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anti-leishmanial

" in MedChemExpress (MCE) Product Catalog:

122

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2

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38

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6

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1

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Cat. No. 상품명 Target 연구분야 Chemical Structure
  • HY-B0219
    Allopurinol
    10+ Cited Publications

    Xanthine Oxidase Infection Neurological Disease Inflammation/Immunology Cancer
    Allopurinol is a potent and orally active xanthine oxidase inhibitor with an IC50 value of 0.2-50 μM. Allopurinol can be used in the research of hyperuricemia and gout. Allopurinol decreases the expression of HIF-1α and HIF-2α protein. Allopurinol shows anti-depressant and anti-nociception activity. Anti-leishmanial effect .
    Allopurinol
  • HY-13685
    Miltefosine
    10+ Cited Publications

    HePC; Hexadecyl phosphocholine

    Akt HIV Parasite Infection Cancer
    Miltefosine is a broad spectrum antimicrobial, anti-leishmanial, phospholipid agent acting by inhibiting the PI3K/Akt activity . Miltefosine is an inhibitor of CTP-phosphocholine cytidyltransferase (CCT) .
    Miltefosine
  • HY-P2310

    Bacterial Parasite Apoptosis HIV HSV CMV TNF Receptor NOD-like Receptor (NLR) DNA/RNA Synthesis Influenza Virus Cardiovascular Disease Infection
    Defensin HNP-1 human is a type of human neutrophil peptide (HNPs). Defensin HNP-1 human possesses immunomodulatory functions and can delay the apoptosis of neutrophils. Defensin HNP-1 human inhibits DNA/RNA/protein synthesis and interferes with metabolic pathways, thus exhibiting broad antibacterial activity. Defensin HNP-1 human has direct inactivation effects on HIV, HSV-1, HSV-2, CMV, influenza virus, etc. Defensin HNP-1 human has antileishmanial activity. Defensin HNP-1 human is involved in endothelial cell dysfunction during the early development of atherosclerosis .
    Defensin HNP-1 human
  • HY-147092
    Oryzalin
    1 Publications Verification

    Environmental Pollutants Microtubule/Tubulin Herbicide Infection
    Oryzalin is a dinitroaniline herbicide with antimitotic and antileishmanial activities. Oryzalin can bind to plant tubulin, inhibit the polymerization of microtubules in plant cells, and affect chromosome migration. Oryzalin can also be used to induce chromosome doubling .
    Oryzalin
  • HY-N7906
    Myricetin 3-O-glucoside
    1 Publications Verification

    Myricetin 3-β-D-glucopyranoside

    Bacterial Parasite Antibiotic Infection Inflammation/Immunology
    Myricetin 3-O-glucoside (Myricetin 3-β-D-glucopyranoside) is a flavonol from Tibouchina paratropica and Hakmeitau beans. Myricetin 3-O-glucoside exhibits anti-Leishmanial, anti-inflammatory and antimicrobial activities .
    Myricetin 3-O-glucoside
  • HY-B0219A
    Allopurinol sodium
    10+ Cited Publications

    Xanthine Oxidase Infection Neurological Disease Inflammation/Immunology Cancer
    Allopurinol sodium is a potent and orally active xanthine oxidase inhibitor with an IC50 value of 0.2-50 μM. Allopurinol sodium can be used in the research of hyperuricemia and gout. Allopurinol sodium decreases the expression of HIF-1α and HIF-2α protein. Allopurinol sodium shows anti-depressant and anti-nociception activity. Anti-leishmanial effect .
    Allopurinol sodium
  • HY-W077028

    Biochemical Assay Reagents Others
    N-(2-Hydroxypropyl)methacrylamide is used to synthesize copolymers for the targeted delivery of antileishmanial agents in Visceral leishmaniasis (VL) .
    N-(2-Hydroxypropyl)methacrylamide
  • HY-P2310A

    Bacterial Parasite Apoptosis HIV HSV CMV TNF Receptor Interleukin Related NOD-like Receptor (NLR) DNA/RNA Synthesis Influenza Virus Cardiovascular Disease Infection
    Defensin HNP-1 human TFA is a type of human neutrophil peptide (HNPs). Defensin HNP-1 human TFA possesses immunomodulatory functions and can delay the apoptosis of neutrophils. Defensin HNP-1 human TFA inhibits DNA/RNA/protein synthesis and interferes with metabolic pathways, thus exhibiting broad antibacterial activity. Defensin HNP-1 human TFA has direct inactivation effects on HIV, HSV-1, HSV-2, CMV, influenza virus, etc. Defensin HNP-1 human TFA has antileishmanial activity. Defensin HNP-1 human TFA is involved in endothelial cell dysfunction during the early development of atherosclerosis .
    Defensin HNP-1 human TFA
  • HY-B0483

