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Results for "

MAO activity

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Monoamine Oxidase (128) 5-HT Receptor (2) Adrenergic Receptor (3) Akt (3) Amylases (1) Amyloid-β (8) Androgen Receptor (2) Antibiotic (7) Apoptosis (21) Aquaporin (2) Autophagy (4) Bacterial (10) Bcl-2 Family (3) Beta-secretase (1) Caspase (2) Cholinesterase (ChE) (24) COX (2) Cuproptosis (1) Cytochrome P450 (4) Dengue Virus (1) DNA/RNA Synthesis (3) Dopamine Receptor (3) Dopamine β-hydroxylase (3) Drug Metabolite (1) DYRK (1) Endogenous Metabolite (5) Environmental Pollutants (2) ERK (1) Estrogen Receptor/ERR (1) Ferroptosis (2) Fluorescent Dye (2) GABA Receptor (4) Glutathione Peroxidase (1) Glycosidase (3) Guanylate Cyclase (1) HDAC (1) HIF/HIF Prolyl-Hydroxylase (1) Histamine Receptor (1) Histone Demethylase (8) HSP (1) iGluR (2) IKK (3) Imidazoline Receptor (3) Influenza Virus (3) Interleukin Related (2) Isotope-Labeled Compounds (8) JAK (1) Keap1-Nrf2 (3) LDLR (1) Lipoxygenase (1) mGluR (4) Microtubule/Tubulin (1) mTOR (1) nAChR (3) NF-κB (12) NO Synthase (1) NOD-like Receptor (NLR) (1) Nuclear Factor of activated T Cells (NFAT) (1) Opioid Receptor (3) P-glycoprotein (1) p38 MAPK (1) PAK (1) Parasite (4) PARP (2) PCSK9 (1) PGC-1α (4) PI3K (4) PKC (5) PPAR (1) Pregnane X Receptor (PXR) (2) Pyroptosis (1) RANKL/RANK (2) Reactive Oxygen Species (ROS) (7) Reference Standards (21) Reverse Transcriptase (2) Sigma Receptor (1) Survivin (2) Tau Protein (1) Telomerase (2) TNF Receptor (5) Wnt (1) α-synuclein (1) β-catenin (1)
By Research Areas:	Cancer (33) Cardiovascular Disease (15) Endocrinology (4) Infection (18) Inflammation/Immunology (31) Metabolic Disease (14) Neurological Disease (116)
Click Chemistry:	Alkynes (10)

154

Inhibitors & Agonists

Fluorescent Dye

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Targets Recommended: Monoamine Oxidase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N0453

Hypericin Maximum Cited Publications 8 Publications Verification	Apoptosis Influenza Virus Antibiotic Monoamine Oxidase PKC Cytochrome P450 Dopamine β-hydroxylase Reverse Transcriptase Telomerase	Infection Neurological Disease Cancer
Hypericin is a naturally occurring substance found in Hyperlcurn perforatum L. Hypericin is an inhibitor of PKC (protein kinase C), *MAO* (monoaminoxidase), dopamine-beta-hydroxylase, reverse transcriptase, telomerase and CYP (cytochrome P450). Hypericin shows antitumor, antiviral, antidepressive activities, and can induce apoptosis .

HY-A0091A

Pargyline 3 Publications Verification	Monoamine Oxidase	Cardiovascular Disease Cancer
Pargyline is an irreversible monoamine oxidase (MAO) inhibitor with K_is of 13 μM and 0.5 μM for *MAO-A* and *MAO-B, respectively. Pargyline has antihypertensive and anticancer activities* . Pargyline is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-14605A

Rasagiline Maximum Cited Publications 7 Publications Verification (R)-AGN1135; TVP1012	Monoamine Oxidase	Neurological Disease
Rasagiline (R-AGN1135) is a highly potent selective irreversible mitochondrial monoamine oxidase (MAO) inhibitor with IC₅₀s of 4.43 nM and 412 nM for rat brain MAO B and A activity, respectively . Rasagiline is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-129388B

Pulrodemstat benzenesulfonate 4 Publications Verification CC-90011 benzenesulfonate; LSD1-IN-7 benzenesulfonate	Histone Demethylase	Inflammation/Immunology Cancer
Pulrodemstat (CC-90011) benzenesulfonate is a potent, selective, reversible and orally active inhibitor of lysine specific demethylase-1 (LSD1) with an IC₅₀ of 0.25 nM. Pulrodemstat benzenesulfonate is less enzymatic inhibition against LSD2, MAO-A, and MAO-B. Pulrodemstat benzenesulfonate induces acute myeloid leukemia (AML) and small cell lung cancer (SCLC) cells differentiation and has potent anticancer activity .

HY-A0091

Pargyline hydrochloride 3 Publications Verification	Monoamine Oxidase	Cardiovascular Disease Cancer
Pargyline hydrochloride is an irreversible monoamine oxidase (MAO) inhibitor with K_is of 13 μM and 0.5 μM for *MAO-A* and *MAO-B, respectively. Pargyline hydrochloride has antihypertensive and anticancer activities* . Pargyline (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-14605

Rasagiline mesylate Maximum Cited Publications 7 Publications Verification (R)-AGN1135 mesylate; TVP1012 mesylate	Monoamine Oxidase Autophagy Apoptosis	Neurological Disease
Rasagiline (R-AGN1135) mesylate is a highly potent selective irreversible mitochondrial monoamine oxidase (MAO) inhibitor with IC₅₀s of 4.43 nM and 412 nM for rat brain MAO B and A activity, respectively . Rasagiline (mesylate) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-B0886A

Iproniazid 2 Publications Verification	Monoamine Oxidase Apoptosis	Neurological Disease Metabolic Disease Endocrinology
Iproniazid is an orally active, irreversible, non-selective monoamine oxidase (MAO) inhibitor. Iproniazid inhibits MAO activity and enhances Rotenone (HY-B1756)-induced Apoptosis. Iproniazid modulates neurotransmitter levels, affects neuronal function, induces hepatic necrosis, and interferes with the endocrine system. Iproniazid can be used in the research of depression, Parkinson's disease, and hepatotoxicity .

HY-N0464

D-(-)-Quinic acid 3 Publications Verification	Endogenous Metabolite Glycosidase Monoamine Oxidase	Neurological Disease Metabolic Disease
D-(-)-Quinic acid scavenges hydrogen peroxide (IC₅₀=87.11 μg/mL) and exhibits antioxidant activity. D-(-)-Quinic acid is the inhibitor for *MAO* and α-Glucosidase (IC₅₀ =93.75 μg/mL). D-(-)-Quinic acid is orally active .

HY-14855B

Tedizolid phosphate 3 Publications Verification TR-701FA	Bacterial Antibiotic Monoamine Oxidase	Infection
Tedizolid phosphate (TR-701FA) is a *MAO-A* and *MAO-B* inhibitor with activity against Gram-positive bacteria .

HY-B0678

Metaxalone AHR438; NSC170959	NF-κB PGC-1α	Neurological Disease Inflammation/Immunology
Metaxalone (AHR438; NSC170959) is an FDA-approved muscle relaxant. Metaxalone acts mainly on the central nervous system and achieves muscle relaxation by inhibiting polysynaptic reflex arcs. In addition, Metaxalone is an inhibitor of MAO-A, which has anti-inflammatory and antioxidant effects. Metaxalone inhibits IL-1β-induced inflammatory phenotype, modulates NF-κB and other related signaling pathways, and decreases MAO-A expression and activity in IL-1β-treated microglia .

