PZ-1129
PZ-1129 is a selective 5-HT7 receptor ligand with a Ki of 7 nM. PZ-1129 shows Ki values of 159 and 24 nM for 5-HT1A receptor and D2 receptor. PZ-1129 can inhibit the constitutive cAMP production mediated by the Gs signaling pathway (EC50 = 13.7 nM). PZ-1129 can be used for the research of emotional disorders, such as depression and bipolar disorder.
For research use only. We do not sell to patients.
- CAS No.: 1919029-61-0
- Formula: C25H27FN2O3S
- Molecular Weight:454.56
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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5-HT7 Receptor 7 nM (Ki) |
D2 Receptor 24 nM (Ki) |
5-HT1A Receptor 159 nM (Ki) |
5-HT2A Receptor 113 nM (Ki) |
5-HT6 Receptor 524 nM (Ki) |
Chemical Information
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CAS No. 1919029-61-0
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Molecular Weight 454.56
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Formula C25H27FN2O3S
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SMILES
O=S(NC1CCN(CC1)CCOC2=C(C3=CC=CC=C3)C=CC=C2)(C4=CC=C(C=C4)F)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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