74 Results for "

Bleomycin

" in MedChemExpress (MCE) Product Catalog:
Products (74)

74 Results for "Bleomycin" in MCE Product Catalog:

194
Bleomycin sulfate
Bleomycin sulfate
0 Images
194 Publications Verification
Cat. No.: HY-17565
CAS No.: 9041-93-4
Synonyms: Bleomycin sulfate
Category:  

Microorganisms Antibiotics Resistance Selection Mammalian Cell Culture Disease Research Anticancer Disease Research Fields Other Antibiotics Cancer

Target:  

DNA/RNA Synthesis Antibiotic

Bleomycin sulfate is a DNA synthesis inhibitor. Bleomycin hydrochloride is a DNA damaging agent. Bleomycin sulfate is an antitumor antibiotic .
194
Bleomycin hydrochloride
Bleomycin hydrochloride
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194 Publications Verification
Cat. No.: HY-17565A
CAS No.: 67763-87-5
Target:  

DNA/RNA Synthesis Antibiotic

Research Areas:  

Cancer

Bleomycin hydrochloride is a DNA synthesis inhibitor. Bleomycin hydrochloride is a DNA damaging agent. Bleomycin hydrochloride is an antitumor antibiotic .
30
Entrectinib
Entrectinib
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30 Cited Publications
Cat. No.: HY-12678
CAS No.: 1108743-60-7
Purity:  99.79%
Synonyms: NMS-E628; RXDX-101
Target:  

ROS Kinase Trk Receptor Anaplastic lymphoma kinase (ALK) Autophagy

Research Areas:  

Cancer

Entrectinib (NMS-E628) is an orally active, BBB-penetrated and centrally active inhibitor of TrkA/B/C, ROS1 and ALK, with IC50 values of 1, 3, 5, 12 and 7 nM, respectively. Entrectinib induces apoptosis and cycle arrest in cancer cells, has antitumor activity, and attenuates bleomycin-induced lung fibrosis in mice .
16
Crocin
Crocin
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16 Cited Publications
Cat. No.: HY-N0697
CAS No.: 42553-65-1
Synonyms: Crocin I
Category:  

Neurological Disease Anti-aging Lridaceae Plants Crocus sativus L. Functional Molecules Terpenoids Research of Health Products Diterpenoids Disease Research Fields Inflammation/Immunology Cancer

Target:  

Endogenous Metabolite JAK Apoptosis

Crocin (Crocin I) is an orally active natural product that can be isolated from the stigma of Crocus sativus. Crocin inhibits tumor cell proliferation and promotes apoptosis through JAK pathway. Crocin has anti-inflammatory, antioxidant and antitumor activities .
3
AR-C118925XX
AR-C118925XX
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3 Cited Publications
Cat. No.: HY-110126
CAS No.: 216657-60-2
Purity:  98.27%
Target:  

P2Y Receptor

Research Areas:  

Inflammation/Immunology Cancer

AR-C118925XX is a selective P2Y2 receptor antagonist. AR-C118925XX inhibits ATP-induced IL-6 production and phosphorylation of p38. AR-C118925XX also inhibits Bleomycin (HY-108345)-induced dermal fibrosis in mice. AR-C118925XX also inhibits ATP-induced tumor growth .
2
Fresolimumab
Fresolimumab
0 Images
2 Cited Publications
Cat. No.: HY-P99020
CAS No.: 948564-73-6
Synonyms: GC1008

Target:  

TGF-beta/Smad

Research Areas:  

Inflammation/Immunology Cancer

Fresolimumab (GC1008) is a human monoclonal antibody against TGF-β that neutralizes all mammalian active subtypes of TGF-β. The binding affinity of Fresolimumab to TGF-β2 is 1.8 nM. Fresolimumab improves Bleomycin (HY-108345)-induced acute lung injury. Fresolimumab radiolabeled with 89Zr can be used for PET analysis of TGF-β expression, antibody uptake and organ distribution. Fresolimumab can be used in the study of cancer, osteogenesis imperfecta, fibrosis and kidney disease .
2
Curdione
Curdione
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2 Cited Publications
Cat. No.: HY-N0353
CAS No.: 13657-68-6
Synonyms: (+)-Curdione
Category:  

Terpenoids Sesquiterpenes Other Diseases Plants Curcuma phaeocaulis Valeton Disease Research Fields Zingiberaceae

Target:  

Ferroptosis Apoptosis Reactive Oxygen Species (ROS) Autophagy Glutathione Peroxidase Keap1-Nrf2 Heme Oxygenase (HO) TGF-β Receptor Indoleamine 2,3-Dioxygenase (IDO)