HY-127109

Tisolagiline KDS2010	Monoamine Oxidase	Neurological Disease Cancer
Tisolagiline (KDS2010) is the selective, reversible and orally active inhibitor for *MAO-B* with an IC₅₀ of 8 nM. Tisolagiline exhibits neuroprotective and anti-neuroinflammatory activities .

HY-131036

MAO-IN-M30 dihydrochloride	Monoamine Oxidase	Neurological Disease
MAO-IN-M30 dihydrochloride is an orally active, brain-permeable, and brain selective irreversible *MAO-A* (IC₅₀=37 nM) and *MAO-B* (IC₅₀=57 nM) inhibitor. MAO-IN-M30 dihydrochloride is a potent iron chelator and radical scavenger. MAO-IN-M30 dihydrochloride has a neuroprotective effect against Dexamethasone-induced brain cell apoptosis. MAO-IN-M30 dihydrochloride also exhibits neurorestorative activity in post MPTP and lactacystin models of Parkinson's disease . MAO-IN-M30 (dihydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-100588

VU0364770	mGluR	Neurological Disease
VU0364770 is a selective and potent positive allosteric modulator (PAM) of mGlu4. VU0346770 exhibits EC₅₀s of 290 nM and 1.1 μM at rat mGlu4 and human mGlu4 receptor, respectively. VU0364770 exhibits antagonist activity at mGlu5 with a potency of 17.9 μM and PAM activity at mGlu6 with a potency of 6.8 μM. VU0364770 also possesses activity at MAO with K_i values of 8.5 and 0.72 μM for human MAO-A and human MAO-B, respectively .

HY-14200

(S)-Rasagiline 1 Publications Verification TVP1022; S-PAI	Monoamine Oxidase	Neurological Disease
(S)-Rasagiline (TVP1022) is the relatively inactive S-enantiomer form of Rasagiline. Rasagiline is a highly potent selective irreversible *MAO* inhibitor with IC₅₀s of 4.43 nM and 412 nM for rat brain MAO B and A activity, respectively . (S)-Rasagiline is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-B0886

Iproniazid phosphate 2 Publications Verification	Monoamine Oxidase Apoptosis	Neurological Disease Metabolic Disease Endocrinology
Iproniazid phosphate is an orally active, irreversible, non-selective monoamine oxidase (MAO) inhibitor. Iproniazid phosphate inhibits MAO activity and enhances Rotenone (HY-B1756)-induced Apoptosis. Iproniazid phosphate modulates neurotransmitter levels, affects neuronal function, induces hepatic necrosis, and interferes with the endocrine system. Iproniazid phosphate can be used in the research of depression, Parkinson's disease, and hepatotoxicity .

HY-14260

RS 8359	Monoamine Oxidase	Neurological Disease
RS 8359 is a selective and reversible *MAO-A* inhibitor, with antidepressant activity.

HY-129388A

Pulrodemstat 4 Publications Verification CC-90011; LSD1-IN-7	Histone Demethylase	Inflammation/Immunology Cancer
Pulrodemstat (CC-90011) is a potent, selective, reversible and orally active inhibitor of lysine specific demethylase-1 (LSD1) with an IC₅₀ of 0.25 nM. Pulrodemstat is less enzymatic inhibition against LSD2, MAO-A, and MAO-B. Pulrodemstat induces acute myeloid leukemia (AML) and small cell lung cancer (SCLC) cells differentiation and has potent anticancer activity .

HY-10399A

Ladostigil hydrochloride TV-3326 hydrochloride	Monoamine Oxidase Cholinesterase (ChE)	Neurological Disease
Ladostigil (TV-3326) hydrochloride is an orally active dual inhibitor of cholinesterase and brain-selective monoamine oxidase (MAO), with IC₅₀s of 37.1 and 31.8 μM for *MAO-B* and AChE, respectively. Ladostigil hydrochloride exhibits neuroprotective, antioxidant and anti-inflammatory activities. Ladostigil can be used for the research of depression and Alzheimer's disease . Ladostigil (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-101169

Tetrindole mesylate 1 Publications Verification	Monoamine Oxidase	Neurological Disease
Tetrindole mesylate is a selective inhibitor of *monoamine oxidase A (MAO* A)*. Tetrindole mesylate inhibits rat brain mitochondrial MAO* A in a competitive manner with a K_i value of 0.4 μM and inhibits MAO B with a K_i of 110 μM. Tetrindole mesylate has antidepressant activity .

HY-B1558A

Bifemelane hydrochloride 2 Publications Verification MCI-2016	Monoamine Oxidase	Neurological Disease
Bifemelane hydrochloride (MCI-2016) is a potent, selective and competitive inhibitor of monoamine oxidase A (MAO-A), with a K_i of 4.20 μM. Bifemelane hydrochloride also inhibits *MAO-B* noncompetitively with a K_i of 46.0 μM. Bifemelane hydrochloride has a potent antidepressant activity and can be used for the research of cognitive and emotional disturbances related to cerebrovascular disease .

HY-127109A

Tisolagiline monomethylsulfate KDS2010 monomethylsulfate	Monoamine Oxidase	Neurological Disease Cancer
Tisolagiline methylsulfate (KDS2010) is the selective, reversible and orally active inhibitor for *MAO-B* with an IC₅₀ of 8 nM. Tisolagiline methylsulfate exhibits neuroprotective and anti-neuroinflammatory activities .

HY-10399

Ladostigil TV-3326	Monoamine Oxidase Cholinesterase (ChE)	Neurological Disease
Ladostigil (TV-3326) is an orally active dual inhibitor of cholinesterase and brain-selective monoamine oxidase (MAO), with IC₅₀s of 37.1 and 31.8 μM for *MAO-B* and AChE, respectively. Ladostigil exhibits neuroprotective, antioxidant and anti-inflammatory activities. Ladostigil can be used for the research of depression and Alzheimer's disease . Ladostigil is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-101169A

Tetrindole hydrochloride	Monoamine Oxidase	Neurological Disease
Tetrindole hydrochloride is a selective inhibitor of *monoamine oxidase A (MAO* A)*. Tetrindole hydrochloride inhibits rat brain mitochondrial MAO* A in a competitive manner with a K_i value of 0.4 μM and inhibits MAO B with a K_i of 110 μM. Tetrindole hydrochloride has antidepressant activity .

HY-176271

MAO-B-IN-45	Ferroptosis Monoamine Oxidase Glutathione Peroxidase Reactive Oxygen Species (ROS) Tau Protein Amyloid-β	Neurological Disease
MAO-B-IN-45 is a dual inhibitor of ferroptosis and *MAO-B. MAO-B-IN-45 shows selectivity towards MAO-B* with an IC₅₀ of 87.47 nM and selectivity exceeding 229-fold for *MAO-B* over MAO-A. MAO-B-IN-45 has excellent antiferroptosis activity through modulation of the iron metabolic pathway and GSH-GPX4 axis in vitro. MAO-B-IN-45 improves cognitive and behavioral impairments in 3×Tg (APP/Tau/Ps1) AD mouse and significantly reduced the levels of ferritin heavy chain 1 (FTH1), APP, and Tau phosphorylation (p-Tau) proteins in the brain.

