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ATPase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Na+/K+ ATPase (108) 11β-HSD (1) 5-HT Receptor (1) ABA Receptor (3) Akt (7) Aldose Reductase (1) Amino Acid Derivatives (1) AMPK (1) Amyloid-β (3) Antibiotic (24) Apoptosis (101) Aryl Hydrocarbon Receptor (1) Atg8/LC3 (12) ATP Synthase (19) Autophagy (47) Bacterial (84) BCRP (11) Beclin1 (2) Biochemical Assay Reagents (7) Calcium Channel (35) Calmodulin (2) CaMK (1) Caspase (5) Cathepsin (1) CDK (7) CFTR (1) Checkpoint Kinase (Chk) (1) Cholinesterase (ChE) (2) COX (3) Cytochrome P450 (15) Dengue Virus (1) Dihydroorotate Dehydrogenase (2) DNA Alkylator/Crosslinker (1) DNA Glycosylase (1) DNA/RNA Synthesis (28) Drug Derivative (5) Drug Intermediate (2) Drug Metabolite (9) Dynamin (1) E1/E2/E3 Enzyme (1) EAAT (1) EGFR (5) EHD Protein (1) Endogenous Metabolite (22) Enterovirus (2) Environmental Pollutants (7) Epigenetic Reader Domain (12) ERK (4) Estrogen Receptor/ERR (8) Eukaryotic Initiation Factor (eIF) (1) Exosomes (4) Ferroptosis (2) Fluorescent Dye (6) Fructose-1,6-bisphosphate aldolase (1) Fungal (26) GCGR (1) Glutathione Peroxidase (3) GSK-3 (2) HCN Channel (2) HCV (1) Hedgehog (1) Heme Oxygenase (HO) (2) HIF/HIF Prolyl-Hydroxylase (2) HIV (2) HIV Integrase (1) HSP (37) HSV (6) IFNAR (2) IKK (1) Influenza Virus (1) Insecticide (4) Interleukin Related (17) IRAK (2) Isotope-Labeled Compounds (43) JAK (1) Keap1-Nrf2 (2) Kinesin (15) Ligands for Target Protein for PROTAC (3) Lipoxygenase (2) LXR (1) MDM-2/p53 (2) Microtubule/Tubulin (4) Mitochondrial Metabolism (4) Mitophagy (2) MMP (1) mRNA (1) mTOR (1) Myosin (24) Necroptosis (1) NF-κB (11) NKCC (1) NO Synthase (2) NOD-like Receptor (NLR) (9) NTPDase (4) Nuclear Factor of activated T Cells (NFAT) (1) Oxidative Phosphorylation (7) P-glycoprotein (14) P2X Receptor (2) p38 MAPK (4) p97 (17) PAI-1 (2) Parasite (17) PARP (1) PD-1/PD-L1 (1) PERK (1) Phosphatase (5) Phosphodiesterase (PDE) (5) Phospholipase (1) PI3K (3) PKA (2) PKC (3) PKG (2) Polo-like Kinase (PLK) (1) Potassium Channel (7) Prostaglandin Receptor (4) PROTACs (3) Proton Pump (128) PTHR (1) Ras (1) Reactive Oxygen Species (ROS) (6) Reference Standards (63) RIO Kinase (1) RSV (3) SARS-CoV (8) Small Interfering RNA (siRNA) (1) SOD (2) Sodium Channel (3) SphK (1) STAT (3) STING (1) SWI/SNF Complex (5) Tau Protein (2) TGF-beta/Smad (2) Thrombin (2) Thyroid Hormone Receptor (2) TNF Receptor (12) Toll-like Receptor (TLR) (3) TOPK (5) Topoisomerase (5) TRP Channel (6) ULK (1) Virus Protease (1) VSV (1)
By Research Areas:	Cancer (251) Cardiovascular Disease (65) Endocrinology (26) Infection (118) Inflammation/Immunology (106) Metabolic Disease (85) Neurological Disease (68)
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Inhibitors & Agonists

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Targets Recommended: Na+/K+ ATPase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-13757

Tamoxifen Citrate 225+ Cited Publications ICI 46474; (Z)-Tamoxifen Citrate; trans-Tamoxifen Citrate	Estrogen Receptor/ERR HSP Autophagy Apoptosis	Infection Neurological Disease Inflammation/Immunology Cancer
Tamoxifen Citrate (ICI 46474) is an orally active, selective estrogen receptor modulator (SERM) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells.Tamoxifen Citrate is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen Citrate also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC₅₀ of 0.1 μM and 1.8 μM, respectively. Tamoxifen Citrate activates autophagy and induces apoptosis. Tamoxifen Citrate can also be used to induce gene knockout in CreER transgenic mice .

HY-N1446B

Oleic acid sodium 60+ Cited Publications Sodium oleate; 9-cis-Octadecenoic acid sodium; 9Z-Octadecenoic acid sodium	Environmental Pollutants Apoptosis Na+/K+ ATPase	Metabolic Disease Cancer
Sodium oleate (Oleic acid sodium) is an abundant monounsaturated fatty acid sodium . Sodium oleate is a Na ⁺/K ⁺ ATPase activator .

HY-119374

BRM/BRG1 ATP Inhibitor-1 35+ Cited Publications	Epigenetic Reader Domain	Cancer
BRM/BRG1 ATP Inhibitor-1 (compound 14) is an orally active allosteric dual brahma homolog (BRM)/SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily A member 2 (SMARCA2) and brahma related gene 1 (BRG1)/SMARCA4 ATPase activity inhibitor, both IC₅₀s are below 0.005 µM. BRM/BRG1 ATP Inhibitor-1 has anticancer activity .

HY-W019981C

Magnesium chloride hexahydrate, for cell culture MgCl2 hexahydrate, for cell culture	Calcium Channel Biochemical Assay Reagents	Metabolic Disease
Magnesium chloride hexahydrate (MgCl₂ hexahydrate), for cell culture is the hexahydrate form of magnesium dichloride. Magnesium chloride hexahydrate, for cell culture can be used as a source of magnesium ion and a co-foactor for many enzymes. Magnesium chloride hexahydrate, for cell culture increases the activity of Ca ²⁺ ATPase .

HY-12861

CB-5083 45+ Cited Publications	p97	Cancer
CB-5083 is a first-in-class, potent, selective, and orally bioavailable inhibitor of the p97 AAA ATPase/VCP. CB-5083 selectively inhibits p97 through its D2 site with the IC₅₀ of 11 nM .

HY-122632

Ciliobrevin D 4 Publications Verification	Hedgehog	Cancer
Ciliobrevin D is a cell-permeable, reversible and specific inhibitor of AAA+ ATPase motor cytoplasmic dynein. Ciliobrevin D inhibits Hedgehog (Hh) signaling and primary cilia formation. Ciliobrevin D inhibits dynein-dependent microtubule gliding and ATPase activity in vitro .

HY-169422

GSK4418959 IDE275	DNA/RNA Synthesis	Cancer
GSK4418959 (IDE275) is a selective, reversible and orally active WRN helicase inhibitor. GSK4418959 shows >10,000-fold selectivity over other helicases. GSK4418959 inhibits ATPase and DNA unwinding functions in an ATP-competitive manner. GSK4418959 can be used for the study of microsatellite instability-high (MSI-H) cancer, such as colorectal cancer (CRC) and endometrial cancer (EC) .

HY-15098

Apoptozole 10+ Cited Publications Apoptosis Activator VII	HSP Apoptosis	Cancer
Apoptozole (Apoptosis Activator VII) is an inhibitor of the ATPase domain of Hsc70 and Hsp70, with K_ds of 0.21 and 0.14 μM, respectively, and can induce apoptosis.

HY-B0656

Rabeprazole 5 Publications Verification LY307640	Proton Pump Apoptosis Bacterial	Inflammation/Immunology Cancer
Rabeprazole (LY307640) is a second-generation proton pump inhibitor (PPI) that irreversibly inactivates gastric H ⁺/K ⁺-ATPase. Rabeprazole induces apoptosis. Rabeprazole acts as an uridine nucleoside ribohydrolase (UNH) inhibitor with an IC₅₀ of 0.3 μM. Rabeprazole can be used for the research of gastric ulcerations and gastroesophageal reflux .

HY-W011102

S-Trityl-L-cysteine 2 Publications Verification NSC 83265; S-Tritylcysteine; 3-Tritylthio-L-alanine	Kinesin Apoptosis	Cancer
S-Trityl-L-cysteine (NSC 83265) is a selective and allosteric kinesin Eg5 inhibitor with an IC₅₀ of 1 μM for the inhibition of basal ATPase activity and 140 nM for the microtubule-activated ATPase activity. S-Trityl-L-cysteine has antitumor activities .

HY-B0656A

Rabeprazole sodium 5 Publications Verification LY307640 sodium	Proton Pump Apoptosis Bacterial	Inflammation/Immunology Cancer
Rabeprazole sodium (LY307640 sodium) is a second-generation proton pump inhibitor (PPI) that irreversibly inactivates gastric H ⁺/K ⁺-ATPase. Rabeprazole sodium induces apoptosis. Rabeprazole sodium acts as an uridine nucleoside ribohydrolase (UNH) inhibitor with an IC₅₀ of 0.3 μM. Rabeprazole sodium can be used for the research of gastric ulcerations and gastroesophageal reflux .

HY-123872

MSC1094308 1 Publications Verification	p97	Cancer
MSC1094308 is a non-competitive and reversible VPS4B/p97 (VCP) (I/II type AAA ATPase) allosteric inhibitor, with IC₅₀ values of 0.71 μM and 7.2 μM for VPS4B and p97, respectively . MSC1094308 inhibits the D2 ATPase activity by binding to a agentable hotspot of p97. MSC1094308 can be used in study of cancer .

HY-122815

Fusicoccin Fusicoccin A	Apoptosis	Cancer
Fusicoccin (Fusicoccin A), a fungal pytotoxin, is a stabilizer of specific 14-3-3 protein-protein interactions. Fusicoccin sabilizes H ⁺-ATPase/14-3-3 cmplex in pants, maintaining the enzyme in activated state. Fusicoccin also stabilizes 14-3-3 protein interactions with binding partners containing a C-terminal 14-3-3 recognition motif (a mode 3 motif), such as ERα, GPIbα, TASK3, CTFR, and p53. Fusicoccin induces apoptosis in cancer cells and has anticancer activity .

HY-16690

BTS 3 Publications Verification N-Benzyl-p-toluenesulfonamide; N-Tosylbenzylamine	Myosin	Others
BTS (N-Benzyl-p-toluenesulfonamide) is a potent and selective inhibitor of skeletal muscle myosin II subfragment 1 (S1) ATPase activity, with an IC₅₀s of ~5 µM for actin- and Ca ²⁺-stimulated myosin S1 ATPase. BTS specifically inhibits the contraction of fast skeletal muscle fibers .

