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LPS-stimulated macrophages

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (1) Autophagy (1) Bacterial (1) Endogenous Metabolite (1) ERK (3) HDAC (1) Interleukin Related (1) JNK (2) NF-κB (5) NO Synthase (6) p38 MAPK (2) Parasite (1) Phosphatase (1) Prostaglandin Receptor (1) Reference Standards (1) TNF Receptor (1)
By Research Areas:	Cancer (5) Cardiovascular Disease (1) Infection (2) Inflammation/Immunology (16) Metabolic Disease (4)

Inhibitors & Agonists

Natural
Products

Art. -Nr.	Produktname	Target	Forschungsgebiete	Chemical Structure

HY-13982

JSH-23 Maximum Cited Publications 141 Publications Verification	NF-κB	Metabolic Disease Inflammation/Immunology Cancer
JSH-23 is an NF-κB inhibitor which inhibits NF-κB transcriptional activity with an IC₅₀ of 7.1 μM in lipopolysaccharide (LPS)-stimulated macrophages RAW 264.7. JSH-23 inhibits nuclear translocation of NF-κB p65 without affecting IκBα degradation .

HY-N0577

Apiin 1 Publications Verification Apigenin 7-O-apiosylglucoside; Apigenin 7-(2-O-apiosylglucoside)	NO Synthase	Inflammation/Immunology
Apiin is a flavonoid glycoside-based iNOS inhibitor. Apiin inhibits the expression of inducible nitric oxide synthase in activated macrophages. Apiin exhibits anti-inflammatory activity .

HY-N2149A

Tomatidine hydrochloride 5+ Cited Publications	NF-κB JNK Autophagy Endogenous Metabolite	Cardiovascular Disease Inflammation/Immunology
Tomatidine hydrochloride acts as an anti-inflammatory agent by blocking NF-κB and JNK signaling . Tomatidine hydrochloride activates autophagy either in mammal cells or C elegans .

HY-N1195

Sugiol (+)-Sugiol; 10-Deoxoxanthoperol	p38 MAPK ERK JNK Interleukin Related TNF Receptor	Inflammation/Immunology
Sugiol is an abietane diterpenoid, can be isolated from Calocedrus formosana bark. Sugiol has anti-inflammatory activity, could effectively reduce intracellular reactive oxygen species (ROS) production in lipopolysaccharide (LPS)-stimulated macrophages .

HY-W001174

2,5-Dihydroxyacetophenone	ERK NF-κB	Inflammation/Immunology
2,5-Dihydroxyacetophenone, isolated from Rehmannia glutinosa, inhibits the production of inflammatory mediators in activated macrophages by blocking the ERK1/2 and NF-κB signaling pathways .

HY-N7697F

Chitobiose	Others	Metabolic Disease
Chitobiose is an orally active chitosan oligosaccharide (degree of polymerization 2). Chitobiose shows hepatoprotective activity and counteracts CCl₄-induced elevation of plasma aspartate transaminase and alanine transaminase activities in rats. Chitobiose can be used for the research of carbon tetrachloride-induced acute hepatotoxicity .

HY-N4233

Bisabolangelone	p38 MAPK	Inflammation/Immunology
Bisabolangelone, a sesquiterpene derivative, is isolated from the roots of Osterici Radix. Bisabolangelone possesses anti-inflammatory properties, which inhibits LPS-stimulated inflammation through the blocking of NF-kappaB and MAPK pathways in macrophages. Bisabolangelone has anti-ulcer activities .

HY-115770

8-Methylsulfinyloctyl isothiocyanate	Bacterial	Inflammation/Immunology
8-Methylsulfinyloctyl isothiocyanate, an isothiocyanate, has antimicrobial activity and remarkable inhibitory activity against plant growth . 8-Methylsulfinyloctyl isothiocyanate impair COX-2 mediated inflammatory responses in LPS stimulated raw macrophages .

HY-N1912

Andropanolide	Others	Cancer
Andropanolide is a natural product that exerts cytotoxicity toward carcinoma cells and significantly inhibits the overproduction of nitric oxide (NO) in Lipopolysaccharides (HY-D1056) (LPS)-stimulated RAW264.7 macrophages .

HY-N7422

Kauran-16,17-diol ent-Kauran-16β,17-diol	Apoptosis	Inflammation/Immunology Cancer
Kauran-16,17-diol (ent-Kauran-16β,17-diol), a natural diterpene, posseses anti-tumor and inducing-apoptosis activity, with a IC₅₀ of 17 μM on inhibiting NO production in LPS-stimulated RAW 264.7 macrophages .