HY-149820

MAO-B-IN-22	Monoamine Oxidase	Neurological Disease
MAO-B-IN-22 (compound 6h) is a potent *MAO-B* inhibitor with an IC₅₀ of 0.014 μM. MAO-B-IN-22 has high antioxidant activity, good metal chelating ability, proper BBB permeability and significant neuroprotective effect .

HY-W193398

N-2-Cyclohexylethyl-N-methylamine	Monoamine Oxidase	Cardiovascular Disease
N-2-Cyclohexylethyl-N-methylamine is an amine from A.ridigula Benth for a reduction of monoamine oxidase (MAO) activity .

HY-127109B

Tisolagiline methylsulfate KDS2010 methylsulfate	Monoamine Oxidase	Neurological Disease
Tisolagiline (KDS2010) methylsulfate is the selective, reversible and orally active inhibitor for *MAO-B* with an IC₅₀ of 8 nM. Tisolagiline methylsulfate exhibits neuroprotective and anti-neuroinflammatory activities .

HY-W845607

Milacemide	Monoamine Oxidase	Neurological Disease
Milacemide, a glycinamide derivative, is an orally active *MAO-B* inhibitor with anticonvulsant activity. Milacemide reduces the levels of dihydroxyphenylacetic acid and homovanilic acid, but increases the levels of dopamine and serotonin in the caudate nucleus. Milacemide is promising for research of Alzheimer's disease .

HY-179126

BChE/MAO-A-IN-1	Cholinesterase (ChE) Monoamine Oxidase	Inflammation/Immunology
BChE/MAO-A-IN-1 (compound 7j) is a *BChE/MAO-A* inhibitor. BChE/MAO-A-IN-1 exhibits inhibitory activity against BChE (IC₅₀ = 0.03 nM) and MAO-A (IC₅₀ = 0.32 nM), while also having inhibitory effects on MAO-B. BChE/MAO-A-IN-1 has good anti glycation, antioxidant activity, and low cytotoxicity. BChE/MAO-A-IN-1 can be used in the research of diabetes and Alzheimer's disease .

HY-163618

DHMQ	Fluorescent Dye Monoamine Oxidase	Cancer
DHMQ is a NIR fluorescent probe that binds to the propylamino group of monoamine oxidase A (MAO-A). DHMQ tracks MAO-A activity in real-time by using fluorescence imaging on mice and cells .

HY-W207699

MAO-B-IN-46	Monoamine Oxidase Amylases	Neurological Disease Metabolic Disease Inflammation/Immunology
MAO-B-IN-46 (Compound 16) is a selective hMAO-B inhibitor (IC₅₀: 26.8 nM), with weak activity against hMAO-A (IC₅₀: 7.2054 μM). MAO-B-IN-46 (Compound 8) also acts as an α-amylase inhibitor (IC₅₀: 19.46 μM). MAO-B-IN-46 exhibits certain neuroprotective effects and shows no significant toxicity to human gingival fibroblasts and SH-SY5Y cells. Additionally, MAO-B-IN-46 can scavenge DPPH and ABTS free radicals, with IC₅₀ values of 17.86 μM and 17.71 μM, respectively. MAO-B-IN-46 can be used in the research of neurodegenerative diseases such as Parkinson's disease, diabetes, and diseases related to oxidative stress resistance .

HY-B1495

Quipazine maleate	5-HT Receptor	Neurological Disease
Quipazine maleate is a 5-HT agonist that causes behavioural changes such as hyperactivity. Quipazine maleate also shows a weak reversible *MAO* inhibitory activity .

HY-129388C

Pulrodemstat hydrochloride CC-90011 hydrochloride; LSD1-IN-7 hydrochloride	Histone Demethylase	Inflammation/Immunology Cancer
Pulrodemstat (CC-90011) hydrochloride is a potent, selective, reversible and orally active inhibitor of lysine specific demethylase-1 (LSD1) with an IC₅₀ value of 0.25 nM. Pulrodemstat hydrochloride is less enzymatic inhibition against LSD2, MAO-A, and MAO-B. Pulrodemstat hydrochloride induces acute myeloid leukemia (AML) and small cell lung cancer (SCLC) cells differentiation and has potent anticancer activity .

HY-15608R

MPTP hydrochloride (Standard)	Reference Standards Dopamine Receptor Apoptosis	Neurological Disease Cancer
Iproniazid (phosphate) (Standard) is the analytical standard of Iproniazid (phosphate). This product is intended for research and analytical applications. Iproniazid phosphate is a non-selective, irreversible monoamine oxidase (MAO) inhibitor of the hydrazine class. Iproniazid phosphate has antidepressive activity .

HY-176254

LSD1-IN-43	Histone Demethylase Amyloid-β	Neurological Disease
LSD1-IN-43 is a highly selective, reversible, orally active and brain-penetrant LSD1 inhibitor with an IC₅₀ value of 0.8 μM. LSD1-IN-43 has low inhibitory activity against MAO-A and MAO-B, two homologs of LSD1. LSD1-IN-43 significantly inhibits Aβ aggregation and enhances Aβ-induced neuronal cell viability. LSD1-IN-43 can be used for the study of Alzheimer’s disease (AD).

HY-157517

MAO-B-IN-29	Monoamine Oxidase	Neurological Disease
MAO-B-IN-29 (compound 9a) is a inhibitor against *MAO-B* activity .

HY-157087

AChE/MAO-B-IN-4	Cholinesterase (ChE) Monoamine Oxidase	Neurological Disease
AChE/MAO-B-IN-4 (compound 4a) is a selective dual AChE and *MAO-B* inhibitor. AChE/MAO-B-IN-4 shows no significant inhibition activity against BChE and h-MAO-A. AChE/MAO-B-IN-4 can be used for the Alzheimer’s disease (AD) research .

HY-158732

MAO-B-IN-33	Monoamine Oxidase	Inflammation/Immunology
MAO-B-IN-33 (compound C3) is a potent, reversible and selective monoamine oxidase-B (MAO-B) inhibitor with an IC₅₀ of 0.021 μM and 26.805 μM for MAO-B and MAO-A, respectively. The selectivity of MAO-B-IN-33 is attributed to the steric clash arising from the residue differences between Phe208 (MAO-A) and Ile199 (MAO-B). MAO-B-IN-33 inhibits cerebral MAO-B activity and alleviates MPTP (HY-15608)-induced dopaminergic neuronal loss in the mouse. MAO-B-IN-33 has the potential for Parkinson's disease research .

HY-161240

MAO-B-IN-30	Monoamine Oxidase	Neurological Disease Inflammation/Immunology
MAO-B-IN-30 (compound IS7) is a potent, selective and cross the blood-brain barrier *MAO-B* inhibitor with IC₅₀ values of 19.176, 0.082 µM for MAO-A and MAO-B, respectively. MAO-B-IN-30 shows antiproliferative activity and non-cytotoxic. MAO-B-IN-30 reduces TNF-alpha, IL-6, NF-kB levels. MAO-B-IN-30 has the potential for the research of Parkinson's disease .

HY-146149

MAO-B-IN-11	Monoamine Oxidase	Neurological Disease
MAO-B-IN-11 (Compound 8c) is a potent monoamine oxidase B (MAO-B) inhibitor with an IC₅₀ of 1.3 μM. MAO-B-IN-11 shows a neuroprotective activity .