HY-Y0413

Biacetyl monoxime Diacetyl monoxime; DAM	Na+/K+ ATPase Myosin	Cardiovascular Disease Metabolic Disease
Biacetyl monoxime (Diacetyl monoxime), a myosin ATPase inhibitor, is a skeletal and cardiac muscle contraction inhibitor. Biacetyl monoxime is also a well-characterized non-competitive inhibitor of chemical and motile activity of skeletal muscle myosin-II. Biacetyl monoxime induces sarcoplasmic reticulum Ca ²⁺ release .

HY-17421

Tenatoprazole TU-199	Proton Pump	Infection Inflammation/Immunology
Tenatoprazole (TU-199) is an orally active imidazopyridine-based proton pump inhibitor with a prolonged plasma half-life. Tenatoprazole inhibits hog gastric H ⁺/K ⁺-ATPase activity with an IC₅₀ of 6.2 μM. Tenatoprazole blocks the interaction of ubiquitin with the ESCRT-1 factor Tsg101, inhibits production of several enveloped viruses, including EBV .

HY-110185

NSC 617145 3 Publications Verification	DNA/RNA Synthesis	Cancer
NSC 617145 is a selective werner syndrome helicase (WRN) helicase inhibitor with an IC₅₀ value of 230 nM. NSC 617145 inhibits WRN ATPase, and induces double-strand breaks (DSB) and chromosomal abnormalities. NSC 617145 shows selective for WRN over BLM, FANCJ, ChlR1, RecQ, and UvrD helicases .

HY-116683

116-9e 2 Publications Verification MAL2-11B	HSP DNA/RNA Synthesis	Infection Cancer
116-9e (MAL2-11B) is a Hsp70 co-chaperone DNAJA1 inhibitor. 116-9e inhibits Simian Virus 40 (SV40) replication and DNA synthesis. 116-9e inhibits tumor antigen (TAg)’s endogenous ATPase activity and the TAg-mediated activation of Hsp70 .

HY-N2877

Annonacin 1 Publications Verification	Potassium Channel Sodium Channel Na+/K+ ATPase Calcium Channel Apoptosis	Neurological Disease Cancer
Annonacin is an acetylgenin that is toxic by inhibiting the pathway of the mitochondrial complex. Annonacin increases tau phosphorylation in R406W ^+/+ mice. Annonacin acts as an inhibitor of the sodium/potassium and *sarcoplasmic reticulum (SERCA) ATPase* pumps**. Annonacin has significant killing effect on ovarian cancer cell, cervical cancer cell, breast cancer cell, bladder cancer cell and skin cancer cell. Annonacin induces apoptosis through Bax and Caspase-3-related pathways .

HY-131873

Dynapyrazole-A	Dynamin	Infection
Dynapyrazole A is a specific inhibitor of microtubule dynamin that specifically inhibits the ATPase activity of microtubule-stimulated dynamin without blocking microtubule-independent basal activity .

HY-144896

FHT-1015 2 Publications Verification	Epigenetic Reader Domain	Cancer
FHT-1015 is a selective SMARCA4 (IC₅₀ = 4 nM) and SMARCA2 (IC₅₀ = 5 nM) (also known as BRG1 and BRM) inhibitor. FH-1015 is an allosteric inhibitor that causes conformation change in the BRG1/BRM protein upon interaction with an allosteric site, inhibiting ATPase activity. FH-1015 interferes with tumor cell growth and migration. FH-1015 can be studied in research for uveal melanoma and hematologic cancer .

HY-P3278

Caloxin 2A1 2 Publications Verification	Proton Pump	Metabolic Disease
Caloxin 2A1 is an extracellular *plasma membrane Ca ²⁺-ATPase* (PMCA)** peptide inhibitor. Caloxin 2A1 does not affect basal Mg ²⁺-ATPase or Na ⁺-K ⁺-ATPase .

HY-138820

SW02	HSP	Neurological Disease
SW02 is a potent activator of *ATPase* activity of Hsp70, with an EC₅₀ of 150 μM. SW02 leads to accumulation of both total tau and phosphorylated tau (pTau) .

HY-D1435

Oxonol VI	Na+/K+ ATPase Fluorescent Dye	Metabolic Disease
Oxonol VI is an optical indicator of membrane potential in lipid vesicles (excitation/emission wavelengths: 614/646 nm). Oxonol VI can be used to detect changes in membrane potential associated with (Na ⁺ + K ⁺)-ATPase activity in reconstituted vesicles .

HY-124805

MAL3-101	HSP	Cancer
MAL3-101 is a potent HSP70 allosteric inhibitor. MAL3-101 inhibits HSP70 ATPase activity by blocking Hsp40 co-chaperone interaction. MAL3-101 can be used for researching muscle invasive bladder cancer (MIBC) .

HY-N6745

Citreoviridin	Na+/K+ ATPase Apoptosis	Infection Cardiovascular Disease
Citreoviridin, a toxin from Penicillium citreoviride NRRL 2579, inhibits brain synaptosomal Na ⁺/K ⁺-ATPase whereas in microsomes, both Na ⁺/K ⁺-ATPase and Mg ²⁺-ATPase activities are significantly stimulated in a dose-dependent manner . Citreoviridin inhibits cell proliferation and enhances apoptosis of human umbilical vein endothelial cells .

HY-146074

*RUVBL1/2 ATPase-IN-1*	Proton Pump	Cancer
RUVBL1/2 ATPase-IN-1 (compound 18) is a potent and selective inhibitor of RUVBL1/2 ATPase with IC₅₀ values of 6.0 and 7.7 μM, respectively. RUVBL1 and RUVBL2 are highly conserved AAA ATPases (ATPases Associated with various cellular Activities) and highly relevant to the progression of cancer. RUVBL1/2 ATPase-IN-1 has the potential for the research of cancer diseases .

HY-168325

UP12	p97	Others
UP12 is an *ATPase* activity activator that activates the ATPase activity of valosin-containing protein (VCP), with an EC₅₀ of 1.24 μM. UP12 is applicable to research related to multisystem proteinopathies .

HY-W754708

Ouabagenin	LXR Na+/K+ ATPase	Cardiovascular Disease
Ouabagenin is a naturally occurring LXR ligand with LXR selective agonist activity. Ouabagenin acts as an EC 3.6.3.9 (Na(+)/K(+)- transport ATPase) inhibitor .

HY-144897

FHT-1204	Epigenetic Reader Domain	Cancer
FHT-1204 is a potent SMARCA4/SMARCA2 ATPase (BRG1 and BRM) inhibitor with IC₅₀s of ≤10 nM (WO2020160180A1; compound 70) .

HY-152949

Myosin V-IN-1	Myosin	Neurological Disease
Myosin V-IN-1 (compound 8) is a potent and selective Myosin V inhibitor, with a K_i of 6 μM. Myosin V-IN-1 shows acute inhibition of myosin V. Myosin V-IN-1 slows the actin-activated myosin V ATPase by specifically inhibiting ADP release from the actomyosin complex .

HY-150206

NLRP3-IN-13	NOD-like Receptor (NLR)	Neurological Disease Inflammation/Immunology
NLRP3-IN-13 (Compound C77 in reference patent) is a selective and potent NLRP3 inhibitor (IC₅₀: 2.1 μM). NLRP3-IN-13 inhibits NLRP3 andNLRC4 inflammasomes, and inhibits NLRP3-mediated IL-1β production. NLRP3-IN-13 also inhibits NLRP3 ATPase activity. NLRP3-IN-13 can be used in the research of neuroinflammatory disorders .

HY-13757AS

Tamoxifen-d5 ICI 47699-d5; (Z)-Tamoxifen-d₅; trans-Tamoxifen-d₅	Isotope-Labeled Compounds Estrogen Receptor/ERR HSP Autophagy Apoptosis	Cancer
Tamoxifen-d₅ is a deuterium labeled Tamoxifen. Tamoxifen (ICI 47699) is an orally active, selective estrogen receptor modulator (SERM). Tamoxifen is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity .

HY-P3278A

Caloxin 2A1 TFA 2 Publications Verification	Proton Pump	Metabolic Disease
Caloxin 2A1 TFA is an extracellular *plasma membrane Ca ²⁺-ATPase* (PMCA)** peptide inhibitor. Caloxin 2A1 TFA does not affect basal Mg ²⁺-ATPase or Na ⁺-K ⁺-ATPase .

HY-158415

ATPase-IN-4	ATP Synthase EHD Protein	Cancer
ATPase-IN-4 (Compound MS1) inhibits the ATPase activity of EHD4 (IC₅₀: 0.92 μM). ATPase-IN-4 also inhibits EHD2 enzymatic activity

HY-148041

ATPase-IN-2	ATP Synthase	Others
ATPase-IN-2 is an *ATPase* inhibitor with an IC₅₀ value of 0.9 μM. ATPase-IN-2 inhibits C. difficile toxin B (TcdB) glycohydrolase activity with an AC₅₀ value of 30.91 μM. ATPase-IN-2 can be used for the research of ATP-related .

HY-B1726

Phenacaine Holocaine	Phosphodiesterase (PDE)	Metabolic Disease
Phenacaine (Holocaine) is a local agent that can suppress or relieve pain. Phenacaine inhibits the specific calmodulin-dependent stimulation of erythrocyte Ca ²⁺-ATPase and cyclic nucleotide phosphodiesterases from brain and heart .

HY-107657

(+)-Blebbistatin 1 Publications Verification	Myosin	Others
(+)-Blebbistatin is the inactive enantiomer of (–)-Blebbistatin. (–)-Blebbistatin is a selective inhibitor of myosin II ATPase .

HY-111002

Displurigen NSC375009	HSP	Others
Displurigen (NSC375009) disrupts human embryonic stem cell pluripotency by targeting HSPA8. Displurigen inhibits ATPase activity of HSP70 (IC₅₀ = 225 μM) .

HY-152184

SEW84 SEW04784	HSP	Metabolic Disease
SEW84 is an inhibitor of Aha1-stimulated Hsp90 (ASH) ATPase activity. SEW84 inhibits Aha1-stimulated Hsp90 (ASH) activity with an IC₅₀ value of 0.3 μM. SEW84 can be used in the study of protein deposition diseases .

HY-146676

UR-MB108	BCRP	Cancer
UR-MB108 is a selective ABCG2 inhibitor with an IC₅₀ value of 79 nM. UR-MB108 acts as a potent inhibitor of ABCG2 transport and ATPase activity. UR-MB108 can be used in cancer-related research .