HY-13982R

JSH-23 (Standard)	NF-κB	Metabolic Disease Inflammation/Immunology Cancer
JSH-23 (Standard) is the analytical standard of JSH-23. This product is intended for research and analytical applications. JSH-23 is an NF-κB inhibitor which inhibits NF-κB transcriptional activity with an IC50 of 7.1 μM in lipopolysaccharide (LPS)-stimulated macrophages RAW 264.7. JSH-23 inhibits nuclear translocation of NF-κB p65 without affecting IκBα degradation .

HY-W573700

Methyl everninate	Others	Others
Methyl everninate is the major constituent of the deuterochloroform. Methyl everninate, rhodomollosides A and B are the derivatives of Methyl everninate, with cytotoxicity against RAW264.7 cells. Both of they shows inhibitory effects with a lipopolysaccharide (LPS)-stimulated murine macrophages RAW 264.7 cells model .

HY-174144

RJG-2036	Prostaglandin Receptor	Inflammation/Immunology
RJG-2036 is a potent covalent inhibitor of human prostaglandin reductase 2 (PTGR2)(IC₅₀=100 nM). RJG-2036 inhibits NADPH-dependent reduction, significantly reducing secretion of proinflammatory cytokines like TNF-α and multiple eicosanoids in LPS-stimulated THP-1 macrophages. RJG-2036 is promising for research of inflammatory diseases .

HY-N1117

Tristin	Phosphatase NO Synthase	Infection Metabolic Disease Cancer
Tristin is a PTP1B inhibitor (IC₅₀=21.2 μM) with antioxidant and antifungal activities. Tristin inhibits lipid peroxidation and NO production in LPS-stimulated macrophages, and also exhibits activity against a variety of phytopathogenic fungi. Tristin is also able to inhibit cancer cell proliferation. Tristin can be used in the research of diseases associated with phytopathogenic fungal infection, leukemia, type 2 diabetes and inflammatory responses .

HY-130743

Dieugenol Bis-eugenol; Dehydrodieugenol	Parasite	Infection
Dieugenol is a neolignan that has been found in N. leucantha and has antioxidative and antiprotozoal activities. It inhibits the formation of thiobarbituric acid reactive substances (TBARS) and scavenges superoxide anions, but not hydroxyl radicals, in cell-free assays. It has anti-trypanosomal activity against T. cruzi amastigotes and trypomastigotes (IC₅₀s=15.1 and 11.5 μM, respectively) but is cytotoxic to NCTC L-929 fibroblasts with a 50% cytotoxic concentration (CC50) value of 58.2 μM.2 Dieugenol (15 μM) disrupts the integrity of the T. cruzi trypomastigote plasma membrane but does not induce the production of reactive oxygen species (ROS) in trypomastigotes or LPS-stimulated and unstimulated isolated mouse peritoneal macrophages.

HY-163368

HDAC6-IN-34	HDAC	Inflammation/Immunology
HDAC6-IN-34 (compound 21) is an oral active and selective HDAC6 inhibitor with the IC₅₀ of 18 nM. HDAC6-IN-34 increases the acetylation level of tubulin without affecting histone acetylation in cutaneous T-cell lymphoma cells and inhibits TNF-α secretion in LPS (HY-D1056)-stimulated macrophage cells. HDAC6-IN-34 shows excellent anti-arthritic efficacy in rat .

HY-N17528

Triptohypol E	NO Synthase	Inflammation/Immunology
Triptohypol E is a triterpenoid compound and nitric oxide production inhibitor that can be isolated from the leaves of Rhododendron dauricum L. Triptohypol E inhibits nitric oxide production in LPS-stimulated macrophages in a dose-dependent manner .

HY-N13781

(-)-Sesamin 2,2'-diol	NO Synthase	Inflammation/Immunology
(-)-Sesamin 2,2'-diol is a nitric oxide (NO) production inhibitor with an IC₅₀ of 310 μM for inhibiting LPS-induced NO production. (-)-Sesamin 2,2'-diol can be isolated from the aerial parts of Isodon japonicus. (-)-Sesamin 2,2'-diol abrogates NO production in LPS-stimulated macrophages without inducing cytotoxicity .

HY-N1192

Sutherlandin trans-p-coumarate	NO Synthase	Inflammation/Immunology
Sutherlandin trans-p-coumarate is a selective γ-hydroxynitrile glycoside compound with moderate inhibitory activity on nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages (56.9% inhibition at a concentration of 25 μg/mL). Sutherlandin trans-p-coumarate can be naturally extracted from the dried aerial parts of Sorbaria sorbifolia (a plant of the genus Sorbaria in the Rosaceae family) .

