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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
238 Results for "
POPS-containing bilayers
" in MedChemExpress (MCE) Product Catalog:
Products (238)
238 Results for "POPS-containing bilayers" in MCE Product Catalog:
13
13 Publications Verification
Cat. No.: HY-D0986
CAS No.: 115534-33-3
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Category:
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11
11 Cited Publications
Cat. No.: HY-P1902
CAS No.: 115722-23-1
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11
11 Cited Publications
Cat. No.: HY-P1902A
CAS No.: 2918768-05-3
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10
Category:
Infection Antibiotics Microorganism Disease Research Anticancer Disease Research Fields Other Antibiotics
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10
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Ferroptosis Reactive Oxygen Species (ROS) NOD-like Receptor (NLR) Glutathione Peroxidase ACSL Family Keap1-Nrf2 Heme Oxygenase (HO)
Research Areas:
Cardiovascular Disease Neurological Disease Metabolic Disease
UAMC-3203 (FXT-001) is a potent ferroptosis inhibitor with an IC50 of 12 nM. UAMC-3203 inhibits NLRP3 inflammasome activation and reactive oxygen species (ROS) production, maintains intracellular glutathione, and acts as a radical-trapping antioxidant in lipid bilayers. UAMC-3203 promotes NRF2/HO-1 antioxidant signaling while restoring GPX4 and xCT and inhibiting ACSL4. UAMC-3203 can be used in research on diabetic peripheral neuropathy, post-stroke cognitive impairment, atherosclerosis, corneal epithelial injury, spinal cord injury, acute iron poisoning, and aortic dissection .
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10 Cited Publications
Synonyms: FXT-001 hydrochloride
Target:
Ferroptosis Reactive Oxygen Species (ROS) NOD-like Receptor (NLR) Glutathione Peroxidase ACSL Family Keap1-Nrf2 Heme Oxygenase (HO)
Research Areas:
Cardiovascular Disease Neurological Disease Metabolic Disease
UAMC-3203 (FXT-001) hydrochloride is a potent ferroptosis inhibitor with an IC50 of 12 nM. UAMC-3203 hydrochloride inhibits NLRP3 inflammasome activation and reactive oxygen species (ROS) production, maintains intracellular glutathione, and acts as a radical-trapping antioxidant in lipid bilayers. UAMC-3203 hydrochloride promotes NRF2/HO-1 antioxidant signaling while restoring GPX4 and xCT and inhibiting ACSL4. UAMC-3203 hydrochloride can be used in research on diabetic peripheral neuropathy, post-stroke cognitive impairment, atherosclerosis, corneal epithelial injury, spinal cord injury, acute iron poisoning, and aortic dissection .
8
8 Cited Publications
Cat. No.: HY-W009756
CAS No.: 90-30-2
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N-Phenyl-1-naphthylamine is a dye that fluoresces strongly when bound to the inner phospholipid bilayer of Gram-negative bacteria. N-Phenyl-1-naphthylamine can be used to measure outer membrane permeability. N-Phenylnaphthalen-1-amine is a fluorescence probe for odorant-binding proteins (OBP) with a dissociation constant of 1.67 μM. N-Phenylnaphthalen-1-amine exhibits an excitation wavelength of 337 nM and an emission wavelength of 407 nM .
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7 Cited Publications
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3
3
3 Cited Publications
Synonyms: Dioleoylphosphatidylglycerol sodium
DOPG sodium is a naturally occurring anionic phospholipid, containing oleic acid (18:1) inserted at the sn-1 and sn-2 positions. DOPG can form a lipid bilayer in an aqueous solution and is used in the generation of micelles, liposomes, and other artificial membranes. DOPG also exhibits anti-inflammatory properties .
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3 Cited Publications
Cat. No.: HY-135416
CAS No.: 98072-47-0
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2
2 Cited Publications
Synonyms: DMPC; 1,2-Dimyristoyl-sn-glycero-3-phosphocholine; Dimyristoyl phosphatidylcholine
Colfosceril miristate (DMPC) is a synthetic phospholipid. Colfosceril miristate has antiproliferative effects on various tumors. Colfosceril miristate is used to study lipid monolayers, bilayers and drug delivery .
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2 Cited Publications
Cat. No.: HY-140739A
CAS No.: 185844-12-6
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DSPE-PEG2000-Maleimide free acid is a phospholipid-PEG conjugate. DSPE-PEG2000-Maleimide free acid utilizes the amphiphilicity of DSPE to insert into the lipid bilayer of liposomes or nanoparticles. DSPE-PEG2000-Maleimide free acid covalently couples to the sulfhydryl (-SH) of ligands (such as antibodies, peptides, or proteins) via thiol-maleimide click chemistry, giving the particles targeting capabilities. DSPE-PEG2000-Maleimide free acid can be used in the researches of breast cancer, lymphoma, and inherited retinal degeneration .
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1
1 Cited Publications
Ionizable lipid-1 (compound II-10) is an ionizable lipid (pKa=6.16) that can be used to prepare lipid nanoparticles (LNP) with bilayer structure .
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1 Cited Publications
Cat. No.: HY-W035091
CAS No.: 16903-35-8
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Tetrachloroauric acid is an Au (III) compound and bilayer disruptor that can be used to damage red blood cells. Tetrachloroauric acid specifically disrupts the bilayer structure of representative phospholipids (dimyristoylphosphatidylcholine and dimyristoylphosphatidylethanolamine) in human red blood cell membranes, and induces morphological changes in intact human red blood cells. Tetrachloroauric acid causes downregulation of MT I-II and GFAP expression in the mouse brain following chronic treatment. Tetrachloroauric acid is being used in studies related to neurotoxicity and hematotoxicity, including analyses of human red blood cells and molecular models of red blood cell membranes, as well as immunohistochemical evaluation of the mouse brain .
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Propoxycaine hydrochloride is a voltage-gated sodium channel inhibitor. Propoxycaine hydrochloride delays monophasic A spike action potential recovery. Propoxycaine hydrochloride increases bulk lateral, rotational, and annular lipid fluidity in neuronal membrane lipid bilayers, with greater inner monolayer fluidization, and induces membrane protein clustering. Propoxycaine hydrochloride can be used for the research of pain .
1
1-Stearoyl-2-docosahexaenoyl-sn-glycero-3-phosphoethanolamine (18:0-22:6 PE) is a lipid compound that can be used for liposome preparation. Liposomes are the main component of vesicles with concentric phospholipid bilayer membranes, which can be used to construct drug delivery systems for anti-cancer and anti-infection fields. Highly polar water-soluble loads can be captured in the internal aqueous space of liposomes, while lipophilic loads can be distributed into the lipid bilayer and become part of the lipid bilayer. Especially for the delivery of antisense oligonucleotides, it can overcome the problems of inefficient cellular uptake and rapid loss in the body.
The product specifications provided below refer solely to the active content of 1-Stearoyl-2-docosahexaenoyl-sn-glycero-3-phosphoethanolamine.
The product specifications provided below refer solely to the active content of 1-Stearoyl-2-docosahexaenoyl-sn-glycero-3-phosphoethanolamine.
1
1 Cited Publications
Bragsin2 is a potent, selective and noncompetitive nucleotide exchange factor BRAG2 inhibitor, with an IC50 of 3 μM. Bragsin2 binds at the interface between the PH domain of BRAG2 and the lipid bilayer, leads BRAG2 unable to activate lipidated Arf GTPase. Bragsin2 affects breast cancer stem cells .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
