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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
183 Results for "
mutagenicity
" in MedChemExpress (MCE) Product Catalog:
Products (183)
183 Results for "mutagenicity" in MCE Product Catalog:
16
16 Publications Verification
Cat. No.: HY-W001187
CAS No.: 2564-83-2
Research Areas:
Tempo is a nitric oxide radical and a selective scavenger of ROS in mitochondria. Tempo is also an organocatalyst that disproportionates superoxide and oxidizes primary alcohols to aldehydes in a catalytic cycle. Tempo has mutagenic and antioxidant effects and can induceDNA strand breaks. Tempo also exerts cytotoxic and mutagenic properties in mouse lymphoma cells .
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16 Publications Verification
Cat. No.: HY-N0527
CAS No.: 14937-32-7
Synonyms: Penta-O-galloyl-β-D-glucose; 1,2,3,4,6-Pentagalloyl glucose
15
Target:
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Methylnitronitrosoguanidine (MNNG) is an orally active alkylating agent with toxic and mutagenic effects. Methylnitronitrosoguanidine can as a carcinogen and mutagen . 50% water content, specifications are based on dry weight.
15
15 Cited Publications
Synonyms: 3,5-Dicaffeoylquinic acid; 3,5-CQA
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8
8 Cited Publications
Cat. No.: HY-15930A
CAS No.: 64285-73-0
Synonyms: BM blue dihydrochloride; Sure Blue TMB dihydrochloride
8
8 Cited Publications
Cat. No.: HY-15930B
CAS No.: 207738-08-7
Synonyms: Sure Blue TMB dihydrochloride x.hydrate
8
8 Cited Publications
Cat. No.: HY-15930C
CAS No.: 54827-18-8
Synonyms: BM blue monosulfate; Sure Blue TMB monosulfate
7
7 Cited Publications
Synonyms: (S,S)-SDG; (S,S)-LGM2605
Category:
Cardiovascular Disease Neurological Disease Lignans Plants Linum usitatissimum Linn. Linaceae Phenols Polyphenols Phenylpropanoids Disease Research Fields
Target:
6
6 Cited Publications
Synonyms: Clerodol; Monogynol B; Fagarasterol
Target:
5
5 Cited Publications
Cat. No.: HY-44076
CAS No.: 85073-19-4
Synonyms: Lithium phenyl-2,4,6-trimethylbenzoylphosphinate
5
Category:
Human Gut Microbiota Metabolites Natural Products Microorganisms Disease markers Endocrine diseases Nervous System Disorder Endogenous metabolite Disease Research Fields Cancer
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4
4 Cited Publications
Target:
Research Areas:
JH-RE-06, a potent REV1-REV7 interface inhibitor (IC50=0.78 μM; Kd=0.42 μM), targets REV1 that interacts with the REV7 subunit of POLζ. JH-RE-06 disrupts mutagenic translesion synthesis (TLS) by preventing recruitment of mutagenic POLζ. JH-RE-06 improves chemotherapy .
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4
4 Cited Publications
Cat. No.: HY-W011950
CAS No.: 52417-22-8
Target:
Research Areas:
Acridin-9-amine (9-Aminoacridine) hydrochloride hydrate is a mutagen and DNA modifier. Acridin-9-amine hydrochloride hydrate induces mutagenic lesions during DNA replication .
3
Research Areas:
Hydralazine hydrochloride is an orally active, blood-brain barrier-permeable DNA methyltransferase inhibitor with vasodilatory, arterial smooth muscle relaxant and hypotensive activities. Hydralazine hydrochloride reactivates silenced tumor suppressor genes via mediating DNA demethylation, while exerting neuroprotective and anti-inflammatory properties. Hydralazine hydrochloride inhibits NOS-2 (iNOS) and COX-2, and reduces the production of NO and PGEE2; meanwhile, Hydralazine hydrochloride scavenges reactive oxygen species and inhibits macrophage activation. Hydralazine hydrochloride alleviates motor dysfunction, neuropathic inflammatory pain, and formalin-induced somatic and emotional pain responses. In addition, Hydralazine hydrochloride directly induces DNA strand breaks and sister chromatid exchange, exhibiting certain mutagenic characteristics. Hydralazine hydrochloride has been widely used in studies on hypertension, various cancers (such as cervical cancer, leukemia), spinal cord injury and the mechanisms of inflammatory pain .
3
Research Areas:
Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
Hydralazine is an orally active, blood-brain barrier-permeable DNA methyltransferase inhibitor with vasodilatory, arterial smooth muscle relaxant and hypotensive activities. Hydralazine reactivates silenced tumor suppressor genes via mediating DNA demethylation, while exerting neuroprotective and anti-inflammatory properties. Hydralazine inhibits NOS-2 (iNOS) and COX-2, and reduces the production of NO and PGEE2; meanwhile, Hydralazine scavenges reactive oxygen species and inhibits macrophage activation. Hydralazine alleviates motor dysfunction, neuropathic inflammatory pain, and formalin-induced somatic and emotional pain responses. In addition, Hydralazine directly induces DNA strand breaks and sister chromatid exchange, exhibiting certain mutagenic characteristics. Hydralazine has been widely used in studies on hypertension, various cancers (such as cervical cancer, leukemia), spinal cord injury and the mechanisms of inflammatory pain .
2
2
2 Cited Publications
Synonyms: Iodoquinol; 5,7-Diiodo-8-hydroxyquinoline; 5,7-Diiodo-8-quinolinol
Target:
Research Areas:
Diiodohydroxyquinoline (Iodoquinol, 5,7-Diiodo-8-hydroxyquinoline, 5,7-Diiodo-8-quinolinol) has an orally active and satisfactory antiparasitic properties. Diiodohydroxyquinoline exhibits mutagenic potential in mice and potent anti-SARS-CoV-2 activity with an EC50 value of 1.38 μM in VeroE6 cells. Diiodohydroxyquinoline's antimutagen is ascorbic acid. Diiodohydroxyquinoline is promising for research in inflammationin, testinal amebiasis, amebic liver abscess and chronic nonspecific diarrheas .
2
Bithionol sulfoxide is an anti-infection agent for parasites. Bithionol sulfoxide has mutagenic activity. Bithionol sulfoxide can be used in the research of parasite infection, such as paragonimiasis, flukes andcestodes infection .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
