3870 Results for "

membrane

" in MedChemExpress (MCE) Product Catalog:
Products (3870)

3870 Results for "membrane" in MCE Product Catalog:

1715
Ferrostatin-1
Ferrostatin-1
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1715 Publications Verification
Cat. No.: HY-100579
CAS No.: 347174-05-4
Purity:  99.71%
Synonyms: Fer-1
Target:  

Ferroptosis Fungal

Research Areas:  

Cancer

Ferrostatin-1 (Fer-1), a potent and selective ferroptosis inhibitor, suppresses Erastin-induced ferroptosis in HT-1080 cells (EC50=60 nM). Ferrostatin-1, a synthetic antioxidant, acts via a reductive mechanism to prevent damage to membrane lipids and thereby inhibits cell death. Ferrostatin-1 exhibits antifungal activity .
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379
Dimethyl sulfoxide, meets analytical specification of Ch.P.
Dimethyl sulfoxide, meets analytical specification of Ch.P.
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379 Cited Publications
Cat. No.: HY-Y0320
CAS No.: 67-68-5
Synonyms: DMSO, meets analytical specification of Ch.P.
Dimethyl sulfoxide (DMSO), meets analytical specification of Ch.P. is an aprotic solvent that dissolves polar and non-polar compounds, including water-insoluble therapeutic and toxic agents. Dimethyl sulfoxide (DMSO) has a strong affinity for water and can rapidly penetrate or enhance the penetration of other substances into biological membranes. Dimethyl sulfoxide also has potential free radical scavenging and anticholinesterase effects and may affect coagulation activity. Dimethyl sulfoxide also induces histamine release from mast cells but is thought to have low systemic toxicity. Dimethyl sulfoxide also exhibits antifreeze and antibacterial properties .
MCE provides Dimethyl sulfoxide that complies with the inspection standards (Ch.P) of Part 4 of the Chinese Pharmacopoeia (2020 Edition). Amicrobic, low endotoxin, can be used in various biochemical experiments such as drug dissolution.
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334
SC79
SC79
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334 Cited Publications
Cat. No.: HY-18749
CAS No.: 305834-79-1
Target:  

Akt

Research Areas:  

Neurological Disease Inflammation/Immunology Cancer

SC79, a unique specific and BBB permeable Akt activator, activates Akt in the cytosol and inhibits Akt membrane translocation. SC79 specifically binds to the PH domain of Akt .
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312
MitoSOX Red
MitoSOX Red
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312 Cited Publications
Cat. No.: HY-D1055
CAS No.: 1003197-00-9
MitoSOX Red is a live cell fluorescent probe that specifically targets mitochondria and is cell membrane permeable. MitoSOX Red enters mitochondria and is oxidized by superoxide but not by other ROS or RNS generating systems. The oxidized MitoSOX Red then binds to nucleic acids in mitochondria/nucleus, producing strong red fluorescence. MitoSOX Red can be used as a fluorescent indicator to specifically detect superoxide. In addition, superoxide dismutase (SOD) can prevent the oxidation of MitoSOX Red.
Excitation/emission wavelength: 510/580 nm.
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249
Nigericin sodium salt
Nigericin sodium salt
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249 Cited Publications
Cat. No.: HY-100381
CAS No.: 28643-80-3
Purity:  99.37%
Category:  

Infection Microorganisms Antibiotics Disease Research Disease Research Fields Other Antibiotics Cancer

Target:  

Potassium Channel NOD-like Receptor (NLR) Bacterial Antibiotic Pyroptosis Wnt β-catenin

Nigericin sodium salt is an antibiotic derived from Streptomyces hygroscopicus that act as a K +/H + ionophore, promoting K +/H + exchange across mitochondrial membranes. Nigericin sodium salt is a NLRP3 activator. Nigericin sodium salt shows promising anti-cancer activities through decreasing intracellular pH (pHi), and inactivation of Wnt/β-catenin signals. Nigericin sodium salt induces pyroptosis through caspase 1/GSDMD in TNBC .
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249
Nigericin
Nigericin
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249 Cited Publications
Cat. No.: HY-127019
CAS No.: 28380-24-7
Purity:  99.43%
Target:  