HY-162935

*V-ATPase-IN-1*	Proton Pump	Others
V-ATPase-IN-1 (Compound 3b-03) is a Vacuolar-type H ⁺-ATPases (V-ATPase) inhibitor (IC₅₀ = 194.80 μM) that can effectively target the *V-ATPase* subunit A (K_d = 0.803 μM). V-ATPase-IN-1 exhibits insecticidal activity against M. separata (LC₅₀ = 2.64 mM) and contributes to research in the development of chemical insecticides .

HY-P5965

BiP substrate	HSP	Others
BiP substrate is a peptide substrate of BiP that can be used to measure the BiP ATPase activity .

HY-N6574

Marinobufogenin	Na+/K+ ATPase	Cardiovascular Disease Neurological Disease Metabolic Disease
Marinobufogenin is a strong inhibitor of Na ⁺/K ⁺ ATPase that has been identified in mammalian plasma .

HY-124776

NPD8733	p97	Cancer
NPD8733 is an inhibitor of cancer cell-enhanced fibroblast migration. NPD8733 specifically binds to valosin-containing protein (VCP)/p97, a member of the ATPase-associated with diverse cellular activities (AAA+) protein family. NPD8733 has the potential for the research of cancer diseases .

HY-168528

WS-917 1 Publications Verification	P-glycoprotein	Cancer
WS-917 is a potent and orally active ABCB1 modulator. WS-917 enhances ABCB1 ATPase activity. WS-917 significantly enhances the antitumor effect of paclitaxel combined with anti-PD-1 antibody. WS-917 promotes CD8 ⁺ T-cell activation .

HY-N1446BR

Oleic acid sodium (Standard) Sodium oleate (Standard); 9-cis-Octadecenoic acid sodium (Standard); 9Z-Octadecenoic acid sodium (Standard)	Reference Standards Na+/K+ ATPase Apoptosis	Metabolic Disease Cancer
Sodium oleate (Standard) is the analytical standard of Sodium oleate. This product is intended for research and analytical applications. Sodium oleate (Oleic acid sodium) is an abundant monounsaturated fatty acid sodium[1]. Sodium oleate is a Na+/K+ ATPase activator[2].

HY-N16375

(3R,6S)-Bassiatin	Drug Metabolite Fungal ATP Synthase	Infection
(3R,6S)-Bassiatin (Compound 5) is an enantiomer of the fungal metabolite Bassiatin (HY-165143). Bassianin is a compound isolated from fungi that has the activity of inhibiting erythrocyte membrane ATPase and causing cell lysis. Its inhibitory effect on *ATPase* may be due to membrane disruption .

HY-150622

SARS-CoV-2 nsp13-IN-1	SARS-CoV	Infection
SARS-CoV-2 nsp13-IN-1 (compound C1) is a potent nsp13 (non-structural protein 13) inhibitor. SARS-CoV-2 nsp13-IN-1 only inhibits nsp13 ssDNA ⁺ ATPase, with an IC₅₀ of 6 μM. SARS-CoV-2 nsp13-IN-1 does not inhibit ssDNA ^- ATPase. SARS-CoV-2 nsp13-IN-1 can be used for COVID-19 research .

HY-W494890

SMARCA2-IN-10	Epigenetic Reader Domain	Cancer
SMARCA2-IN-10 (Compound 4) is a highly selective SMARCA2 ATPase domain inhibitor (IC₅₀=17.676 μM). SMARCA2-IN-10 induces cell death in SMARCA4-deficient tumors. SMARCA2-IN-10 is promising for research of SMARCA4-mutant non-small cell lung cancer, small cell ovarian carcinoma, and melanoma .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-100558

Bafilomycin A1 Maximum Cited Publications 802 Publications Verification BafA1	Infection Microorganisms Macrolide Antibiotics Classification of Application Fields Antibiotics Disease Research Anticancer Disease Research Fields Source Classification	Proton Pump Autophagy Antibiotic Bacterial Apoptosis
Bafilomycin A1 (BafA1) is a specific and reversible inhibitor of vacuolar H ⁺-ATPase (V-ATPase) with IC₅₀ values of 4-400 nmol/mg. Bafilomycin A1, a macrolide antibiotic, is also used as an autophagy inhibitor at the late stage. Bafilomycin A1 blocks autophagosome-lysosome fusion and inhibits acidification and protein degradation in lysosomes of cultured cells. Bafilomycin A1 induces apoptosis .

HY-13433

Thapsigargin 135+ Cited Publications	Infection Classification of Application Fields Terpenoids Diterpenoids Umbelliferae Plants Disease Research Fields Source Classification Thapsia garganica L. Cancer	Calcium Channel SARS-CoV Apoptosis
Thapsigargin, an endoplasmic reticulum (ER) stress inducer, is an inhibitor of microsomal Ca ²⁺-ATPase. Thapsigargin efficiently inhibits coronavirus (HCoV-229E, MERS-CoV, SARS-CoV-2) replication in different cell types .

HY-N1446

Oleic acid Maximum Cited Publications 64 Publications Verification 9-cis-Octadecenoic acid; 9Z-Octadecenoic acid	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification Cancer	Environmental Pollutants Na+/K+ ATPase Endogenous Metabolite Apoptosis
Oleic acid (9-cis-Octadecenoic acid) is an abundant monounsaturated fatty acid . Oleic acid is a Na ⁺/K ⁺ ATPase activator .

HY-16589

Oligomycin A 50+ Cited Publications MCH 32	Infection Microorganisms Antifungal Macrolide Antibiotics Classification of Application Fields Antibiotics Disease Research Disease Research Fields Source Classification	ATP Synthase Fungal Antibiotic
Oligomycin A (MCH 32), created by Streptomyces, acts as a mitochondrial *F₀F₁-ATPase* inhibitor, with a K_i of 1 μM; Oligomycin A shows anti-fungal activity.

HY-W010918

Adenosine 5'-diphosphate 5+ Cited Publications Adenosine diphosphate; ADP	Structural Classification Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Endogenous Metabolite
Adenosine 5'-diphosphate (Adenosine diphosphate) is a nucleoside diphosphate. Adenosine 5'-diphosphate is the product of ATP dephosphorylation by ATPases. Adenosine 5'-diphosphate induces human platelet aggregation and inhibits stimulated adenylate cyclase by an action at P_2T-purinoceptors.

HY-N6687

Calcimycin 20+ Cited Publications A-23187; Antibiotic A-23187	Infection Structural Classification Microorganisms Classification of Application Fields Antibiotics Antibacterial Disease Research Disease Research Fields Polyether Antibiotics Source Classification	Oxidative Phosphorylation Bacterial Fungal Apoptosis Autophagy Antibiotic
Calcimycin (A-23187) is an antibiotic and a unique divalent cation ionophore (like calcium and magnesium). Calcimycin induces Ca ²⁺-dependent cell death by increasing intracellular calcium concentration. Calcimycin inhibits the growth of Gram-positive bacteria and some fungi. Calcimycin also inhibits the activity of ATPase and uncouples oxidative phosphorylation (OXPHOS) of mammalian cells. Calcimycin induces apoptosis and autophagy .

HY-N1446B

Oleic acid sodium 60+ Cited Publications Sodium oleate; 9-cis-Octadecenoic acid sodium; 9Z-Octadecenoic acid sodium	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Environmental Pollutants Apoptosis Na+/K+ ATPase
Sodium oleate (Oleic acid sodium) is an abundant monounsaturated fatty acid sodium . Sodium oleate is a Na ⁺/K ⁺ ATPase activator .

HY-N1724

Concanamycin A 25+ Cited Publications Antibiotic X 4357B; Folimycin; X 4357B	Infection Natural Products Microorganisms Classification of Application Fields Disease Research Fields Source Classification	Proton Pump Bacterial Antibiotic
Concanamycin A (Folimycin; Antibiotic X 4357B) is a macrolide antibiotic, a vacuolar type H ⁺-ATPase (V-ATPase) inhibitor. Concanamycin A is also an inhibitor of lysosomal acidification, can be used to T cell-mediated inflammation research ^- .

HY-N0039

Ginsenoside Rb1 10+ Cited Publications Gypenoside III	Panax ginseng C. A. Meyer Triterpenes Classification of Application Fields Terpenoids Plants Disease Research Fields Araliaceae Source Classification Cancer	Na+/K+ ATPase IRAK NF-κB Autophagy Mitophagy HSV
Ginsenoside Rb1, a main constituent of the root of Panax ginseng, inhibits Na ⁺, K ⁺-ATPase activity with an IC₅₀ of 6.3±1.0 μM. Ginsenoside also inhibits IRAK-1 activation and phosphorylation of NF-κB p65 .

HY-N0877

Bufalin 5+ Cited Publications	Animals Classification of Application Fields Disease Research Fields Steroids Source Classification Cancer	Na+/K+ ATPase
Bufalin is an active component isolated from Chan Su, acts as a potent Na ⁺/K ⁺-ATPase inhibitor, binds to the subunit α1, α2 and α3, with K_d of 42.5, 45 and 40 nM, respectively . Anti-cancer activity .

HY-N6771

Cyclopiazonic acid 5+ Cited Publications	Alkaloids Structural Classification Microorganisms Pyrrole Alkaloids Classification of Application Fields Other Diseases Disease Research Fields Indole Alkaloids Source Classification	Calcium Channel 5-HT Receptor MDM-2/p53 Apoptosis RSV
Cyclopiazonic acid is an endoplasmic reticulum calcium ATPase (ECAs) inhibitor and human respiratory syncytial virus (RSV) inhibitor (EC₅₀ value of 4.13 μ M), which can reduce the antagonistic effect of 5-HT receptors in rat thoracic aorta, induce p53 dependent cell apoptosis and reproductive toxicity in mouse testes, and inhibit the biological activation of aflatoxin B ^[1][4][5].

HY-100560

Abscisic acid 3 Publications Verification (S)-(+)-Abscisic acid; ABA	Structural Classification Classification of Application Fields Metabolic Disease Plants Endogenous metabolite Agricultural Research Microorganisms other families Animals Terpenoids Sesquiterpenes Abscisic acid Phytohormone Disease Research Fields Source Classification	Environmental Pollutants Endogenous Metabolite ABA Receptor Proton Pump
Abscisic acid ((S)-(+)-Abscisic acid), an orally active phytohormone in fruits and vegetables, is an endogenously produced mammalian hormone. Abscisic acid is a growth inhibitor and can regulate many aspects of plant growth and development. Abscisic acid inhibits proton pump (H ⁺-ATPase) and leads to the plasma membrane depolarization in a Ca ²⁺-dependent manner. Abscisic acid, a LANCL2 natural ligand, is a potent insulin-sensitizing compound and has the potential for pre-diabetes, type 2 diabetes and metabolic syndrome .