Curdione ((+)-Curdione) is an orally active sesquiterpenoid. Curdione inhibits platelet aggregation. Curdione induces ferroptosis in colorectal cancer via m6A methylation mediated by METTL14 and YTHDF2. Curdione inhibits ferroptosis in Isoproterenol (HY-B0468)-induced myocardial infarction by regulating the Keap1/Trx1/GPX4 signaling pathway, suppressing oxidative stress (ROS) and apoptosis. Curdione ameliorates Doxorubicin (HY-15142)-induced cardiotoxicity by inhibiting oxidative stress (ROS) and activating the Nrf2/HO-1 pathway. Curdione ameliorates sepsis-induced lung injury by inhibiting platelet-mediated neutrophil extracellular trap formation. Curdione ameliorates Bleomycin (HY-17565A)-induced pulmonary fibrosis by inhibiting TGF-β-induced fibroblast-to-myofibroblast differentiation. Curdione exhibits neuroprotective effects against focal cerebral ischemia-reperfusion injury in rats. Curdione exerts antiproliferative effects against human uterine leiomyosarcoma by targeting IDO1. Curdione protects vascular endothelial cells and atherosclerosis by regulating DNMT1-mediated ERBB4 promoter methylation. Curdione inhibits inducible prostaglandin E2 production (IC50 = 1.1 μM) and cyclooxygenase 2 expression .
2
Phleomycin D1
Phleomycin D1
0 Images
2 Cited Publications
Cat. No.: HY-111428
CAS No.: 11031-11-1
Synonyms: PLM D1
Target:  

Antibiotic

Research Areas:  

Infection

Phleomycin D1 (PLM D1), a glycopeptide antibiotic, is a member of the Bleomycin/Phleomycin family. Phleomycin D1 causes cell death by binding and cleaving DNA. Phleomycin D1 induces cell cycle arrest at S phase .
1
Bleomycin A5
Bleomycin A5
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1 Cited Publications
Cat. No.: HY-N10470
CAS No.: 11116-32-8
Synonyms: Pingyangmycin
Category:  

Natural Products Microorganisms Animals

Target:  

Antibiotic DNA/RNA Synthesis Apoptosis Dynamin PINK1/Parkin Mitophagy

Bleomycin A5 (Pingyangmycin) is a glycopeptide antibiotic with multiple biological activities, which can be isolated from Streptomyces. Bleomycin A5 exerts cytotoxic effects by binding to Fe 2+ to form a complex, inducing single-strand and double-strand DNA breaks, and inhibiting DNA replication. Bleomycin A5 inhibits Drp1-mediated mitochondrial fission and suppresses PINK1/Parkin pathway-mediated mitophagy, ultimately triggering mitochondria-mediated cellular apoptosis. Bleomycin A5 can be used in cancer research .
1
Dermatan sulphate sodium
Dermatan sulphate sodium
0 Images
1 Cited Publications
Cat. No.: HY-N8278
CAS No.: 54328-33-5
Category:  

Natural Products Animals Disease Research Fields Inflammation/Immunology

Target:  

Thrombin

Dermatan sulphate sodium is an oral active glycosaminoglycan and thrombin inactivator with antithrombotic activity. It selectively catalyzes the heparin cofactor II-mediated inactivation of thrombin without interacting with antithrombin III. Dermatan sulphate sodium promotes stem cell differentiation, exhibits high bioavailability, and alleviates pulmonary fibrosis injury induced by Bleomycin (HY-108345). Dermatan sulphate sodium can be used in research related to cardiovascular diseases, inflammation, and stem cell differentiation .
1
TGFβ-IN-2
TGFβ-IN-2
0 Images
1 Cited Publications
Cat. No.: HY-146434
CAS No.: 2387678-02-4
Purity:  99.37%
Target:  

TGF-beta/Smad

Research Areas:  

Inflammation/Immunology

TGFβ-IN-2 is an orally active TGF-β inhibitor. TGFβ-IN-2 suppresses the TGF-β-induced protein expression of COL1A1, α-SMA, and p-Smad3 in vitro. TGFβ-IN-2 demonstrates excellent anti-fibrotic efficacy in Bleomycin (HY-108345)-induced pulmonary fibrosis model. TGFβ-IN-2 can be used for the study of pulmonary fibrosis .
Bleomycin
Bleomycin
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Cat. No.: HY-108345
CAS No.: 11056-06-7
Target:  

Antibiotic

Research Areas:  

Cancer

Bleomycin is a glycopeptide antibiotic. Bleomycin has potent antitumour activities against a range of lymphomas, head and neck cancers and germ-cell tumours. Bleomycin can be used for the research of cancer and chemotherapy .
CCG-232601
CCG-232601
0 Images
Cat. No.: HY-111432
CAS No.: 1922099-21-5
Purity:  99.00%
Target:  