Potassium Channel NOD-like Receptor (NLR) Bacterial Antibiotic Pyroptosis Wnt β-catenin

Research Areas:  

Infection Cancer

Nigericin is an antibiotic derived from Streptomyces hygroscopicus that act as a K +/H + ionophore, promoting K +/H + exchange across mitochondrial membranes. Nigericin is a NLRP3 activator. Nigericin shows promising anti-cancer activities through decreasing intracellular pH (pHi), and inactivation of Wnt/β-catenin signals. Nigericin induces pyroptosis through caspase 1/GSDMD in TNBC .
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238
JC-1
JC-1
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238 Cited Publications
Cat. No.: HY-15534
CAS No.: 3520-43-2
Purity:  98.71%
Synonyms: CBIC2
JC-1 (CBIC2) is an ideal fluorescent probe widely used to detect mitochondrial membrane potential. JC-1 accumulates in mitochondria in a potential dependent manner and can be used to detect the membrane potential of cells or purified mitochondria. In normal mitochondria, JC-1 aggregates in the mitochondrial matrix to form a polymer, which emits strong red fluorescence (Ex=585 nm, Em=590 nm); When the mitochondrial membrane potential is low, JC-1 cannot aggregate in the matrix of mitochondria and produce green fluorescence (ex=510 nm, em= 527 nm) .
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192
Thiazolyl Blue
Thiazolyl Blue
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192 Cited Publications
Cat. No.: HY-15924
CAS No.: 298-93-1
Synonyms: MTT; Thiazolyl Blue Tetrazolium bromide; Methylthiazolyldiphenyl-tetrazolium bromide
Thiazolyl Blue (MTT) is a cell-permeable and positively charged tetrazolium dye that is used to detect reductive metabolism in cells. Thiazolyl Blue is taken up by cells through the plasma membrane and then reduced to formazan by intracellular NAD (P) H-oxidoreductases. Thiazolyl Blue is frequently used in colorimetric assays to measure cell proliferation, cytotoxicity, and apoptosis .
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188
Dihydroethidium
Dihydroethidium
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188 Cited Publications
Cat. No.: HY-D0079
CAS No.: 104821-25-2
Synonyms: Hydroethidine; PD-MY 003
Dihydroethidium, also known as DHE, is a peroxide indicator. Dihydroethidium penetrates cell membranes to form a fluorescent protein complex with blue fluoresces. After entering the cells, Dihydroethidium is mainly localized in the cell membrane, cytoplasm and nucleus, and the staining effect is the strongest in the nucleus. Dihydroethidium produces inherent blue fluorescence with a maximum excitation wavelength of 370 nm and a maximum emission wavelength of 420 nm; after dehydrogenation, Dihydroethidium combines with RNA or DNA to produce red fluorescence with a maximum excitation wavelength of 300 nm and a maximum emission wavelength of 610 nm. 535 nm can also be used as the excitation wavelength for actual observation .
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179
MitoTEMPO hydrate
MitoTEMPO hydrate
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179 Cited Publications
Cat. No.: HY-125944
CAS No.: 1569257-94-8
Purity:  98.03%
Target:  

Mitochondrial Metabolism PINK1/Parkin NOD-like Receptor (NLR) Autophagy Calcium Channel Apoptosis

Research Areas:  

Cardiovascular Disease Neurological Disease Metabolic Disease Endocrinology

MitoTEMPO hydrate is a mitochondria-targeted antioxidant . MitoTEMPO hydrate induces mitophagy by activating the PINK1/Parkin pathway, inhibits NLRP3 inflammasome activation, restores mitochondrial membrane potential, and improves renal function and podocyte injury. MitoTEMPO hydrate regulates Ca 2+ homeostasis, inhibits Bnip3 overexpression, shortens action potential duration, and exerts antiarrhythmic effects. MitoTEMPO hydrate reverses premature senescence, reduces trabecular bone loss, and decreases cell apoptosis. MitoTEMPO hydrate can be used in studies of chronic kidney disease, age-related cardiac dysfunction, postmenopausal osteoporosis, and ischemic stroke .
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179
Mito-TEMPO
Mito-TEMPO
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179 Cited Publications
Cat. No.: HY-112879
CAS No.: 1334850-99-5
Purity:  99.19%
Target:  

