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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
94 Results for "
polyketide
" in MedChemExpress (MCE) Product Catalog:
Products (94)
94 Results for "polyketide" in MCE Product Catalog:
6
6 Publications Verification
Synonyms: Immunomycin; FR-900520; FK520
Category:
Microorganisms Neurological Disease Macrolide Antibiotics Antifungal Anti-inflammation/Immunoregulatory Antibiotics Disease Research Disease Research Fields Inflammation/Immunology
Target:
2
2 Cited Publications
Art. -Nr.: HY-N6796
CAS. Nr.: 52665-74-4
1
Target:
1
1 Cited Publications
Synonyms: 1,3,6,8-THN; T4HN
Target:
Forschungsgebiete:
1,3,6,8-Tetrahydroxynaphthalene (T4HN) is an indispensable precursor to DHN (1,8-Dihydroxynaphthalene) melanin and is an unique symmetrical compound of polyketide origin .
Target:
Art. -Nr.: HY-141466A
Reinheit: 97.85%
Forschungsgebiete:
Crotonyl-CoA tetrasodium, a high-energy acyl donor, is an intermediate in the fermentation of butyric acid, and in the metabolism of lysine and tryptophan. Crotonyl-CoA tetrasodium is important in the metabolism of fatty acids and amino acids. Crotonyl-CoA tetrasodium acts as a substrate for p300’s histone crotonyltransferase activity, competing with acetyl-CoA for p300-mediated histone acylation reactions. Crotonyl-CoA tetrasodium regulates global and gene-specific histone crotonylation levels in cells, with cellular concentration changes altering histone crotonylation at regulatory elements of activated genes. Crotonyl-CoA tetrasodium serves as the substrate for crotonyl-CoA reductase/carboxylase (CCRC)-catalyzed NADPH-mediated reduction and carbon dioxide trapping to form unusual alkylmalonyl-CoA polyketide synthase extender units. Crotonyl-CoA tetrasodium can be used for the research of LPS-induced inflammatory response .
TAM-16 is a potent and orally active polyketide synthase 13 (Pks13) inhibitor with an IC50 value of 0.32 μM. TAM-16 has promising activity against Mycobacterium tuberculosis. TAM-16 inhibits hERG cardiac ion channel .
Art. -Nr.: HY-19828
CAS. Nr.: 142861-00-5
Synonyms: GEX1A
Category:
Microorganisms Ketones, Aldehydes, Acids Disease Research Fields Biological Pesticide Research Cancer Agricultural Research
Target:
Art. -Nr.: HY-N4301
CAS. Nr.: 30485-16-6
Target:
Target:
Art. -Nr.: HY-B0767
CAS. Nr.: 131929-60-7
Category:
Microorganisms Macrolide Antibiotics Antibiotics Other Diseases Anti-parasitic Disease Research Antibacterial Disease Research Fields
Target:
Synonyms: (-)-TAN2162
Kendomycin ((−)-TAN 2162) is a polyketide antibiotic with remarkable antibacterial and cancer cells cytotoxic activities. Kendomycin tends to be bacteriostatic rather than bactericidal and inhibits the growth of the methicillin-resistant Staphylococcus aureus (MRSA) strain COL at a low concentration (MIC of 5 μg/mL). Kendomycin is a potent antagonist of the endothelin receptor and a calcitonin receptor agonist which plays its role as an anti-osteoporotic agent .
Art. -Nr.: HY-N10449
CAS. Nr.: 20004-62-0
Category:
Target:
Thiophene-2 (TP2) is a specific polyketide synthase 13 (Pks13) inhibitor. Thiophene-2 inhibits mycolic acid biosynthesis and rapidly leads to mycobacterial cell death. Thiophene-2 is active against Mycobacterium tuberculosis with a MIC value of 1 μM, and has potent anti-tuberculosis activity .
Category:
Target:
Art. -Nr.: HY-W010554
CAS. Nr.: 637-88-7
Target:
Forschungsgebiete:
1,4-Cyclohexanedione is a drug intermediate. 1,4-Cyclohexanedione is an accepted substrate of EryKR1 domain which takes on a certain biocatalyst activity and stereospecificity .
Art. -Nr.: HY-W073762
CAS. Nr.: 2241669-86-1
Target:
Forschungsgebiete:
FBnG is a component of non-ribosomal peptide synthetase/polyketide synthase (NRPS/PKS), which is associated with the biosynthesis of fabrubactin (FBN). FBnG can be used for synthesis of AUTAC4 as part of FBnG-(Cys-acetamide)-CH2-PEG3-CH2-CH2-CH2-NH2 (HY-150408) .
Category:
Cardiovascular Disease Veratrum nigrum Linn. Liliaceae Plants Disease Research Fields Steroids
Target:
Category:
Human Gut Microbiota Metabolites Microorganisms Neurological Disease Ketones, Aldehydes, Acids Phenols Polyphenols Endogenous metabolite Disease Research Fields Inflammation/Immunology
Target:
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
