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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
1431 Results for "
fluorometric imaging plate reader
" in MedChemExpress (MCE) Product Catalog:
Products (1431)
1431 Results for "fluorometric imaging plate reader" in MCE Product Catalog:
Cat. No.: HY-NP163A
Synonyms: WGA-AF488
Cat. No.: HY-P11287A
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Cat. No.: HY-P5362A
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Cat. No.: HY-P992340
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Cat. No.: HY-113553
CAS No.: 102185-28-4
Synonyms: (p-Aminophenyl)phosphocholine; p-Aminophenylphosphorylcholine; 4-APPC
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4-Aminophenylphosphorylcholine ((p-Aminophenyl) phosphocholine; p-Aminophenylphosphorylcholine; 4-APPC) is a phosphatidylcholine derivative that serves as a coupling ligand and antigen probe. When conjugated with gold nanoclusters, the phosphocholine head epitope of 4-Aminophenylphosphorylcholine is specifically recognized by anti-Pc IgM and CRP. It can be covalently coupled to human serum albumin (HSA) or glutathione-protected gold nanoclusters (Au-GSH) via covalent chemistry, respectively. The 4-Aminophenylphosphorylcholine-HSA complex acts as an ELISA coating antigen for detecting endogenous anti-Pc IgM antibodies in plasma; 4-Aminophenylphosphorylcholine-modified Au-GSH can be used to construct an ultra-stealthy NIR-II fluorescent gold nanocluster probe for imaging-related studies in mouse breast cancer and colon cancer models .
Cat. No.: HY-131025
CAS No.: 1811539-88-4
Synonyms: JF585, SE; JF585, NHS
Synonyms: JF646, Tetrazine
Cat. No.: HY-141637S
CAS No.: 478518-95-5
Cat. No.: HY-160184
CAS No.: 524699-85-2
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COX-1-IN-5 (example 13, compound PS13) is a potent and selective COX-1 inhibitor (COX-1 IC50 = 1 nM, COX-2 IC50 > 0.1 μM) exhibiting >1000-fold selectivity over COX-2. COX-1-IN-5 possesses strong anti-inflammatory, antipyretic, analgesic, antithrombotic, anti-cancer activities. COX-1-IN-5 can be used for COX-mediated diseases research, such as inflammatory conditions and pain. COX-1-IN-5 radiolabeled with 11C can be used as a selective PET tracer for whole‑body imaging of COX‑1 distribution and target engagement in vivo .
Cat. No.: HY-165424
CAS No.: 3036456-18-2
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Cat. No.: HY-165426
CAS No.: 3031522-14-9
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HB-230 is a Transglutaminase-2 (TG2) (human IC50 = 4.9 μM) inhibitor and a selective fluorescent imaging probe for active TG2 localization. HB-230 modifies TG2 Cys277 to sustain the enzyme open conformation. HB-230 forms a ternary complex with TG2 and α2-macroglobulin, undergoes receptor-mediated endocytosis, and trafficks directly to lysosomes without early/late endosome fusion. HB-230 exhibits TG2 activity-dependent and α2-macroglobulin-dependent uptake. HB-230 can be used for the research of celiac disease, (Ex/Em = 649/665 nm) .
Cat. No.: HY-174322
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SHP2-IN-38 is a novel green-fluorescent SHP2 inhibitor with IC50 values of 2.89 μM (SHP2), 8.73 μM (SHP1), 11.08 μM (PTP1B), 33.07 μM (TCPTP). SHP2-IN-38 blocks the SHP2-mediated ERK signaling pathway and inhibits MV4-11 cells proliferation in vitro with IC50 of 7.90 μM. SHP2-IN-38 has an excitation wavelength of 360 nm, with a maximum emission wavelength of 550 nm in DMSO and 540 nm in DMF. SHP2-IN-38 shows green fluorescence imaging in HeLa cells and zebrafish.
Cat. No.: HY-19888
CAS No.: 1001389-72-5
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GSK-1482160 is an orally active and blood-brain barrier penetrant P2X7 receptor (P2X7R) negative allosteric modulator with pIC50s of 8.5 (human) and 6.5 (rat). GSK-1482160 reduces the efficacy of ATP at the P2X7 receptor without affecting its affinity, thereby inhibiting the release of IL-1β. GSK-1482160 is an effective radioligand and can be labeled with radioactive isotopes like 11C or 18F to image P2X7R. GSK-1482160 can be used for the studies of chronic joint pain and chronic constriction injury (CCI) .
Cat. No.: HY-400882
CAS No.: 958233-17-5
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Tosylate-DPA-714 is a GMP-grade precursor for the radiosynthesis of DPA-714 (HY-122607). It crosses the blood-brain barrier and exhibits steroidogenic activity. DPA-714 is a specific ligand for the 18 kDa translocator protein (TSPO) with a Ki of 7.0 nM. Tosylate-DPA-714 is safe and does not bind to central benzodiazepine receptors (benzodiazepine receptor). As a radiolabeling precursor, Tosylate-DPA-714 reacts with 18F via nucleophilic aliphatic substitution to form 18F-DPA-714, enabling specific targeted binding to TSPO. 18F-DPA-714 accurately reflects the level of neuroinflammation mediated by microglial activation, and is used for PET molecular imaging of neurological diseases such as Alzheimer's disease and multiple sclerosis .
Cat. No.: HY-D0920
CAS No.: 166196-17-4
Cat. No.: HY-D1991
CAS No.: 906664-68-4
Cat. No.: HY-D3108
CAS No.: 2569032-08-0
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BV-1 is a fluorescent probe for viscosity detection and imaging in living cells. BV-1 can be used to detect changes in intracellular viscosity and mitochondrial viscosity in living cells. BV-1 responds to environmental viscosity via a molecular rotor mechanism. In a low-viscosity environment, the centrally located unsaturated structure induces a twisted intramolecular charge transfer (TICT) state and promotes non-radiative transitions, resulting in fluorescence quenching; when viscosity increases, molecular rotation is restricted, the TICT state is attenuated, and fluorescence is enhanced with a red shift. BV-1 can be used for real-time monitoring of changes in cytoplasmic viscosity and the viscosity increase during cell apoptosis. Ex/Em = 480/570 nm .
Cat. No.: HY-D3189
CAS No.: 2370825-44-6
Cat. No.: HY-D3197
Cat. No.: HY-D3351
CAS No.: 2668963-61-7
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PNO1 is a fluorescent probe for pulmonary fibrosis detection. The detection mechanism of PNO1 relies on sensing upregulated nitric oxide (NO) in the pulmonary fibrosis (PF) microenvironment. PNO1 contains an aniline group that reacts with NO or its derivatives under acidic conditions to form an N-nitrosylated intermediate, which is subsequently converted into a diazonium salt and undergoes deamination, eliminating the intramolecular electron transfer quenching effect and triggering a fluorescence turn-on response. The excitation wavelength of PNO1 includes 545 nm in in vitro solution studies, while an excitation range of 520-550 nm is used for cell, tissue and in vivo imaging; its emission wavelength centers at 572 nm in the unreacted state, and shifts to 559 nm with enhanced fluorescence intensity upon binding to NO. PNO1 can be used for pulmonary fibrosis research .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