HY-146150

MAO-B-IN-12	Monoamine Oxidase	Neurological Disease
MAO-B-IN-12 (Compound 16c) is a potent monoamine oxidase B (MAO-B) inhibitor with an IC₅₀ of 1.3 μM. MAO-B-IN-12 shows a neuroprotective activity .

HY-149984

MAO-B-IN-21	Monoamine Oxidase	Neurological Disease Inflammation/Immunology
MAO-B-IN-21 is an excellent *MAO-B* inhibitor with antioxidant activity and anti-Aβ aggregation activity. MAO-B-IN-21 also exhibits metal-ion chelating ability, anti-neuroinflammation (NO, TNF-α), neuroprotective activity and BBB permeability. MAO-B-IN-21 significantly improves the memory and cognitive impairment in Aβ1-42 induced Alzheimer's disease mice model .

HY-105041

Tedizolid phosphate sodium TR-701FA sodium	Antibiotic Bacterial Monoamine Oxidase	Infection
Tedizolid phosphate (TR-701FA) sodium is a *MAO-A* and *MAO-B* inhibitor with activity against Gram-positive bacteria .

HY-170887

MAO-B-IN-39	Keap1-Nrf2 Monoamine Oxidase	Inflammation/Immunology
MAO-B-IN-39 (compound11) is a selective monoamine oxidase B (MAO-B) inhibitor. MAO-B-IN-39 inhibits *MAO-B*with an IC₅₀ of 3.61 μM. MAO-B-IN-39 demonstrates a potent NRF2 induction capacity. MAO-B-IN-39 exhibits potent anti-inflammatory and neuroprotective activity in OS (oxidative stress)-related in vitro models. MAO-B-IN-39 demonstrates high liver microsomal stability and favorable pharmacokinetics in mice. MAO-B-IN-39 is potential for Parkinson’s disease (PD) research .

HY-152110

AChE/MAO-IN-2	Cholinesterase (ChE) Monoamine Oxidase	Neurological Disease
Dual AChE-MAO B-IN-5, indanone derivative, is a potent dual *AChE/MAO-B* inhibitior with IC₅₀ values of 0.0224, 0.0412, and 0.1116 μM for AChE, MAO-B and MAO-A, respectively. Dual AChE-MAO B-IN-5 has antioxidant activity and prevents β-amyloid plaque aggregation. Dual AChE-MAO B-IN-5 can be used for Alzheimer’s disease (AD) research .

HY-147953

MAO-B-IN-13	Monoamine Oxidase	Neurological Disease
MAO-B-IN-13 (compound 12a) is a highly potent, reversible and blood-brain barrier (BBB) penetrant *MAO-B* inhibitor with an IC₅₀ value of 10 nM. MAO-B-IN-13 has neuroprotective and antioxidant activity. MAO-B-IN-13 can be used for researching Parkinson’s disease .

HY-W067583

Norharmine	Monoamine Oxidase DYRK	Others
Norharmine is a Harmine analogue and an alkaloid. Norharmine is the inhibitors of *MAO-A* and DYRK1A. Norharmine has weak inhibitory activity against *MAO-A* and certain inhibitory activity against DYRK1A .

HY-149528

MAO-B-IN-24	Monoamine Oxidase Cholinesterase (ChE)	Cancer
MAO-B-IN-24 (compound 11h) is a selective, reversible, competitive inhibitor of MAO-B (IC₅₀: 1.60 μM). MAO-B-IN-24 also inhibited MAO-A (22.42 μM); at 10 μM concentration, it also reduced AChE and BChE activities to 54.58% and 88.43% .

HY-162606

MAO-A/B-IN-3	Monoamine Oxidase Cholinesterase (ChE)	Neurological Disease
MAO-A/B-IN-3 (Compound 12) stands out as a key dual *MAO-AChE* inhibitor, displaying excellent multi-target efficacy against *MAO-A, MAO-B, and AChE* with IC₅₀ values of 67 nM, 29 nM, and 1370 nM respectively. MAO-A/B-IN-3 is adept at altering the A site (hydrophobic ring) and C site (semicarbazone chain) within ketone amine-based MTDLs to bolster the inhibitory potential against *MAO-A/B* while notably diminishing activity against AChE. MAO-A/B-IN-3 is poised for research applications in the field of neurodegenerative diseases .

HY-175723

MAO-A/B-IN-4	Bacterial Monoamine Oxidase	Infection
MAO-A/B-IN-4 is an orally active *MAO-A/B* inhibitor, with IC₅₀ values of 51.3 μM and 47.0 μM, respectively. MAO-A/B-IN-4 exhibits potent activity against S. aureus, MSSA, MRSA, LRSA, and LREFa. MAO-A/B-IN-4 demonstrates potent antibacterial efficacy in a mouse model of LRSA peritonitis infection. MAO-A/B-IN-4 can be used for the study of bacterial infections .

Cat. No.	Product Name	Type

HY-D3221

MAO Probe 1

Fluorescent Dye

MAO Probe 1 is a reactive two-photon fluorescent probe capable of crossing the blood-brain barrier, which is used to detect the activity of monoamine oxidases (MAO-A/MAO-B), with K_m values of 70 μM (MAO-A) and 75 μM (MAO-B), respectively. IBC 2 (benzo[g]imino-coumarin 2), the enzymatic product of MAO Probe 1, can further specifically bind to and image Aβ plaques, enabling in vivo two-photon co-monitoring of MAO activity and Aβ plaques. MAO Probe 1 can be used in Alzheimer's disease research (IBC 2: Ex/Em = 850 nm/570-620 nm) .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0453

Hypericin Maximum Cited Publications 8 Publications Verification	Quinones Structural Classification Classification of Application Fields Anthraquinones Guttiferae Hyperlcurn perforatum L. Plants Disease Research Fields Source Classification Cancer	Apoptosis Influenza Virus Antibiotic Monoamine Oxidase PKC Cytochrome P450 Dopamine β-hydroxylase Reverse Transcriptase Telomerase
Hypericin is a naturally occurring substance found in Hyperlcurn perforatum L. Hypericin is an inhibitor of PKC (protein kinase C), *MAO* (monoaminoxidase), dopamine-beta-hydroxylase, reverse transcriptase, telomerase and CYP (cytochrome P450). Hypericin shows antitumor, antiviral, antidepressive activities, and can induce apoptosis .

HY-101392

Harmane 1 Publications Verification	Alkaloids other families Pyridine Alkaloids Plants Indole Alkaloids Source Classification	Imidazoline Receptor Monoamine Oxidase Adrenergic Receptor nAChR GABA Receptor Opioid Receptor
Harmane is a benzodiazepine receptor inhibitor (IC₅₀=7 μM), with IC₅₀ values for mACh, Opioid Receptor, *MAO-A/B, and α2-adrenergic receptor* of 24 μM, 2.8 μM, 0.5 μM, 5 μM, and 18 μM, respectively. Harmane inhibits the I1 imidazoline receptor (IC₅₀ = 30 nM) to reduce blood pressure and has antidepressant, anti-anxiety, anticonvulsant, and analgesic effects. Harmane inhibits dopamine biosynthesis by decreasing tyrosine hydroxylase (TH) activity and enhancing L-DOPA-induced cytotoxicity in PC12 cells. Additionally, Harmane can increase the mutagenic effect induced by 2-acetylaminofluorene (AAF) .