HY-N2033

Chebulinic acid 3 Publications Verification	Infection Classification of Application Fields Combretaceae Phenols Polyphenols Terminalia chebula Retz. Plants Disease Research Fields Source Classification	DNA/RNA Synthesis TGF-beta/Smad Proton Pump
Chebulinic acid is a potent natural inhibitor of M. tuberculosis DNA gyrase, also can inhibit SMAD-3 phosphorylation, inhibit H+ K+-ATPase activity.

HY-N2070

Acevaltrate 4 Publications Verification	Iridoids Terpenoids Valeriana officinalis Linn. Plants Valerianaceae Source Classification	Na+/K+ ATPase
Acevaltrate inhibits the Na ⁺/K ⁺-ATPase activity in the rat kidney and brain hemispheres with IC₅₀s of 22.8 μM and 42.3 μM, respectively .

HY-103312

Xestospongin C 5+ Cited Publications (-)-Xestospongin C	Alkaloids Piperidine Alkaloids Animals Source Classification	Calcium Channel Apoptosis
Xestospongin C ((-)-Xestospongin C) is a selective, reversible inositol 1,4,5-trisphosphate receptor (IP3R) inhibitor. Xestospongin C acts as an inhibitor of the sarcoplasmic/endoplasmic reticulum Ca ²⁺ ATPase (SERCA) pump of internal stores. Xestospongin C blocks IP3-induced Ca ²⁺ release from cerebellar microsomes with an IC₅₀ of 358 nM. Xestospongin C is a valuable tool for investigating the structure and function of IP3Rs and Ca ²⁺ signaling in neuronal and nonneuronal cells .

HY-114252

Strophanthidin 1 Publications Verification	Cardiovascular Disease Classification of Application Fields Plants Brassicaceae Disease Research Fields Steroids Erysimum cheiranthoides Linn. Source Classification	Na+/K+ ATPase
Strophanthidin is a naturally available cardiac glycoside . Strophanthidin 0.1 and 1 nmol/L increases and 1~100 μmol/L inhibits the *Na+/K+-ATPase* activities, but Strophanthidin 10 and 100 nmol/L does not affect *Na+/K+-ATPase* activities in cardiac sarcolemmal . Strophanthidin increases both diastolic and systolic intracellular Ca ²⁺ concentration .

HY-N1381

Periplocin 5+ Cited Publications	Classification of Application Fields Asclepiadaceae Plants Periploca sepium Bunge Inflammation/Immunology Disease Research Fields Steroids Source Classification	Apoptosis
Periplocin is a cardiotonic steroid isolated from root-bark Periploca sepium Bunge. Periplocin promotes tumor cell apoptosis and inhibits tumor growth. Periplocin has the potential to facilitate wound healing through the activation of Src/ERK and PI3K/Akt pathways mediated by Na/K-ATPase .

HY-N6778

Paxilline 5+ Cited Publications	Alkaloids Structural Classification Microorganisms other families Neurological Disease Classification of Application Fields Terpenoids Diterpenoids Plants Disease Research Fields Indole Alkaloids Source Classification	Potassium Channel Calcium Channel Reactive Oxygen Species (ROS)
Paxilline is an indole alkaloid mycotoxin derived from Penicillium paxilli, which effectively inhibits the BK channel through a channel-blocking mechanism. Paxilline also inhibits sarco/endoplasmic reticulum Ca ²⁺-stimulated ATPase (SERCA), with IC₅₀ values ranging from 5 μM to 50 μM for different SERCA isoforms. Paxilline exhibits significant anticonvulsant and neuroprotective effects, as well as certain antioxidant activity .

HY-D0199

Adenosine 5'-diphosphate disodium 5+ Cited Publications Adenosine diphosphate disodium; ADP disodium	Structural Classification Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Endogenous Metabolite
Adenosine 5'-diphosphate disodium is a nucleoside diphosphate. Adenosine 5'-diphosphate disodium is the product of ATP dephosphorylation by ATPases. Adenosine 5'-diphosphate disodium is a platelet aggregation agent for hemostasis and the development and extension of arterial thrombosis .

HY-A0154

Deslanoside Deacetyllanatoside C; Desacetyllanatoside C	Digitalis purpurea Linn. Cardiovascular Disease Structural Classification Classification of Application Fields Cardiacglycosides Scrophulariaceae Plants Disease Research Fields Steroids Source Classification	Na+/K+ ATPase Drug Metabolite
Deslanoside (Desacetyllanatoside C) is a rapidly acting cardiac glycoside used to treat congestive heart failure and supraventricular arrhythmias due to reentry mechanisms, and to control ventricular rate in the treatment of chronic atrial fibrillation. Deslanoside inhibits the *Na-K-ATPase* membrane pump, resulting in an increase in intracellular sodium and calcium concentrations .

HY-122815

Fusicoccin Fusicoccin A	Microorganisms Classification of Application Fields Terpenoids Diterpenoids Disease Research Fields Source Classification Cancer	Apoptosis
Fusicoccin (Fusicoccin A), a fungal pytotoxin, is a stabilizer of specific 14-3-3 protein-protein interactions. Fusicoccin sabilizes H ⁺-ATPase/14-3-3 cmplex in pants, maintaining the enzyme in activated state. Fusicoccin also stabilizes 14-3-3 protein interactions with binding partners containing a C-terminal 14-3-3 recognition motif (a mode 3 motif), such as ERα, GPIbα, TASK3, CTFR, and p53. Fusicoccin induces apoptosis in cancer cells and has anticancer activity .

HY-13719

Oleandrin 5 Publications Verification PBI-05204	Apocynaceae Structural Classification Classification of Application Fields Nerium indicum Mill. Plants Disease Research Fields Steroids Source Classification Cancer	Na+/K+ ATPase
Oleandrin (PBI-05204) inhibits the Na ⁺, K ⁺-ATPase activity with an IC₅₀ of 620 nM.

HY-N2532

Diphyllin 3 Publications Verification	Infection Monophenols Classification of Application Fields Lignans Phenols Dysosma versipellis (Hance) M. Cheng ex Ying Phenylpropanoids Plants Berberidaceae Inflammation/Immunology Disease Research Fields Source Classification	VSV HIV Proton Pump Influenza Virus
Diphyllin is an orally active *V-ATPase* inhibitor (IC₅₀=17 nM) and HIV-1 inhibitor (IC₅₀=0.38 μM). Diphyllin blocks the acidification of osteoclast lysosomes and bone resorption lacunas (IC₅₀=0.6 nM for acid influx inhibition)， thereby inhibiting bone resorption. Diphyllin can effectively inhibit osteoclast-mediated bone resorption and has no effect on osteoblastic bone formation. Diphyllin can be used in the research of bone metabolism-related diseases and has the potential to inhibit diseases related to excessive bone resorption .

HY-N2877

Annonacin 1 Publications Verification	Natural Products Neurological Disease Classification of Application Fields Annona muricata Linn. Plants Annonaceae Disease Research Fields Source Classification	Potassium Channel Sodium Channel Na+/K+ ATPase Calcium Channel Apoptosis
Annonacin is an acetylgenin that is toxic by inhibiting the pathway of the mitochondrial complex. Annonacin increases tau phosphorylation in R406W ^+/+ mice. Annonacin acts as an inhibitor of the sodium/potassium and *sarcoplasmic reticulum (SERCA) ATPase* pumps**. Annonacin has significant killing effect on ovarian cancer cell, cervical cancer cell, breast cancer cell, bladder cancer cell and skin cancer cell. Annonacin induces apoptosis through Bax and Caspase-3-related pathways .

HY-113410

3-Methylglutaric acid	Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Disease markers Endocrine diseases Metabolic Disease Nervous System Disorder Endogenous metabolite Disease Research Fields Cardiovascular System Disorder Source Classification	Na+/K+ ATPase Mitochondrial Metabolism Reactive Oxygen Species (ROS)
3-Methylglutaric acid is a non-selective inhibitor of mitochondrial function and Na ⁺, K ⁺-ATPase, with an inhibition rate of 30% on rat cortical synaptosomal Na ⁺, K ⁺-ATPase. 3-Methylglutaric acid can induce reactive oxygen species (ROS) generation, thereby causing oxidative damage and inhibiting mitochondrial redox potential and ion pump function of cell membranes. 3-Methylglutaric acid can be used to study the neuropathological mechanisms of metabolic diseases and the role of oxidative stress-mediated neuronal damage in neurodegeneration .

HY-126679

Apoptolidin	Natural Products Microorganisms Disease Research Fields Source Classification Cancer	ATP Synthase Apoptosis
Apoptolidin is a polyketide isolated from Nocardiopsis bacteria . Apoptolidin is a selective mitochondrial F₁F_O ATPase inhibitor. Apoptolidin is an apoptosis inducer and induces apoptotic cell death in cells transformed with the adenovirus type 12 oncogenes including ElA (IC₅₀=10-17 ng/ml) but not in normal cells .

HY-N8441

Neriifolin 17β-Neriifolin	Apocynaceae Classification of Application Fields Cardiacglycosides Cerbera manghas Linn. Plants Inflammation/Immunology Disease Research Fields Steroids Source Classification	Atg8/LC3 Na+/K+ ATPase Apoptosis Beclin1
Neriifolin, a CNS-penetrating cardiac glycoside, is an inhibitor of the Na ⁺, K ⁺-ATPase. Neriifolin can target beclin 1, inhibits the formation of LC3-associated phagosomes and ameliorates experimental autoimmune encephalomyelitis (EAE) development. Neriifolin induces cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells ^[2.

HY-N1431

Tabersonine 3 Publications Verification	Apocynaceae Alkaloids Structural Classification Plants Indole Alkaloids Catharanthus roseus (L.) G. Don Source Classification	NOD-like Receptor (NLR) Apoptosis Cytochrome P450 NF-κB PI3K Akt CDK Caspase Interleukin Related p38 MAPK
Tabersonine is a selective, orally active NLRP3 inhibitor. Tabersonine directly binds to the NACHT domain of NLRP3, inhibiting its ATPase activity and oligomerization, thereby blocking ASC spot formation and caspase-1 activation, and reducing the release of pro-inflammatory cytokines such as IL-1β. Tabersonine also inhibits K63-linked ubiquitination of TRAF6, blocking NF-κB, PI3K/Akt, and p38 MAPK signaling pathways. Tabersonine can inhibit inflammatory responses, induce apoptosis of liver cancer cells through mitochondrial pathways and death receptor pathways, reduce mitochondrial membrane potential, promote cytochrome c release, and activate caspase proteins. Tabersonine is mainly used in the study of NLRP3-driven inflammatory diseases (such as acute lung injury, sepsis, peritonitis) and tumors such as liver cancer .

