1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. TRP Channel
  3. AMG 333

AMG 333 

Cat. No.: HY-112703
Handling Instructions

AMG 333 is a potent and highly selective TRPM8 antagonist with an IC50 of 13 nM.

For research use only. We do not sell to patients.

AMG 333 Chemical Structure

AMG 333 Chemical Structure

CAS No. : 1416799-28-4

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Description

AMG 333 is a potent and highly selective TRPM8 antagonist with an IC50 of 13 nM.

IC50 & Target

IC50: 13 nM (TRPM8)[1]

Clinical Trial
Molecular Weight

453.32

Formula

C₂₀H₁₂F₅N₃O₄

CAS No.

1416799-28-4

SMILES

FC1=CC=CN=C1[[email protected]](C2=CC(F)=C(OC(F)(F)F)C=C2)NC(C3=NC=C(C(O)=O)C=C3)=O

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

DMSO : ≥ 125 mg/mL (275.74 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2059 mL 11.0297 mL 22.0595 mL
5 mM 0.4412 mL 2.2059 mL 4.4119 mL
10 mM 0.2206 mL 1.1030 mL 2.2059 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.59 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (4.59 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.59 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Product Name:
AMG 333
Cat. No.:
HY-112703
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