HY-N16774

Balanophonin B	NO Synthase	Inflammation/Immunology
Balanophonin B is a selective inhibitor (IC₅₀=1.46 μg/mL) that targets the lipopolysaccharide (LPS)-induced nitric oxide (NO) production pathway and can be isolated from Lithocarpus pachylepis. Balanophonin B inhibits the production of NO in LPS-stimulated RAW264.7 macrophages and exerts anti-inflammatory activity to reduce the inflammatory response. Balanophonin B can be used for anti-inflammatory drug development and biological activity research of natural lignan compounds .

HY-W001174R

2,5-Dihydroxyacetophenone (Standard)	Reference Standards ERK NF-κB	Inflammation/Immunology
2,5-Dihydroxyacetophenone, isolated from Rehmannia glutinosa, inhibits the production of inflammatory mediators in activated macrophages by blocking the ERK1/2 and NF-κB signaling pathways .

Apiin 1 Publications Verification Apigenin 7-O-apiosylglucoside; Apigenin 7-(2-O-apiosylglucoside)	Structural Classification Flavonoids Classification of Application Fields Flavones Phenols Polyphenols Umbelliferae Plants Baccharis sarothroides A.Gray Inflammation/Immunology Disease Research Fields Source Classification	NO Synthase
Apiin is a flavonoid glycoside-based iNOS inhibitor. Apiin inhibits the expression of inducible nitric oxide synthase in activated macrophages. Apiin exhibits anti-inflammatory activity .

Tomatidine hydrochloride 5+ Cited Publications	Cardiovascular Disease Classification of Application Fields Solanum lycopersicum L. Solanaceae Plants Disease Research Fields Steroids Source Classification	NF-κB JNK Autophagy Endogenous Metabolite
Tomatidine hydrochloride acts as an anti-inflammatory agent by blocking NF-κB and JNK signaling . Tomatidine hydrochloride activates autophagy either in mammal cells or C elegans .

Sugiol (+)-Sugiol; 10-Deoxoxanthoperol	Cupressaceae Terpenoids Diterpenoids Calocedrus formosana (Florin) Florin Plants	p38 MAPK ERK JNK Interleukin Related TNF Receptor
Sugiol is an abietane diterpenoid, can be isolated from Calocedrus formosana bark. Sugiol has anti-inflammatory activity, could effectively reduce intracellular reactive oxygen species (ROS) production in lipopolysaccharide (LPS)-stimulated macrophages .

2,5-Dihydroxyacetophenone	Classification of Application Fields Phenols Polyphenols Scrophulariaceae Plants Rehmannia glutinosa (Gaert.) Libosch. ex Fisch. et Mey Inflammation/Immunology Disease Research Fields Source Classification	ERK NF-κB
2,5-Dihydroxyacetophenone, isolated from Rehmannia glutinosa, inhibits the production of inflammatory mediators in activated macrophages by blocking the ERK1/2 and NF-κB signaling pathways .

Chitobiose	Polysaccharides Microorganisms Animals Classification of Application Fields Other Diseases Disease Research Fields Saccharides Source Classification	Others
Chitobiose is an orally active chitosan oligosaccharide (degree of polymerization 2). Chitobiose shows hepatoprotective activity and counteracts CCl₄-induced elevation of plasma aspartate transaminase and alanine transaminase activities in rats. Chitobiose can be used for the research of carbon tetrachloride-induced acute hepatotoxicity .

Bisabolangelone	Classification of Application Fields Terpenoids Sesquiterpenes Plants Umbelliferae Disease Research Fields Inflammation/Immunology Echinacea angustifolia DC. Source Classification	p38 MAPK
Bisabolangelone, a sesquiterpene derivative, is isolated from the roots of Osterici Radix. Bisabolangelone possesses anti-inflammatory properties, which inhibits LPS-stimulated inflammation through the blocking of NF-kappaB and MAPK pathways in macrophages. Bisabolangelone has anti-ulcer activities .

8-Methylsulfinyloctyl isothiocyanate	Natürliche Produkte Classification of Application Fields Plants Brassicaceae Inflammation/Immunology Disease Research Fields Rorippa indica (L.) Hiern Source Classification	Bacterial
8-Methylsulfinyloctyl isothiocyanate, an isothiocyanate, has antimicrobial activity and remarkable inhibitory activity against plant growth . 8-Methylsulfinyloctyl isothiocyanate impair COX-2 mediated inflammatory responses in LPS stimulated raw macrophages .