HY-126415

Magnesium Lithospermate B 1 Publications Verification	Cardiovascular Disease Neurological Disease Classification of Application Fields Simple Phenylpropanols Labiatae Samanea saman (Jacq.) Merr. Phenylpropanoids Plants Disease Research Fields Source Classification	Na+/K+ ATPase
Magnesium Lithospermate B, is a derivative of caffeic acid tetramer and an inhibitor of Na+/K+ ATPase, which can be extracted from Salviae miltiorrhizae. Magnesium Lithospermate B is widely used for the research of cardiovascular diseases, and it can protect against glucose-induced intracellular oxidative damage. Magnesium Lithospermate B also suppresses neuroin?ammation and attenuates neurodegeneration .

HY-136933

Gitoxin	Digitalis purpurea Linn. Cardiovascular Disease Structural Classification Classification of Application Fields Scrophulariaceae Plants Disease Research Fields Steroids Source Classification	Na+/K+ ATPase
Gitoxin is a degradation metabolite of Digitoxin (HY-B1357) and a non-competitive Na ⁺/K ⁺-ATPase inhibitor, with an IC₅₀ of 1.18e-6 M against the porcine high-affinity subtype and an IC₅₀ of 2.85e-5 M against the porcine low-affinity subtype. Gitoxin regulates atrial contractility and rhythmicity. Gitoxin is applicable to research related to congestive heart failure .

HY-N10455

24-Epicastasterone 2 Publications Verification 24-epi-Castasterone	Structural Classification Natural Products Microorganisms Classification of Application Fields Other Diseases Brassinolide Phytohormone Disease Research Fields Source Classification Agricultural Research	Drug Derivative
24-Epicastasterone (24-epi-Castasterone) is a bioactive brassinosteroid and a ligand of ABCB1 and ABCB19 in Arabidopsis thaliana. 24-Epicastasterone stimulates the ATPase activity of ABCB19 and the ATP hydrolysis activity of ABCB1, which drive the efflux of substances from plant cells. 24-Epicastasterone increases the activities of catalase and guaiacol peroxidase in the roots of wheat seedlings. 24-Epicastasterone alleviates heat-induced lipid peroxidation through a ROS-dependent mechanism and enhances the heat tolerance of common wheat seedlings .

HY-N10424

Brazilein 2 Publications Verification	Structural Classification Classification of Application Fields Leguminosae Caesalpinia sappan L. Phenols Polyphenols Pigments Plants Inflammation/Immunology Disease Research Fields Source Classification Food Research	Na+/K+ ATPase Apoptosis Interleukin Related NO Synthase Bacterial Parasite
Brazilein is a compound with anti-inflammatory and neuroprotective activities, with an IC₅₀ of 500 μM against guinea pig Na ⁺,K ⁺-ATPase. Brazilein reduces iNOS mRNA expression, thereby inhibiting nitric oxide production in immune cells. Brazilein suppresses inflammatory responses by reducing the mRNA expression of TNF-α and IL-6, but has no effect on IL-1β expression. Brazilein reduces the cerebral infarction volume and improves the neurological function scores of rats with cerebral ischemia-reperfusion injury. Brazilein induces apoptosis of splenic lymphocytes in mice. Brazilein inhibits humoral immune responses in mice, and causes thymus and spleen atrophy as well as body weight loss in mice. Brazilein also possesses antimalarial and antibacterial activities. Brazilein is also a red dye. Brazilein can be used in studies related to the infection, nervous system, cardiovascular system and inflammatory diseases .

HY-N6745

Citreoviridin	Cardiovascular Disease Natural Products Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Endogenous metabolite Disease Research Fields Source Classification	Na+/K+ ATPase Apoptosis
Citreoviridin, a toxin from Penicillium citreoviride NRRL 2579, inhibits brain synaptosomal Na ⁺/K ⁺-ATPase whereas in microsomes, both Na ⁺/K ⁺-ATPase and Mg ²⁺-ATPase activities are significantly stimulated in a dose-dependent manner . Citreoviridin inhibits cell proliferation and enhances apoptosis of human umbilical vein endothelial cells .

HY-130173

Bafilomycin C1 1 Publications Verification	Infection Microorganisms Macrolide Antibiotics Antibiotics Antibacterial Disease Research Anticancer Disease Research Fields Source Classification Cancer	Bacterial Fungal Na+/K+ ATPase Apoptosis Antibiotic
Bafilomycin C1 is a macrolide antibiotic isolated from Streptomyces sp. Bafilomycin C1 is a potent, specific and reversible inhibitor of vacuolar-type H ⁺-ATPases (V-ATPases). Bafilomycin C1 inhibits growth of gram-positive bacteria and fungi . Bafilomycin C1 induces cell apoptosis and can be used for the study of hepatocellular carcinoma (HCC) .

HY-N6015

Bacopasaponin C	Triterpenes Classification of Application Fields Terpenoids Scrophulariaceae Plants Disease Research Fields Bacopa monnieri (Linn.) Wettst. Source Classification Cancer	Parasite P-glycoprotein
Bacopasaponin C is an orally active natural glycoside. Bacopasaponin C can be isolated from Bacopa monniera. Bacopasaponin C inhibits Verapamil (HY-14275)-stimulated P-gp ATPase activity with an IC₅₀ of 57.83 μg/mL. Bacopasaponin C has antitumor activity against sarcomas. Bacopasaponin C has antiparasitic activity against Leishmania donovani .

HY-N6711

Equisetin	Infection Microorganisms Classification of Application Fields Antibiotics Antibacterial Disease Research Disease Research Fields Other Antibiotics Source Classification	HIV Integrase Bacterial Antibiotic Reactive Oxygen Species (ROS) STAT AMPK 11β-HSD
Equisetin is an N-methylserine-derived acyl tetramic acid, quorum sensing inhibitor (QSI), herbicides and antibiotics. Equisetin specifically inhibits the anionic carriers of substrates in the inner mitochondrial membrane. Equisetin inhibits the activity of HIV-1 integrase, 11β-HSD1, and 2,4-dinitrophenol (Dnp)-stimulated *ATPase* (IC₅₀ = ~8 nmol per mg of protein). Equisetin exhibits growth inhibition of bacteria, anti-inflammatory, amelioration of lipid-associated disorders, and cytotoxic effects .

HY-W754708

Ouabagenin	Microorganisms Cardiacglycosides Endogenous metabolite Steroids Source Classification	LXR Na+/K+ ATPase
Ouabagenin is a naturally occurring LXR ligand with LXR selective agonist activity. Ouabagenin acts as an EC 3.6.3.9 (Na(+)/K(+)- transport ATPase) inhibitor .

HY-N6738

Bafilomycin B1 1 Publications Verification	Infection Structural Classification Microorganisms Macrolide Antibiotics Classification of Application Fields Antibiotics Antibacterial Disease Research Disease Research Fields Source Classification	Antibiotic Bacterial Fungal Proton Pump
Bafilomycin B1 is a macrolide antibiotic that can be isolated from mycelium of Streptomyces gresuis. Bafilomycin B1 is neuroprotective against Chloroquine (HY-17589A)-induced death. Bafilomycin B1 is a structural analog of Bafilomycin A1 and has the ability to inhibit *V-ATPase*. Bafilomycin B1 inhibits significantly the oxidized low density lipoprotein (LDL)-induced accumulation of lipid droplets .

HY-117025A

Manzamine A hydrochloride 2 Publications Verification Keramamine A hydrochloride	Infection Alkaloids Piperidine Alkaloids Neurological Disease Classification of Application Fields Animals Marine natural products Pyridine Alkaloids Sponge Disease Research Fields Indole Alkaloids Source Classification	GSK-3 CDK Parasite Proton Pump HSV Autophagy
Manzamine A hydrochloride, an orally active beta-carboline alkaloid, inhibits specifically GSK-3β and CDK-5 with IC₅₀s of 10.2 μM and 1.5 μM, respectively. Manzamine A hydrochloride targets vacuolar ATPases and inhibits autophagy in pancreatic cancer cells. Manzamine A hydrochloride has antimalarial and anticancer activities. Manzamine A hydrochloride also shows potent activity against HSV-1 .

HY-117025

Manzamine A Keramamine A	Infection Alkaloids Neurological Disease Classification of Application Fields Animals Marine natural products Sponge Disease Research Fields Cancer	GSK-3 CDK Parasite Proton Pump HSV Autophagy
Manzamine A, an orally active beta-carboline alkaloid, inhibits specifically GSK-3β and CDK-5 with IC₅₀s of 10.2 μM and 1.5 μM, respectively. Manzamine A targets vacuolar ATPases and inhibits autophagy in pancreatic cancer cells. Manzamine A has antimalarial and anticancer activities. Manzamine A also shows potent activity against HSV-1 .

HY-100560R

Abscisic acid (Standard) (S)-(+)-Abscisic acid (Standard); ABA (Standard)	Structural Classification Microorganisms other families Animals Terpenoids Sesquiterpenes Plants Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite Proton Pump ABA Receptor
Abscisic acid (Standard) is the analytical standard of Abscisic acid. This product is intended for research and analytical applications. Abscisic acid ((S)-(+)-Abscisic acid), an orally active phytohormone in fruits and vegetables, is an endogenously produced mammalian hormone. Abscisic acid is a growth inhibitor and can regulate many aspects of plant growth and development. Abscisic acid inhibits proton pump (H+-ATPase) and leads to the plasma membrane depolarization in a Ca2+-dependent manner. Abscisic acid, a LANCL2 natural ligand, is a potent insulin-sensitizing compound and has the potential for pre-diabetes, type 2 diabetes and metabolic syndrome .

HY-N0885

Telocinobufagin 1 Publications Verification Telobufotoxin; Telocinobufogenin	Structural Classification Animals Classification of Application Fields Other Diseases Disease Research Fields Steroids Source Classification	JAK STAT mTOR PI3K Akt Polo-like Kinase (PLK) Na+/K+ ATPase Apoptosis Bacterial
Telocinobufagin (Telobufotoxin; Telocinobufogenin) is an orally active bufadienolide with potential anti-tumor effects. Telocinobufagin exerts its anti-cancer effects on non-small cell carcinoma, osteosarcoma, thyroid cancer, breast cancer and head and neck squamous cell carcinoma by inhibiting the STAT3, JAK2/STAT3, LARP1-mTOR, PI3K/Akt/Snail and PLK1 pathways, and can also induce tumor cell apoptosis. Telocinobufagin enhances the Th1 immune response and protects against Salmonella typhimurium infection. Telocinobufagin has a strong cardiac-stimulating effect by inhibiting the activity of Na ⁺/K ⁺-ATPase, and it can promote renal fibrosis. Telocinobufagin demonstrates non-opioid analgesic effects in various acute pain models .

