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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
15 Results for "
DU145 human prostate cancer cells
" in MedChemExpress (MCE) Product Catalog:
Products (15)
15 Results for "DU145 human prostate cancer cells" in MCE Product Catalog:
2
2 Cited Publications
Research Areas:
EF24, a curcumin analogue, is an NF-kB inhibitor with great anti-tumor efficacy and oral bioavailability via deactivation of the MAPK/ERK signaling pathway in oral squamous cell carcinoma (OSCC). EF24 is active against melanoma and breast cancer cell lines with GI50 values of 0.7 μM and 0.8 μM, respectively. EF24 induces cell cycle arrest and apoptosis in MDA-MB-231 human breast cancer cells and DU-145 human prostate cancer cells. EF24 increases the levels of activated caspase 3 and 9, and decreases the phosphorylated forms of MEK1 and ERK .
Cat. No.: HY-P5990
CAS No.: 380225-52-5
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MJ-33 lithium salt is a competitive phospholipase A2 (PLA2) inhibitor with an IC50 of 0.3 μM. MJ-33 lithium salt inhibits NOX2 activation and reduces ROS production by blocking the PLA2 activity of Prdx6. MJ-33 lithium salt effectively inhibits the activity of acidic PLA2 (pH 4.0) and reduces the degradation of alveolar surfactant phosphatidylcholine (PC), but exerts no effect on alkaline PLA2 (pH 8.5). MJ-33 lithium salt significantly alleviates lung oxidative injury induced by ischemia-reperfusion (I/R). MJ-33 lithium salt significantly inhibits the invasion, migration and adhesion abilities of prostate cancer cells by suppressing the MAPK, AKT, NF-κB and AP-1 signaling pathways. MJ-33 lithium salt can be used for the research of ROS-related diseases and prostate cancer .
ATR-IN-4 is a potent ATR (Ataxia telangiectasia mutated gene Rad 3-associated kinase) inhibitor. ATR-IN-4 inhibits growth of human prostate cancer cells DU145 and human lung cancer cells NCI-H460 with IC50s of 130.9 nM and 41 .33 nM, respectively. (Patent CN112142744A, compound 13) .
Cat. No.: HY-N15449
CAS No.: 33211-22-2
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Cat. No.: HY-N17795
CAS No.: 208997-29-9
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Target:
Cat. No.: HY-65036
CAS No.: 36953-37-4
Synonyms: 4-Bromo-2-pyridone
Research Areas:
4-Bromo-2-hydroxypyridine (4-Bromo-2-pyridone) is a brominated pyridine/pyridone chemical building block. 4-Bromo-2-hydroxypyridine exists in tautomeric forms between 2-hydroxypyridine and pyridin-2 (1H)-one. 4-Bromo-2-hydroxypyridine is used for the synthesis of bromopyridone nucleoside analogs, phosphoramidite intermediates, and 4-phenylpyridin-2-one derivatives. 4-Bromo-2-hydroxypyridine is applied in studies on heterocyclic synthesis and oligonucleotide modification chemistry .
Cat. No.: HY-139090
CAS No.: 136587-07-0
Synonyms: 28-O-Acetyl-3-Oxobetulin; 3-oxo-28-O-Acetylbetulin
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3-Oxobetulin acetate (28-O-Acetyl-3-Oxobetulin; 3-oxo-28-O-Acetylbetulin) is a derivative of betulin (HY-N0083), a cholesterol biosynthesis inhibitor. 3-Oxobetulin acetate inhibits the growth of P388 murine lymphocytic leukemia cells (EC50=0.12 μg/mL) and human MCF-7 breast cancer, SF-268 CNS cancer, H460 lung cancer, and KM20L2 colon cancer cells (GI50s=8, 10.6, 5.2, and 12.7 μg/mL), but not BxPC-3 pancreatic cancer cells or DU145 prostate cancer cells (GI50s=>10 μg/mL for both). 3-Oxobetulin acetate inhibits the replication of X4-tropic recombinant HIV (NL4.3-Ren) in MT-2 lymphoblastoid cells (IC50=13.4 μM). 3-Oxobetulin acetate is also effective against Listeria donovani amastigotes.
Cat. No.: HY-N16691
CAS No.: 24177-16-0
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Cat. No.: HY-N18126
CAS No.: 59863-00-2
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Cat. No.: HY-181694
SeSA-HCPT is an orally active dual-target inhibitor integrating Topo I and HDAC inhibition. SeSA-HCPT induces potent DNA damage, apoptosis, S-phase arrest in prostate cancer cells. SeSA-HCPT inhibits cancer cells proliferation and migration. SeSA-HCPT impairs homologous recombination by suppressing KIF4A-RAD51 signaling. SeSA-HCPT markedly inhibits CRPC tumor growth with minimal systemic toxicity .
Cat. No.: HY-185775
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ADC Control Human IgG1 (C214S light chain, C226V and C229V heavy chain)-Tesirine is an isotype control antibody-drug conjugate for MEDI3726 (HY-185729). It carries hinge mutations including C214S in the light chain and C226V/C229V in the heavy chain, and the toxic molecule-linker conjugate is Tesirine (HY-128952). ADC Control Human IgG1 (C214S light chain, C226V and C229V heavy chain)-Tesirine can be used in the research of prostate cancer and metastatic castration-resistant prostate cancer .
Cat. No.: HY-128795
CAS No.: 2095304-61-1
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KH176m is the major active metabolite of KH176 (HY-121577). KH176m is a microsomal prostaglandin E synthase-1 (mPGES-1) inhibitor that can cross the blood-brain barrier, with an IC50 of 0.16 µM against mouse mPGES-1 and 1.51 µM against human mPGES-1. KH176m blocks LPS- or IL-1β-induced PGE2 production, scavenges ROS, inhibits lipid peroxidation, accelerates NADPH consumption, suppresses the growth of prostate cancer spheroids, reduces the CD44 + CD24 − prostate cancer stem cell population, and protects fibroblasts with oxidative phosphorylation defects from redox stress-induced death. KH176m can be used in research related to mitochondrial diseases, inflammatory pain, inflammatory neurological diseases, inflammatory cancers, and prostate cancer .
Cat. No.: HY-123827
CAS No.: 1808115-35-6
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GPA512 is an orally active STAT3 inhibitor and a prodrug of Galiellalactone (HY-125170). GPA512 inhibits the binding of STAT3 to DNA, downregulates STAT3-activated genes, and suppresses tumor growth in prostate cancer xenograft models. GPA512 is rapidly converted to Galiellalactone in plasma. GPA512 can be used in research related to castration-resistant prostate cancer .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