    Carbonic Anhydrase Parasite Autophagy Apoptosis Infection Inflammation/Immunology Cancer
    Tioxolone is an inhibitor for the carbonic anhydrase. Tioxolone exhibits anti-leishmanial, antitumor, and anti-inflammatory activities. Tioxolone can be used in research of acne and psoriasis .
    Tioxolone
  • HY-101011

    Opioid Receptor Infection Neurological Disease
    Naloxonazine dihydrochloride is a specific μ-opioid receptor antagonist with an IC50 of 5.4 nM. Naloxonazine dihydrochloride also shows anti-leishmanial activity .
    Naloxonazine dihydrochloride
  • HY-75247
    Coumaran
    2 Publications Verification

    2,3-Dihydrobenzofuran

    Cholinesterase (ChE) Endogenous Metabolite Parasite Infection Neurological Disease Inflammation/Immunology
    Coumaran (2,3-Dihydrobenzofuran) is an AChE inhibitor with antileishmanial activity. Coumaran may acquire antiparasitic capabilities through activation of macrophages and exert immunomodulatory activity. Coumaran can be used as a biopesticide. .
    Coumaran
  • HY-N1453
    Hypocrellin B
    1 Publications Verification

    Apoptosis Fungal Parasite Infection Cancer
    Hypocrellin B, a pigment isolated from the fungi Hypocrella bambusae and Shiraia bambusicola, is an apoptosis inducer. Hypocrellin B can be used as a photosensitizer for photodynamic therapy of cancer. Hypocrellin B also has antimicrobial and antileishmanial activities .
    Hypocrellin B
  • HY-N7926

    Environmental Pollutants Apoptosis Parasite TNF Receptor Interleukin Related Infection Inflammation/Immunology
    Pentadecane is an orally active natural plant volatile alkane with anti-inflammatory, analgesic, antipyretic and anti-leishmanial activities. Pentadecane presents IC50 values of 65.3 μM, 60.5 μM and 194.8 μM against Leishmania infantum promastigotes, amastigotes and intracellular amastigotes, respectively. Pentadecane downregulates the mRNA expression of TNF-α and IL-12 and inhibits the release of inflammatory mediators. Pentadecane arrests the cell cycle of Leishmania infantum and induces apoptosis. Pentadecane can be applied to the research of inflammation and leishmaniasis .
    Pentadecane
  • HY-W075770

    Nickel monoxide

    Environmental Pollutants Apoptosis Reactive Oxygen Species (ROS) Caspase TGF-beta/Smad p38 MAPK Akt PI3K Infection Metabolic Disease Cancer
    Nickel(II) oxide (nickel monoxide) is a chemical warfare agent that can enter the body through the respiratory tract and other routes, distributing to organs such as the lungs and testes. The nanoparticle form of nickel(II) oxide (NiO NPs) exhibits antibacterial, anti-leishmanial, anti-diabetic, and anti-cancer activities. NiO NPs can be activated by ultraviolet and visible light, generating reactive oxygen species (ROS). Nickel(II) oxide induces oxidative stress by generating reactive oxygen species, activating the TGF-β1-mediated MAPK and PI3K/AKT pathways, disrupting the MMPs/TIMPs balance, and upregulating the expression of inflammatory factors (IL-1β, IL-6) and apoptosis-related molecules (Bax, caspase-3, p53), while inhibiting the activity of the anti-apoptotic molecule Bcl-2. Nickel(II) oxide induces cytotoxicity, promotes fibrosis, triggers inflammatory responses, and causes apoptosis. Nickel(II) oxide can be applied in research on the safety assessment of nanomaterials, such as in the context of pulmonary fibrosis and reproductive system toxicity .
    Nickel(II) oxide
  • HY-121368

    Parasite Infection Inflammation/Immunology Cancer
    Mahanine is a carbazole alkaloid with various biological properties. Mahanine is a potent anticancer agent against different types of cancer cells. Mahanine exhibits antileishmanial activity and can be used for Leishmania infection research research.
    Mahanine
  • HY-W012634S

    Isotope-Labeled Compounds Bacterial Cancer
    Benzothiazole-d4 is a deuterium labeled Benzothiazole (HY-W012634). Benzothiazole is a natural occurring heterocyclic nuclei. Benzothiazole nucleus possesses a number of biological activities such as anticancer, antimicrobial, antidiabetic, anti-inflammatory, antileishmanial, and antiviral .
    Benzothiazole-d4
  • HY-155520

