Cathepsin
Cathepsins are protease enzymes, categorized into multiple families. Cathepsins can be serine protease, cysteine protease, or aspartyl protease. There are about 15 classes of cathepsins in humans (Cathepsin A, B, C, D, E, F, G, H, K, L, O, S, V, W, and Z). Cathepsins are active in the low pH milieu of lysosomes and are versatile in their functions. Like other enzymes, they are vital for the normal physiological functions such as digestion, blood coagulation, bone resorption, ion channel activity, innate immunity, complement activation, apoptosis, vesicular trafficking, autophagy, angiogenesis, proliferation, and metastasis, among scores of others.
Numerous pathologies have been attributed to the dysregulated cathepsins, some of which include arthritis, periodontitis, pancreatitis, macular degeneration, muscular dystrophy, atherosclerosis, obesity, stroke, Alzheimer's disease, schizophrenia, tuberculosis, and Ebola.
Cathepsin Isoform Specific Products
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Cathepsin Inhibitors
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Cathepsin Antagonist
(1)
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Cathepsin Activators
(7)
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Cathepsin Inducers
(3)
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Cathepsin Degrader
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Cathepsin Control
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Cathepsin Substrates
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Cathepsin Ligand
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Cathepsin Proteins
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Cathepsin B Proteins
(5)
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Cathepsin C Proteins
(4)
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Cathepsin D Proteins
(5)
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Cathepsin E Proteins
(3)
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Cathepsin K Proteins
(1)
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Cathepsin L1 Proteins
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Cathepsin S Proteins
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Cathepsin Related Products (302)
Related Products (302)
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Recombinant Proteins (35)
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Antibodies (6)
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Cathepsin Isoform Comparison
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Cathepsin L-IN-3 TFA
0 ImagesCat. No.: HY-P10118APurity: 98.18%Cathepsin L-IN-3 (Compound cat L inh. 7) TFA is selective a noncovalent cathepsin L inhibitor with a Ki of 4.3 nM.
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Kgp-IN-1 hydrochloride
0 ImagesCat. No.: HY-128523ACAS No.: 2097865-47-7Kgp-IN-1 hydrochloride is an arginine-specific gingipain (Rgp) inhibitor extracted from patent WO2017201322A1, compound 13-R.
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CTSE Human Pre-designed siRNA Set A
0 ImagesCat. No.: HY-RS03331CTSE Human Pre-designed siRNA Set A contains three designed siRNAs for CTSE gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
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Cysteine Protease inhibitor hydrochloride
0 ImagesCat. No.: HY-17541ACAS No.: 2197053-49-7Cysteine Protease inhibitor hydrochloride, an inhibitor of Cysteine Protease, binds to acetylcholinesterase (AChE). Cysteine Protease inhibitor hydrochloride is applicable to the research of Alzheimer's disease.
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CTSC Human Pre-designed siRNA Set A
0 ImagesCat. No.: HY-RS03325CTSC Human Pre-designed siRNA Set A contains three designed siRNAs for CTSC gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
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SNJ-1945
0 ImagesSNJ-1945 is an orally active, blood-brain barrier-penetrant Calpain inhibitor. SNJ-1945 inhibits Cathepsin L, Cathepsin B, and Ca2+ -independent proteases. SNJ-1945 suppresses ROS production and downregulates Cyclooxygenase-2 and Caspase-1. SNJ-1945 alleviates left ventricular systolic dysfunction, reduces cerebral ischemia-induced injury, and decreases the score of experimental autoimmune encephalomyelitis in mouse models. SNJ-1945 can be used in research related to post-cardiac arrest reperfusion injury, Parkinson's disease, multiple sclerosis, and proliferative retinopathy.
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Z-Phe-Tyr(tBu)-diazomethylketone
0 ImagesZ-Phe-Tyr(tBu)-diazomethylketone is a potent cathepsin L inhibitor. Z-Phe-Tyr(tBu)-diazomethylketone mediates reovirus disassembly. Z-Phe-Tyr(tBu)-diazomethylketone decreases viral detection.
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Ctsd Mouse Pre-designed siRNA Set A
0 ImagesCat. No.: HY-RS03329Ctsd Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ctsd gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
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Kgp-IN-1
0 ImagesCat. No.: HY-128523CAS No.: 2097865-36-4Kgp-IN-1 is an arginine-specific gingipain (Rgp) inhibitor extracted from patent WO2017201322A1, compound 13-R.
