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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
356 Results for "
Proline
" in MedChemExpress (MCE) Product Catalog:
Products (356)
356 Results for "Proline" in MCE Product Catalog:
42
42 Publications Verification
Synonyms: Val-boroPro mesylate; PT100 mesylate
Target:
Research Areas:
Talabostat mesylate (Val-boroPro mesylate; PT100 mesylate) is an orally active and nonselective dipeptidyl peptidase IV (DPP-IV) inhibitor (IC50 < 4 nM; Ki = 0.18 nM) and the inhibitor of fibroblast activation protein (FAP) (IC50 = 560 nM), inhibits DPP8/9 (IC50 = 4/11 nM; Ki = 1.5/0.76 nM), quiescent cell proline dipeptidase (QPP) (IC50 = 310 nM), DPP2, and some other DASH family enzymes. Antineoplastic and hematopoiesis- stimulating activities .
27
Target:
27
27 Cited Publications
Synonyms: (S)-(+)-Arginine hydrochloride
Target:
10
Target:
8
8 Cited Publications
Target:
Research Areas:
Ipragliflozin (L-Proline) is a highly potent and selective SGLT2 inhibitor with an IC50 of 2.8 nM; little and NO potency for SGLT1/3/4/5/6.
7
Category:
Other Diseases Disease markers Endocrine diseases Amino acids Nervous System Disorder Endogenous metabolite Disease Research Fields
Target:
6
5
5 Cited Publications
Cat. No.: HY-P72975
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: DPP4; DPP IV; Prev. ADCP2; TP103; Prev. CD26; Post-Proline Dipeptidyl Aminopeptidase IV; Adenosine Deaminase Complexing Protein 2; Xaa-Pro-Dipeptidylaminopeptidase; T-Cell Activation Antigen CD26; Gly-Pro Naphthylamidase; Dipeptidyl Peptidase IV; Dipeptid
Species:
Human
Source:
HEK293
4
4 Cited Publications
Cat. No.: HY-P70700A
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: STING1; HSTING; Prev. TMEM173; N-Terminal Methionine-Proline-Tyrosine-Serine Plasma Membrane Tetraspanner; Transmembrane Protein 173; Stimulator Of Interferon Response CGAMP Interactor-DeltaC; STING; Stimulator Of Interferon Response CGAMP Interactor-Delt
Species:
Human
Source:
E. coli
4
4 Cited Publications
Cat. No.: HY-P80644
Synonyms: DNM1L; DLP1; DRP1; Dynamin-1-like protein; Dnm1p/Vps1p-like protein; DVLP; Dynamin family member Proline-rich carboxyl-terminal domain less; Dymple; Dynamin-like protein; Dynamin-like protein 4; Dynamin-like protein IV; HdynIV; Dynamin-rela
2
2 Cited Publications
Cat. No.: HY-P1259A
Target:
Research Areas:
2
Target:
Research Areas:
PYCR1-IN-1 (compound 4) is a pyrroline-5-carboxylate reductase 1 (PYCR1) inhibitor with an IC50 of 8.8 µM. PYCR1-IN-1 has anticancer effects .
2
Target:
Research Areas:
2
2 Cited Publications
Target:
Research Areas:
2-APQC is an orally active and selective agonist of Sirtuin-3 (SIRT3) (Kd=2.756 μM), antagonizes Isoproterenol/ISO (HY-B0468)-induced cytotoxicity. 2-APQC activates the SIRT3-PYCR1 axis to enhance mitochondrial proline metabolism and inhibit the ROS-p38MAPK pathway by inhibiting signaling pathways such as mTOR-p70S6K, JNK, and TGF-β/Smad3. 2-APQC also activates the AMPK-Parkin axis to alleviate myocardial hypertrophy and fibrosis and protect cardiac function. 2-APQC can be used in the study of heart failure .
2
2 Cited Publications
Cat. No.: HY-P70700
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: STING1; HSTING; Prev. TMEM173; N-Terminal Methionine-Proline-Tyrosine-Serine Plasma Membrane Tetraspanner; Transmembrane Protein 173; Stimulator Of Interferon Response CGAMP Interactor-DeltaC; STING; Stimulator Of Interferon Response CGAMP Interactor-Delt
Species:
Human
Source:
E. coli
2
2 Cited Publications
Cat. No.: HY-P72659A
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: FAP; Prolyl Endopeptidase FAP; Fibroblast Activation Protein Alpha; Dipeptidyl Peptidase FAP; Seprase; FAPalpha; DPPIV; SIMP; 170 KDa Melanoma Membrane-Bound Gelatinase; CDNA FLJ60298, Highly Similar To Seprase; Gelatine Degradation Protease FAP; Fibroblast Activation Protein, Alpha; Integral Membrane Serine Protease; Serine Integral Membrane Protease; Post-Proline Cleaving Enzyme; FAPA; Surface-Expressed Protease
Species:
Human
Source:
HEK293
1
Category:
Alkaloids Human Gut Microbiota Metabolites Pyrrole Alkaloids Metabolic Disease Endogenous metabolite Disease Research Fields
Target:
1
1
1 Cited Publications
Target:
Research Areas:
Velagliflozin proline hydrate is the clinical form of Velagliflozin (HY-109018). Velagliflozin is an oral sodium-glucose cotransporter 2 (SGLT2) inhibitor with antidiabetic activity. Velagliflozin reduces renal glucose reabsorption and stimulates glycosuria, which lowers blood sugar and insulin concentrations .
1
1 Cited Publications
Target:
Research Areas:
Velagliflozin proline is an oral sodium-glucose cotransporter 2 (SGLT2) inhibitor with antidiabetic activity. Velagliflozin proline reduces renal glucose reabsorption and stimulates glycosuria, which lowers blood sugar and insulin concentrations .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
