Neurological Disease

N-Oleoyldopamine (Standard) is the analytical standard of N-Oleoyldopamine (HY-108448). This product is intended for research and analytical applications. N-Oleoyldopamine (OLDA) is a product of condensation of oleic acid and dopamine (DA) and an endogenous TRPV1 selective agonist. N-Oleoyldopamine (OLDA) can crosses the blood-brain barrier. N-oleoyl-dopamine protects the heart against ischemia-reperfusion injury via activation of TRPV1.

ZINC12613047 is a selective BChE inhibitor with an IC₅₀ of 0.021 μM against huBChE. ZINC12613047 can be used for the research of Alzheimer's disease.

Foscarbidopa (Standard) is the analytical standard of Foscarbidopa (HY-109131). This product is intended for research and analytical applications. Foscarbidopa (ABBV-951; Carbidopa 4′-monophosphate) is a proagent of Carbidopa, acts as a dopamine receptor agonist.

ABT-670 is a selective, oral bioavailable agonist of dopamine D₄ receptor, with EC₅₀ of 89 nM, 160 nM, and 93 nM for human D₄, ferret D₄, and rat D₄, respectively.

Amodiaquine (Standard) is the analytical standard of Amodiaquine. This product is intended for research and analytical applications. Amodiaquine (Amodiaquin), a 4-aminoquinoline class of antimalarial agent, is a potent and orally active histamine N-methyltransferase inhibitor. Amodiaquine is also a Nurr1 agonist and specifically binds to Nurr1-LBD (ligand binding domain) with an EC50 of ~20 μM. Anti-inflammatory effect.

Azidothiorphan is an irreversible photoaffinity ligand and Endopeptidase 24.11 inhibitor, with a K_i value of 0.75 nM against Endopeptidase 24.11. Upon UV irradiation, Azidothiorphan binds to the active site of enkephalinase, resulting in irreversible loss of enzyme activity. Azidothiorphan produces long-lasting analgesic effects in mice. Azidothiorphan can be used in pain-related research.

Mirodenafil (dihydrochloride) (Standard) is the analytical standard of Mirodenafil (dihydrochloride). This product is intended for research and analytical applications. Mirodenafil (SK3530) dihydrochloride is an orally active, potent, reversible, and selective phosphodiesterase 5 (PDE5) inhibitor. Mirodenafil dihydrochloride is a glucocorticoid receptor (GR) modulator Mirodenafil dihydrochloride activates the Wnt/β-catenin signaling pathway by downregulating Dkk1 expression. Mirodenafil dihydrochloride can be used for the research of erectile dysfunction (ED), Alzheimer’s disease (AD) and systemic sclerosis (SSc).

α-Synuclein-IN-24 is an α-synuclein (α-Syn) aggregation inhibitor with an IC₅₀ of 4.0 μM. α-Synuclein-IN-24 stabilizes the secondary conformation of α-synuclein monomers, inhibits β-sheet formation, reduces oligonucleation during the aggregation lag phase, dissociates preformed aggregates, and blocks reaggregation. α-Synuclein-IN-24 reduces α-synuclein inclusions in neuronal cells and scavenges ROS. α-Synuclein-IN-24 can be used for the research of Parkinson's disease.

JJKK 048 (Standard) is the analytical standard of JJKK 048 (HY-108613). This product is intended for research and analytical applications. JJKK 048 is a highly selective and potent monoacylglycerol lipase (MAGL) inhibitor with IC₅₀ values of 214 pM, 275 pM and 363 pM for human, rat, and mouse MAGL. JJKK 048 displays low cross-reactivity with other endocannabinoid targets. JJKK 048 can be used in the research of diseases such as cancer, neurodegenerative diseases, and pain.

Napitane mesylate (ABT 200 mesylate) is an inhibitor for norepinephrine reuptake and an antagonist for presynaptic α2 receptor. Napitane mesylate exhibits antidepressant activity .

JNJ-10258859 is a potent and selective phosphodiesterase type 5 inhibitor, with a K_i of 0.23 nM. JNJ-10258859 can be used for erectile dysfunction research.