Calcium Channel PINK1/Parkin Mitochondrial Metabolism Apoptosis Autophagy NOD-like Receptor (NLR)

Research Areas:  

Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology

Mito-TEMPO is a mitochondria-targeted antioxidant. Mito-TEMPO induces mitophagy by activating the PINK1/Parkin pathway, inhibits NLRP3 inflammasome activation, restores mitochondrial membrane potential, and improves renal function and podocyte injury. Mito-TEMPO regulates Ca 2+ homeostasis, inhibits Bnip3 overexpression, shortens action potential duration, and exerts antiarrhythmic effects. Mito-TEMPO reverses premature senescence, reduces trabecular bone loss, and decreases cell apoptosis. Mito-TEMPO can be used in studies of chronic kidney disease, age-related cardiac dysfunction, postmenopausal osteoporosis, and ischemic stroke .
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175
DAPI dihydrochloride
DAPI dihydrochloride
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175 Cited Publications
Cat. No.: HY-D0814
CAS No.: 28718-90-3
Synonyms: 4',6-Diamidino-2-phenylindole dihydrochloride
DAPI (4',6-Diamidino-2-phenylindole) dihydrochloride is a DAPI dye. DAPI is a fluorescent dye that binds strongly to DNA. It binds to the AT base pair of the double-stranded DNA minor groove, and one DAPI molecule can occupy three base pair positions. The fluorescence intensity of DAPI molecules bound to double-stranded DNA is increased by about 20 times, and it is commonly observed with fluorescence microscopy, and the amount of DNA can be determined based on the intensity of fluorescence. DAPI cannot penetrate intact cell membranes and is commonly used for staining damaged and fixed cells . DAPI (Compound 3) is an acid-sensing ion channel 3 (ASIC3) inhibitor. DAPI binds to ASIC3 and blocks the channel function. DAPI can be used in the study of chronic pain treatment (Ex/Em = 356/451 nm).
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170
Brefeldin A
Brefeldin A
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170 Cited Publications
Cat. No.: HY-16592
CAS No.: 20350-15-6
Synonyms: BFA; Cyanein; Decumbin
Category:  

Infection Microorganisms Macrolide Antibiotics Antibiotics Antiviral Disease Research Anticancer Disease Research Fields

Target:  

Autophagy Mitophagy HSV Antibiotic Bacterial

Brefeldin A (BFA) is a lactone antibiotic and a specific inhibitor of protein trafficking. Brefeldin A blocks the transport of secreted and membrane proteins from endoplasmic reticulum to Golgi apparatus . Brefeldin A is also an autophagy and mitophagy inhibitor . Brefeldin A inhibits HSV-1 and has anti-cancer activity .
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165
JC-1 Mitochondrial Membrane Potential Assay Kit
JC-1 Mitochondrial Membrane Potential Assay Kit
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165 Cited Publications
Cat. No.: HY-K0601

MCE JC-1 Mitochondrial Membrane Potential Assay Kit uses JC-1 to detect the mitochondrial membrane potential in variety of cell types, as well as intact tissues and isolated mitochondria.