Ras

Research Areas:  

Others

CCG-232601 (compound 8f) is a potent and orally active Rho/MRTF/SRF transcriptional pathway inhibitor. CCG-232601 inhibits the development of Bleomycin-induced dermal fibrosis in mice. CCG-232601 has the potential for the research of antifibrotic for systemic scleroderma .
AX-202
AX-202
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Cat. No.: HY-P991363

Target:  

Myosin STAT

Research Areas:  

Inflammation/Immunology

AX-202 is a humanized IgG4 monoclonal antibody targeting S100A4. AX-202 neutralizes the activity of S100A4. AX-202 effectively reverses established fibrosis and reduces inflammation and fibrosis-related biomarkers in a mouse model of skin fibrosis. AX-202 is applicable for the research of fibrotic and inflammatory diseases .
Licoricesaponin G2
Licoricesaponin G2
0 Images
Cat. No.: HY-N6983
CAS No.: 118441-84-2
Category:  

Other Terpenoids Leguminosae Terpenoids Plants Disease Research Fields Glycyrrhiza uralensis Fisch. Cancer

Target:  

TNF Receptor PI3K Akt mTOR Reactive Oxygen Species (ROS)

Licoricesaponin G2 is an orally active component found in Licorice. Licoricesaponin G2 significantly ameliorates Bleomycin (HY-108345)-induced pulmonary fibrosis by inhibiting the TNF-α signaling pathway, reducing epithelial-mesenchymal transition, and decreasing extracellular matrix deposition. Licoricesaponin G2 inhibits cancer cells proliferation, migration, inhibits PI3K/AKT/mTOR signaling pathway and increases ROS production. Licoricesaponin G2 can be used for the research of lung cancer and pulmonary fibrosis .
Rosmantuzumab
Rosmantuzumab
0 Images
Cat. No.: HY-P99401
CAS No.: 1684393-04-1
Synonyms: OMP-131R10

Target:  

Wnt

Research Areas:  

Cancer

Rosmantuzumab (OMP-131R10) is an anti-R-spondin 3 (RSPO3) humanized monoclonal antibody. Rosmantuzumab can be used for the research of advanced telapsed and refractory solid tumors .
ATUX-1215
ATUX-1215
0 Images
Cat. No.: HY-156420
CAS No.: 2910929-53-0
Purity:  99.94%
Target:  

Phosphatase Apoptosis

Research Areas:  

Inflammation/Immunology Cancer

ATUX-1215 is an activator of protein phosphatase 2A (PP2A). ATUX-1215 reduced the phosphorylation of ERK, p38, JNK, and Akt and the secretion of IL-12p70, GM-CSF, and IL1α in Bleomycin hydrochloride (HY-17565A)-treated animals. ATUX-1215 can slow the progression of lung fibrosis .
Bleomycin B4
Bleomycin B4
0 Images
Cat. No.: HY-N10469
CAS No.: 9060-11-1
Synonyms: Phleomycin F
Category:  

Microorganisms Antibiotics Disease Research Fields Cancer

Target:  

Antibiotic

Bleomycin B4 (Phleomycin F) is an antibiotic. Bleomycin B4 has antitumor activity. Bleomycin B4 can be used for the research of cancer .
L-Gulose
L-Gulose
0 Images
Cat. No.: HY-128394
CAS No.: 6027-89-0
Purity:  ≥95.0%
Category:  

Metabolic Disease Endogenous metabolite Disease Research Fields Saccharides Monosaccharides

Target:  

Drug Intermediate

L-Gulose is a rare L-aldohexose in nature, and serves as a key structural unit for the synthesis of a variety of important active compounds (e.g., vitamin C) .
Bleomycin A5 hydrochloride
Bleomycin A5 hydrochloride
0 Images
Cat. No.: HY-125918
CAS No.: 55658-47-4
Synonyms: Pingyangmycin hydrochloride
Category:  

Microorganisms Antibiotics

Target:  

Antibiotic DNA/RNA Synthesis Apoptosis Dynamin PINK1/Parkin Mitophagy

Bleomycin A5 (Pingyangmycin) hydrochloride is a glycopeptide antibiotic with multiple biological activities, which can be isolated from Streptomyces. Bleomycin A5 hydrochloride exerts cytotoxic effects by binding to Fe 2+ to form a complex, inducing single-strand and double-strand DNA breaks, and inhibiting DNA replication. Bleomycin A5 hydrochloride inhibits Drp1-mediated mitochondrial fission and suppresses PINK1/Parkin pathway-mediated mitophagy, ultimately triggering mitochondria-mediated cellular apoptosis. Bleomycin A5 hydrochloride can be used in cancer research .
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