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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
89 Results for "
Cu2+
" in MedChemExpress (MCE) Product Catalog:
Products (89)
89 Results for "Cu2+" in MCE Product Catalog:
155
155 Publications Verification
Synonyms: Tetraethylthiuram disulfide; TETD
Research Areas:
Disulfiram (Tetraethylthiuram disulfide) is a specific inhibitor of aldehyde-dehydrogenase (ALDH1), used for the treatment of chronic alcoholism by producing an acute sensitivity to alcohol. Disulfiram inhibits gasdermin D (GSDMD) pore formation in liposomes and inflammasome-mediated pyroptosis and IL-1β secretion in human and mouse cells. Disulfiram, a copper ion carrier, with Cu 2+ increases intracellular ROS levels and induces cuproptosis [2] .
7
7 Cited Publications
Research Areas:
Cu(II)-Elesclomol is a complex formed by Elesclomol (HY-12040) and Cu 2+ (copper ions). Cu(II)-Elesclomol is also a weak inhibitor of DNA topoisomerase I. Cu(II)-Elesclomol exerts anticancer effects by inducing oxidative stress and DNA damage through copper chelation. Cu(II)-Elesclomol can inhibit tumor cell proliferation and induce cell cycle arrest and apoptosis. Cu(II)-Elesclomol can be used in the study of cancer [2].
6
6 Cited Publications
Synonyms: Iodochlorohydroxyquinoline
Research Areas:
Infection Neurological Disease Inflammation/Immunology Cancer
Clioquinol (Iodochlorhydroxyquin) is a topical antifungal agent with anticancer activity. Clioquinol acts as an oral antimicrobial agent for the research of diarrhea and skin infections. Antibiotic . Clioquinol is a chelator that binds to Zn 2+ and Cu 2+ with a greater affinity than it binds to Ca 2+ and Mg 2+. Clioquinol freely crosses the blood-brain barrier. Clioquinol can be used for the study of Alzheimer's disease [2].
6
ATN-224 is an orally active Cu 2+/Zn 2+-superoxide dismutase 1 (SOD1) inhibitor. ATN-224 inhibits SOD1 activity in endothelial cells, an effect that is dose dependent with an IC50 of 17.5 nM.
4
Target:
4
3
3 Cited Publications
2
2 Cited Publications
Excitation/emission wavelength:
Conventional detection: 510/578 nm.
Sulfite detection: 554 nm absorption, 574 nm emission (due to the formation of Rhodamine B fluorescent product).
1
1 Cited Publications
Cat. No.: HY-P1146
CAS No.: 80714-61-0
Target:
Research Areas:
Cardiovascular Disease Neurological Disease Inflammation/Immunology
1
Category:
Olax imbricata Ketones, Aldehydes, Acids Olacaceae Other Diseases Plants Disease Research Fields
Target:
1
1 Cited Publications
Cat. No.: HY-P1146A
CAS No.: 2828433-33-4
Target:
Research Areas:
Cardiovascular Disease Neurological Disease Inflammation/Immunology
1
1 Cited Publications
Cat. No.: HY-D1601
CAS No.: 98907-26-7
1
1 Cited Publications
Target:
Research Areas:
NSC 689534 can form copper chelate with Cu 2+. NSC 689534/Cu 2+ complex is a potent oxidative stress inducer, and has antitumor activity .
Cat. No.: HY-N0627
CAS No.: 16290-07-6
Category:
Flavonols other families Flavonoids Phenols Polyphenols Plants Disease Research Fields Inflammation/Immunology
Target:
Synonyms: Tetraethylthiuram disulfide (Standard); TETD (Standard)
Target:
Reference Standards Aldehyde Dehydrogenase (ALDH) Interleukin Related Pyroptosis Apoptosis Cuproptosis
Research Areas:
Disulfiram (Standard) is the analytical standard of Disulfiram. This product is intended for research and analytical applications. Disulfiram (Tetraethylthiuram disulfide) is a specific inhibitor of aldehyde-dehydrogenase (ALDH1), used for the treatment of chronic alcoholism by producing an acute sensitivity to alcohol. Disulfiram inhibits gasdermin D (GSDMD) pore formation in liposomes and inflammasome-mediated pyroptosis and IL-1β secretion in human and mouse cells. Disulfiram + Cu 2+ increases intracellular ROS levels triggering apoptosis of ovarian cancer stem cells [1-6].
Cat. No.: HY-D0874
CAS No.: 68399-78-0
Target:
Research Areas:
1-Palmitoyl-2-hydroxy-sn-glycero-3-PE is a naturally occurring lysophospholipid. 1-Palmitoyl-2-hydroxy-sn-glycero-3-PE also acts as an immune response regulator and toxicity alleviator produced by Microcystis aeruginosa under Cu 2+ stress [2].
Cat. No.: HY-W015695
CAS No.: 137-00-8
Target:
Cat. No.: HY-W012572
CAS No.: 351-50-8
Category:
Target:
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
