Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
376 Results for "
TNF expression
" in MedChemExpress (MCE) Product Catalog:
Products (376)
376 Results for "TNF expression" in MCE Product Catalog:
539
539 Publications Verification
Synonyms: TAK-242; CLI-095
Research Areas:
Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Resatorvid (TAK-242) is a selective Toll-like receptor 4 (TLR4) inhibitor. Resatorvid inhibits NO, TNF-α and IL-6 production with IC50s of 1.8 nM, 1.9 nM and 1.3 nM, respectively. Resatorvid downregulates expression of TLR4 downstream signaling molecules MyD88 and TRIF. Resatorvid inhibits autophagy and plays pivotal role in various inflammatory diseases .
510
Target:
Research Areas:
BAY 11-7082 is an IκBα phosphorylation and NF-κB inhibitor. BAY 11-7082 selectively and irreversibly inhibits the TNF-α-induced phosphorylation of IκB-α, and decreases NF-κB and expression of adhesion molecules. BAY 11-7082 inhibits ubiquitin-specific protease USP7 and USP21 (IC50=0.19, 0.96 μM, respectively). BAY 11-7082 inhibits gasdermin D (GSDMD) pore formation in liposomes and inflammasome-mediated pyroptosis and IL-1β secretion in human and mouse cells .
26
26 Cited Publications
Synonyms: Astringenin; trans-Piceatannol
Category:
Microorganisms Rheum palmatum L. Stilbenes Plants Disease Research Fields Polygonaceae Extract Cancer
Target:
13
Target:
Research Areas:
CU-CPT 4a (TLR3-IN-1) is a potent, highly selective TLR3 signaling inhibitor. CU-CPT 4a represses the expression of downstream signaling pathways mediated by the TLR3/dsRNA complex, including TNF-α and IL-1β .
9
9 Cited Publications
Cat. No.: HY-N0509
CAS No.: 29838-67-3
Category:
Flavanonols Flavonoids Microorganisms Phenols Polyphenols Plants Other Families Extract Disease Research Fields Cancer
Target:
8
8 Cited Publications
Cat. No.: HY-N1949
CAS No.: 17680-84-1
Category:
Flavonoids Flavones Cassia Phenols Polyphenols Plants Disease Research Fields Inflammation/Immunology Labiatae Extract
Target:
8
8 Cited Publications
Cat. No.: HY-N6607
CAS No.: 13220-57-0
7
7 Cited Publications
Cat. No.: HY-W013636C
CAS No.: 997-43-3
Synonyms: Alpha-Ketoglutaric acid potassium
6
6 Cited Publications
Cat. No.: HY-N0604
CAS No.: 63223-86-9
Synonyms: Prosapogenin A2; Sanchinoside B2; Sanchinoside Rh1
5
Category:
Lonicera japonica Thunb. Simple Phenylpropanols Phenols Polyphenols Phenylpropanoids Plants Caprifoliaceae Extract Disease Research Fields Cancer
Target:
5
Category:
Infection Polysaccharides Animals Disease Research Fields Inflammation/Immunology Saccharides
Target:
5
5 Cited Publications
Cat. No.: HY-N0619
CAS No.: 102841-42-9
5
4
4 Cited Publications
Cat. No.: HY-N0617
CAS No.: 80651-76-9
Category:
Cardiovascular Disease Moraceae Extract Plants Flavanonols Flavonoids Phenols Polyphenols Disease Research Fields Inflammation/Immunology Morus alba Linn.
Target:
4
4 Cited Publications
Target:
Research Areas:
DPQ is a selective PARP-1 inhibitor that blocks PARP-1-mediated DNA damage repair and NAD +/ATP consumption, thereby inhibiting excessive inflammatory responses. DPQ inhibits NF-κB pathway activation, reduces the expression of pro-inflammatory factors (such as TNF-α, IL-6) and oxidative stress. DPQ can be used in inflammation-related studies of acute lung injury, myocardial infarction, and neurodegenerative diseases .
4
4 Cited Publications
Cat. No.: HY-W424851
CAS No.: 84050-22-6
Synonyms: 6,7-Dimethoxy-2-(1-piperazinyl)-4-quinazolinamine hydrochloride
Target:
Research Areas:
DPQ hydrochloride is a blood-brain barrier permeable and selective PARP-1 inhibitor that blocks PARP-1-mediated DNA damage repair and NAD +/ATP consumption, thereby inhibiting excessive inflammatory responses. DPQ hydrochloride inhibits NF-κB pathway activation, reduces the expression of pro-inflammatory factors (such as TNF-α, IL-6) and oxidative stress. DPQ hydrochloride can be used in inflammation-related studies of acute lung injury, myocardial infarction, and neurodegenerative diseases .
3
3
3 Cited Publications
Cat. No.: HY-N2322
CAS No.: 32449-98-2
Category:
Alkaloids Piperidine Alkaloids Solanum nigrum Linn. Plants Disease Research Fields Cancer Solanaceae Extract
Target:
3
Category:
Flavonols Flavonoids Burseraceae Extract Plants Disease Research Fields Inflammation/Immunology Boswellia carterii
Target:
3
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
