122 Results for "

Flavone

" in MedChemExpress (MCE) Product Catalog:
Products (122)

122 Results for "Flavone" in MCE Product Catalog:

28
Nobiletin
Nobiletin
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28 Publications Verification
Cat. No.: HY-N0155
CAS No.: 478-01-3
Category:  

Flavonoids Neurological Disease Flavones Rutaceae Plants Disease Research Fields Inflammation/Immunology Citrus reticulata Blanco

Target:  

ROR Reactive Oxygen Species (ROS) Apoptosis Autophagy

Nobiletin is a poly-methoxylated flavone from the citrus peel that improves memory loss. Nobiletin is a retinoid acid receptor-related orphan receptors (RORs) agonist. Nobiletin can reduce reactive oxygen species (ROS) levels in differentiated C2C12 myotubes and has anti-inflammation and anti-cancer properties, including anti-angiogenesis, anti-proliferation, anti-metastasis and induced apoptosis .
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24
Scutellarin
Scutellarin
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24 Cited Publications
Cat. No.: HY-N0751
CAS No.: 27740-01-8
Category:  

Infection Flavonoids Flavones Labiatae Phenols Polyphenols Plants Disease Research Fields Medicago truncatula Gaertn.

Target:  

STAT Akt HIV

Scutellarin, an active flavone isolated from Scutellaria baicalensis, can down-regulates the STAT3/Girdin/Akt signaling in HCC cells, and inhibits RANKL-mediated MAPK and NF-κB signaling pathway in osteoclasts. Scutellarin is active against HIV-1IIIB, HIV-1(74V) and HIV-1KM018 with EC50s of 26 μM, 253 μM and 136 μM, respectively.
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14
Vitexin
Vitexin
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14 Cited Publications
Cat. No.: HY-N0013
CAS No.: 3681-93-4
Category:  

Cardiovascular Disease Neurological Disease Anti-aging Flavones Metabolic Disease Plants Flavonoids Leguminosae Phenols Polyphenols Disease Research Fields Trigonella foenum-graecum Linn. Cancer

Target:  

Autophagy

Vitexin is a c-glycosylated flavone, and is found in various medicinal plants species such as Trigonella foenum-graecum Linn. Vitexin has a wide range of pharmacological effects, including anti-oxidant, anti-cancer, anti-inflammatory, anti-hyperalgesic, and neuroprotective effects .
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7
Hispidulin
Hispidulin
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7 Cited Publications
Cat. No.: HY-N1950
CAS No.: 1447-88-7
Synonyms: Dinatin
Category:  

Flavonoids Flavones Labiatae Cassia Phenols Polyphenols Plants Disease Research Fields Cancer

Target:  

Pim

Hispidulin is a natural flavone with a broad spectrum of biological activities. Hispidulin is a Pim-1 inhibitor with an IC50 of 2.71 μM.
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3
Cirsilineol
Cirsilineol
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3 Cited Publications
Cat. No.: HY-119347
CAS No.: 41365-32-6
Purity:  ≥98.0%
Category:  

Laburnum anagyroides Medic. Flavonoids Monophenols Flavones Phenols Plants Compositae Disease Research Fields Inflammation/Immunology

Target:  

IFNAR STAT

Cirsilineol, a natural flavone compound, selectively inhibits IFN-γ/STAT1/T-bet signaling in intestinal CD4 + T cells. Cirsilineol has potent immunosuppressive and anti-tumor properties. Cirsilineol significantly ameliorates trinitro-benzene sulfonic acid (TNBS)-induced T-cell-mediated experimental colitis in mice .
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2
5-Hydroxyflavone
5-Hydroxyflavone
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2 Cited Publications
Cat. No.: HY-22024
CAS No.: 491-78-1
Synonyms: 5-OH-Flavone
Category:  

other families Flavonoids Monophenols Flavones Phenols Plants Disease Research Fields Cancer

Target:  

Cytochrome P450

5-Hydroxyflavone (5-OH-Flavone) is a flavonoid compound that undergoes oxidation-mediated conversion to 5,7-dihydroxyflavone and 5,6,7-trihydroxyflavone by human cytochrome P450 enzymes .
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2
Ginkgolide C
Ginkgolide C
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2 Cited Publications
Cat. No.: HY-N0785
CAS No.: 15291-76-6
Synonyms: BN-52022
Category:  

Ginkgoaceae Terpenoids Diterpenoids Plants Endogenous metabolite Ginkgo biloba

Target:  

AMPK Sirtuin MMP Endogenous Metabolite

Ginkgolide C is a flavone isolated from Ginkgo biloba leaves, possessing multiple biological functions, such as decreasing platelet aggregation and ameliorating Alzheimer disease.
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2
Licoflavonol
Licoflavonol
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2 Cited Publications
Cat. No.: HY-N6583
CAS No.: 60197-60-6
Category:  

Infection Flavonols Flavonoids Leguminosae Phenols Polyphenols Plants Disease Research Fields Glycyrrhiza uralensis Fisch.