HY-N7204

4-Hydroxyderricin 1 Publications Verification	Chalcones Monophenols Flavonoids Phenols Umbelliferae Plants Ondetia linearis Benth.	Monoamine Oxidase Dopamine β-hydroxylase Apoptosis
4-Hydroxyderricin, the major active ingredients of Angelica keiskei Koidzumi, is an orally active, potent selective MAO-B (Monoamine oxidase inhibitors) inhibitor with an IC₅₀ of 3.43 μM. 4-Hydroxyderricin also mildly inhibits dopamine β (DBH)-hydroxylase activity. 4-Hydroxyderricin has antidepressant activity, anti-allergic, anti-diabetic, anti-oxidant, and antitumor effects. 4-Hydroxyderricin promotes apoptosis and cell cycle arrest through regulating PI3K/AKT/mTOR pathway in hepatocellular cells. 4-Hydroxyderricin inhibits osteoclast formation and accelerates osteoblast differentiation . 4-Hydroxyderricin is promising for research of inflammatory diseases .

HY-N0464

D-(-)-Quinic acid 3 Publications Verification	Infection Microorganisms other families Classification of Application Fields Ketones, Aldehydes, Acids Plants Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite Glycosidase Monoamine Oxidase
D-(-)-Quinic acid scavenges hydrogen peroxide (IC₅₀=87.11 μg/mL) and exhibits antioxidant activity. D-(-)-Quinic acid is the inhibitor for *MAO* and α-Glucosidase (IC₅₀ =93.75 μg/mL). D-(-)-Quinic acid is orally active .

HY-Y0265

Isatin Indoline-2,3-dione	Cardiovascular Disease Alkaloids other families Neurological Disease Classification of Application Fields Plants Disease Research Fields Indole Alkaloids Source Classification	Monoamine Oxidase Apoptosis
Isatin (Indoline-2,3-dione) is a potent inhibitor of monoamine oxidase (MAO) with an IC₅₀ of 3 μM. Also binds to central benzodiazepine receptors (IC₅₀ against clonazepam, 123 μM) . Also acts as an antagonist of both atrial natriuretic peptide stimulated and nitric oxide-stimulated guanylate cyclase activity . Shows effect on the serotonergic system .

HY-N0026

2'-Acetylacteoside 1 Publications Verification 2'-AA	Structural Classification Classification of Application Fields Simple Phenylpropanols Other Diseases Scrophulariaceae Phenylpropanoids Plants Disease Research Fields Brandisia hancei Hook. f. Source Classification	Monoamine Oxidase RANKL/RANK TNF Receptor NF-κB IKK
2'-Acetylacteoside (2'-AA) is a natural compound with oral activity and blood-brain barrier permeability. 2'-Acetylacteosideexhibits MAO‑B inhibitory activity (IC₅₀ = 17.71 μM, K_i = 13.81 μM). 2'-Acetylacteoside downregulates the expression of RANK, TRAF6, NF‑κB, NFATc1 and IKKβ, disrupts the RANKL/RANK interaction, blocks downstream signaling pathways, and increases the level of phosphorylated Akt. 2'-Acetylacteoside possesses potent anti-osteoclastogenic, anti-bone resorptive, pro-neurogenic, neuroprotective and antioxidant activities. 2'-Acetylacteoside can be used in the research of osteoporosis, ischemic stroke and Parkinson's disease .

HY-N2554

Osthenol Ostenol	Coumarins Phenols Polyphenols Phenylpropanoids Kleinia odora (Forssk.) DC. Umbelliferae Plants Source Classification	Monoamine Oxidase PI3K Akt Apoptosis
Osthenol (Ostenol) is a reversible, selective, competitive inhibitor of hMAO-A (IC₅₀=0.74 μM, K_i=0.26 μM), with antifungal and antibacterial activity. Osthenol inhibits the oxidative deamination of hMAO-A and regulates the metabolism of monoamine neurotransmitters. Osthenol also inhibits the PI3K/AKT signaling pathway to induce apoptosis of colon cancer cells, arrest the cell cycle at the G1 phase, and inhibit cell proliferation. Osthenol is mainly used in the study of neurological diseases and cancer, especially depression-related MAO-A targeted intervention and colon cancer .

HY-N0381

Maackiain 1 Publications Verification DL-Maackiain	Infection Structural Classification Natural Products Monophenols other families Classification of Application Fields Phenols Plants Disease Research Fields Source Classification	Keap1-Nrf2 p38 MAPK NOD-like Receptor (NLR) NF-κB mTOR Monoamine Oxidase Nuclear Factor of activated T Cells (NFAT) PKC Apoptosis Pyroptosis Autophagy Dengue Virus
Maackiain (DL-Maackiain) is an orally active multi-target inhibitor with anti-tumor activity and neuroprotective effects. Maackiain activates the AMPK, NLRP3 and Nrf2/HO-1 pathways, and inhibits key targets such as *NF-κB, mTOR, MAO-B, NFATc1* and PKCδ, thereby precisely regulating processes including apoptosis, autophagy and pyroptosis. Maackiain also effectively inhibits microglial activation, osteoclast formation, and proliferation and invasion of tumor cells, and protects dopaminergic neurons from damage. Maackiain is applicable to the research of various diseases such as Alzheimer's disease, osteoporosis, sepsis and dengue fever 。

HY-N4246

Bacopaside I	Triterpenes Structural Classification Terpenoids Scrophulariaceae Plants Bacopa monnieri (Linn.) Wettst. Source Classification	Aquaporin PKC Akt PI3K Apoptosis Monoamine Oxidase Pregnane X Receptor (PXR)
Bacopaside I is an orally active aquaporin AQP1 inhibitor and PKC modulator with neuroprotective and anticancer activities. Bacopaside I specifically blocks the water channel and cGMP-gated ion channel activities of AQP1 without affecting AQP4, thereby inhibiting the migration of colon cancer cells expressing AQP1. Bacopaside I activates the Akt pathway by interacting with PI3K, specifically inhibits *MAO-A, effectively alleviates neuron necrosis and apoptosis induced by oxygen-glucose deprivation, reduces oxidative stress, and regulates the surface expression of neuroreceptors. When combined with Bacopaside II (HY-N6016), Bacopaside I significantly reduces the viability, proliferation and invasion ability of breast cancer cells, and binds to the pregnane X receptor* (PXR). Bacopaside I is applicable to the research of colon cancer, breast cancer, vascular dementia, cerebral ischemia and other related diseases .

HY-101392A

Harmane hydrochloride 1 Publications Verification	Apocynaceae Alkaloids Other Alkaloids Plants Rauwolfia canescens Source Classification	Imidazoline Receptor Monoamine Oxidase Adrenergic Receptor nAChR GABA Receptor Opioid Receptor
Harmane hydrochloride is a benzodiazepine receptor inhibitor (IC₅₀=7 μM), with IC₅₀ values for mACh, Opioid Receptor, *MAO-A/B, and α2-adrenergic receptor* of 24 μM, 2.8 μM, 0.5 μM, 5 μM, and 18 μM, respectively. Harmane hydrochloride inhibits the I1 imidazoline receptor (IC₅₀ = 30 nM) to reduce blood pressure and has antidepressant, anti-anxiety, anticonvulsant, and analgesic effects. Harmane hydrochloride inhibits dopamine biosynthesis by decreasing tyrosine hydroxylase (TH) activity and enhancing L-DOPA-induced cytotoxicity in PC12 cells. Additionally, Harmane hydrochloride can increase the mutagenic effect induced by 2-acetylaminofluorene (AAF) .

