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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
44 Results for "
hydroxyproline
" in MedChemExpress (MCE) Product Catalog:
Products (44)
44 Results for "hydroxyproline" in MCE Product Catalog:
Cat. No.: HY-W343900
CAS No.: 6912-67-0
Synonyms: DL-hydroxyproline
Research Areas:
Hydroxyproline (DL-Hydroxyproline) is a non-essential amino acid and one of the main components of collagenous tissues. Hydroxyproline acts as a substrate for mitochondrial hydroxyproline oxidase to generate ROS. Hydroxyproline promotes the synthesis of glutathione, DNA, heme and proteins via conversion to Glycine (HY-Y0966). Hydroxyproline promotes the activation of caspase-9 and apoptosis in cancer cells treated with Doxorubicin . Hydroxyproline serves as a biochemical marker. Hydroxyproline is used in research related to various diseases including colon cancer, diabetes and arthritis .
17
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Cardiovascular Disease Inflammation/Immunology Endocrinology Cancer
2
2 Cited Publications
Synonyms: (2S,4R)-4-Hydroxypyrrolidine-2-carboxylic acid
Category:
Alkaloids Immune System Disorder Pyrrole Alkaloids Other Diseases Disease markers Endocrine diseases Nervous System Disorder Endogenous metabolite Disease Research Fields
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1
Category:
Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Inflammation/Immunology
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1
1 Cited Publications
Category:
Natural Products Animals Marine natural products Other marine organisms Disease Research Fields Cancer
Target:
1
1 Cited Publications
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Research Areas:
Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
N-Propargylglycine is a brain-penetrant and orally active PRODH inhibitor. N-Propargylglycine covalently modifies enzyme-bound FAD and active site lysine, causing enzyme structural distortion, protein decay, and irreversible inhibition of proline and 4-hydroxyproline catabolism. N-Propargylglycine induces UPRmt, upregulates mitochondrial chaperones and YME1L1, enhances mitochondrial proteostasis, blocks astrocytic L-proline consumption, and abolishes L-proline’s ATP-maintaining and viability-protective effects. N-Propargylglycine stimulates neural processes, increases brain proline, hydroxyproline, and sarcosine levels, partially normalizes Huntington’s disease whole brain transcriptomes. N-Propargylglycine reduces hyperoxaluria, prevents calcium oxalate stone formation, reduces kidney tubular damage, and restores weight and survival in Grhpr knockout mice. N-Propargylglycine can be used for the research of breast cancer, neurodegenerative disorders, Huntington’s disease, and primary hyperoxaluria type 2 .
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Cat. No.: HY-40135S
CAS No.: 1356016-86-8
Cat. No.: HY-W337672
CAS No.: 18684-24-7
Synonyms: Prolylhydroxyproline; Pro-Hyp
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Cat. No.: HY-W129161
CAS No.: 827306-88-7
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Cat. No.: HY-W654232
CAS No.: 2734920-51-3
Synonyms: (2S,4R)-4-Hydroxypyrrolidine-2-carboxylic acid-d4
Synonyms: SCH-10304
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Clonixin (SCH-10304) is an orally active non-steroidal anti-inflammatory agent (NSAID) that inhibits COX synthesis. Clonixin acts as a voltage-gated L-type calcium channel blocker, exerts vasodilatory effects by antagonizing Ca 2+ in vascular smooth muscle. Clonixin inhibits TGF-β, reduces lung coefficient, immune cell infiltration level, oxidative stress response, airway resistance, hydroxyproline content and collagen deposition. Clonixin can be used in research related to inflammation such as idiopathic pulmonary fibrosis and moderate to severe pain .
Synonyms: (2S,4R)-4-Hydroxypyrrolidine-2-carboxylic acid (Standard)
Cat. No.: HY-P10447
CAS No.: 103651-09-8
Synonyms: Fengycin IX; SNA-60-367-3
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Cat. No.: HY-W008205
CAS No.: 88050-17-3
Synonyms: Fmoc-L-hydroxyproline
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Cat. No.: HY-P4755
CAS No.: 282726-24-3
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Cat. No.: HY-N6928
CAS No.: 88901-37-5
Cat. No.: HY-157512
CAS No.: 2413035-43-3
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SJF-0661 is a variant of the von Hippel-Lindau (VHL) protein ligand with no targeted degradation ability and can be used as a control reagent for the VHL ubiquitin ligase ligand. SJF-0661 is a variant obtained by inverting the stereocenter of the key hydroxyproline group in the VHL ligand .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