    Parasite Infection
    Antileishmanial agent-19 (Compound F27) is an antileishmanial agent, with a IC50 of 3.39 μM for L. donovani promastigotes. Antileishmanial agent-19 inhibits Leishmania prolyl-tRNA synthetase. Antileishmanial agent-19 inhibits host PI3K/Akt/CREB axis-mediated IL-10 secretion. Antileishmanial agent-19 induces autophagy-mediated apoptosis in L. donovani promastigotes. Antileishmanial agent-19 reduces parasite burden in L.d-infected animals .
    Antileishmanial agent-19
  • HY-B0219R

    Reference Standards Xanthine Oxidase Infection Neurological Disease Inflammation/Immunology Cancer
    Allopurinol (Standard) is the analytical standard of Allopurinol. This product is intended for research and analytical applications. Allopurinol is a potent and orally active xanthine oxidase inhibitor with an IC50 value of 0.2-50 μM. Allopurinol can be used in the research of hyperuricemia and gout. Allopurinol decreases the expression of HIF-1α and HIF-2α protein. Allopurinol shows anti-depressant and anti-nociception activity. Anti-leishmanial effect .
    Allopurinol (Standard)
  • HY-W015818
    2-Benzoxazolinone
    1 Publications Verification

    2-Benzoxazolone; 1,3-Benzoxazol-2(3H)-one; 2-Hydroxybenzoxazole

    Parasite Infection
    2-Benzoxazolinone is an anti-leishmanial agent with an LC50 of 40 μg/mL against L. donovani . A building block in chemical synthesis. 1,3-Benzoxazol-2(3H)-one derivatives have antimicrobial activity against a selection of Gram-positive, Gram-negative bacteria and yeasts . Derivatives as anti-quorum sensing agent .
    2-Benzoxazolinone
  • HY-134467

    Parasite NO Synthase Infection
    Phylloflavan is an antileishmanial (Antileishmanial) agent with an EC50 of 3.2 nM against intracellular amastigotes of Leishmania donovani. Phylloflavan is isolated from Phyllocldus plants. Phylloflavan induces moderate levels of NO release. Phylloflavan also inhibits the cytopathic effect of encephalomyocarditis virus on L929 fibroblasts (38 U/mL) .
    Phylloflavan
  • HY-N1077

    Cholinesterase (ChE) Endogenous Metabolite Others
    Vomifoliol, a compound related to abscisie acid (ABA), has a modified 2,4-pentadiene side chain and has activity equal to that displayed by ABA. Vomifoliol exhibits antiacetylcholinesterase activity and displays moderate antileishmanial activity .
    Vomifoliol
  • HY-151935

    Parasite Infection
    Antileishmanial agent-13 is a quinoline-isatin hybrid, acts as an antileishmanial agent against L. Major Leishmania strain. Antileishmanial agent-13 acquires the antileishmanial activity via the anti-folate mechanism. Antileishmanial agent-13 has potent inhibition against both promastigote and amastigote forms with IC50s of 0.604 μM and 0.508 μM, respectively .
    Antileishmanial agent-13
  • HY-13685R

    HePC (Standard); Hexadecyl phosphocholine (Standard)

    Akt HIV Parasite Reference Standards Infection Cancer
    Miltefosine (Standard) is the analytical standard of Miltefosine. This product is intended for research and analytical applications. Miltefosine is a broad spectrum antimicrobial, anti-leishmanial, phospholipid agent acting by inhibiting the PI3K/Akt activity . Miltefosine is an inhibitor of CTP-phosphocholine cytidyltransferase (CCT) .
    Miltefosine (Standard)
  • HY-B0219S1

    Isotope-Labeled Compounds Xanthine Oxidase Infection Neurological Disease Inflammation/Immunology Cancer
    Allopurinol- 13C, 15N2 is the 13C- and 15N-labeled labeled Allopurinol (HY-B0219). Allopurinol is a potent and orally active xanthine oxidase inhibitor with an IC50 value of 0.2-50 μM. Allopurinol can be used in the research of hyperuricemia and gout. Allopurinol decreases the expression of HIF-1α and HIF-2α protein. Allopurinol shows anti-depressant and anti-nociception activity. Anti-leishmanial effect .
    Allopurinol-13C,15N2
  • HY-N6054

    Parasite Topoisomerase Infection Inflammation/Immunology
    Niranthin, a lignan with a wide spectrum of pharmacological activities. Niranthin is a potent and non-competitive inhibitor of heterodimeric type IB topoisomerase of L. donovani. Niranthin can be used for the research of drug-resistant leishmaniasis research.
    Niranthin
  • HY-N7985

