2. Epigenetics
  3. Histone Methyltransferase
  4. RL5a

RL5a (compund C23) is a SETD8 inhibitor.

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RL5a

RL5a Chemical Structure

CAS No. : 133671-66-6

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Based on 1 publication(s) in Google Scholar

RL5a Related Antibodies

Top Publications Citing Use of Products

View All Histone Methyltransferase Isoform Specific Products:

View All Isoforms
EZH1 EZH2 DOT1L SMYD2 SMYD3 SUV39H2/KMT1B EHMT2/G9a/KMT1C EHMT1/GLP/KMT1D ASH1L/KMT2H SETDB1/KMT2G SETD2/KMT3A NSD2/MMSET/WHSC1 NSD3/WHSC1L1 SETD7/KMT7 SETD8/KMT5A PRMT1 PRMT3 PRMT4 PRMT5 PRMT6 PRMT7 PRMT8

  • Biological Activity

  • Purity & Documentation

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  • Customer Review

Description

RL5a (compund C23) is a SETD8 inhibitor[1].

IC50 & Target

SETD8[1]
Molecular Weight

281.35

Formula

C17H19N3O
CAS No.
Appearance

Solid

Color

Light yellow to light brown

SMILES

CN(C)CCNC1=CC(C2=CC=CO2)=NC3=CC=CC=C13
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 40 mg/mL (142.17 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5543 mL 17.7715 mL 35.5429 mL
5 mM 0.7109 mL 3.5543 mL 7.1086 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.6%

SDS (251 KB)

COA (251 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.5543 mL 17.7715 mL 35.5429 mL 88.8573 mL
5 mM 0.7109 mL 3.5543 mL 7.1086 mL 17.7715 mL
10 mM 0.3554 mL 1.7771 mL 3.5543 mL 8.8857 mL
15 mM 0.2370 mL 1.1848 mL 2.3695 mL 5.9238 mL
20 mM 0.1777 mL 0.8886 mL 1.7771 mL 4.4429 mL
25 mM 0.1422 mL 0.7109 mL 1.4217 mL 3.5543 mL
30 mM 0.1185 mL 0.5924 mL 1.1848 mL 2.9619 mL
40 mM 0.0889 mL 0.4443 mL 0.8886 mL 2.2214 mL
50 mM 0.0711 mL 0.3554 mL 0.7109 mL 1.7771 mL
60 mM 0.0592 mL 0.2962 mL 0.5924 mL 1.4810 mL
80 mM 0.0444 mL 0.2221 mL 0.4443 mL 1.1107 mL
100 mM 0.0355 mL 0.1777 mL 0.3554 mL 0.8886 mL
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RL5a Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RL5a133671-66-6Histone MethyltransferaseInhibitorinhibitorinhibit

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