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160
Propidium Iodide
Propidium Iodide
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160 Cited Publications
Cat. No.: HY-D0815
CAS No.: 25535-16-4
Propidium Iodide (PI) is a nuclear staining agent that stains DNA. Propidium Iodide is an analogue of ethidine bromide that emits red fluorescence upon embedding in double-stranded DNA. Propidium Iodide cannot pass through living cell membranes, but it can pass through damaged cell membranes to stain the nucleus. Propidium Iodide has a fluorescence wavelength of 493/617 nm and a wavelength of 536/635 nm after Mosaic with DNA. Propidium Iodide is commonly used in the detection of apoptosis (apoptosis) or necrosis (necrosis), and is often used in flow cytometry analysis.
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159
DAPI
DAPI
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159 Cited Publications
Cat. No.: HY-D2868
CAS No.: 47165-04-8
Synonyms: 4',6-Diamidino-2-phenylindole
DAPI (4',6-Diamidino-2-phenylindole) is a DAPI dye. DAPI is a fluorescent dye that binds strongly to DNA. It binds to the AT base pair of the double-stranded DNA minor groove, and one DAPI molecule can occupy three base pair positions. The fluorescence intensity of DAPI molecules bound to double-stranded DNA is increased by about 20 times, and it is commonly observed with fluorescence microscopy, and the amount of DNA can be determined based on the intensity of fluorescence. DAPI cannot penetrate intact cell membranes and is commonly used for staining damaged and fixed cells . DAPI (Compound 3) is an acid-sensing ion channel 3 (ASIC3) inhibitor. DAPI binds to ASIC3 and blocks the channel function. DAPI can be used in the study of chronic pain treatment (Ex/Em = 356/451 nm).
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146
BAPTA-AM
BAPTA-AM
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146 Cited Publications
Cat. No.: HY-100545
CAS No.: 126150-97-8
Purity:  99.23%
BAPTA-AM is a well-known membrane permeable Ca 2+ chelator. BAPTA-AM inhibits hERG channels, hKv1.3 and hKv1.5 channels in HEK 293 cells with IC50s of 1.3 μM, 1.45 μM and 1.23 μM, respectively .
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129
DAPI dilactate
DAPI dilactate
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129 Cited Publications
Cat. No.: HY-D1738
CAS No.: 28718-91-4
Synonyms: 4',6-Diamidino-2-phenylindole dilactate
DAPI (4',6-Diamidino-2-phenylindole) dilactate is a DAPI dye. DAPI is a fluorescent dye that binds strongly to DNA. It binds to the AT base pair of the double-stranded DNA minor groove, and one DAPI molecule can occupy three base pair positions. The fluorescence intensity of DAPI molecules bound to double-stranded DNA is increased by about 20 times, and it is commonly observed with fluorescence microscopy, and the amount of DNA can be determined based on the intensity of fluorescence. DAPI cannot penetrate intact cell membranes and is commonly used for staining damaged and fixed cells . DAPI (Compound 3) is an acid-sensing ion channel 3 (ASIC3) inhibitor. DAPI binds to ASIC3 and blocks the channel function. DAPI can be used in the study of chronic pain treatment (Ex/Em = 356/451 nm) .
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126
BODIPY 493/503
BODIPY 493/503
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126 Cited Publications
Cat. No.: HY-W090090
CAS No.: 121207-31-6
Synonyms: Pyrromethene 546
BODIPY493/503 is a BODIPY dye. BODIPY dye is a small molecule dye with strong ultraviolet absorption ability, its fluorescence peak is relatively sharp, and the quantum yield is high. They are relatively insensitive to the polarity and pH of the environment and are relatively stable under different physiological conditions. Due to its structural asymmetry, BODIPY derives a variety of structural products. BODIPY lipid droplet dyes can well pass through the cell membrane into the cell, and localize the neutral lipids in the cell to specifically stain the lipid droplets, which can be used for labeling of live cells and fixed cells . Maximum excitation/emission wavelength: 493/503 nm .
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119
CFDA-SE
CFDA-SE
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119 Cited Publications
Cat. No.: HY-D0938
CAS No.: 150347-59-4
Synonyms: CFSE; 5(6)-Carboxyfluorescein diacetate succinimidyl ester; 5(6)-CFDA N-succinmidyl ester
CFDA-SE is a fluorescent dye that can penetrate the cell membrane. It can react with the free amine group in the cytoskeleton protein inside the cell, and finally form a protein complex with fluorescence. After entering the cell, CFDA-SE locates in the cell membrane, cytoplasm and nucleus, and the fluorescence staining is strongest in the nucleus . CFDA-SE dye can be uniformly inherited by the cells with cell division and proliferation, and its attenuation is proportional to the number of cell divisions. This phenomenon can be detected and analyzed by flow cytometry under the excitation light of 488 nm, and can be used to detect the proliferation of cells .
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