1. Protein Tyrosine Kinase/RTK
    Stem Cell/Wnt
  2. PKA
  3. CREBtide

CREBtide 

Cat. No.: HY-P1595
Handling Instructions

CREBtide, a synthetic 13 amino acid peptide, has been reported as a PKA substrate.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

CREBtide Chemical Structure

CREBtide Chemical Structure

CAS No. : 149155-45-3

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Description

CREBtide, a synthetic 13 amino acid peptide, has been reported as a PKA substrate.

IC50 & Target

PKA[1]

In Vitro

delta-CREB is a spliced variant of cAMP response element binding protein (CREB). CREBtide (KRREILSRRPSYR), a synthetic peptide based on the phosphorylation sequence in delta-CREB. delta-CREB and CREBtide are tested as substrates of cAMP-dependent protein kinase (cAK). The apparent Km of CREBtide phosphorylation by cAK is 3.9 μM, which is 10-fold lower than that of Kemptide (Km=39 μM), the synthetic peptide substrate most often employed for cAK measurement. The Vmax values are 12.4 mumol/(min.mg) for CREBtide and 9.8 mumol/(min.mg) for Kemptide. The apparent Km of CREBtide phosphorylation by cGMP-dependent protein kinase (cGK) is 2.9 μM and the Vmax value is 3.2 mumol/(min.mg). Both delta-CREB and CREBtide are phosphorylated at a much slower rate by cGK as compared with cAK, implying that the high cAK/cGK specificity exhibits by delta-CREB is retained by the peptide[2].

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Molecular Weight

1716.99

Formula

C₇₃H₁₂₉N₂₉O₁₉

CAS No.

149155-45-3

Sequence

Lys-Arg-Arg-Glu-Ile-Leu-Ser-Arg-Arg-Pro-Ser-Tyr-Arg

Sequence Shortening

KRREILSRRPSYR

Shipping

Room temperature in continental US; may vary elsewhere

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

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C1   V1   C2   V2

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CREBtide
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CREBtide

Cat. No.: HY-P1595