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Art. -Nr.: HY-184597

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PARP1-IN-57

PARP1-IN-57 is a selective PARP1 inhibitor, with an IC₅₀ of 5 nM against PARP1. PARP1-IN-57 can be used in cancer-related research.

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CAS. Nr.: 3081722-98-4
Formel: C₂₅H₂₄F₂N₄O₄
Molecular Weight:482.48

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

PARP1-IN-57 Chemical Structure

CAS. Nr.: 3081722-98-4

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

PARP1-IN-57 is a selective PARP1 inhibitor, with an IC₅₀ of 5 nM against PARP1. PARP1-IN-57 can be used in cancer-related research^[1].

IC₅₀ & Target^[1]

PARP-1

5 nM (IC₅₀)

Alle PARP Isoform-spezifische Produkte anzeigen :

In Vitro

PARP1-IN-57 (compound 3) exhibits significant inhibitory activity against recombinant PARP1 enzyme (IC₅₀ = 8 nM), while it shows only extremely weak inhibitory activity against recombinant PARP2 enzyme (IC₅₀ > 100 μM)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 3081722-98-4
Molecular Weight 482.48
Formel C₂₅H₂₄F₂N₄O₄
SMILES

O=C(NC1CC1)C(N=C2F)=CC=C2OC([C@H]3C)CN3CC4=CC=C(C(OCC5)=C5C(N6)=O)C6=C4F
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Zhou X, et al. Development of Selective PARP1 Inhibitors for Treatment of Cancer. ACS medicinal chemistry letters. 2025 Oct 09;16(10):1914-1917. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
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PARP1-IN-57

Alle PARP Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

PARP1-IN-57 Related Classifications

HY-184597 Related Classifications