1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. TRP Channel
  3. AMG 333

AMG 333 

Cat. No.: HY-112703 Purity: 99.76%
Handling Instructions

AMG 333 is a potent and highly selective TRPM8 antagonist with an IC50 of 13 nM.

For research use only. We do not sell to patients.

AMG 333 Chemical Structure

AMG 333 Chemical Structure

CAS No. : 1416799-28-4

Size Price Stock Quantity
10 mM * 1  mL in DMSO USD 100 In-stock
Estimated Time of Arrival: December 31
5 mg USD 100 In-stock
Estimated Time of Arrival: December 31
10 mg USD 160 In-stock
Estimated Time of Arrival: December 31
25 mg USD 380 In-stock
Estimated Time of Arrival: December 31
50 mg USD 690 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

* Please select Quantity before adding items.

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Based on 1 publication(s) in Google Scholar

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Description

AMG 333 is a potent and highly selective TRPM8 antagonist with an IC50 of 13 nM.

IC50 & Target

IC50: 13 nM (TRPM8)[1]

Clinical Trial
Molecular Weight

453.32

Formula

C₂₀H₁₂F₅N₃O₄

CAS No.

1416799-28-4

SMILES

FC1=CC=CN=C1[[email protected]](C2=CC(F)=C(OC(F)(F)F)C=C2)NC(C3=NC=C(C(O)=O)C=C3)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 125 mg/mL (275.74 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2059 mL 11.0297 mL 22.0595 mL
5 mM 0.4412 mL 2.2059 mL 4.4119 mL
10 mM 0.2206 mL 1.1030 mL 2.2059 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.17 mg/mL (4.79 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.17 mg/mL (4.79 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.17 mg/mL (4.79 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

AMG 333AMG333AMG-333TRP ChannelTransient receptor potential channelsInhibitorinhibitorinhibit

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Product Name:
AMG 333
Cat. No.:
HY-112703
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