    Parasite Bacterial Infection Cancer
    Pendulone is a isoflavanquinone with good antiplasmodial activity with an IC50 of 7.0 µM. Pendulone also has antileishmanial, antibacterial and anticancer activity .
    Pendulone
  • HY-131300

    Parasite Infection
    Colchicoside is a bioactive tropolone alkaloid with anti-leishmanial and anti-leishmanial?activities .
    Colchicoside
  • HY-149958

    Parasite Infection
    Antileishmanial agent-17 is a coumarin hybrid compound with antileishmanial effects (IC50 <0.78 μM). Antileishmanial agent-17 is safe to normal VERO cells. Antileishmanial agent-17 binds to folate pathway enzymes pteridine reductase and DHFR-TS. And Antileishmanial agent-17 shows the most potent with IC50 value of 0.40 μM against promastigote and 0.68 μM against amastigote, respectivley.
    Antileishmanial agent-17
  • HY-127160

    Environmental Pollutants Bacterial Parasite Infection
    Benzoxonium chloride is an anti-leishmanial agent. Benzoxonium chloride inhibits bacteria, certain protozoa, yeasts and non-spore forming organisms .
    Benzoxonium chloride
  • HY-178784

    Parasite Infection
    Antileishmanial agent-37 (Compound 1b) is an antileishmanial agent, TbPTR1 (an IC50 value of 17.1 μM) and LmPTR1 inhibitor. Anti-leishmaniasis agent-37 has a moderate effect against Leishmania infantum .
    Antileishmanial agent-37
  • HY-178456

    Parasite Reactive Oxygen Species (ROS) Apoptosis Infection
    Antileishmanial agent-36 (compound 4f) is an indole-dihydropyrimidinone derivative with anti-leishmanial activity. Antileishmanial agent-36 induces reactive oxygen species (ROS)-mediated mitochondrial dysfunction and apoptosis. Antileishmanial agent-36 exhibits potent activity against L. donovani (IC50 =4.54 μM) with low cytotoxicity against J774.1 macrophage. Antileishmanial agent-36 clears the parasite burden in a visceral leishmaniasis (VL) model. Antileishmanial agent-36 can be used for VL research .
    Antileishmanial agent-36
  • HY-147857

    Parasite Infection
    Antileishmanial agent-12 (compound 5a) is a potent anti-leishmanial agent. Antileishmanial agent-12 shows antiprotozoal activity against Leishmania brazilensis, Leishmania infantum, and T. cruzi, with IC50 values of 14.9, 21.3 and 9.3 μM, respectively .
    Antileishmanial agent-12
  • HY-147856

    Parasite Infection
    Antileishmanial agent-11 (compound 4d) is a potent anti-leishmanial agent. Antileishmanial agent-11 shows antiprotozoal activity against Leishmania brazilensis, Leishmania infantum, and T. cruzi, with IC50 values of 28.3, 24.8 and 13.0 μM, respectively .
    Antileishmanial agent-11
  • HY-W779244

    Isotope-Labeled Compounds Biochemical Assay Reagents Drug Intermediate Infection
    1H-Pyrazole-3,4,5-d3 is the deuterium labeled 1H-pyrazole (HY-76228). 1H-pyrazole is a nitrogen-containing heterocyclic compound composed of a five-membered ring and two nitrogen atoms. 1H-pyrazole is an intermediate in organic synthesis. 1H-pyrazole coordinates with metal ions. 1H-pyrazole derivatives have antibacterial, anti-inflammatory, anti-malarial, and anti-leishmanial activities .
    1H-Pyrazole-3,4,5-d3
  • HY-155845

    Parasite Infection
    Antileishmanial agent-21 (compound 4e) is an antileishmanial agent that targets the Leishmania pteridine reductase 1 (Lm-PTR1). Antileishmanial agent-21 has an anti-folate mechanism, and folic acid and leucovorin can reverse the anti-leishmanial activity of Antileishmanial agent-21. Antileishmanial agent-21 inhibits the Chloroquine (HY-17589A)-resistant strain of Plasmodium falciparum (RKL9) with an IC50 of 0.0198-0.096 μM .
    Antileishmanial agent-21
  • HY-133838

    BM41440

    Parasite PKC Infection Cancer
    Ilmofosine (BM41440) is a potent and selective protein kinase C inhibitor. Ilmofosine induces cell cycle arrest at the G2 phase. Ilmofosine also is an anti-leishmanial agent .
    Ilmofosine
  • HY-N6816

    Parasite Infection
    Ludaconitine, isolated from Aconitum spicatum (Bruhl) Stapf, exhibits antileishmanial activity with an IC50 of 36.10 μg/mL .
    Ludaconitine
  • HY-B0221A

