitoyl tripeptide-5 diTFA Chemical Structure

CAS No.: 623172-56-5

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

^[7]

Collagen I

Collagen III

Collagen IV

All TGF-β Receptor Isoforms :

All MMP Isoforms :

In Vitro

Oxidative StressOthers

Oxidative Stress

Palmitoyl tripeptide-5 diTFA spherical peptide nanospheres produce approximately twice the free radical scavenging effect of free Palmitoyl tripeptide-5 in the cell-free DPPH assay^[3].

Others

Palmitoyl tripeptide-5 diTFA spherical peptide nanospheres (0.625-10 ppm; 24 h) maintain HSF and HaCaT cell viability at >90%, indicating cytocompatibility^[3].
Palmitoyl tripeptide-5 diTFA is encapsulated by CPA-NLP, with an encapsulation efficiency of 92.3%^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[3]

Cell Line:

HSF and HaCaT cells
Concentration:

0.625, 1.25, 2.5, 5, 10 ppm
Incubation Time:

24 h
Result:

Cell viability remained above 90% in both HSF and HaCaT at all tested concentrations.
No evident cytotoxicity was observed.

In Vivo

Palmitoyl tripeptide-5 diTFA nanoparticles (Aqueous immersion; 24 h) enhanced collagen-related gene expression in developing zebrafish embryos^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

CAS No. 623172-56-5
Appearance Solid
Molecular Weight 839.96
Formula C₃₇H₆₇F₆N₅O₉
Color White to off-white
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (119.05 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.1905 mL

5.9527 mL

11.9053 mL

5 mM

0.2381 mL

1.1905 mL

2.3811 mL

10 mM

0.1191 mL

0.5953 mL

1.1905 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

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Volume _(final) Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Working solution concentration: 0.22 mg/mL

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Schneider A L. Evaluation of the penetration and efficacy of topical anti-aging compounds[D]. Monash University, 2010.

[2]. Wang M, et al. Pioneering ionic liquids in neuro-soothing: Enhanced transdermal delivery of collagen peptides and their synergistic anti-aging functions. Materials Today Bio. 2025 Apr 1;31:101527. [Content Brief]

[3]. Zhang L, et al. A Reverse Micellar Peptide Nanosphere Strategy Enhancing Transdermal Delivery and Anti-Aging Performance of Palmitoyl Tripeptide-5. Journal of Dermatologic Science and Cosmetic Technology. 2026 May 20:100172.

[4]. Han F, et al. Nanoliposomes codelivering bioactive peptides produce enhanced anti-aging effect in human skin. Journal of Drug Delivery Science and Technology. 2020 Jun 1;57:101693.

[5]. Yang F, et al. Clinical Evaluation of a Multi‐Component Facial Mask for Moisturizing, Repairing, and Anti‐Aging Effects. Journal of Cosmetic Dermatology. 2025 Aug;24(8):e70355.

[6]. Pai VV, et al. Topical peptides as cosmeceuticals. Indian journal of dermatology, venereology and leprology. 2017;83(1):9-18. [Content Brief]

[7]. Karpuzoglu E. How Peptides Strengthen Skin Barrier[J].

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.1905 mL	5.9527 mL	11.9053 mL	29.7633 mL
	5 mM	0.2381 mL	1.1905 mL	2.3811 mL	5.9527 mL
	10 mM	0.1191 mL	0.5953 mL	1.1905 mL	2.9763 mL
	15 mM	0.0794 mL	0.3968 mL	0.7937 mL	1.9842 mL
	20 mM	0.0595 mL	0.2976 mL	0.5953 mL	1.4882 mL
	25 mM	0.0476 mL	0.2381 mL	0.4762 mL	1.1905 mL
	30 mM	0.0397 mL	0.1984 mL	0.3968 mL	0.9921 mL
	40 mM	0.0298 mL	0.1488 mL	0.2976 mL	0.7441 mL
	50 mM	0.0238 mL	0.1191 mL	0.2381 mL	0.5953 mL
	60 mM	0.0198 mL	0.0992 mL	0.1984 mL	0.4961 mL
	80 mM	0.0149 mL	0.0744 mL	0.1488 mL	0.3720 mL
	100 mM	0.0119 mL	0.0595 mL	0.1191 mL	0.2976 mL

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Palmitoyl tripeptide-5 diTFA

All TGF-β Receptor Isoforms

All MMP Isoforms