HY-N1989

Bacoside A	Triterpenes Structural Classification Classification of Application Fields Terpenoids Scrophulariaceae Metabolic Disease Plants Disease Research Fields Bacopa monnieri (Linn.) Wettst. Source Classification	Na+/K+ ATPase CaMK Apoptosis Cholinesterase (ChE) NO Synthase NF-κB
Bacoside A is an orally active, blood-brain barrier-permeable triterpenoid saponin that modulates the activities of ATPases, AChE, CaMK2A and iNOS. Derived from Bacopa monniera. Bacoside A exerts significant antioxidant, anti-inflammatory and anti-apoptotic effects by maintaining ion balance, scavenging reactive oxygen species, stabilizing cell membranes, and regulating the expression of NF-κB and apoptosis-related proteins. Bacoside A counteracts morphine-induced reductions in Na ⁺/K ⁺-ATPase, Ca ²⁺-ATPase and Mg ²⁺-ATPase activities, increases mitochondrial membrane potential, and decreases intracellular reactive oxygen species levels. Bacoside A specifically binds to calcium/calmodulin-dependent protein kinase IIA to trigger endoplasmic reticulum calcium release. Bacoside A exhibits non-apoptotic cytotoxicity against glioblastoma cells while protecting normal nerve cells from stress-induced damage. Bacoside A is applicable to the research of Parkinson's disease and glioblastoma multiforme .

HY-N4184

Licoflavone B	Infection Flavonoids Classification of Application Fields Flavones Leguminosae Glycyrrhiza inflata Batal. Phenols Polyphenols Plants Glycyrrhiza uralensis Fisch. Disease Research Fields Source Classification	Parasite
Licoflavone B is a flavonoid isolated from Glycyrrhiza inflata, inhibits S. mansoni *ATPase* (IC₅₀, 23.78 µM) and ADPase (IC₅₀, 31.50 µM) activity. Anti-schistosomiasis activity .

HY-N1446R

Oleic acid (Standard) 9-cis-Octadecenoic acid (Standard); 9Z-Octadecenoic acid (Standard)	Structural Classification Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Reference Standards Na+/K+ ATPase Endogenous Metabolite Apoptosis
Oleic acid (Standard) is the analytical standard of Oleic acid. This product is intended for research and analytical applications. Oleic acid (9-cis-Octadecenoic acid) is an abundant monounsaturated fatty acid . Oleic acid is a Na+/K+ ATPase activator .

HY-W010918R

Adenosine 5'-diphosphate (Standard) Adenosine diphosphate (Standard); ADP (Standard)	Structural Classification Human Gut Microbiota Metabolites Microorganisms Ketones, Aldehydes, Acids Disease markers Nervous System Disorder Endogenous metabolite Cardiovascular System Disorder Source Classification	Reference Standards Endogenous Metabolite
Adenosine 5'-diphosphate (Standard) is the analytical standard of Adenosine 5'-diphosphate. This product is intended for research and analytical applications. Adenosine 5'-diphosphate (Adenosine diphosphate) is a nucleoside diphosphate. Adenosine 5'-diphosphate is the product of ATP dephosphorylation by ATPases. Adenosine 5'-diphosphate induces human platelet aggregation and inhibits stimulated adenylate cyclase by an action at P_2T-purinoceptors. In Vitro: Adenosine 5'-diphosphate consists of the pyrophosphate group, the pentose sugar ribose, and the nucleobase adenine. Adenosine 5'-diphosphate is the product of ATP dephosphorylation by ATPases. ADP is converted back to ATP by ATP synthases. ATP is an important energy transfer molecule in cells. Adenosine 5'-diphosphate is utilized in a wide number of cellular processes, including respiration, biosynthetic reactions, motility, and cell division.

HY-D0199R

Adenosine 5'-diphosphate disodium (Standard) Adenosine diphosphate disodium (Standard); ADP disodium (Standard)	Structural Classification Natural Products Endogenous metabolite Source Classification	Endogenous Metabolite Reference Standards
Adenosine 5'-diphosphate (disodium) (Standard) is the analytical standard of Adenosine 5'-diphosphate (disodium). This product is intended for research and analytical applications. Adenosine 5'-diphosphate disodium is a nucleoside diphosphate. Adenosine 5'-diphosphate disodium is the product of ATP dephosphorylation by ATPases. Adenosine 5'-diphosphate disodium is a platelet aggregation agent for hemostasis and the development and extension of arterial thrombosis .

HY-N6574

Marinobufogenin	Classification of Application Fields Neurological Disease Animals Metabolic Disease Disease Research Fields Steroids Source Classification	Na+/K+ ATPase
Marinobufogenin is a strong inhibitor of Na ⁺/K ⁺ ATPase that has been identified in mammalian plasma .

HY-108970

Bafilomycin D	Natural Products Microorganisms Source Classification	Proton Pump Bacterial Fungal
Bafilomycin D is a specific inhibitor of vacuolar-type ATPase (V-ATPase). Bafilomycin D has antimicrobial, insecticidal, herbicidal and cytotoxic activity .

HY-N11690

Oleandrigenin	Apocynaceae Structural Classification Cardiacglycosides Nerium indicum Mill. Plants Steroids Source Classification	Na+/K+ ATPase
Oleandrigenin is a potent cardiotonic steroid. Oleandrigenin shows Na ⁺/K ⁺-ATP-ase inhibiting and cytotoxic activities .

Cat. No.	Product Name	Chemical Structure

HY-N1446S2

Oleic acid-13C18 1 Publications Verification
Oleic acid- ¹³C₁₈ is the ¹³C labeled Oleic acid (HY-N1446). Oleic acid (9-cis-Octadecenoic acid) is an abundant monounsaturated fatty acid . Oleic acid is a Na+/K+ ATPase activator .

HY-N1446S5

Oleic acid-d9
Oleic acid-d₉ is deuterium labeled Oleic acid (HY-N1446). Oleic acid is an abundant monounsaturated fatty acid. Oleic acid is a Na+/K+ ATPase activato .

HY-N1446S1

Oleic acid-d2 1 Publications Verification
Oleic acid-d₂) is the deuterium labeled Oleic acid (HY-N1446). Oleic acid (9-cis-Octadecenoic acid) is an abundant monounsaturated fatty acid ]. Oleic acid is a Na+/K+ ATPase activator .

HY-N1446S

Oleic acid-13C
Oleic acid- ¹³C is the ¹³C labeled Oleic acid (HY-N1446). Oleic acid (9-cis-Octadecenoic acid) is an abundant monounsaturated fatty acid . Oleic acid is a Na+/K+ ATPase activator .

HY-13757AS

Tamoxifen-d5
Tamoxifen-d₅ is a deuterium labeled Tamoxifen. Tamoxifen (ICI 47699) is an orally active, selective estrogen receptor modulator (SERM). Tamoxifen is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity .

HY-100560S

Abscisic acid-d6
Abscisic acid-d₆ is deuterium labeled Abscisic acid. Abscisic acid inhibits proton pump (H ⁺-ATPase) .

HY-W010918S2

Adenosine 5'-diphosphate-15N5 dilithium

Adenosine 5'-diphosphate- ¹⁵N₅ (Adenosine diphosphate- ¹⁵N₅ dilithium) dilithium is ¹⁵N labeled Adenosine 5'-diphosphate (HY-W010918). Adenosine 5'-diphosphate (Adenosine diphosphate) is a nucleoside diphosphate. Adenosine 5'-diphosphate is the product of ATP dephosphorylation by ATPases. Adenosine 5'-diphosphate induces human platelet aggregation and inhibits stimulated adenylate cyclase by an action at P_2T-purinoceptors.

HY-B0113S

Omeprazole-d3

1 Publications Verification

Omeprazole-d₃ (H 16868-d₃) is deuterium labeled Omeprazole. Omeprazole (H 16868) is an orally active H ⁺,K ⁺-ATPase inhibitor and a proton pump inhibitor. Omeprazole competitively inhibits CYP2C19, CYP3A4, and CYP2C9 activity. Omeprazole inhibits gastric acid secretion and can be used for acid-related gastrointestinal disorders. Omeprazole inhibits pancreatic cancer cell proliferation, induces apoptosis, autophagosome accumulation (elevated LC3-I and LC3-II levels), oxidative stress, and cytogenetic imbalance, modulates lysosomal transport, reduces inflammatory cytokines. Omeprazole alters small intestinal morphology and magnesium absorption, and induces gastric mucosa morphologic changes. Omeprazole aslo has neuroprotective and antibacterial effects .

HY-N1446S3

Oleic acid-d17
Oleic acid-d₁₇ is the deuterium labeled Oleic acid (HY-N1446). Oleic acid (9-cis-Octadecenoic acid) is an abundant monounsaturated fatty acid . Oleic acid is a Na+/K+ ATPase activator .

HY-W010918S3

Adenosine 5'-diphosphate-13C5

Adenosine 5'-diphosphate- ¹³C₅ (Adenosine diphosphate- ¹³C₅) is the ¹³C-labeled Adenosine 5'-diphosphate (HY-W010918). Adenosine 5'-diphosphate (Adenosine diphosphate) is a nucleoside diphosphate. Adenosine 5'-diphosphate is the product of ATP dephosphorylation by ATPases. Adenosine 5'-diphosphate induces human platelet aggregation and inhibits stimulated adenylate cyclase by an action at P2T-purinoceptors.

HY-B0113S3

Omeprazole-13C,d3

Omeprazole- ¹³C,d₃ is a ¹³C-labeled and deuterium labeled Omeprazole. Omeprazole (H 16868) is an orally active H ⁺,K ⁺-ATPase inhibitor and a proton pump inhibitor. Omeprazole competitively inhibits CYP2C19, CYP3A4, and CYP2C9 activity. Omeprazole inhibits gastric acid secretion and can be used for acid-related gastrointestinal disorders. Omeprazole inhibits pancreatic cancer cell proliferation, induces apoptosis, autophagosome accumulation (elevated LC3-I and LC3-II levels), oxidative stress, and cytogenetic imbalance, modulates lysosomal transport, reduces inflammatory cytokines. Omeprazole alters small intestinal morphology and magnesium absorption, and induces gastric mucosa morphologic changes. Omeprazole aslo has neuroprotective and antibacterial effects .

HY-N1446S4

Oleic acid-13C-1
Oleic acid- ¹³C-1 is the ¹³C labeled Oleic acid (HY-N1446). Oleic acid (9-cis-Octadecenoic acid) is an abundant monounsaturated fatty acid . Oleic acid is a Na+/K+ ATPase activator .

