Potassium Channel
KcsA
Potassium channels are the most widely distributed type of ion channel and are found in virtually all living organisms. They form potassium-selective pores that span cell membranes. Potassium channels are found in most cell types and control a wide variety of cell functions. Potassium channels function to conduct potassium ions down their electrochemical gradient, doing so both rapidly and selectively. Biologically, these channels act to set or reset the resting potential in many cells. In excitable cells, such asneurons, the delayed counterflow of potassium ions shapes the action potential. By contributing to the regulation of the action potential duration in cardiac muscle, malfunction of potassium channels may cause life-threatening arrhythmias. Potassium channels may also be involved in maintaining vascular tone.
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Potassium Channel Inhibitors
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Potassium Channel Agonists
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Potassium Channel Antagonists
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Potassium Channel Activators
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Potassium Channel Modulators
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Potassium Channel Chemical
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Potassium Channel Controls
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Potassium Channel Related Products (1155)
Related Products (1155)
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Antibodies (6)
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Related Compound Screening Libraries (1)
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SKA-121 (Standard)
0 ImagesCat. No.: HY-107414RCAS No.: 1820708-73-3
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MRT2000769
0 ImagesCat. No.: HY-122638CAS No.: 1214573-32-6MRT2000769 is a Kir7.1 inhibitor with an IC50 of 2 μM. MRT2000769 induces sustained contractions in the uterine muscle of pregnant mice. MRT2000769 is applicable for the research of postpartum hemorrhage.
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Almitrine mesylate (Standard)
0 ImagesSynonyms: Almitrine bismesylate (Standard); Almitrine bismethanesulfonate (Standard); Almitrine dimesylate (Standard)Almitrine mesylate (Standard) (Almitrine bismesylate (Standard)) is the analytical standard of Almitrine mesylate (HY-107319). This product is intended for research and analytical applications. Almitrine mesylate, a peripheral chemoreceptor agonist, inhibits selectively the Ca2+-dependent K+ channel.
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Siponimod (Standard)
0 ImagesSynonyms: BAF-312 (Standard)Siponimod (BAF-312) (Standard) is the analytical standard of Siponimod. This product is intended for research and analytical applications. Siponimod is an orally active, blood-brain barrier penetrant dual agonist of S1P1/S1P5, with EC50 values of 0.39 nM and 0.98 nM, respectively. Siponimod induces S1P1 internalization, activates GIRK channels, inhibits lymphocyte egress, reduces peripheral lymphocyte counts, triggers transient bradycardia, prevents synaptic neurodegeneration, promotes remyelination, alleviates demyelination, and prevents the loss of GABAergic interneurons. Siponimod can be used in research related to multiple sclerosis.
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N-Acetylprocainamide hydrochloride (Standard)
0 ImagesCat. No.: HY-101433RCAS No.: 34118-92-8Synonyms: Acecainide hydrochloride (Standard); NAPA hydrochloride (Standard)N-Acetylprocainamide (Acecainide) hydrochloride (Standard) is the analytical standard of N-Acetylprocainamide hydrochloride (HY-101433). This product is intended for research and analytical applications. N-Acetylprocainamide hydrochloride is a class III antiarrhythmic, which blocks K+ channels. N-Acetylprocainamide hydrochloride exerts inhibitory effects on the maximum following frequency (MFF) of isolated rabbit atria. N-Acetylprocainamide hydrochloride can be used for the study of arrhythmias.
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U-56324
0 ImagesCat. No.: HY-187737CAS No.: 75587-96-1U-56324 is an orally effective ATP-sensitive potassium channel (KATP) inhibitor with an EC50 of 233 µM. U-56324 inhibits KATP channel activity in the plasma membrane of pancreatic B cells in a concentration-dependent and reversible manner, without affecting single-channel conductance. U-56324 can be used for research on type 2 diabetes and insulin secretion.
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Daurisoline-d2
0 ImagesCat. No.: HY-N0221SSynonyms: (R,R)-Daurisoline-d2Daurisoline-d2 is the deuterium labeled Daurisoline (HY-N0221). Daurisoline is a bis-benzylisoquinoline alkaloid that can be isolated from Menispermum dauricum and Rhizoma Menispermi. Daurisoline exerts a blocking effect on hERG and has antiarrhythmic effects. Daurisoline is a potent autophagy blocker that can be used for the research of cancer.
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Antioxidant agent-26
0 ImagesCat. No.: HY-189531CAS No.: 24978-47-0Antioxidant agent-26 is a DPPH free radical scavenger. Antioxidant agent-26 has broad-spectrum ultraviolet absorption properties and iron-reducing ability. Antioxidant agent-26 blocks the hERG potassium channel and reduces the tail current. Antioxidant agent-26 inhibits the proliferation of dermatophytes and tumor cells. Antioxidant agent-26 can be used in research related to T-cell leukemia, melanoma, and dermatophytosis.
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PD-118057 (Standard)
0 ImagesCat. No.: HY-108594RCAS No.: 313674-97-4
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Disopyramide (Standard)
0 ImagesDisopyramide (Standard) is the analytical standard of Disopyramide. This product is intended for research and analytical applications. Disopyramide (Dicorantil) is a class IA antiarrhythmic agent with efficacy in ventricular and atrial arrhythmias. Disopyramide blocks the fast inward sodium current of cardiac muscle and prolongs the duration of cardiac action potentials. Disopyramide inhibits HERG encoded potassium channels. Disopyramide also exhibits complex protein binding, and has a potent negative inotropic action.