HY-142026

Vitisin A (+)-Vitisin A	Structural Classification Vitis vinifera cv. Zalema Phenols Polyphenols Plants Vitaceae Source Classification	Caspase ERK NF-κB Influenza Virus PAK LDLR PPAR PCSK9 Androgen Receptor Keap1-Nrf2 Monoamine Oxidase Cholinesterase (ChE) IKK Wnt β-catenin Reactive Oxygen Species (ROS) Apoptosis Cuproptosis
Vitisin A ((+)-Vitisin A) is an orally active natural product with multiple pharmacological activities including anti-inflammatory, anti-tumor, anti-oxidant, anti-pathogenic microorganism, hypoglycemic and lipid-regulating, anti-osteoporotic, neuroprotective and cardiovascular protective effects. Vitisin A exhibits inhibitory effects on human AChE and *MAO-B* with IC₅₀ values of 1.29 µM and 4.94 µM, respectively. Vitisin A inhibits the ERK, MAPK, NF-κB, STAT1, HMGCR and TRAF6 pathways, downregulates the related phosphorylation and protein expression, while activates the Nrf2/HO-1 pathway and upregulates p21 expression. Vitisin A induces tumor cell apoptosis and cell cycle arrest, inhibits adipogenesis and lipid accumulation, while alleviates oxidative stress, suppresses inflammatory responses, blocks hepatic fibrosis, Cuproptosis and cholesterol synthesis, and increases the expression levels of central BDNF and TrkB. Vitisin A can be used in the research of tumors, infectious diseases, metabolic diseases, bone and joint diseases, liver diseases, skin injuries, as well as neurodegenerative and cognitive dysfunction-related diseases .

HY-N0453R

Hypericin (Standard) Maximum Cited Publications 8 Publications Verification	Natural Products Classification of Application Fields Guttiferae Phenols Hyperlcurn perforatum L. Plants Disease Research Fields Source Classification Cancer	Reference Standards Apoptosis Influenza Virus Antibiotic Monoamine Oxidase PKC Cytochrome P450 Dopamine β-hydroxylase Reverse Transcriptase Telomerase
Hypericin (Standard) is the analytical standard of Hypericin. This product is intended for research and analytical applications. Hypericin is a naturally occurring substance found in Hyperlcurn perforatum L. Hypericin is an inhibitor of PKC (protein kinase C), *MAO* (monoaminoxidase), dopamine-beta-hydroxylase, reverse transcriptase, telomerase and CYP (cytochrome P450). Hypericin shows antitumor, antiviral, antidepressive activities, and can induce apoptosis .

HY-N15657

Geiparvarin	Terpenoids Rutaceae Diterpenoids Geijera parviflora Lindl. Plants Source Classification	Apoptosis COX Caspase Microtubule/Tubulin Monoamine Oxidase
Geiparvarin is an anticancer agent and an inhibitor of *MAO-B* (pIC₅₀ = 6.84 μM). Geiparvarin exerts anti-tumor effects by downregulating COX2 expression and inhibiting angiogenesis. Geiparvarin blocks the cell cycle at the G₁ phase and induces apoptosis of cancer cells. Geiparvarin has anti-microtubule activity and destroys the cytoskeleton to exert anti-proliferative effects. Geiparvarin has research significance for lung cancer, leukemia, and breast cancer .

HY-N12134

Methyl piperate	Piper longum Linn. Structural Classification Natural Products Piperaceae Plants Source Classification	Monoamine Oxidase
Methylpiperic acid is a piperine alkaloid with significant MAO inhibitory activity (IC₅₀3.6 μM). Methylpiperic acid is less effective against MAO-B (IC 501.6 μM) than MAO-A (IC₅₀27.1 μM) has a bidirectional inhibitory effect. Methylphenidate is used to research mental disorders .

HY-N1638

1-Methyl-2-undecyl-4(1H)-quinolone	Alkaloids Evodia rutaecarpa (Juss.) Benth. Rutaceae Quinoline Alkaloids Plants Source Classification	Monoamine Oxidase
1-Methyl-2-undecyl-4(1H)-quinolone is a potent, irreversible and selective inhibitor of type B monoamine oxidase (MAO-B). 1-Methyl-2-undecyl-4(1H)-quinolone shows a selective inhibition of *MAO-B* activity with the IC₅₀ and K_i values of 15.3 μM and 9.91 μM, respectively, but did not inhibit type A MAO (MAO-A) activity. Methyl-2-undecyl-4(1H)-quinolone, as a quinolone alkaloid, is isolated from fresh leaves and fruits of Evodia rutaecarpa HOOK. f. et THOMS .

HY-N9329

Glicoricone	Flavonoids Classification of Application Fields Leguminosae Phenols Polyphenols Metabolic Disease Plants Disease Research Fields Glycyrrhiza uralensis Fisch. Isoflavones Source Classification	Monoamine Oxidase Estrogen Receptor/ERR
Glicoricone, a phenolic compound, is isolated from a species of licorice. Glicoricone is an inhibitor of monoamine oxidase (MAO), with an IC₅₀ of 140 μM. Glicoricone binds to estrogen receptor (ER) and shows estrogen antagonist activity .

HY-N0464R

D-(-)-Quinic acid (Standard)	Structural Classification Microorganisms other families Ketones, Aldehydes, Acids Plants Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite Glycosidase Monoamine Oxidase
D-(-)-Quinic acid (Standard) is the analytical standard of D-(-)-Quinic acid. This product is intended for research and analytical applications. D-(-)-Quinic acid scavenges hydrogen peroxide (IC₅₀=87.11 μg/mL) and exhibits antioxidant activity. D-(-)-Quinic acid is the inhibitor for *MAO* and α-Glucosidase (IC₅₀ =93.75 μg/mL). D-(-)-Quinic acid is orally active .

HY-Y0265R

Isatin (Standard) Indoline-2,3-dione (Standard)	Alkaloids Structural Classification other families Plants Indole Alkaloids Source Classification	Reference Standards Monoamine Oxidase Apoptosis
Isatin (Standard) is the analytical standard of Isatin. This product is intended for research and analytical applications. Isatin (Indoline-2,3-dione) is a potent inhibitor of monoamine oxidase (MAO) with an IC50 of 3 μM. Also binds to central benzodiazepine receptors (IC50 against clonazepam, 123 μM) . Also acts as an antagonist of both atrial natriuretic peptide stimulated and nitric oxide-stimulated guanylate cyclase activity . Shows effect on the serotonergic system .