Target:  

Bacterial

Licoflavonol, a minor flavone from the roots of Glycyrrhiza uralensis, is an inhibitor of the Salmonella type III secretion system (T3SS) .
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2
Vitexin (Standard)
Vitexin (Standard)
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2 Cited Publications
Cat. No.: HY-N0013R
CAS No.: 3681-93-4
Category:  

Flavonoids Leguminosae Flavones Phenols Polyphenols Plants Trigonella foenum-graecum Linn.

Target:  

Reference Standards Autophagy

Vitexin (Standard) is the analytical standard of Vitexin. This product is intended for research and analytical applications. Vitexin is a c-glycosylated flavone, and is found in various medicinal plants species such as Trigonella foenum-graecum Linn. Vitexin has a wide range of pharmacological effects, including anti-oxidant, anti-cancer, anti-inflammatory, anti-hyperalgesic, and neuroprotective effects .
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1
Rhoifolin
Rhoifolin
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1 Cited Publications
Cat. No.: HY-N0755
CAS No.: 17306-46-6
Category:  

Rhus succedanea Flavonoids Flavones Plants Disease Research Fields Endocrinology Cancer Anacardiaceae

Target:  

Insulin Receptor GLUT NF-κB p38 MAPK Autophagy

Rhoifolin is a flavone glycoside can be isolated from Rhus succedanea. Rhoifolin has anti-diabetic effect acting through enhanced adiponectin secretion, tyrosine phosphorylation of insulin receptor-β and glucose transporter 4 (GLUT 4) translocation. Rhoifolin has an anti-inflammatory action via multi-level regulation of inflammatory mediators. Rhoifolin ameliorates titanium particle-stimulated osteolysis and attenuates osteoclastogenesis via RANKL-induced NF-κB and MAPK pathways. Rhoifolin also has cytotoxic activity against different cancer cell lines .
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1
Flavanone
Flavanone
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1 Cited Publications
Cat. No.: HY-N7128
CAS No.: 487-26-3
Category:  

Flavonoids Leguminosae Flavonones Plants Sophora flavescens Aiton Disease Research Fields Cancer

Target:  

Cytochrome P450 ERK p38 MAPK NF-κB MMP PAI-1

Flavanone is a naturally occurring flavone. Flavanone has inhibitory activity for human estrogen synthetase (aromatase). Flavanone is the inhibitor for ERK/p38/NF-κB signaling pathway. Flavanone exhibits oral activity and antitumor efficacy .
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1
Kuwanon A
Kuwanon A
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1 Cited Publications
Cat. No.: HY-N2300
CAS No.: 62949-77-3
Category:  

Flavones Metabolic Disease Plants Moraceae other families Flavonoids Morus alba L. Phenols Polyphenols Disease Research Fields Inflammation/Immunology

Target:  

NO Synthase

Kuwanon A is a flavone derivative isolated from the root barks of the mulberry tree (Morus alba L.); inhibits nitric oxide production with an IC50 of 10.5 μM.
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1
3',4',7-Trimethoxyquercetin
3',4',7-Trimethoxyquercetin
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1 Cited Publications
Cat. No.: HY-N7641
CAS No.: 6068-80-0
Synonyms: Quercetin 3′,4′,7-trimethyl ether
Category:  

Flavonols other families Flavonoids Other Diseases Phenols Polyphenols Plants Disease Research Fields

Target:  

P-glycoprotein

3',4',7-Trimethoxyquercetin (Quercetin 3′,4′,7-trimethyl ether) is a polymethoxyflavonoid that can be isolated from Taraxacum mongolicum. 3',4',7-Trimethoxyquercetin is also a derivative of Quercetin hydrate (HY-18085A). 3',4',7-Trimethoxyquercetin has anti-tumor activity .
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1
5,​7,​3'-​Trihydroxy-​6,​4',​5'-​trimethoxyflavone
5,​7,​3'-​Trihydroxy-​6,​4',​5'-​trimethoxyflavone
0 Images
1 Cited Publications
Cat. No.: HY-N6259
CAS No.: 78417-26-2
Category:  

other families Flavonoids Flavones Other Diseases Phenols Polyphenols Plants Disease Research Fields

Target:  

Others

5,7,3'-Trihydroxy-6,4',5'-trimethoxyflavone is a methylated flavones from Artemisia frigida.
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1
Tricetin 3',4',5'-trimethyl ether
Tricetin 3',4',5'-trimethyl ether
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1 Cited Publications
Cat. No.: HY-N7150
CAS No.: 18103-42-9
Synonyms: 5,7-Dihydroxy-3',4',5'-trimethoxyFlavone
Category:  

Flavonols Haplopteris anguste-elongata (Hayata) E. H. Crane Chrysanthemum × morifolium (Ramat.) Hemsl. Flavonoids Pteridaceae Plants Compositae

Target:  

