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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
80 Results for "
cytoskeleton
" in MedChemExpress (MCE) Product Catalog:
Products (80)
80 Results for "cytoskeleton" in MCE Product Catalog:
125
125 Publications Verification
Cat. No.: HY-D0938
CAS No.: 150347-59-4
Synonyms: CFSE; 5(6)-Carboxyfluorescein diacetate succinimidyl ester; 5(6)-CFDA N-succinmidyl ester
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25 Cited Publications
Cat. No.: HY-P0028
CAS No.: 17466-45-4
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11
11 Cited Publications
Cat. No.: HY-16931
CAS No.: 340316-62-3
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SMIFH2 is a formin specific inhibitor. SMIFH2 inhibits actin polymerization by Formins and affects the actin cytoskeleton .
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2
2 Cited Publications
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Pfn1-IN-1 (compound C1) is a Pfn1 inhibitor that inhibits the angiogenic capacity of endothelial cells (EC). Pfn1 is a regulator of the actin cytoskeleton, inducing actin polymerization and essential cellular activities. Pfn1-IN-1 inhibits Pfn1-Actin interaction and Actin polymerization.
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1
1 Cited Publications
Cat. No.: HY-P2031
CAS No.: 26645-35-2
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Cat. No.: HY-P0131A
CAS No.: 2828432-44-4
Synonyms: Laminin (925-933) TFA
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Laminin peptide CDPGYIGSR TFA (Laminin (925-933) TFA) is a peptide fragment derived from the laminin B1 chain that binds to laminin receptors, and acts as a ligand for the laminin receptor. Laminin peptide CDPGYIGSR TFA mediates cell spreading, induces the clustering of receptors with vinculin and α-actinin, regulates the actin cytoskeleton, promotes the formation of stress fibers, and enhances epithelial cell adhesion. Laminin peptide CDPGYIGSR TFA can be used in studies related to tumor metastasis and nerve injury .
Cat. No.: HY-N6588
CAS No.: 86632-03-3
Synonyms: 3,4,5-triCQA
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Phosphatidylinositols, soya, sodium salts is a mixture of phosphatidylinositols. Phosphoinositides are lipids involved in the vesicular transport of proteins and lipids between the different compartments of eukaryotic cells. They act by recruiting and/or activating effector proteins and thus are involved in regulating various cellular functions, such as vesicular budding, membrane fusion and cytoskeleton dynamics .
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Ganglioside GM2 is a human tumor antigen predominantly found in human tumor cells and fetal brain tissue. As a sialylated glycosphingolipid, Ganglioside GM2 is involved in processes such as cell signaling, adhesion, and motility. Ganglioside GM2 abnormal expression and accumulation are associated with tumors and neurodegenerative disorders. Ganglioside GM2 promotes tumor cell migration and invasion by directly binding to the integrin β1 receptor, activating the FAK/Src/Erk-MAPK signaling pathway, and inducing actin cytoskeleton remodeling .
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PSMA-Val-Cit-PAB-MMAE is a small-molecule conjugate targeting PSMA, with Monomethyl auristatin E (MMAE) (HY-15162) as its cytotoxic payload. PSMA-Val-Cit-PAB-MMAE binds to PSMA, thereby being delivered into PSMA-expressing prostate cancer cells. Subsequently, the Val-Cit linker is cleaved under the mediation of cathepsin B, releasing active MMAE. PSMA-Val-Cit-PAB-MMAE inhibits CYP3A4 activity (IC50 = 11.2 μM), induces intracellular ROS production and oxidative stress, disrupts the cytoskeleton through microtubule destabilization, and induces prostate cancer cell death. PSMA-Val-Cit-PAB-MMAE can be used in research related to prostate cancer .
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Protein kinase inhibitor H-7 dihydrochloride is a selective inhibitor of PKC and cyclic nucleotide-dependent protein kinases, with a Ki value of 6.0 μM for rabbit protein kinase C, a Ki value of 3.0 μM for rabbit cAMP-dependent protein kinase, and a Ki value of 5.8 μM for porcine cGMP-dependent protein kinase. Protein kinase inhibitor H-7 dihydrochloride has no effect on Ca 2+-calmodulin-dependent enzymes. Protein kinase inhibitor H-7 dihydrochloride regulates the Actin cytoskeleton, inhibits contractility, disrupts stress fibers, induces protrusive activity, stabilizes intercellular junctions, and triggers rapid and reversible cytoskeletal reorganization. Protein kinase inhibitor H-7 dihydrochloride serves as a research tool for elucidating the functions of protein kinase C-mediated signaling systems .
Cat. No.: HY-P1189
CAS No.: 154303-05-6
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Cat. No.: HY-18256
CAS No.: 253426-24-3
Synonyms: AVE8062 hydrochloride; AC7700 hydrochloride
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Ombrabulin hydrochloride is a derivative of CA-4 phosphate, which is known to exhibit antivascular effects through selective disruption of the tubulin cytoskeleton of endothelial cells.
Synonyms: AVE8062; AC7700
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Ombrabulin (AVE8062) is a derivative of CA-4 phosphate, which is known to exhibit antivascular effects through selective disruption of the tubulin cytoskeleton of endothelial cells.
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Cat. No.: HY-DY1009
CAS No.: 150347-59-4
Solvent and concentration: DMSO: 5 mM
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Research Areas:
Protein kinase inhibitor H-7 is a selective inhibitor of PKC and cyclic nucleotide-dependent protein kinases, with a Ki value of 6.0 μM for rabbit protein kinase C, a Ki value of 3.0 μM for rabbit cAMP-dependent protein kinase, and a Ki value of 5.8 μM for porcine cGMP-dependent protein kinase. Protein kinase inhibitor H-7 has no effect on Ca 2+-calmodulin-dependent enzymes. Protein kinase inhibitor H-7 regulates the Actin cytoskeleton, inhibits contractility, disrupts stress fibers, induces protrusive activity, stabilizes intercellular junctions, and triggers rapid and reversible cytoskeletal reorganization. Protein kinase inhibitor H-7 serves as a research tool for elucidating the functions of protein kinase C-mediated signaling systems .
Cat. No.: HY-N4031
CAS No.: 82375-29-9
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