Lazertinib (Standard) is the analytical standard of Lazertinib (HY-109061). This product is intended for research and analytical applications. Lazertinib (YH25448) is a potent, selective, CNS-penetrant, orally available and irreversible EGFR tyrosine K_inase inhibitor, exhibiting high selectivity for activating (EGFRm) and T790M resistance mutations. Lazertinib inhibits phosphorylation of EGFR, AKT and ERK, leading to apoptosis and suppression of tumor growth in mouse H1975-luc brain metastasis xenograft models. Lazertinib can be used in the study of non-small cell lung cancer.

L-5-Hydroxytryptophan-d₃ (L-5-HTP-d₃) hydrate is the deuterium labeled L-5-Hydroxytryptophan (HY-B1716). L-5-Hydroxytryptophan-d₃ is the deuterium labeled L-5-Hydroxytryptophan. L-5-Hydroxytryptophan (L-5-HTP), a naturally occurring amino acid and a dietary supplement for use as an antidepressant, appetite suppressant, and sleep aid, is the immediate precursor of the neurotransmitter serotonin and a reserpine antagonist. L-5-Hydroxytryptophan (L-5-HTP) is used to treat fibromyalgia, myoclonus, migraine, and cerebellar ataxia.

VU0650786 (Standard) is the analytical standard of VU0650786 (HY-108710). This product is intended for research and analytical applications. VU0650786 is a potent and selective CNS penetrant negative allosteric modulator of metabotropic glutamate receptor subtype 3 (mGlu3 NAM), with an IC₅₀ of 392 nM. VU0650786 has antidepressant and anxiolytic activity in rodents.

Fipexide (hydrochloride) (Standard) is the analytical standard of Fipexide (hydrochloride). This product is intended for research and analytical applications. Fipexide hydrochloride, a parachloro-phenossiacetic acid derivative, is an orally active nootropic agent. Fipexide hydrochloride reduces striatal adenylate cyclase activity. Fipexide hydrochloride has positive effect on cognitive performance by dopaminergic neurotransmission. Fipexide hydrochloride is used for senile dementia research. Fipexide hydrochloride acts as a chemical inducer in callus formation, shoot regeneration and Agrobacterium infection.

VBIT-4 (Standard) is the analytical standard of VBIT-4 (HY-129122). This product is intended for research and analytical applications. VBIT-4 is an inhibitor of voltage-dependent anion channel 1 (VDAC1) oligomerization with a binding affinity (K_d) of 17 μM. VBIT-4, as an apoptosis inhibitor, can be used for therapeutic purposes in apoptosis-associated disorders, such as neurodegenerative and cardiovascular diseases.

Resatorvid (Standard) is the analytical standard of Resatorvid (HY-11109). This product is intended for research and analytical applications. Resatorvid (TAK-242) is a selective Toll-like receptor 4 (TLR4) inhibitor. Resatorvid inhibits NO, TNF-α and IL-6 production with IC₅₀s of 1.8 nM, 1.9 nM and 1.3 nM, respectively. Resatorvid downregulates expression of TLR4 downstream signaling molecules MyD88 and TRIF. Resatorvid inhibits autophagy and plays pivotal role in various inflammatory diseases.

TP-024 (Standard) (FTBMT (Standard)) is the analytical standard of TP-024 (HY-101787). This product is intended for research and analytical applications. TP-024 (FTBMT), a chemical probe, is a selective GPR52 agonist with an EC₅₀ of 75 nM. TP-024 has antipsychotic and procognitive properties.

NNC 05-2090 hydrochloride (Standard) is the analytical standard of NNC 05-2090 hydrochloride (HY-103509). This product is intended for research and analytical applications. NNC 05-2090 hydrochloride is a GABA uptake inhibitor and inhibitor of the β-GABA transporter (BGT-1) (IC₅₀< /sub>: 10.6 μM). NNC 05-2090 hydrochloride also inhibits mGAT2 with a K_i value of 1.4 μM. NNC 05-2090 has anticonvulsant activity and can be used in the study of epilepsy and neurological diseases.

Palonosetron N-oxide is a metabolite of the serotonin (5-HT) receptor subtype 5-HT3 antagonist Palonosetron (HY-A0018).