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  3. PROTAC BRD4 Degrader-15

PROTAC BRD4 Degrader-15 

Cat. No.: HY-139294
Handling Instructions

PROTAC BRD4 Degrader-15 is a potent BRD4 degrader, with IC50s of 7.2 nM and 8.1 nM for BRD4 BD1 and BD2, respectively. PROTAC BRD4 Degrader-15 is capable of potently degrading the BRD4 protein in PC3 prostate cancer cells.

For research use only. We do not sell to patients.

PROTAC BRD4 Degrader-15 Chemical Structure

PROTAC BRD4 Degrader-15 Chemical Structure

CAS No. : 2417370-67-1

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Description

PROTAC BRD4 Degrader-15 is a potent BRD4 degrader, with IC50s of 7.2 nM and 8.1 nM for BRD4 BD1 and BD2, respectively. PROTAC BRD4 Degrader-15 is capable of potently degrading the BRD4 protein in PC3 prostate cancer cells[1].

IC50 & Target[1]

BRD4 BD1

7.2 nM (IC50)

BRD4 BD2

8.1 nM (IC50)

In Vitro

PROTAC BRD4 Degrader-15 (compound 13) (4 h) inhibits suppresses MYC gene transcript in MV4-11 AML cells, with an IC50 of 15 nM[1].
PROTAC BRD4 Degrader-15 (6 days) inhibits the proliferation of HL-60 and PC3-S1 cells, with an IC50 of 4.2 nM and 91 nM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

1149.29

Formula

C₅₇H₆₂F₂N₁₀O₁₀S₂

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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PROTAC BRD4 Degrader-15
Cat. No.:
HY-139294
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