HY-N0026R

2'-Acetylacteoside (Standard) 2'-AA (Standard)	Structural Classification Simple Phenylpropanols Scrophulariaceae Phenylpropanoids Plants Brandisia hancei Hook. f. Source Classification	Reference Standards Monoamine Oxidase RANKL/RANK TNF Receptor NF-κB IKK
2'-Acetylacteoside (Standard) is the analytical standard of 2'-Acetylacteoside (2'-AA) (HY-N0026). This product is intended for research and analytical applications. 2'-Acetylacteoside is a natural compound with oral activity and blood-brain barrier permeability. 2'-Acetylacteosideexhibits MAO‑B inhibitory activity (IC₅₀ = 17.71 μM, K_i = 13.81 μM). 2'-Acetylacteoside downregulates the expression of RANK, TRAF6, NF‑κB, NFATc1 and IKKβ, disrupts the RANKL/RANK interaction, blocks downstream signaling pathways, and increases the level of phosphorylated Akt. 2'-Acetylacteoside possesses potent anti-osteoclastogenic, anti-bone resorptive, pro-neurogenic, neuroprotective and antioxidant activities. 2'-Acetylacteoside can be used in the research of osteoporosis, ischemic stroke and Parkinson's disease .

HY-N4246R

Bacopaside I (Standard)	Triterpenes Structural Classification Terpenoids Scrophulariaceae Plants Bacopa monnieri (Linn.) Wettst. Source Classification	Reference Standards PKC Akt PI3K Apoptosis Pregnane X Receptor (PXR) Monoamine Oxidase Aquaporin
Bacopaside I (Standard) is the analytical standard of Bacopaside I. This product is intended for research and analytical applications. Bacopaside I is an orally active aquaporin AQP1 inhibitor and PKC modulator with neuroprotective and anticancer activities. Bacopaside I specifically blocks the water channel and cGMP-gated ion channel activities of AQP1 without affecting AQP4, thereby inhibiting the migration of colon cancer cells expressing AQP1. Bacopaside I activates the Akt pathway by interacting with PI3K, specifically inhibits *MAO-A, effectively alleviates neuron necrosis and apoptosis induced by oxygen-glucose deprivation, reduces oxidative stress, and regulates the surface expression of neuroreceptors. When combined with Bacopaside II (HY-N6016), Bacopaside I significantly reduces the viability, proliferation and invasion ability of breast cancer cells, and binds to the pregnane X receptor* (PXR). Bacopaside I is applicable to the research of colon cancer, breast cancer, vascular dementia, cerebral ischemia and other related diseases .

HY-N15470

MAO-B-IN-52	Structural Classification Flavonoids Polygonaceae Persicaria perfoliata (L.) H. Gross Plants Other Flavonoids Source Classification	Monoamine Oxidase
MAO-B-IN-52 (Compound 7) is a *MAO-B* inhibitor with an IC₅₀ of 83.7 μM. MAO-B-IN-52 has antioxidant activity. MAO-B-IN-52 can be used in the research of Alzheimer's disease .

HY-N1636

1-Methyl-2-nonyl-4(1H)-quinolone	Alkaloids Neurological Disease Classification of Application Fields Rutaceae Quinoline Alkaloids Plants Disease Research Fields Source Classification	Monoamine Oxidase
1-Methyl-2-nonyl-4(1H)-quinolone, a quinolone alkaloid, is a potent and selective *MAO-B* (monoamine oxidase) inhibitor. 1-Methyl-2-nonyl-4(1H)-quinolone exhibites inhibitory activity on leukotriene biosynthesis, with an IC₅₀ of 12.1 μM .

Cat. No.	Product Name	Chemical Structure

HY-Y0882S1

Hydroxylamine-d3 hydrochloride

Hydroxylamine-d₃ (hydrochloride) is the deuterium labeled Hydroxyamine hydrochloride. Hydroxylamine hydrochloride is a selective Monoamine oxidase (MAO) inhibitor used for inhibiting of platelet aggregation. Hydroxylamine hydrochloride is an intermediate of nitrogen cycle in aerobic ammonium oxidizers microorganisms, such as ammonium oxidizing bacteria (AOB), ammonium oxidizing archaea (AOA) and complete ammonium oxidizing bacteria (comammox). Hydroxylamine hydrochloride impacts NO and N₂O emissions by aerobic ammonium oxidizers microorganisms and inhibits nitrite oxidizing bacteria (NOB) activity .

HY-W015490S

1,4-Naphthoquinone-d6

1,4-Naphthoquinone-d₆ is the deuterium labeled 1,4-Naphthoquinone. 1,4-Naphthoquinone is an inhibitor with broad-spectrum inhibitory activity targeting DNA polymerase, NF-κB and monoamine oxidase (MAO-A/B), with antibacterial and anti-biofilm efficacy. 1,4-Naphthoquinone is a competitive inhibitor of MAO-B (Ki=1.4 μM) and a non-competitive inhibitor of MAO-A (Ki=7.7 μM). 1,4-Naphthoquinone inhibits DNA polymerase pol α, β, γ, δ, ε, λ with IC₅₀ ranging from 5.57-128 μM. 1,4-Naphthoquinone inhibits tumor cell proliferation, induces apoptosis and necrosis, and has anti-angiogenic and anti-inflammatory activities by inducing oxidative stress, depleting glutathione (GSH), inhibiting DNA polymerase-mediated DNA synthesis and blocking NF-κB nuclear translocation. 1,4-Naphthoquinone can be used in anti-bacterial , anti-tumor and anti-inflammatory studies, including inhibition of melanoma and colon cancer cell growth and endothelial cell function, as well as LPS-induced inflammation models .

HY-N0464S

Quinic acid-13C3
Quinic acid- ¹³C₃ is the ¹³C-labeled D-(-)-Quinic acid. D-(-)-Quinic acid scavenges hydrogen peroxide (IC₅₀=87.11 μg/mL) and exhibits antioxidant activity. D-(-)-Quinic acid is the inhibitor for *MAO* and α-Glucosidase (IC₅₀ =93.75 μg/mL). D-(-)-Quinic acid is orally active .

HY-14605S

Rasagiline-13C3 mesylate
Rasagiline- ¹³C₃ ((R)-AGN1135- ¹³C₃; TVP1012- ¹³C₃) mesylate is the deuterium labeled Rasagiline (mesylate) (HY-14605) . Rasagiline (R-AGN1135) mesylate is a highly potent selective irreversible mitochondrial monoamine oxidase (MAO) inhibitor with IC₅₀s of 4.43 nM and 412 nM for rat brain MAO B and A activity, respectively .

HY-B0678S

Metaxalone-d3

Metaxalone-d₃ is the deuterium labeled Metaxalone. Metaxalone (AHR438; NSC170959) is an FDA-approved muscle relaxant. Metaxalone acts mainly on the central nervous system and achieves muscle relaxation by inhibiting polysynaptic reflex arcs. In addition, Metaxalone is an inhibitor of MAO-A, which has anti-inflammatory and antioxidant effects. Metaxalone inhibits IL-1β-induced inflammatory phenotype, modulates NF-κB and other related signaling pathways, and decreases MAO-A expression and activity in IL-1β-treated microglia .

HY-B0678S1

Metaxalone-d6

Metaxalone-d₆ is deuterium labeled Metaxalone. Metaxalone (AHR438; NSC170959) is an FDA-approved muscle relaxant. Metaxalone acts mainly on the central nervous system and achieves muscle relaxation by inhibiting polysynaptic reflex arcs. In addition, Metaxalone is an inhibitor of MAO-A, which has anti-inflammatory and antioxidant effects. Metaxalone inhibits IL-1β-induced inflammatory phenotype, modulates NF-κB and other related signaling pathways, and decreases MAO-A expression and activity in IL-1β-treated microglia .

