β-glucuronidase
GUSB
β-glucuronidase is a glycoside hydrolase widely distributed in mammalian tissues, body fluids, microbiota, plants, fish, insects and mollusks. β-glucuronidase belongs to GH family 1, 2, 30, 79, 154 and GH-A. β-glucuronidase can hydrolyze estrogen glucuronides, regulate the enterohepatic circulation and reabsorption of estrogen, and affect estrogen metabolism. β-glucuronidase can also hydrolyze the extracellular sugar residues on the TRPV5 channel, trapping it in the plasma membrane, maintaining calcium channel activity and membrane calcium permeability. This target is related to many disease areas. For example, in cancer, its increased activity is related to the occurrence and development of colorectal cancer, breast cancer, ovarian cancer, etc.; in metabolic diseases, it is related to diabetes and its induced periodontitis; in inflammatory diseases, it involves bacterial peritonitis, bacterial meningitis, pelvic inflammatory disease, etc.; in addition, it is also related to diseases such as endometriosis[1][2][3][4][5][6][7].
References:
- [1]. Wei Y, et al. Gut dysbiosis-derived β-glucuronidase promotes the development of endometriosis. Fertil Steril. 2023 Sep;120(3 Pt 2):682-694. [Content Brief]
- [2]. Awolade P, et al. Therapeutic significance of β-glucuronidase activity and its inhibitors: A review. European Journal of Medicinal Chemistry, 2020, 187: 111921.
- [3]. Kim DH, et al. Intestinal bacterial beta-glucuronidase activity of patients with colon cancer. Arch Pharm Res. 2001 Dec;24(6):564-7. [Content Brief]
- [4]. Chang Q, et al. The beta-glucuronidase klotho hydrolyzes and activates the TRPV5 channel. Science. 2005 Oct 21;310(5747):490-3. [Content Brief]
- [5]. Sui Y, et al. The Role of Gut Microbial β-Glucuronidase in Estrogen Reactivation and Breast Cancer. Front Cell Dev Biol. 2021 Aug 12;9:631552. [Content Brief]
- [6]. Liu Z, et al. A novel allosteric driver mutation of β-glucuronidase promotes head and neck squamous cell carcinoma progression through STT3B-mediated PD-L1 N-glycosylation. MedComm (2020). 2025 Jan 19;6(2):e70062. [Content Brief]
- [7]. Paigen K. Mammalian beta-glucuronidase: genetics, molecular biology, and cell biology. Prog Nucleic Acid Res Mol Biol. 1989;37:155-205. [Content Brief]
All Product Categories
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β-glucuronidase Related Products (54)
Related Products (54)
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Telmisartan acyl-β-D-glucuronide
0 ImagesCat. No.: HY-137959CAS No.: 250780-40-6Telmisartan acyl-β-D-glucuronide is an acyl-β-D-glucuronide and a metabolite of Telmisartan (HY-13955). Telmisartan acyl-β-D-glucuronide can be converted back to Telmisartan upon incubation with Glucuronidase. Partial acyl migration of Telmisartan acyl-β-D-glucuronide occurs under physiological conditions.
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Dipropyl phthalate
0 ImagesDipropyl phthalate is an immunomodulator. Dipropyl phthalate alters the activities of acid phosphatase, phenoloxidase and superoxide dismutase, increases the activity of β-glucuronidase in a dose-dependent manner, and elevates the mRNA level of hemocyanin in shrimp. Dipropyl phthalate activates the FoxO signaling pathway, interferes with cell proliferation and apoptosis, downregulates chondrocyte-related genes, and induces craniofacial cartilage developmental malformations in zebrafish embryos. Dipropyl phthalate can be used in studies related to Aeromonas veronii infection and micrognathia syndrome.
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Ganoderenic acid A
0 ImagesCat. No.: HY-N2998CAS No.: 100665-40-5Ganoderenic acid A is a lanostane-type triterpene. Ganoderenic acid A is a potent inhibitor of β-glucuronidase. Ganoderenic acid A has a potent hepatoprotective effect against CCl4-induced liver injury.