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CTSB Human Pre-designed siRNA Set A
0 ImagesCat. No.: HY-RS03322CTSB Human Pre-designed siRNA Set A contains three designed siRNAs for CTSB gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
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Gü2602
0 ImagesGü2602 is a potent, reversible cathepsin K (CatK) inhibitor with a Ki of 0.013 nM for mature CatK (mCatK). Gü2602 suppresses the autocatalytic activation of the cathepsin K zymogen.
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GSK-2793660 free base
0 ImagesCat. No.: HY-112318CAS No.: 1613458-70-0GSK-2793660 (free base) is an oral, irreversible inhibitor of Cathepsin C (CTSC). GSK-2793660 (free base) can be used for the research of bronchiectasis.
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SID 26681509 quarterhydrate
0 ImagesCat. No.: HY-103353APurity: 98.02%SID 26681509 quarterhydrate is a potent, reversible, competitive, and selective inhibitor of human cathepsin L with an IC50 of 56 nM. SID 26681509 quarterhydrate inhibits in vitro propagation of malaria parasite Plasmodium falciparum and inhibits Leishmania major with IC50s of 15.4 μM and 12.5 μM, respectively. SID 26681509 quarterhydrate shows no inhibitory activity against cathepsin G.
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Diazepinomicin
0 ImagesCat. No.: HY-N6674CAS No.: 733035-26-2Synonyms: ECO-4601; TLN-4601; BU 4664LDiazepinomicin (ECO-4601) is an anticancer and antibacterial agent. Diazepinomicin can be produced by a Micromonospora strain. Diazepinomicin induces Apoptosis. Diazepinomicin inhibits the proteases Rhodesain and Cathepsin L at an IC50 of 70-90 μM. Diazepinomicin possesses anti-inflammatory and anti-tumor activity. Diazepinomicin has demonstrated activity against hepatocellular carcinoma. Diazepinomicin shows antiparasitic activity against trypomastigote forms of Trypanosoma brucei with an IC50 of 13.5 μM. Diazepinomicin exhibits moderate antibacterial activity against specific Gram-positive bacteria, with an MIC of approximately 32 μg/mL.
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Z-Val-Val-Nle-diazomethylketone
0 ImagesCat. No.: HY-P5898CAS No.: 155026-49-6Synonyms: Z-Val-Val-Nle-CHN2Z-Val-Val-Nle-diazomethylketone is a cathepsin S (CATS) inhibitor. Z-Val-Val-Nle-diazomethylketone significantly inhibits the IFNg-induced upregulation of the MHCII molecules HLA-DR and Ii-p33/35 with an increase of Ii-p10 protein level. Z-Val-Val-Nle-diazomethylketone can be used for dermatological diseases like psoriasis, atopic dermatitis and actinic keratosis research.
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Z-DEVD-CMK
0 ImagesZ-DEVD-CMK is an irreversible inhibitor of most of the cathepsins in vitro.
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JNJ-10311795
0 ImagesCat. No.: HY-122161CAS No.: 518062-14-1Synonyms: RWJ-355871JNJ-10311795 (RWJ-355871), a potent dual inhibitor of neutrophil cathepsin G (Ki = 38 nM) and mast cell chymase (Ki = 2.3 nM), exhibits noteworthy antiinflammatory activity.
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AZD5248
0 ImagesAZD5248 is an orally active, selective dipeptidyl peptidase 1 (cathepsin C) inhibitor, with IC50 values of 1 nM and 17 nM against human CatC, 44 nM against human DPP1, and 67 nM against rat DPP1. It exhibits low clearance and high bioavailability in animal models. AZD5248 forms an irreversible covalent bond with the catalytic Cys234 residue of CatC, exerts reversible inhibition via its nitrile moiety, blocks CatC-dependent amyloid formation, and reduces the activation levels of neutrophil serine proteases in bone marrow and blood. AZD5248 reacts with aortic elastin aldehydes to form stable 4-imidazolinones, induces ultrastructural changes in aortic tissue, and has an α-amino acid-based backbone. AZD5248 reduces the severity of acute pancreatitis in mouse models. AZD5248 can be used in research on chronic obstructive pulmonary disease, acute pancreatitis, neurodegenerative diseases, lysosomal storage disorders, acute lung injury, cystic fibrosis, and neutrophil-mediated inflammatory diseases.
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Gallinamide A TFA
0 ImagesGallinamide A TFA is a linearly depositing peptide and a potent inhibitor of cathepsin L (CatL) (IC50: 17.6 pM). Gallinamide A TFA inhibits SARS-CoV-2 infection by inhibiting CatL (EC50: 28 nM). Gallinamide A TFA also inhibits Plasmodium falciparum (IC50: 50 nM).