HY-W777360

Harman-13C2,15N

Harman- ¹³C₂, ¹⁵N is ¹³C and ¹⁵N labeled Harmane. Harmane is a benzodiazepine receptor inhibitor (IC₅₀=7 μM), with IC₅₀ values for mACh, Opioid Receptor, MAO-A/B, and α2-adrenergic receptor of 24 μM, 2.8 μM, 0.5 μM, 5 μM, and 18 μM, respectively. Harmane also inhibits haloperidol and serotonin, with IC₅₀ values of 163 μM and 101 μM, respectively. Harmane inhibits the I1 imidazoline receptor (IC₅₀=30 nM) to reduce blood pressure and has antidepressant, anti-anxiety, anticonvulsant, and analgesic effects. Harmane inhibits dopamine biosynthesis by decreasing tyrosine hydroxylase (TH) activity and enhancing L-DOPA-induced cytotoxicity in PC12 cells. Additionally, Harmane can increase the mutagenic effect induced by 2-acetylaminofluorene (AAF) .

HY-Y0882S

Hydroxylamine-15N hydrochloride

Hydroxylamine- ¹⁵N hydrochloride is the ¹⁵N-labeled Hydroxylamine hydrochloride (HY-Y0882). Hydroxylamine hydrochloride is a selective Monoamine oxidase (MAO) inhibitor used for inhibiting of platelet aggregation. Hydroxylamine hydrochloride is an intermediate of nitrogen cycle in aerobic ammonium oxidizers microorganisms, such as ammonium oxidizing bacteria (AOB), ammonium oxidizing archaea (AOA) and complete ammonium oxidizing bacteria (comammox). Hydroxylamine hydrochloride impacts NO and N2O emissions by aerobic ammonium oxidizers microorganisms and inhibits nitrite oxidizing bacteria (NOB) activity .

HY-W700834

Harman-d3

Harman-d₃ is deuterium labeled Harmane. Harmane is a benzodiazepine receptor inhibitor (IC₅₀=7 μM), with IC₅₀ values for mACh, Opioid Receptor, MAO-A/B, and α2-adrenergic receptor of 24 μM, 2.8 μM, 0.5 μM, 5 μM, and 18 μM, respectively. Harmane also inhibits haloperidol and serotonin, with IC₅₀ values of 163 μM and 101 μM, respectively. Harmane inhibits the I1 imidazoline receptor (IC₅₀=30 nM) to reduce blood pressure and has antidepressant, anti-anxiety, anticonvulsant, and analgesic effects. Harmane inhibits dopamine biosynthesis by decreasing tyrosine hydroxylase (TH) activity and enhancing L-DOPA-induced cytotoxicity in PC12 cells. Additionally, Harmane can increase the mutagenic effect induced by 2-acetylaminofluorene (AAF) .

Cat. No.	Product Name		Classification

HY-A0091A

Pargyline 3 Publications Verification		Alkynes
Pargyline is an irreversible monoamine oxidase (MAO) inhibitor with K_is of 13 μM and 0.5 μM for *MAO-A* and *MAO-B, respectively. Pargyline has antihypertensive and anticancer activities* . Pargyline is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-14605A

Rasagiline Maximum Cited Publications 7 Publications Verification (R)-AGN1135; TVP1012		Alkynes
Rasagiline (R-AGN1135) is a highly potent selective irreversible mitochondrial monoamine oxidase (MAO) inhibitor with IC₅₀s of 4.43 nM and 412 nM for rat brain MAO B and A activity, respectively . Rasagiline is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-A0091

Pargyline hydrochloride 3 Publications Verification		Alkynes
Pargyline hydrochloride is an irreversible monoamine oxidase (MAO) inhibitor with K_is of 13 μM and 0.5 μM for *MAO-A* and *MAO-B, respectively. Pargyline hydrochloride has antihypertensive and anticancer activities* . Pargyline (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-14605

Rasagiline mesylate Maximum Cited Publications 7 Publications Verification (R)-AGN1135 mesylate; TVP1012 mesylate		Alkynes
Rasagiline (R-AGN1135) mesylate is a highly potent selective irreversible mitochondrial monoamine oxidase (MAO) inhibitor with IC₅₀s of 4.43 nM and 412 nM for rat brain MAO B and A activity, respectively . Rasagiline (mesylate) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-131036

MAO-IN-M30 dihydrochloride		Alkynes
MAO-IN-M30 dihydrochloride is an orally active, brain-permeable, and brain selective irreversible *MAO-A* (IC₅₀=37 nM) and *MAO-B* (IC₅₀=57 nM) inhibitor. MAO-IN-M30 dihydrochloride is a potent iron chelator and radical scavenger. MAO-IN-M30 dihydrochloride has a neuroprotective effect against Dexamethasone-induced brain cell apoptosis. MAO-IN-M30 dihydrochloride also exhibits neurorestorative activity in post MPTP and lactacystin models of Parkinson's disease . MAO-IN-M30 (dihydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-14200

(S)-Rasagiline 1 Publications Verification TVP1022; S-PAI		Alkynes
(S)-Rasagiline (TVP1022) is the relatively inactive S-enantiomer form of Rasagiline. Rasagiline is a highly potent selective irreversible *MAO* inhibitor with IC₅₀s of 4.43 nM and 412 nM for rat brain MAO B and A activity, respectively . (S)-Rasagiline is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-10399A

Ladostigil hydrochloride TV-3326 hydrochloride		Alkynes
Ladostigil (TV-3326) hydrochloride is an orally active dual inhibitor of cholinesterase and brain-selective monoamine oxidase (MAO), with IC₅₀s of 37.1 and 31.8 μM for *MAO-B* and AChE, respectively. Ladostigil hydrochloride exhibits neuroprotective, antioxidant and anti-inflammatory activities. Ladostigil can be used for the research of depression and Alzheimer's disease . Ladostigil (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-10400

Ladostigil hemitartrate TV-3326 hemitartrate		Alkynes
Ladostigil (TV-3326) hemitartrate is an orally active dual inhibitor of cholinesterase and brain-selective monoamine oxidase (MAO) that can cross the blood-brain barrier, with IC₅₀s of 37.1 and 31.8 μM for *MAO-B* and AChE, respectively. Ladostigil hemitartrate exhibits neuroprotective, antioxidant and anti-inflammatory activities. Ladostigil hemitartrate can be used for the research of depression and Alzheimer's disease . Ladostigil (hemitartrate) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-10399

Ladostigil TV-3326		Alkynes
Ladostigil (TV-3326) is an orally active dual inhibitor of cholinesterase and brain-selective monoamine oxidase (MAO), with IC₅₀s of 37.1 and 31.8 μM for *MAO-B* and AChE, respectively. Ladostigil exhibits neuroprotective, antioxidant and anti-inflammatory activities. Ladostigil can be used for the research of depression and Alzheimer's disease . Ladostigil is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-175524

BChE/MAO-B-IN-2		Alkynes
BChE/MAO-B-IN-2 is a dual inhibitor of BChE (IC₅₀ = 0.05 μM, K_i = 0.01 μM) and *MAO-B* (IC₅₀ = 0.45 μM, K_i = 0.08 μM) with good blood-brain barrier permeability. BChE/MAO-B-IN-2 exhibits antioxidant activity, including DPPH radical scavenging, CUPRAC copper ion reduction, and superoxide anion scavenging. BChE/MAO-B-IN-2 can be used for the study of Alzheimer's disease (AD) .

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