Drug Metabolite
Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.
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Drug Metabolite Related Products (2022)
Related Products (2022)
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Antibodies (1)
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Related Compound Screening Libraries (1)
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4-Hydroxy atorvastatin hemicalcium
0 ImagesCat. No.: HY-137310CAS No.: 265989-44-44-Hydroxy atorvastatin hemicalcium is a metabolite of Atorvastatin (HY-B0589). Atorvastatin is an orally active HMG-CoA reductase inhibitor, has the ability to effectively decrease blood lipids. Atorvastatin is metabolized by the cytochrome P450 (CYP) isoform CYP3A4 to form 4-hydroxy atorvastatin.
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N-Desethyl Sunitinib-d5 hydrochloride
0 ImagesCat. No.: HY-10873S2CAS No.: 1261432-14-7Synonyms: SU-12662-d5 hydrochlorideN-Desethyl Sunitinib-d5 (hydrochloride) is a deuterated labeled N-Desethyl Sunitinib. N-Desethyl Sunitinib (SU-12662) is a metabolite of sunitinib. Sunitinib is a potent, ATP-competitive VEGFR, PDGFRβ and KIT inhibitor with Ki values of 2, 9, 17, 8 and 4 nM for VEGFR -1, -2, -3, PDGFRβ and KIT, respectively.
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Nordoxepin hydrochloride (Standard)
0 ImagesSynonyms: Desmethyldoxepin hydrochloride (Standard)Nordoxepin hydrochloride (Standard) (Desmethyldoxepin hydrochloride (Standard)) is the analytical standard of Nordoxepin hydrochloride (HY-100046). This product is intended for research and analytical applications. Nordoxepin hydrochloride is an active metabolite of the tricyclic antidepressant Doxepin (HY-B0725A). Nordoxepin hydrochloride can be used in research on depression-related disorders.
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Didesmethylsibutramine hydrochloride (Standard)
0 ImagesCat. No.: HY-110034RCAS No.: 84484-78-6Synonyms: BTS 54-505 (Standard)Didesmethylsibutramine (hydrochloride) (Standard) is the analytical standard of Didesmethylsibutramine (hydrochloride). This product is intended for research and analytical applications. Didesmethylsibutramine (BTS 54-505) hydrochloride is the primary amine metabolite of Sibutramine (antidepressant and anti-obesity agent). Didesmethylsibutramine hydrochloride inhibits NMDA-evoked activity. Didesmethylsibutramine hydrochloride is also a reuptake inhibitor. Didesmethylsibutramine hydrochloride induces thermogenesis.
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Desmethylnortriptyline (Standard)
0 ImagesCat. No.: HY-100651RCAS No.: 4444-42-2Desmethylnortriptyline (Standard) is the analytical standard of Desmethylnortriptyline (HY-100651). This product is intended for research and analytical applications. Desmethylnortriptyline is a metabolite of Amitriptyline (HY-B0527) and Nortriptyline (HY-118620). Desmethylnortriptylineinhibits serotonin and noradrenaline uptake, antagonizes acetylcholine-induced contraction. Desmethylnortriptyline can be used for the research of depression.
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Tetrachlorohydroquinone
0 ImagesSynonyms: TCHQ; TetrachloroquinolTetrachlorohydroquinone (TCHQ) is a metabolite of Pentachlorophenol. Tetrachlorohydroquinone induces reactive oxidant stress (ROS), inhibits apoptosis and induces necrosis in primary mouse splenocytes. Tetrachlorohydroquinone increases DNA lesions and induces oxidative stress in rodents.
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10-Undecen-1-ol (Standard)
0 Images10-Undecen-1-ol,98% (stabilized with MEHQ) (Standard) is the analytical standard of 10-Undecen-1-ol,98% (stabilized with MEHQ). This product is intended for research and analytical applications. 10-Undecen-1-ol, converted from ricinoleic acid, can be used as a comonomer for the introduction of functional groups[1][2].
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Salnacedin
0 ImagesCat. No.: HY-121456CAS No.: 87573-01-1Synonyms: G-201Salnacedin (G-201) has anti-inflammatory and keratolytic activity. Salnacedin can be used in the research of seborrhoeic dermatitis and acne.