Xanthine Oxidase

Tricetin 3',4',5'-trimethyl ether (5,7-Dihydroxy-3',4',5'-trimethoxyflavone) is a flavone glucoside, that can be isolated the flowers of Chrysanthemum sinensea. Tricetin 3',4',5'-trimethyl ether displays xanthine oxidase competitive-type inhibitory activity, with an IC50 of 0.51 μM and a Ki of 0.37 μM .
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1
3',4'-Dimethoxyflavone
3',4'-Dimethoxyflavone
0 Images
1 Cited Publications
Cat. No.: HY-N8572
CAS No.: 4143-62-8
Category:  

other families Flavonoids Flavones Coniogramme japonica (Thunb.) Diels Plants

Target:  

PARP Reactive Oxygen Species (ROS) Aryl Hydrocarbon Receptor

3',4'-Dimethoxyflavone is a lipophilic flavone, can be isolated from the leaves of Primula veris. 3',4'-Dimethoxyflavone can reduce the synthesis and accumulation of PARP and protect cortical neurones against cell death induced by Parthanatos. 3',4'-Dimethoxyflavone is also an aryl hydrocarbon receptor antagonist in human breast cancer cells. 3',4'-Dimethoxyflavone can promote the proliferation of human hematopoietic stem cells. 3',4'-Dimethoxyflavone has various biological activities, including antioxidant, anti-cancer, anti-inflammatory, anti-atherogenic, hypolipidaemic, and neuroprotective or neurotrophic effects .
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1
4-(Dimethylamino)cinnamaldehyde
4-(Dimethylamino)cinnamaldehyde
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1 Cited Publications
Cat. No.: HY-W016729
CAS No.: 6203-18-5
4-(Dimethylamino) cinnamaldehyde is a staining agent that reacts with flavan-3-ols and Proanthocyanidins (HY-N0794) bearing meta-dihydroxyl or trihydroxyl phenol structures to form a green chromophore. In acidic media, 4-(Dimethylamino) cinnamaldehyde undergoes a condensation reaction with aromatic primary amines to produce colored and stable quinoid protonated Schiff base salts. 4-(Dimethylamino) cinnamaldehyde can be used to determine indole products of apotryptophanase and tryptophanase, as well as for the detection and analysis of Proanthocyanidins, with the absorbance detection wavelength of the calibration curve set at 640 nm .
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Flavone
Flavone
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Cat. No.: HY-N2424
CAS No.: 525-82-6
Synonyms: 2-Phenyl-4-chromone
Category:  

Flavonoids Flavones Metabolic Disease Endogenous metabolite Disease Research Fields

Target:  

CDK Apoptosis Caspase

Flavone is an anti-tumor compound that targets cell cycle regulatory proteins (such as cyclin B1) and apoptosis-related factors (such as p21waf1, PIG3). Flavone selectively induces mitochondrial-mediated apoptosis pathways in tumor cells, inhibits cyclin B1 protein expression, upregulates p21waf1, and activates p63/p73 proteins. Flavone has immunomodulatory functions that enhance natural killer cell (NK cell) activity and lymphocyte proliferation. Flavone is used in cancer research, especially for its inhibitory potential in solid tumor models such as esophageal cancer and liver cancer .
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Negletein
Negletein
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Cat. No.: HY-N4285
CAS No.: 29550-13-8
Synonyms: 5,6-Dihydroxy-7-methoxyFlavone
Category:  

Flavonoids Flavones Labiatae Phenols Polyphenols Plants Medicago truncatula Gaertn.

Target:  

TNF Receptor Interleukin Related Reactive Oxygen Species (ROS) Keap1-Nrf2 Amyloid-β

Negletein (5,6-Dihydroxy-7-methoxyflavone) is a flavone found in Scutellaria. Negletein shows anti-inflammatory activity via inhibiting TNF-α and IL-1β with IC50 values of 16.4 and 6.4 μM, respectively. Negletein can activate Nrf2 and inhibit ROS production. Negletein can enhance the neuroprotective effect of nerve growth factor. Negletein can inhibit amyloid beta-peptide release and accumulation. Negletein can inhibit pathogens biofilms formation. Negletein can be used for the researches of cancer, infection, inflammation and neurological disease, such as colon cancer and Alzheimer's disease .
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Gossypin
Gossypin
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Cat. No.: HY-125911
CAS No.: 652-78-8
Purity:  98.04%
Category:  

Cardiovascular Disease Malvaceae Flavonols Plants Flavonoids Abelmoschus manihot (Linn.) Medicus Phenols Polyphenols Disease Research Fields Inflammation/Immunology

Target:  

NF-κB Aurora Kinase Ribosomal S6 Kinase (RSK) Apoptosis Caspase Bcl-2 Family PARP Cryptochrome

Gossypin is an orally active flavone isolated from Hibiscus vitifolius. Gossypin has antioxidant, antiinflammatory, anticancer, anticataract, antidiabetic, and hepatoprotective activities. Gossypin inhibits NF-κB and NF-κB-regulated gene expression. Gossypin inhibits AURKA and RSK2. Gossypin inhibits invasion and induces apoptosis. Gossypin can be used for gastric cancer study .
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