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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
85 Results for "
Advanced glycation
" in MedChemExpress (MCE) Product Catalog:
Products (85)
85 Results for "Advanced glycation" in MCE Product Catalog:
1
1 Cited Publications
Cat. No.: HY-N7628
CAS No.: 119170-52-4
Synonyms: Toralactone 9-O-β-D-gentiobioside
Category:
Cassia tora (L.) Roxb. Monophenols Metabolic Disease Phenols Leguminosae Extract Plants Disease Research Fields
Target:
1
Target:
Research Areas:
Tenilsetam (CAS 997) is an antidementia compound. Tenilsetam is an advanced glycation end product (AGE) inhibitor. Tenilsetam inhibits early retinopathy in experimental diabetes rats .
1
1 Cited Publications
Cat. No.: HY-P79079
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: LGALS3; MAC-2; Prev. LGALS2; MAC2; GALIG; Galactoside-Binding Protein; Epididymis Secretory Sperm Binding Protein; MAC-2 Antigen; Advanced glycation End-Product Receptor 3; Mac-2 Antigen; Lectin, Galactoside-Binding, Soluble, 3; Galectin; Carbohydrate-Binding Protein 35; CBP 35; Galactose-Specific Lectin 3; CBP35; Laminin-Binding Protein; Gal-3; IgE-Binding Protein; GAL3; 35 KDa Lectin; L-31; Lectin L-29; L31; Galectin-3; Galectin 3; GALBP
Species:
Mouse
Source:
E. coli
Target:
Cat. No.: HY-NP165
Synonyms: AGEs
Synonyms: LC15-0444 tartrate
Target:
Research Areas:
Gemigliptin tartrate (LC15-0444 tartrate) is a highly selective, reversible and competitive dipeptidyl peptidase-4 (DPP-4) inhibitor, with an IC50 of 10.3 nM for human recombinant DPP-4. Gemigliptin tartrate exhibits potent anti-glycation properties. Gemigliptin tartrate can be used for the research of advanced glycation end products (AGE)-related diabetic complications .
Target:
Research Areas:
Bromelain is an anti-inflammatory agent derived from pineapple stem that acts through down-regulation of plasma kininogen, inhibition of Prostaglandin E2 expression, degradation of advanced glycation end product receptors and regulation of angiogenic biomarkers as well as antioxidant action upstream in the COX-pathway . Bromelain exhibits various fibrinolytic, antiedematous, antithrombotic, and anti-inflammatory activities. Bromelain also possesses some anticancerous activities and promotes apoptotic cell death .
Cat. No.: HY-W019724
CAS No.: 563-96-2
Category:
Flavonols Flavonoids Metabolic Disease Phenols Polyphenols Plants Other Families Extract Disease Research Fields
Target:
Cat. No.: HY-76383
CAS No.: 245075-84-7
Target:
Research Areas:
LR-90 is an advanced glycation end product (AGE) inhibitor, inhibits inflammatory responses in human monocytes . LR-90 is also used in the research of diabetic animal model .
Cat. No.: HY-N1470
CAS No.: 78708-33-5
Category:
Flavonoids Plantaginaceae Extract Flavonones Metabolic Disease Phenols Polyphenols Plantago asiatica L. Plants Disease Research Fields
Target:
Cat. No.: HY-14892
CAS No.: 911637-19-9
Synonyms: LC15-0444
Target:
Research Areas:
Gemigliptin (LC15-0444 ) is a highly selective, reversible and competitive dipeptidyl peptidase-4 (DPP-4) inhibitor, with an IC50 of 10.3 nM for human recombinant DPP-4. Gemigliptin exhibits potent anti-glycation properties. Gemigliptin can be used for the research of advanced glycation end products (AGE)-related diabetic complications .
Target:
Cat. No.: HY-113033
CAS No.: 124505-87-9
Target:
Target:
Aminoguanidine (Pimagedine) is an inhibitor of diamine oxidase (DAO) and nitric oxide synthase (NOS). Aminoguanidine can reduce the formation of advanced glycation end products (AGEs). Aminoguanidine has a dose-dependent inhibitory effect on Doxorubicin (HY-15142)-induced cell apoptosis. Aminoguanidine has antioxidant properties. Aminoguanidine can be used in the research of diabetic nephropathy .
Synonyms: L-Homocarnosine TFA
Target:
Cat. No.: HY-W585874
CAS No.: 5746-03-2
Research Areas:
Nε-(Carboxyethyl) lysine is an advanced glycation end product (AGE). Nε-(Carboxyethyl) lysine induces cross-linking between proteins, thereby affecting protein structure and function and causing protein denaturation. Nε-(Carboxyethyl) lysine binds to the RAGE receptor, affects cell signal transduction, and regulates processes such as inflammatory responses, cell proliferation, and apoptosis. Nε-(Carboxyethyl) lysine affects glutamate transporters, reduces glutamate uptake and S100β protein secretion, influences neurotransmission in the nervous system, and exhibits diabetes-related neurotoxicity .
Target:
Aldose Reductase Glutathione Reductase (GR) p38 MAPK ERK JNK Reactive Oxygen Species (ROS) Apoptosis Drug Intermediate
Research Areas:
Cardiovascular Disease Neurological Disease Metabolic Disease
Glyoxal (40% w/w in water) is an α-oxoaldehyde that inhibits Aldose Reductase, Glutathione Reductase, and NADPH synthase. Glyoxal (40% w/w in water) exhibits cytotoxicity, triggers oxidative stress, induces ROS accumulation, lipid peroxidation, mitochondrial membrane potential collapse, DNA damage, apoptosis, and massive production of advanced glycation end products (AGEs). Glyoxal (40% w/w in water) depletes glutathione and activates MAPK phosphorylation. It has lower toxicity as a fixative than paraformaldehyde (PFA) and serves as a precursor for the synthesis of oxalates and dietary carcinogens. Glyoxal (40% w/w in water) is suitable for research related to calcium oxalate kidney stones, diabetes, atherosclerosis, cardiovascular diseases, retinopathy, and cataracts .
Cat. No.: HY-N8375
CAS No.: 18777-73-6
Category:
Balanophora involucrata Hook. f. Plants Saccharides Balanophoraceae Extract Monosaccharides
Target:
Target:
Research Areas:
Acetohydroxamic acid (Standard) is the analytical standard of Acetohydroxamic acid. This product is intended for research and analytical applications. Acetohydroxamic acid is the inhibitor for bacterial and plant urease that can be used for chronic urinary tract infections. Acetohydroxamic acid selectively inhibits arachidonic acid 5-lipoxygenase that is useful in the research of asthma. Acetohydroxamic acid inhibits the formation of advanced glycation end products, and reduces oxidative stress and inflammatory responses. Acetohydroxamic acid exhibits antiviral activity against HIV .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