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Siastatin B
0 ImagesSiastatin B is an effective broad-spectrum glycosidase inhibitor that can effectively inhibit the activities of sialidase, β-D-glucuronidase, N-acetyl-glucosaminidase, β-glucuronidase, and human heparinase.
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Phenolphthalein glucuronide sodium
0 ImagesPhenolphthalein glucuronide sodium is a substrate to determine the β –glucuronidase.
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TAN-1030A
0 ImagesCat. No.: HY-N16039CAS No.: 126221-76-9TAN-1030A is an indolocarbazole alkaloid with macrophage-activating properties. TAN-1030A induces spreading of a murine macrophage cell line, Mm 1, and augmentes the phagocytic activity, Fc gamma receptor expression and β-glucuronidase activity of murine macrophage cell lines, Mm 1 and J774A.1. TAN-1030A can activate macrophage functions in mice.
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X-Gluc Dicyclohexylamine
0 ImagesX-Gluc Dicyclohexylamine is a dye reagent for the detection of β-glucuronidase, an enzyme produced by Escherichia coli. X-Gluc sodium can be used to detect E. coli contamination in food, water and the urinary tract. X-Gluc sodium is also widely used in molecular biology experiments to label and detect the expression of target genes (GUS reporter system).
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Garcinoic acid
0 ImagesCat. No.: HY-N9454CAS No.: 91893-83-3Garcinoic acid is an orally active anti-inflammatory agent that crosses the blood-brain barrier. Garcinoic acid also enhances efferocytosis and enzyme/receptor regulation, and selectively inhibits human COX-2, porcine α-amylase, Saccharomyces cerevisiae α-glucosidase and human DNA polymerase β (IC50=11 μM), as well as activates human PXR. Garcinoic acid enhances macrophage efferocytosis via receptors such as MerTK and LRP-1, and promotes the production of pro-resolving lipid mediators. Garcinoic acid inhibits NF-κB activation and pro-inflammatory cytokine secretion, interferes with Aβ aggregation, downregulates NLRP3 inflammasome activity, and binds to targets including CD44 and EGFR to inhibit leukemia cell proliferation. The pharmacological activities of Garcinoic acid, such as antioxidant, anti-inflammatory and lipid metabolism-regulating effects, are widely used in studies related to various diseases including atherosclerosis, Alzheimer's disease, type 2 diabetes, inflammatory bowel disease and viral pneumonia.
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β-Glucuronidase, Abalone
0 ImagesCat. No.: HY-P2803Dβ-Glucuronidase, Abalone is a glycosyl hydrolase that hydrolyzes β-glucuronic acid and sulfate esters in urine and other biological fluids, and then releases β-glucuronate.
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Saccharolactone
0 ImagesSaccharolactone is a potent orally active β-glucuronidase inhibitor. Saccharolactone markedly lowers biliary endogenous β-glucuronidase activity in the rat bile. Saccharolactone can stabilize glucuronide metabolites in vitro. Saccharolactone is also a strong inhibitor of CYP1A2, 2D6, 3A4 and 2C8 isoforms (IC50 < 4 mM).
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β-Glucuronidase/hCAII-IN-1
0 ImagesCat. No.: HY-150976CAS No.: 2816080-17-6β-Glucuronidase/hCAII-IN-2 (Compound 12e) is a potent β-glucuronidase and hCA II inhibitor with an IC50 of 440.1 μM and 4.91 μM, respectively.
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β-Glucuronidase-IN-5
0 ImagesCat. No.: HY-W472153CAS No.: 7455-77-8β-Glucuronidase-IN-5 (Compound 19; Compound 5c) is a β-glucuronidase inhibitor with an IC50 of 39.8 μM. β-Glucuronidase-IN-5 does not show significant cytotoxicity towards PC-3 cells, with its IC50 > 30 μM. β-Glucuronidase-IN-5 shows no affinity for adenosine receptors (A₁ and A₂A receptors). β-Glucuronidase-IN-5 can be used to study diseases related to excessive expression of β-glucuronidase (such as colon cancer, arthritis, and AIDS complications).
