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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
334 Results for "
TNF expression
" in MedChemExpress (MCE) Product Catalog:
Products (334)
334 Results for "TNF expression" in MCE Product Catalog:
524
524 Publications Verification
Synonyms: TAK-242; CLI-095
Forschungsgebiete:
Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Resatorvid (TAK-242) is a selective Toll-like receptor 4 (TLR4) inhibitor. Resatorvid inhibits NO, TNF-α and IL-6 production with IC50s of 1.8 nM, 1.9 nM and 1.3 nM, respectively. Resatorvid downregulates expression of TLR4 downstream signaling molecules MyD88 and TRIF. Resatorvid inhibits autophagy and plays pivotal role in various inflammatory diseases .
488
488 Cited Publications
Synonyms: BAY 11-7821
Target:
Forschungsgebiete:
BAY 11-7082 is an IκBα phosphorylation and NF-κB inhibitor. BAY 11-7082 selectively and irreversibly inhibits the TNF-α-induced phosphorylation of IκB-α, and decreases NF-κB and expression of adhesion molecules. BAY 11-7082 inhibits ubiquitin-specific protease USP7 and USP21 (IC50=0.19, 0.96 μM, respectively). BAY 11-7082 inhibits gasdermin D (GSDMD) pore formation in liposomes and inflammasome-mediated pyroptosis and IL-1β secretion in human and mouse cells .
26
26 Cited Publications
Synonyms: Astringenin; trans-Piceatannol
Category:
Microorganisms Rheum palmatum L. Stilbenes Polygonaceae Plants Disease Research Fields Cancer
Target:
13
13 Cited Publications
Synonyms: TLR3-IN-1
Target:
Forschungsgebiete:
CU-CPT 4a (TLR3-IN-1) is a potent, highly selective TLR3 signaling inhibitor. CU-CPT 4a represses the expression of downstream signaling pathways mediated by the TLR3/dsRNA complex, including TNF-α and IL-1β .
9
9 Cited Publications
Art. -Nr.: HY-N0509
CAS. Nr.: 29838-67-3
Category:
Flavanonols other families Flavonoids Microorganisms Phenols Polyphenols Plants Disease Research Fields Cancer
Target:
8
8 Cited Publications
Art. -Nr.: HY-N1949
CAS. Nr.: 17680-84-1
Category:
Flavonoids Flavones Labiatae Cassia Phenols Polyphenols Plants Disease Research Fields Inflammation/Immunology
Target:
8
8 Cited Publications
Art. -Nr.: HY-N6607
CAS. Nr.: 13220-57-0
6
6 Cited Publications
Art. -Nr.: HY-N0604
CAS. Nr.: 63223-86-9
Synonyms: Prosapogenin A2; Sanchinoside B2; Sanchinoside Rh1
6
6 Cited Publications
Art. -Nr.: HY-W013636C
CAS. Nr.: 997-43-3
Synonyms: Alpha-Ketoglutaric acid potassium
5
Category:
Infection Polysaccharides Animals Disease Research Fields Inflammation/Immunology Saccharides
Target:
5
5 Cited Publications
Art. -Nr.: HY-N0619
CAS. Nr.: 102841-42-9
4
Category:
Caprifoliaceae Lonicera japonica Thunb. Simple Phenylpropanols Phenols Polyphenols Phenylpropanoids Plants Disease Research Fields Cancer
Target:
4
4 Cited Publications
Target:
Forschungsgebiete:
DPQ is a selective PARP-1 inhibitor that blocks PARP-1-mediated DNA damage repair and NAD +/ATP consumption, thereby inhibiting excessive inflammatory responses. DPQ inhibits NF-κB pathway activation, reduces the expression of pro-inflammatory factors (such as TNF-α, IL-6) and oxidative stress. DPQ can be used in inflammation-related studies of acute lung injury, myocardial infarction, and neurodegenerative diseases .
4
4 Cited Publications
Art. -Nr.: HY-W424851
CAS. Nr.: 84050-22-6
Synonyms: 6,7-Dimethoxy-2-(1-piperazinyl)-4-quinazolinamine hydrochloride
Target:
Forschungsgebiete:
DPQ hydrochloride is a blood-brain barrier permeable and selective PARP-1 inhibitor that blocks PARP-1-mediated DNA damage repair and NAD +/ATP consumption, thereby inhibiting excessive inflammatory responses. DPQ hydrochloride inhibits NF-κB pathway activation, reduces the expression of pro-inflammatory factors (such as TNF-α, IL-6) and oxidative stress. DPQ hydrochloride can be used in inflammation-related studies of acute lung injury, myocardial infarction, and neurodegenerative diseases .
3
3 Cited Publications
Synonyms: Halite, for molecular biology
3
3 Cited Publications
Art. -Nr.: HY-N0617
CAS. Nr.: 80651-76-9
Category:
Cardiovascular Disease Plants Moraceae Flavanonols Flavonoids Phenols Polyphenols Disease Research Fields Inflammation/Immunology Morus alba Linn.
Target:
3
3 Cited Publications
Art. -Nr.: HY-N2322
CAS. Nr.: 32449-98-2
Category:
Alkaloids Piperidine Alkaloids Solanum nigrum Linn. Plants Solanaceae Disease Research Fields Cancer
Target:
3
Category:
Flavonols Flavonoids Plants Burseraceae Disease Research Fields Inflammation/Immunology Boswellia carterii
Target:
3
3
3 Cited Publications
Art. -Nr.: HY-N0316
CAS. Nr.: 55481-88-4
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
