HSP
Heat shock proteins
HSP (Heat shock proteins) are a group of proteins induced by heat shock, the most prominent members of this group are a class of functionally related proteins involved in the folding and unfolding of other proteins. HSP expression is increased when cells are exposed to elevated temperatures or other stress. This increase in expression is transcriptionally regulated. The dramatic upregulation of the heat shock proteins is a key part of the heat shock response and is induced primarily by heat shock factor (HSF). HSPs are found in virtually all living organisms, from bacteria to humans. Heat shock proteins appear to serve a significant cardiovascular role. Hsp90, Hsp84, Hsp70, Hsp27, Hsp20 and alpha B crystallin all have been reported as having roles in the cardiovasculature.
HSP Isoform Specific Products
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HSP Inhibitors
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HSP Agonists
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HSP Antagonists
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HSP Activators
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HSP Modulators
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HSP Inducers
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HSP Degraders
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HSP Pre-designed Set
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HSP Controls
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HSP Ligands
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HSP Related Products (503)
Related Products (503)
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Antibodies (46)
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HSP Isoform Comparison
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TCI 18
0 ImagesCat. No.: HY-185764CAS No.: 2614310-11-9TCI 18 is a ligand of HSP72 with a Ki value of 4.7 μM. TCI 18 forms a covalent bond with Lys56 residue of HSP72 via a process involving initial reversible binding, conversion to a pre-covalent complex, and subsequent covalent bond formation. TCI 18 addresses the undruggable target HSP72.
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EGFR-IN-182
0 ImagesCat. No.: HY-178955EGFR-IN-182 (Compound 4) is an EGFR inhibitor with an IC50 value of 199 nM. EGFR-IN-182 inhibits HSP90 and PI3K, with IC50 values of 5.007 and 13.596 μM respectively. EGFR-IN-182 exhibits strong anti-proliferative activity against MCF-7 and MDA-MB-231 cells. EGFR-IN-182 downregulates Cyclin D1, inducing cell cycle arrest; it enhances the activity of caspase-9, inducing cell apoptosis. EGFR-IN-182 downregulates the expressions of ERK and AKT. EGFR-IN-182 can be used for research on breast cancer.
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Hsp90-IN-39
0 ImagesCat. No.: HY-170910CAS No.: 3065556-75-1
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HSF1-IN-1
0 ImagesCat. No.: HY-167961CAS No.: 2205018-36-4
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HSP90-IN-9
0 ImagesCat. No.: HY-145814CAS No.: 2765247-36-5HSP90-IN-9 is a potent and selective HSP90 inhibitor. HSP90-IN-9 displays a fungicidal effect in a dose-dependent manner. HSP90-IN-9 inhibits fungal biofilm formation and fungal morphological changes after being combined with FLC. HSP90-IN-9 recovers FLC resistance by down-regulating the expression of related genes (ERG11, CDR1 and CDR2).
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Hsp110-STAT3 PPI-IN-2
0 ImagesCat. No.: HY-168178Hsp110-STAT3 PPI-IN-2 (compound 10b) is a Hsp110-STAT3 interaction disruptor. Hsp110-STAT3 PPI-IN-2 can be used in pulmonary arterial hypertension (PAH) related research.
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MAO A/HSP90-IN-2
0 ImagesCat. No.: HY-155580CAS No.: 2927489-99-2MAO A/HSP90-IN-2 (compound 4-C) is a dual inhibitor of HSP90and MAO A with the IC50 values of 0.016 and 4.58 μM, respectively. MAO A/HSP90-IN-2 increases HSP70 expression and reduces HER2 and phospho-Akt expression, and decreases IFN-γ induced PD-L1 expression in GL26 cells. MAO A/HSP90-IN-2 inhibits the growth of Temozolomide (HY-17364) -sensitive and -resistant GBM cells, colon cancer, leukemia, non-small cell lung and other cancers, and has potential to inhibit tumor immune escape[1].
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TRAP1-IN-2
0 ImagesCat. No.: HY-155064CAS No.: 3031102-92-5TRAP1-IN-2 is a TRAP1-selective inhibitor, with a Kd value of 0.04 μM against human TRAP1. TRAP1-IN-2 exhibits more than 250-fold selectivity for Grp94 and shows no detectable affinity for cytosolic Hsp90α/β. TRAP1-IN-2 selectively induces the degradation of TRAP1 client proteins by inhibiting its ATPase activity, without triggering the heat shock response or affecting cytosolic Hsp90 client proteins. TRAP1-IN-2 suppresses oxidative phosphorylation, shifts cellular metabolism toward glycolysis, disrupts the stability of the TRAP1 tetramer and the mitochondrial membrane potential. TRAP1-IN-2 can be used in studies related to prostate cancer, cervical cancer, and ovarian cancer.
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KU-32
0 ImagesCat. No.: HY-108248CAS No.: 956498-70-7KU-32 is a novel, novobiocin-based Hsp90 inhibitor that can protect against neuronal cell death.
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Hsp90-IN-41
0 ImagesCat. No.: HY-177042CAS No.: 909871-27-8Hsp90-IN-41 (Compound C1) is an inhibitor of Hsp90 (IC50 = 0.044 μM). Hsp90-IN-41 exhibits antifungal and antitumor (IC50 = 0.049 μM) activities in vitro.
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HDAC/HSP90-IN-3
0 ImagesCat. No.: HY-144694CAS No.: 2700035-54-5HDAC/HSP90-IN-3 (compound J5) is a potent and selective fungal Hsp90 and HDAC dual inhibitor, with IC50 values of 0.83 and 0.91 μM, respectively. HDAC/HSP90-IN-3 shows antifungal activity against azole resistant C. albicans. HDAC/HSP90-IN-3 can suppress important virulence factors and down-regulate drug-resistant genes ERG11 and CDR1.
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Hsp90-IN-44
0 ImagesCat. No.: HY-177875CAS No.: 934346-12-0
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17-AEP-GA
0 ImagesCat. No.: HY-133570CAS No.: 75747-23-817-AEP-GA, an HSP90 antagonist, is a potent inhibitor of glioblastoma cell proliferation, survival, migration and invasion. ADCs Toxin.
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HDAC6/HSP90-IN-1
0 ImagesCat. No.: HY-146293CAS No.: 2411955-43-4HDAC6/HSP90-IN-1 (compound 17) is a potent and selective dual inhibitor of HDAC6 and HSP90, with IC50 values of 4.3 and 46.8 nM, respectively. HDAC6/HSP90-IN-1 down-regulates PD-L1 expression in INF-γ treated H1975 lung cancer cells. HDAC6/HSP90-IN-1 inhibits tumor growth in human H1975 xenograft mice.
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Apatorsen sodium scrambled negative control
0 ImagesCat. No.: HY-145722DApatorsen sodium scrambled negative control is the sequence scrambled negative control of Apatorsen sodium.
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HSP90i
0 ImagesCat. No.: HY-174476CAS No.: 1472616-48-0HSP90i is a HSP90 inhibitor. HSP90i can be used as a drug intermediate to synthesize LYTACs, such as dPDL1-4 (HY-174468).