HY-17021S1

Esomeprazole-d3
Esomeprazole-d₃ is deuterium labeled Esomeprazole. Esomeprazole ((S)-Omeprazole) is a potent and orally active proton pump inhibitor and reduces acid secretion through inhibition of the H+, K+-ATPase in gastric parietal cells. Esomeprazole has the potential for symptomatic gastroesophageal reflux disease research .

HY-B0656AS

Rabeprazole-d4 sodium

Rabeprazole-d₄ (sodium) is the deuterium labeled Rabeprazole sodium. Rabeprazole sodium (LY307640 sodium) is a second-generation proton pump inhibitor (PPI) that irreversibly inactivates gastric H+/K+-ATPase. Rabeprazole sodium induces apoptosis. Rabeprazole sodium acts as an uridine nucleoside ribohydrolase (UNH) inhibitor with an IC₅₀ of 0.3 μM. Rabeprazole sodium can be used for the research of gastric ulcerations and gastroesophageal reflux .

HY-17623S

Tegoprazan-d6

Tegoprazan (CJ-12420; RQ-00000004), a potassium-competitive acid blocker, is a reversible, oral active and highly selective inhibitor of gastric H+/K+-ATPase that could control gastric acid secretion and motility, with IC₅₀ values ranging from 0.29-0.52 μM for porcine, canine, and human H ⁺/K ⁺-ATPases in vitro. Tegoprazan significantly improves colitis in mice and enhances the intestinal epithelial barrier function. Tegoprazan is promising for research of Inflammatory bowel, gastric acid-related, motilityimpaired diseases .

HY-B0656S

Rabeprazole-d4
Rabeprazole-d₄ is a deuterium labeled Rabeprazole. Rabeprazole is a second-generation proton pump inhibitor (PPI) that irreversibly inactivates gastric H+/K+-ATPase. Rabeprazole induces apoptosis. Rabeprazole acts as an uridine nucleoside ribohydrolase (UNH) inhibitor with an IC₅₀ of 0.3 μM. Rabeprazole can be used for the research of gastric ulcerations and gastroesophageal reflux .

HY-13757S

Tamoxifen-d3 hydrochloride

Tamoxifen-d₃ hydrochloride is deuterated labeled Tamoxifen (Citrate) (HY-13757). Tamoxifen Citrate (ICI 46474) is an orally active, selective estrogen receptor modulator (SERM) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells .Tamoxifen Citrate is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen Citrate also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC₅₀ of 0.1 μM and 1.8 μM, respectively . Tamoxifen Citrate activates autophagy and induces apoptosis .Tamoxifen Citrate also can induce gene knockout of CreER(T2) transgenic mouse .

HY-17023S

Esomeprazole-d6 sodium
Esomeprazole-d₆ sodium is the deuterium labeled Esomeprazole. Esomeprazole ((S)-Omeprazole) is a potent and orally active proton pump inhibitor and reduces acid secretion through inhibition of the H ⁺, K ⁺-ATPase in gastric parietal cells. Esomeprazole has the potential for symptomatic gastroesophageal reflux disease research .

HY-A0213AS

Tiludronate-d5 sodium
Tiludronate-d₅ (sodium)mis the deuterium labeled Tiludronate disodium. Tiludronate (Tiludronic Acid) disodium, an orally active bisphosphonate, can act an osteoregulator. Tiludronate is used for the research of the metabolic bone disorders. Tiludronate is a potent inhibitor of the osteoclast vacuolar H(+)-ATPase. Antiresorptive and anti-inflammatory properties .

HY-W008614S

Lansoprazole sulfone-d4
Lansoprazole sulfone (AG-1813)-d₄ is the deuterium labeled Lansoprazole sulfone (HY-W008614). Lansoprazole sulfone, Lansoprazole (HY-13662) metabolite, is a H ⁺, K ⁺-ATPase inhibitor. Lansoprazole sulfone has potential applications in duodenal ulcer, gastric ulcer, gastroesophageal reflux disease and Zolinger Ellison disease .

HY-17507S

Pantoprazole-d6

Pantoprazole-d₆ is deuterium labeled Pantoprazole. Pantoprazole (BY10232) is an orally active and potent proton pump inhibitor (PPI) . Pantoprazole, a substituted benzimidazole, is a potent H+/K+-ATPase inhibitor with an IC₅₀ of 6.8 μM. Pantoprazole improves pH stability and has anti-secretory, anti-ulcer activities. Pantoprazole significantly increased tumor growth delay combined with Doxorubicin (HY-15142) .

HY-Z3421S

Vonoprazan-d3 fumarate

Vonoprazan-d₃ fumarate is the deuterium labeled Vonoprazan fumarate (HY-15295). Vonoprazan Fumarate (TAK-438), a proton pump inhibitor (PPI), is a potent and orally active potassium-competitive acid blocker (P-CAB), with antisecretory activity. Vonoprazan Fumarate inhibits H+,K+-ATPase activity in porcine gastric microsomes with an IC50 of 19 nM at pH 6.5. Vonoprazan Fumarate is developed for the research of acid-related diseases, such as gastroesophageal reflux disease and peptic ulcer disease .

HY-B0656AS2

Rabeprazole-d4 potassium

Rabeprazole-d₄ potassium is deuterated labeled Rabeprazole potassium. Rabeprazole (LY307640) is a second-generation proton pump inhibitor (PPI) that irreversibly inactivates gastric H+/K+-ATPase. Rabeprazole induces apoptosis. Rabeprazole acts as an uridine nucleoside ribohydrolase (UNH) inhibitor with an b>IC₅₀ of 0.3 μM. Rabeprazole can be used for the research of gastric ulcerations and gastroesophageal reflux .

HY-W015912S

2-Acetylfuran-d3

2-Acetylfuran-d₃ is deuterated labeled Citreoviridin (HY-N6745). Citreoviridin, a toxin from Penicillium citreoviride NRRL 2579, inhibits brain synaptosomal Na ⁺/K ⁺-ATPase whereas in microsomes, both Na ⁺/K ⁺-ATPase and Mg ²⁺-ATPase activities are significantly stimulated in a dose-dependent manner . Citreoviridin inhibits cell proliferation and enhances apoptosis of human umbilical vein endothelial cells .

HY-B0137AS

Prilocaine-d7 hydrochloride
Prilocaine-d₇ (hydrochloride) is deuterium labeled Prilocaine (hydrochloride). Prilocaine hydrochloride, an amino amide, is a Na, K-ATPase inhibitor. Prilocaine has neurotoxic effects .

HY-W704786

Prilocaine Hydrochloride-d7
Prilocaine Hydrochloride-d₇ is the deuterium labeled Prilocaine hydrochloride (HY-B0137A). Prilocaine hydrochloride, an amino amide, is a Na/K-ATPase inhibitor. Prilocaine has neurotoxic effects .

HY-W709055

Pantoprazole sulfone-d6 (major)
Pantoprazole sulfone-d₆ (major) is the deuterium labeled Pantoprazole sulfone (HY-117225). Pantoprazole sulfone is a metabolite of the gastric H+/K+ ATPase pump inhibitor Pantoprazole (HY-17507) .

HY-113410S

3-Methylglutaric acid-d4

3-Methylglutaric acid-d₄ is the deuterium labeled 3-Methylglutaric acid (HY-113410). 3-Methylglutaric acid is a non-selective inhibitor of mitochondrial function and Na ⁺, K ⁺-ATPase, with an inhibition rate of 30% on rat cortical synaptosomal Na ⁺, K ⁺-ATPase. 3-Methylglutaric acid can induce reactive oxygen species (ROS) generation, thereby causing oxidative damage and inhibiting mitochondrial redox potential and ion pump function of cell membranes. 3-Methylglutaric acid can be used to study the neuropathological mechanisms of metabolic diseases and the role of oxidative stress-mediated neuronal damage in neurodegeneration .

HY-17021S

Esomeprazole-d3 sodium
Esomeprazole-d₃ (sodium) is the deuterium labeled Esomeprazole. Esomeprazole ((S)-Omeprazole) is a potent and orally active proton pump inhibitor and reduces acid secretion through inhibition of the H+, K+-ATPase in gastric parietal cells. Esomeprazole has the potential for symptomatic gastroesophageal reflux disease research .

HY-17021S2

Esomeprazole-d3 potassium
Esomeprazole-d₃ potassium is deuterated labeled Esomeprazole (HY-17021). Esomeprazole ((S)-Omeprazole) is a potent and orally active proton pump inhibitor and reduces acid secretion through inhibition of the H ⁺, K ⁺-ATPase in gastric parietal cells. Esomeprazole has the potential for symptomatic gastroesophageal reflux disease research .

HY-W008614S1

Lansoprazole sulfone-13C6
Lansoprazole sulfone (AG-1813)- ¹³C₆ is ¹³C labeled Lansoprazole sulfone (HY-W008614). Lansoprazole sulfone, Lansoprazole (HY-13662) metabolite, is a H ⁺, K ⁺-ATPase inhibitor. Lansoprazole sulfone has potential applications in duodenal ulcer, gastric ulcer, gastroesophageal reflux disease and Zolinger Ellison disease .

HY-W719463

Rabeprazole sulfide-d4

Rabeprazole sulfide-d₄ is the deuterium labeled Rabeprazole Sulfide (HY-W003467). Rabeprazole Sulfide is an active metabolite of Rabeprazole. Rabeprazole is a proton pump inhibitor that suppresses gastric acid secretion through an interaction with (H+/K+)-ATPase in gastric parietal cells. Rabeprazole markedly inhibits the motility of H. pylori. Rabeprazole has the potential for various peptic diseases treatment .

HY-B0656S1

Rabeprazole-13C,d3

Rabeprazole-13C,d3 is a deuterated labeled Rabeprazole . Rabeprazole (LY307640) is a second-generation proton pump inhibitor (PPI) that irreversibly inactivates gastric H ⁺/K ⁺-ATPase. Rabeprazole induces apoptosis. Rabeprazole acts as an uridine nucleoside ribohydrolase (UNH) inhibitor with an IC₅₀ of 0.3 μM. Rabeprazole can be used for the research of gastric ulcerations and gastroesophageal reflux .

HY-17507S1

Pantoprazole-d3

Pantoprazole-d₃ is deuterium labeled Pantoprazole. Pantoprazole (BY10232) is an orally active and potent proton pump inhibitor (PPI) . Pantoprazole, a substituted benzimidazole, is a potent H+/K+-ATPase inhibitor with an IC₅₀ of 6.8 μM. Pantoprazole improves pH stability and has anti-secretory, anti-ulcer activities. Pantoprazole significantly increased tumor growth delay combined with Doxorubicin (HY-15142) .