    Antibiotic Fungal Bacterial Parasite Infection Inflammation/Immunology Cancer
    Amphotericin B trihydrate, a polyene antibiotic, is first isolated from fermenter cultures of Streptomyces nodosus. Amphotericin B trihydrate also possesses antileishmanial activity .
    Amphotericin B trihydrate
  • HY-N15413

    Parasite Infection
    Thalidasine (compound 3) is a bisbenzyltetrahydroisoquinoline alkaloid. Thalidasine is a anticancer agent against human colon adenocarcinoma cells. Thalidasine exhibits antileishmanial activity and can be used for Leishmania infection research research .
    Thalidasine
  • HY-125648

    alpha-Euphorbol

    Parasite Infection
    Euphorbadienol (alpha-Euphorbol), a triterpenic compound, isolated from the latex of Euphorbia resinifera. The derivatives of Euphorbadienol can be used as elicitors of disease resistance, and has antileishmanial and antitrypanosomal activity .
    Euphorbadienol
  • HY-N2926

    Parasite Infection
    β-Carboline-1-propionic acid is a alkaloid which can be extracted from Ailanthus altissima. β-Carboline-1-propionic acid can be used as an antileishmanial agent .
    β-Carboline-1-propionic acid
  • HY-B0219S

    Isotope-Labeled Compounds Xanthine Oxidase Infection Inflammation/Immunology
    Allopurinol-d2 is deuterium labeled Allopurinol. Allopurinol is a potent xanthine oxidase inhibitor (IC50 values of 0.2 to 50 μM). Allopurinol can be used for the research of hyperuricemia and gout. Antileishmanial effect .
    Allopurinol-d2
  • HY-W011581

    Drug Intermediate Infection Cancer
    6,9-Dichloro-2-methoxyacridine is an aromatic heterocyclic compound. 6,9-Dichloro-2-methoxyacridine is a precursor of ACS03, which exhibits antileishmanial and antitumor activities .
    6,9-Dichloro-2-methoxyacridine
  • HY-22044
    ICA
    1 Publications Verification

    N-[4-(2-Pyridinyl)-2-thiazolyl]-2-pyridinamine

    Parasite Infection Cardiovascular Disease
    ICA (N-(pyridin-2-yl)-4-(pyridin-2-yl)thiazol-2-amine) is a SK channel inhibitor that has antileishmanial activity with an IC50 of 2.1 µM.
    ICA
  • HY-W019829

    Tyrosinase Parasite Infection
    Polyphyllin C (compound 2) is a spirostanol saponin. Polyphyllin C exhibits mild (IC50=36.87 µM) activities against the tyrosinase and moderate (IC50=1.59 µg/mL) antileishmanial activities .
    Polyphyllin C
  • HY-N8471

    Parasite SARS-CoV Infection Inflammation/Immunology
    Niazinin is a thiocarbamate glycoside with antileishmanial activities, with an IC50 value of 5.25 μM. Niazinin also shows a binding affinity with the target protein 3CL protease. Niazinin has promising leishmanicidal, anti-inflammatory and anti-pyretic activity .
    Niazinin
  • HY-19688B

    WR 6026 tosylate

    Parasite Mitochondrial Metabolism Infection
    Sitamaquine (WR6026) tosylate, an orally active 8-aminoquinoline analog, is an antileishmanial agent. Sitamaquine tosylate inhibits mitochondrial complex II (succinate dehydrogenase). Sitamaquine tosylate is a lipophilic weak base that rapidly accumulates in acidic compartments of Leishmania spp., mainly in acidocalcisomes .
    Sitamaquine tosylate
  • HY-149834

    Parasite Infection
    Antileishmanial agent-18 (Compound 1e) is an antileishmanial agent. Antileishmanial agent-18 effectively inhibits growth of L. donovani promastigotes. Antileishmanial agent-18 is safe for host cells .
    Antileishmanial agent-18
  • HY-147535

    Parasite Infection
    Antileishmanial agent-7 (compound 23) is a potent antileishmanial agent. Antileishmanial agent-7 shows antileishmanial activity against Leishmania donovani and L-6, with IC50 values of 6.89 and 259 μM, respectively .
    Antileishmanial agent-7
  • HY-149956

    Parasite Infection
    Antileishmanial agent-15 (compound 13c) is a potent antileishmanial agent. Antileishmanial agent-15 shows antileishmanial and cytotoxic activity against L. major promastigotes and amastigotes, with IC50 values of 0.78 and 0.99 μM, respectively .
    Antileishmanial agent-15

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