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Ilicicolin C
0 ImagesCat. No.: HY-119609CAS No.: 22562-67-0Ilicicolin C exhibits antibacterial activity against Pseudomonas syringae with IC50 of 28.5 µg/mL. Ilicicolin C exhibits weak inhibitory activities against acetylcholinesterase (AChE) and β-glucuronidase with IC50 of 30-43 µg/mL. Ilicicolin C exhibits weak cytoxicity in human lung fibroblasts with IC50 of 64-120 µg/mL. Ilicicolin C affects seed germination and root tip growth of lettuce.
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Ganoderenic acid A (Standard)
0 ImagesCat. No.: HY-N2998RCAS No.: 100665-40-5Carbidopa (monohydrate) (Standard) is the analytical standard of Carbidopa (monohydrate). This product is intended for research and analytical applications. Carbidopa ((S)-(-)-Carbidopa) monohydrate, a peripheral decarboxylase inhibitor, can be used for the research of Parkinson's disease. Carbidopa monohydrate is a selective aryl hydrocarbon receptor (AhR) modulator. Carbidopa monohydrate inhibits pancreatic cancer cell and tumor growth.
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6-Chloro-3-indolyl-β-D-glucuronide cyclohexylammonium
0 ImagesCat. No.: HY-137816CAS No.: 138182-20-46-Chloro-3-indolyl-β-D-glucuronide cyclohexylammonium salt is a chromogenic substrate for β-glucuronidase. 6-Chloro-3-indolyl-β-D-glucuronide cyclohexylammonium salt produces a salmon colored precipitate upon cleavage.
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Forsyshiyanine A
0 ImagesCat. No.: HY-N17236CAS No.: 2767053-65-4Foryshiyanine A is a triterpenoid alkaloid. Foryshiyanine A possesses anti-inflammatory activity, inhibiting the release of β-glucuronidase from rat polymorphonuclear leukocytes. Foryshiyanine A exhibits antiviral activity, with an EC50 of 4.5 μM against respiratory syncytial virus (RSV) and an IC50 of 7.3 μM against influenza A virus (H1N1). Foryshiyanine A reduces viral load by disrupting viral replication and entry. Foryshiyanine A may be used for the researches of inflammation and infection.
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Kushenol X
0 ImagesCat. No.: HY-N3413CAS No.: 254886-77-6Kushenol X, a flavonoid compound isolated from the roots of Sophora flavescens. Kushenol X is a potent β-glucuronidase and human carboxylesterase 2 (hCE2) inhibitor with IC50s of 2.07 μM and 3.05 μM, respectively.
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CH-123
0 ImagesCat. No.: HY-182616CAS No.: 64405-40-9CH-123 is an orally active lipid-lowering agent. CH-123 inhibits the elevated activities of β-glucuronidase, β-galactosidase, N-acetyl-β-glucosaminidase and acid phosphatase in aortic smooth muscle cells and hepatocytes. CH-123 reduces serum total lipid and cholesterol levels, as well as intracellular cholesterol content in aortic smooth muscle cells. CH-123 significantly inhibits lysosomal enzyme activity. CH-123 can be used in the research of atherosclerosis.
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Naphthol AS-OL
0 ImagesNaphthol AS-OL (C.I. 37530) is a glucuronide taht can be used as a substrate of β-glucuronidase. Naphthol AS-OL can be used to detect β-glucuronidase activity.
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6-Keto-PGE1
0 ImagesSynonyms: 6-keto-Prostaglandin E16-Keto-PGE1 (6-keto-Prostaglandin E1) is a biologically active derivative of PGE1. 6-Keto-PGE1 inhibits adenosine diphosphate-induced platelet aggregation. 6-Keto-PGE1 reduces cardiac afterload, decreases the accumulation of plasma myocardial depressant factor (MDF), lowers arterial blood pressure, dilates vascular beds, inhibits the vasoconstrictive response of vascular smooth muscle, and increases pulmonary compliance. 6-Keto-PGE1 directly stabilizes isolated cat liver lysosomes and significantly reduces the release of β-glucuronidase and cathepsin D. 6-Keto-PGE1 prolongs the survival time of traumatized rats and exerts protective effects through hemodynamic and cytoprotective actions. 6-Keto-PGE1 reduces central airway resistance. 6-Keto-PGE1 can be used in studies related to traumatic shock.