Andropanolide	Structural Classification Acanthaceae Classification of Application Fields Simsia foetida (Cav.) S.F.Blake Terpenoids Diterpenoids Plants Inflammation/Immunology Disease Research Fields Source Classification	Others
Andropanolide is a natural product that exerts cytotoxicity toward carcinoma cells and significantly inhibits the overproduction of nitric oxide (NO) in Lipopolysaccharides (HY-D1056) (LPS)-stimulated RAW264.7 macrophages .

Kauran-16,17-diol ent-Kauran-16β,17-diol	Liliaceae Classification of Application Fields Terpenoids Diterpenoids Plants Inflammation/Immunology Disease Research Fields Fritillaria cirrhosa Source Classification	Apoptosis
Kauran-16,17-diol (ent-Kauran-16β,17-diol), a natural diterpene, posseses anti-tumor and inducing-apoptosis activity, with a IC₅₀ of 17 μM on inhibiting NO production in LPS-stimulated RAW 264.7 macrophages .

Methyl everninate	other families Plagiochila bifaria (Sw.) Lindenb. Phenols Plants Source Classification	Others
Methyl everninate is the major constituent of the deuterochloroform. Methyl everninate, rhodomollosides A and B are the derivatives of Methyl everninate, with cytotoxicity against RAW264.7 cells. Both of they shows inhibitory effects with a lipopolysaccharide (LPS)-stimulated murine macrophages RAW 264.7 cells model .

Tristin	Structural Classification Orchidaceae Phenols Polyphenols Plants Dendrobium nobile Lindl. Source Classification	Phosphatase NO Synthase
Tristin is a PTP1B inhibitor (IC₅₀=21.2 μM) with antioxidant and antifungal activities. Tristin inhibits lipid peroxidation and NO production in LPS-stimulated macrophages, and also exhibits activity against a variety of phytopathogenic fungi. Tristin is also able to inhibit cancer cell proliferation. Tristin can be used in the research of diseases associated with phytopathogenic fungal infection, leukemia, type 2 diabetes and inflammatory responses .

Triptohypol E	Triterpenes Structural Classification Terpenoids Celastraceae Tripterygium wilfordii Hook. f. Plants Source Classification	NO Synthase
Triptohypol E is a triterpenoid compound and nitric oxide production inhibitor that can be isolated from the leaves of Rhododendron dauricum L. Triptohypol E inhibits nitric oxide production in LPS-stimulated macrophages in a dose-dependent manner .

(-)-Sesamin 2,2'-diol	Acourtia cordata (Cerv.) B.L.Turner Structural Classification Labiatae Lignans Phenylpropanoids Plants Source Classification	NO Synthase
(-)-Sesamin 2,2'-diol is a nitric oxide (NO) production inhibitor with an IC₅₀ of 310 μM for inhibiting LPS-induced NO production. (-)-Sesamin 2,2'-diol can be isolated from the aerial parts of Isodon japonicus. (-)-Sesamin 2,2'-diol abrogates NO production in LPS-stimulated macrophages without inducing cytotoxicity .

Sutherlandin trans-p-coumarate	Structural Classification Rosaceae Plants Sorbaria sorbifolia (L.) A. Braun Saccharides Monosaccharides Source Classification	NO Synthase
Sutherlandin trans-p-coumarate is a selective γ-hydroxynitrile glycoside compound with moderate inhibitory activity on nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages (56.9% inhibition at a concentration of 25 μg/mL). Sutherlandin trans-p-coumarate can be naturally extracted from the dried aerial parts of Sorbaria sorbifolia (a plant of the genus Sorbaria in the Rosaceae family) .

Balanophonin B	Structural Classification Lignans Phenylpropanoids Plants Fagaceae Lithocarpus pachylepis A. Camus Source Classification	NO Synthase
Balanophonin B is a selective inhibitor (IC₅₀=1.46 μg/mL) that targets the lipopolysaccharide (LPS)-induced nitric oxide (NO) production pathway and can be isolated from Lithocarpus pachylepis. Balanophonin B inhibits the production of NO in LPS-stimulated RAW264.7 macrophages and exerts anti-inflammatory activity to reduce the inflammatory response. Balanophonin B can be used for anti-inflammatory drug development and biological activity research of natural lignan compounds .

2,5-Dihydroxyacetophenone (Standard)	Structural Classification Phenols Polyphenols Scrophulariaceae Plants Rehmannia glutinosa (Gaert.) Libosch. ex Fisch. et Mey Source Classification	Reference Standards ERK NF-κB
2,5-Dihydroxyacetophenone, isolated from Rehmannia glutinosa, inhibits the production of inflammatory mediators in activated macrophages by blocking the ERK1/2 and NF-κB signaling pathways .

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LPS-stimulated macrophages

Inhibitors & Agonists

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