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(3R,5R)-Rosuvastatin
0 ImagesCat. No.: HY-17504CCAS No.: 1094100-06-7(3R,5R)-Rosuvastatin is a hERG potassium channel blocker and HMG-CoA reductase inhibitor that prolongs the action potential duration and QT interval by accelerating channel inactivation, impairing channel folding, reducing hERG mRNA transcription, and promoting the degradation of mature and immature hERG channels. (3R,5R)-Rosuvastatin can be used for research on long QT syndrome.
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SKA-31 (Standard)
0 ImagesSKA-31 (Standard) is the analytical standard of SKA-31. This product is intended for research and analytical applications. SKA-31 is a potent potassium channel activator with EC50s of 260 nM, 1.9 μM, 2.9 μM, and 2.9 μM for KCa3.1, KCa2.2, KCa2.1 and KCa2.3, respectively. SKA-31 potentiates endothelium-derived hyperpolarizing factor response and lowers blood pressure.
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Landiolol hydrochloride (Standard)
0 ImagesCat. No.: HY-100607ARCAS No.: 144481-98-1Synonyms: ONO1101 hydrochloride (Standard)Landiolol (ONO1101) hydrochloride (Standard) is the analytical standard of Landiolol hydrochloride (HY-100607A). This product is intended for research and analytical applications. Landiolol (ONO1101) hydrochloride is a highly selective, ultra-short-acting competitive inhibitor of β1 adrenergic receptors. Landiolol hydrochloride specifically blocks cardiac β1 receptors, reducing heart rate and myocardial oxygen consumption. Landiolol hydrochloride inhibits TNF-α-induced excessive mitochondrial oxygen consumption and reactive oxygen species production in a sepsis model, alleviating renal injury. Landiolol hydrochloride has little effect on cardiac ion channels (such as L-type calcium current and inward rectifier potassium current) and has a weak negative inotropic effect. Landiolol hydrochloride can be used for perioperative tachycardia control and protection studies of sepsis-related acute kidney injury.
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Mefloquine (Standard)
0 ImagesSynonyms: Mefloquin (Standard)Mefloquine (Standard) is the analytical standard of Mefloquine. This product is intended for research and analytical applications. Mefloquine (Mefloquin), an orally active and potent quinoline antimalarial agent, is an anti-SARS-CoV-2 entry inhibitor. Mefloquine is also a K+ channel (KvQT1/minK) antagonist with an IC50 of ~1 μM. Mefloquine can be used for malaria, systemic lupus erythematosus and cancer research.
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Gliquidone sodium
0 ImagesCat. No.: HY-B1114ACAS No.: 62783-47-5Synonyms: AR-DF 26 sodiumGliquidone sodium (AR-DF 26 sodium) can bind to the pancreatic β-cells and increases insulin release to regulate blood glucose levels. Gliquidone sodium significantly decreases LPS (HY-D1056)-induced proinflammatory responses and inhibits ERK/STAT3/NF-κB phosphorylation in BV2 microglial cells. Gliquidone sodium can suppress microgliosis, microglial hypertrophy mediated by LPS, and proinflammatory cytokine COX-2 and IL-6 levels in murine model. Gliquidone sodium also exhibits good anticancer activity in lung carcinoma cells. Gliquidone sodium has antioxidant property. Gliquidone sodium can be studied in research for type 2 diabetes and cancers.
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Indapamide hemihydrate
0 ImagesCat. No.: HY-B0259ACAS No.: 180004-24-4Indapamide hemihydrate is an orally active sulphonamide diuretic agent, that can reduce blood pressure by decreasing vascular reactivity and peripheral vascular resistance. Indapamide hemihydrate is also can reduce left ventricular hypertrophy.
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NS5806 (Standard)
0 ImagesCat. No.: HY-108588RCAS No.: 426834-69-7NS5806 (Standard) is the analytical standard of NS5806 (HY-108588). This product is intended for research and analytical applications. NS5806, a potent potassium current activator, increases KV4.3/KChIP2 peak current amplitudes with an EC50 of 5.3 μM. NS5806 slows KV4.3 and KV4.2 current dacay in channel complexes containing KChIP2.
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Daurisoline-d11
0 ImagesCat. No.: HY-N0221S2Synonyms: (R,R)-Daurisoline-d11Daurisoline-d11 is the deuterium labeled Daurisoline (HY-N0221). Daurisoline is a bis-benzylisoquinoline alkaloid that can be isolated from Menispermum dauricum and Rhizoma Menispermi. Daurisoline exerts a blocking effect on hERG and has antiarrhythmic effects. Daurisoline is a potent autophagy blocker that can be used for the research of cancer.
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Nalanthalide
0 ImagesCat. No.: HY-N8372CAS No.: 145603-76-5Nalanthalide is a voltage-gated potassium channel Kv1.3 blocker (IC50=3.9 µM) and a potential immunosuppressant. Nalanthalide can be used for research on inflammatory immune diseases, such as neuroinflammation.