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Trimethoprim N-oxide
0 ImagesCat. No.: HY-100644CAS No.: 27653-68-5Synonyms: Trimethoprim 1-N-oxideTrimethoprim N-oxide (Trimethoprim 1-N-oxide) belongs to human urinary metabolites. Trimethoprim N-oxide is generated by oxidation of nitrogen atoms in the pyrimidine ring. Trimethoprim N-oxide is formed predominantly by CYP1A2 in human liver microsomes.
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Endoxifen (Standard)
0 ImagesMethicillin (sodium hydrate) (Standard) is the analytical standard of Methicillin (sodium hydrate). This product is intended for research and analytical applications. Methicillin sodium hydrate is a narrow-spectrum β-lactam antibiotic, acts by inhibiting penicillin-binding proteins (PBPs). Methicillin sodium hydrate is active against Staphylococcus aureus and Staphylococcus epidermidis that are resistant to other penicillins. Methicillin sodium hydrate can be used for the research of skin infections, osteomyelitis, and endocarditis.
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(±)19(20)-EpDTE
0 ImagesCat. No.: HY-139267CAS No.: 1359721-83-7(±)19(20)-EpDTE is an oxylipin and an oxidative metabolite of docosapentaenoic acid.
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5'-Deoxy-5-fluorocytidine-d3
0 ImagesCat. No.: HY-W009538SSynonyms: 5-Fluoro-5'-deoxycytidine-d35'-Deoxy-5-fluorocytidine-d3 is deuterated labeled 5'-Deoxy-5-fluorocytidine (HY-W009538). 5'-Deoxy-5-fluorocytidine (5-Fluoro-5'-deoxycytidine) is a cytidine analog and metabolite of Capecitabine (HY-B0016). 5'-Deoxy-5-fluorocytidine is converted from Capecitabine by carboxylesterase in the liver. 5'-Deoxy-5-fluorocytidine is deaminated by cytidine deaminase to generate 5'-deoxy-5-fluorouridine, which is finally converted into 5-fluorouracil (HY-90006) by thymidine phosphorylase in tumor tissues to exert anti-tumor effects. 5'-Deoxy-5-fluorocytidine is used in the researches for solid tumors such as colorectal cancer, non-small cell lung cancer and breast cancer.
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OR-1896-d3
0 ImagesCat. No.: HY-135746SOR-1896-d3 is the deuterium labeled OR-1896 (HY-135746). OR-1896 is an active long-lived metabolite of Levosimendan. OR-1896 is a highly selective phosphodiesterase (PDE) III isoform inhibitor and a powerful vasodilator. OR-1896 can open ATP-sensitive K+ channels and has Ca2+-sensitizing effect. OR-1896 mitigates cardiomyocyte apoptosis, cardiac remodeling and myocardial inflammation.
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2-Phenyl-2-(2-pyridyl)acetonitrile (Standard)
0 ImagesSynonyms: α-Phenyl-2-pyridineacetonitrile (Standard)2-Phenyl-2-(2-pyridyl)acetonitrile (Standard) is the analytical standard of 2-Phenyl-2-(2-pyridyl)acetonitrile. This product is intended for research and analytical applications. 2-Phenyl-2-(2-pyridyl)acetonitrile is the major metabolite of SC 15396 metabolized by the supernatant fraction of rat liver homogenate. SC 15396 is an antigastrin that inhibits gastric secretion[1].
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all-trans-Anhydro Retinol (Standard)
0 Imagesall-trans-Anhydro Retinol (Standard) (Anhydrovitamin A (Standard)) is the analytical standard of all-trans-Anhydro Retinol (HY-N7495). This product is intended for research and analytical applications. all-trans-Anhydro Retinol (Anhydrovitamin A) is an orally active degradation product formed by the dehydration of vitamin A alcohol and its esters under conditions such as acidic catalysis or hydroxylic solvents, with a biological activity only 0.4% of that of Vitamin A (HY-B1342). In rats, all-trans-Anhydro Retinol can be metabolized into hydroxy derivatives and their esters, but it cannot be converted into Vitamin A (HY-B1342) and has a low storage capacity in the body.
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(S)-2-Ketodoxapram
0 ImagesCat. No.: HY-125926ACAS No.: 1415394-64-7Synonyms: (S)-AHR 5955
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Regorafénib N-oxyde (M2)-13C,d3
0 ImagesCat. No.: HY-I0678S1CAS No.: 2140317-01-5
