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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
69 Results for "
Bleomycin
" in MedChemExpress (MCE) Product Catalog:
Products (69)
69 Results for "Bleomycin" in MCE Product Catalog:
Cat. No.: HY-108345
CAS No.: 11056-06-7
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Bleomycin is a glycopeptide antibiotic. Bleomycin has potent antitumour activities against a range of lymphomas, head and neck cancers and germ-cell tumours. Bleomycin can be used for the research of cancer and chemotherapy .
228
Category:
Antibiotics Resistance Selection Mammalian Cell Culture Microorganism Disease Research Anticancer Disease Research Fields Other Antibiotics Cancer
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228 Publications Verification
Cat. No.: HY-17565A
CAS No.: 67763-87-5
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Bleomycin hydrochloride is a DNA synthesis inhibitor. Bleomycin hydrochloride is a DNA damaging agent. Bleomycin hydrochloride is an antitumor antibiotic .
36
36 Cited Publications
Synonyms: NMS-E628; RXDX-101
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Entrectinib (NMS-E628) is an orally active, BBB-penetrated and centrally active inhibitor of TrkA/B/C, ROS1 and ALK, with IC50 values of 1, 3, 5, 12 and 7 nM, respectively. Entrectinib induces apoptosis and cycle arrest in cancer cells, has antitumor activity, and attenuates bleomycin-induced lung fibrosis in mice .
14
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Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Olitigaltin (TD139) is a high-affinity Galectin-3 inhibitor with a Kd value of 14 nM. Olitigaltin inhibits the activity of the AKT/β-catenin pathway, induces Apoptosis, and downregulates SREBP1 expression. Olitigaltin enhances the phosphorylation level of ERK. Olitigaltin alleviates bleomycin (HY-17565A)-induced advanced pulmonary fibrosis in mice. Olitigaltin delays the onset of diabetes, and improves glucose tolerance and serum insulin levels. Olitigaltin alleviates liver injury. Olitigaltin maintains the structure of hippocampal excitatory synapses, restores γ-wave power in the hippocampal CA1 region, inhibits hippocampal neuroinflammation, and improves cognitive function in neuroinflammation models. Olitigaltin can be used in research related to thyroid cancer, idiopathic pulmonary fibrosis, type 1 diabetes, hepatitis, and cognitive dysfunction induced by neuroinflammation .
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4 Cited Publications
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AR-C118925XX is a selective P2Y2 receptor antagonist. AR-C118925XX inhibits ATP-induced IL-6 production and phosphorylation of p38. AR-C118925XX also inhibits Bleomycin (HY-108345)-induced dermal fibrosis in mice. AR-C118925XX also inhibits ATP-induced tumor growth .
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2
2 Cited Publications
Cat. No.: HY-N8278
CAS No.: 54328-33-5
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2
2
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Phleomycin D1 (PLM D1), a glycopeptide antibiotic, is a member of the Bleomycin/Phleomycin family. Phleomycin D1 causes cell death by binding and cleaving DNA. Phleomycin D1 induces cell cycle arrest at S phase .
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1
1 Cited Publications
Cat. No.: HY-N6983
CAS No.: 118441-84-2
1
1 Cited Publications
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TGFβ-IN-2 is an orally active TGF-β inhibitor. TGFβ-IN-2 suppresses the TGF-β-induced protein expression of COL1A1, α-SMA, and p-Smad3 in vitro. TGFβ-IN-2 demonstrates excellent anti-fibrotic efficacy in Bleomycin (HY-108345)-induced pulmonary fibrosis model. TGFβ-IN-2 can be used for the study of pulmonary fibrosis .
CCG-232601 (compound 8f) is a potent and orally active Rho/MRTF/SRF transcriptional pathway inhibitor. CCG-232601 inhibits the development of Bleomycin-induced dermal fibrosis in mice. CCG-232601 has the potential for the research of antifibrotic for systemic scleroderma .
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ATUX-1215 is an activator of protein phosphatase 2A (PP2A). ATUX-1215 reduced the phosphorylation of ERK, p38, JNK, and Akt and the secretion of IL-12p70, GM-CSF, and IL1α in Bleomycin hydrochloride (HY-17565A)-treated animals. ATUX-1215 can slow the progression of lung fibrosis .
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Cat. No.: HY-125918
CAS No.: 55658-47-4
Synonyms: Pingyangmycin hydrochloride
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Cat. No.: HY-N3196
CAS No.: 143120-46-1
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Alkaloids Plant Stemona tuberosa Lour. Extract Disease Research Fields Inflammation/Immunology Indole Alkaloids Stemonaceae Extract
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Cat. No.: HY-120417
CAS No.: 1802937-26-3
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JP-153 is a FAK-paxillin interaction inhibitor. JP-153 prevents the binding of the paxillin LD motif to the FAK FAT domain and disrupts the Src/FAK/paxillin focal adhesion complex, thereby reducing paxillin phosphorylation, YAP nuclear accumulation, and Akt activation. JP-153 selectively impairs mechanotaxis. JP-153 inhibits stiff matrix/TGF-β-induced myofibroblast differentiation and tumor cell invasion, and reduces tumor fibrosis and lung metastasis. JP-153 reduces Bleomycin-induced fibrosis. JP-153 inhibits VEGF-induced retinal endothelial proliferation, migration, and invasion, as well as pathological retinal neovascularization in oxygen-induced retinopathy. JP-153 attenuates tumor fibrosis and lung metastasis in KPC689 subcutaneous tumors. JP-153 can be used for research on pulmonary fibrosis, metastatic pancreatic cancer, and pathological retinal neovascularization .
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IV-255 is a selective small molecule inhibitor of the BRG1 bromodomain. IV-255 increases the extent of DNA damage induced by Temozolomide (HY-17364) and Bleomycin (HY-108345). IV-255 inhibits the invasiveness of GBM cells. IV-255 enhances Temozolomide-induced cell death and the apoptosis-inducing activity of Temozolomide .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