HY-B0656AS1

Rabeprazole-d3 sodium

Rabeprazole-d₃ sodium the deuterium labeled Rabeprazole sodium (HY-B0656A). Rabeprazole sodium (LY307640 sodium) is a second-generation proton pump inhibitor (PPI) that irreversibly inactivates gastric H+/K+-ATPase. Rabeprazole sodium induces apoptosis. Rabeprazole sodium acts as an uridine nucleoside ribohydrolase (UNH) inhibitor with an b>IC₅₀ of 0.3 μM. Rabeprazole sodium can be used for the research of gastric ulcerations and gastroesophageal reflux .

HY-B0656AS3

Rabeprazole-13C,d3 sodium

Rabeprazole- ¹³C,d₃ (sodium) (LY307640- ¹³C,d₃ (sodium)) is ¹³C labeled Rabeprazole (sodium). Rabeprazole sodium (LY307640 sodium) is a second-generation proton pump inhibitor (PPI) that irreversibly inactivates gastric H ⁺/K ⁺-ATPase. Rabeprazole sodium induces apoptosis. Rabeprazole sodium acts as an uridine nucleoside ribohydrolase (UNH) inhibitor with an IC₅₀ of 0.3 μM. Rabeprazole sodium can be used for the research of gastric ulcerations and gastroesophageal reflux .

HY-W739793

Pantoprazole-d8 sodium

Pantoprazole-d₈ (BY1023-d₈) sodium is a deuterium labeled Pantoprazole (HY-17507). Pantoprazole (BY10232) is an orally active and potent proton pump inhibitor (PPI) . Pantoprazole, a substituted benzimidazole, is a potent H ⁺/K ⁺-ATPase inhibitor with an IC₅₀ of 6.8 μM. Pantoprazole improves pH stability and has anti-secretory, anti-ulcer activities. Pantoprazole significantly increased tumor growth delay combined with Doxorubicin (HY-15142) .

HY-17507S4

Pantoprazole-d4

Pantoprazole-d₄ (BY1023-d₄) is deuterium labeled Pantoprazole. Pantoprazole (BY10232) is an orally active and potent proton pump inhibitor (PPI) . Pantoprazole, a substituted benzimidazole, is a potent H ⁺/K ⁺-ATPase inhibitor with an IC₅₀ of 6.8 μM. Pantoprazole improves pH stability and has anti-secretory, anti-ulcer activities. Pantoprazole significantly increased tumor growth delay combined with Doxorubicin (HY-15142) .

HY-17507S2

Pantoprazole-d8

Pantoprazole-d₈ (BY1023-d₈) is deuterium labeled Pantoprazole. Pantoprazole (BY10232) is an orally active and potent proton pump inhibitor (PPI) . Pantoprazole, a substituted benzimidazole, is a potent H ⁺/K ⁺-ATPase inhibitor with an IC₅₀ of 6.8 μM. Pantoprazole improves pH stability and has anti-secretory, anti-ulcer activities. Pantoprazole significantly increased tumor growth delay combined with Doxorubicin (HY-15142) .

HY-W755679

Digitoxigenin-21,23,23-d3

Digitoxigenin-21,23,23-d₃ (Cerberigenin-d₃; Echujetin-d₃) is the deuterium labeled Digitoxigenin (HY-B2151). Digitoxigenin is a steroid derivative commonly found in various plants, especially the foxglove plant (Digitalis purpurea). Digitoxigenin has unique chemical properties that make it an important precursor for the synthesis of cardiac glycosides, a group of drugs used to improve heart failure and certain types of arrhythmias. It works by inhibiting the sodium potassium ATPase pump, thereby increasing the force and efficiency of cardiac contractions.

HY-13757AS1

Tamoxifen-d3

Tamoxifen-d₃ is the deuterium labeled Tamoxifen . Tamoxifen (ICI 47699) is an orally active, selective estrogen receptor modulator (SERM) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells . Tamoxifen is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC50 of 0.1 μM and 1.8 μM, respectively . Tamoxifen activates autophagy and induces apoptosis . Tamoxifen also can induce gene knockout of CreER(T2) transgenic mouse .

HY-W778408

Tamoxifen-13C6

Tamoxifen- ¹³C₆ (ICI 47699- ¹³C₆) is the ¹³C-labeled Tamoxifen (HY-13757A). Tamoxifen (ICI 47699) is an orally active, selective estrogen receptor modulator (SERM) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells . Tamoxifen is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC₅₀ of 0.1 μM and 1.8 μM, respectively . Tamoxifen activates autophagy and induces apoptosis . Tamoxifen also can induce gene knockout of CreER transgenic mouse .

HY-136450S

Triclabendazole sulfoxide-d3

Triclabendazole sulfoxide-d₃ is the deuterium labeled Triclabendazole sulfoxide. Triclabendazole sulfoxide (TCBZ-SO) is an orally active ABCG2 inhibitor with antiparasitic activity. Triclabendazole sulfoxide inhibits ABCG2-mediated active efflux and ATPase activity. Triclabendazole sulfoxide increases the intracellular accumulation of Mitoxantrone (HY-13502). Triclabendazole sulfoxide reduces the apical-directed transepithelial transport of Nitrofurantoin and Danofloxacin, while increasing their basolateral-directed transepithelial transport. Triclabendazole sulfoxide elevates the plasma levels of sulfasalazine in wild-type mice. Triclabendazole sulfoxide decreases ABCG2-mediated secretion of Nitrofurantoin into milk in wild-type lactating mice. Triclabendazole sulfoxide can be used in the research of insecticidal agents and cancers such as breast cancer .

HY-136450S1

Triclabendazole sulfoxide-13C,d3

Triclabendazole sulfoxide- ¹³C,d₃ is the ¹³C- and deuterium labeled Triclabendazole sulfoxide. Triclabendazole sulfoxide (TCBZ-SO) is an orally active ABCG2 inhibitor with antiparasitic activity. Triclabendazole sulfoxide inhibits ABCG2-mediated active efflux and ATPase activity. Triclabendazole sulfoxide increases the intracellular accumulation of Mitoxantrone (HY-13502). Triclabendazole sulfoxide reduces the apical-directed transepithelial transport of Nitrofurantoin and Danofloxacin, while increasing their basolateral-directed transepithelial transport. Triclabendazole sulfoxide elevates the plasma levels of sulfasalazine in wild-type mice. Triclabendazole sulfoxide decreases ABCG2-mediated secretion of Nitrofurantoin into milk in wild-type lactating mice. Triclabendazole sulfoxide can be used in the research of insecticidal agents and cancers such as breast cancer .

HY-B0113S4

Omeprazole-d3 sodium

Omeprazole-d₃ sodium is deuterated labeled Omeprazole (HY-B0113). Omeprazole sodium (H 16868) is an orally active H ⁺,K ⁺-ATPase inhibitor and a proton pump inhibitor. Omeprazole sodium competitively inhibits CYP2C19, CYP3A4, and CYP2C9 activity. Omeprazole sodium inhibits gastric acid secretion and can be used for acid-related gastrointestinal disorders. Omeprazole sodium inhibits pancreatic cancer cell proliferation, induces apoptosis, autophagosome accumulation (elevated LC3-I and LC3-II levels), oxidative stress, and cytogenetic imbalance, modulates lysosomal transport, reduces inflammatory cytokines. Omeprazole sodium alters small intestinal morphology and magnesium absorption, and induces gastric mucosa morphologic changes. Omeprazole sodium aslo has neuroprotective and antibacterial effects .

HY-B0113S2

Omeprazole sulfone (methoxy-d3)

Omeprazole sulfone (methoxy-d₃) is the deuterium labeled Omeprazole sulfone. Omeprazole sulfone (H 16868) is an orally active H ⁺,K ⁺-ATPase inhibitor and a proton pump inhibitor. Omeprazole sulfone competitively inhibits CYP2C19, CYP3A4, and CYP2C9 activity. Omeprazole sulfone inhibits gastric acid secretion and can be used for acid-related gastrointestinal disorders. Omeprazole sulfone inhibits pancreatic cancer cell proliferation, induces apoptosis, autophagosome accumulation (elevated LC3-I and LC3-II levels), oxidative stress, and cytogenetic imbalance, modulates lysosomal transport, reduces inflammatory cytokines. Omeprazole sulfone alters small intestinal morphology and magnesium absorption, and induces gastric mucosa morphologic changes. Omeprazole sulfone aslo has neuroprotective and antibacterial effects .

HY-B0113S5

Omeprazole-d6

Omeprazole-d₆ (H 16868-d₆) is deuterium labeled Omeprazole. Omeprazole (H 16868) is an orally active H ⁺,K ⁺-ATPase inhibitor and a proton pump inhibitor. Omeprazole competitively inhibits CYP2C19, CYP3A4, and CYP2C9 activity. Omeprazole inhibits gastric acid secretion and can be used for acid-related gastrointestinal disorders. Omeprazole inhibits pancreatic cancer cell proliferation, induces apoptosis, autophagosome accumulation (elevated LC3-I and LC3-II levels), oxidative stress, and cytogenetic imbalance, modulates lysosomal transport, reduces inflammatory cytokines. Omeprazole alters small intestinal morphology and magnesium absorption, and induces gastric mucosa morphologic changes. Omeprazole aslo has neuroprotective and antibacterial effects .

HY-B0113S1

Omeprazole-d3-1

Omeprazole-d₃-1 is the deuterium labeled Omeprazole. Omeprazole-1 (H 16868) is an orally active H ⁺,K ⁺-ATPase inhibitor and a proton pump inhibitor. Omeprazole-1 competitively inhibits CYP2C19, CYP3A4, and CYP2C9 activity. Omeprazole-1 inhibits gastric acid secretion and can be used for acid-related gastrointestinal disorders. Omeprazole-1 inhibits pancreatic cancer cell proliferation, induces apoptosis, autophagosome accumulation (elevated LC3-I and LC3-II levels), oxidative stress, and cytogenetic imbalance, modulates lysosomal transport, reduces inflammatory cytokines. Omeprazole-1 alters small intestinal morphology and magnesium absorption, and induces gastric mucosa morphologic changes. Omeprazole-1 aslo has neuroprotective and antibacterial effects .

HY-N6771S

Cyclopiazonic acid-13C20

Cyclopiazonic acid- ¹³C₂₀ is the ¹³C-labeled Cyclopiazonic acid (HY-N6771). Cyclopiazonic acid is an endoplasmic reticulum calcium ATPase (ECAs) inhibitor and human respiratory syncytial virus (RSV) inhibitor (EC₅₀ value of 4.13 μ M), which can reduce the antagonistic effect of 5-HT receptors in rat thoracic aorta, induce p53 dependent cell apoptosis and reproductive toxicity in mouse testes, and inhibit the biological activation of aflatoxin B .

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