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Cat. No.: HY-190945

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Anticancer agent-373

Anticancer agent-373 is a potent antitumor agent with broad-spectrum antitumor activity. Anticancer agent-373 exhibits the strongest inhibitory effect on SH-SY5Y, with an IC₅₀ of 4.87 μM. Anticancer agent-373 has the highest binding energy to the CDK2/cyclin A complex among the tested compounds. Anticancer agent-373 can be used for research on various tumors.

For research use only. We do not sell to patients.

Formula: C₃₁H₄₀N₂O₈
Molecular Weight:568.66

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (287 KB)

Anticancer agent-373 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

IC₅₀ & Target

^[1]

cdk2/cyclin A

All CDK Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
FaDu	IC₅₀	6.74 μM	Cytotoxicity against human FaDu squamous cell carcinoma cells assessed as viability reduction by SRB assay. Cytotoxicity against human FaDu squamous cell carcinoma cells assessed as viability reduction by SRB assay.	42959959
HT-29	IC₅₀	19.40 μM	Cytotoxicity against human HT29 colorectal adenocarcinoma cells assessed as viability reduction by SRB assay. Cytotoxicity against human HT29 colorectal adenocarcinoma cells assessed as viability reduction by SRB assay.	42959959
MDA-MB-231	IC₅₀	22.39 μM	Cytotoxicity against human MDA-MB-231 breast adenocarcinoma cells assessed as viability reduction by SRB assay. Cytotoxicity against human MDA-MB-231 breast adenocarcinoma cells assessed as viability reduction by SRB assay.	42959959
A549	IC₅₀	6.02 μM	Cytotoxicity against human A549 lung carcinoma cells assessed as viability reduction by SRB assay. Cytotoxicity against human A549 lung carcinoma cells assessed as viability reduction by SRB assay.	42959959
SH-SY5Y	IC₅₀	4.87 μM	Cytotoxicity against human SH-SY5Y neuroblastoma cells assessed as viability reduction by SRB assay. Cytotoxicity against human SH-SY5Y neuroblastoma cells assessed as viability reduction by SRB assay.	42959959

In Vitro

Anti-cancerOthers

Anti-cancer

Anticancer agent-373 (compound 4b) (0.1-50 μM) exhibits the strongest cytotoxicity against SH-SY5Y human neuroblastoma cells with an IC₅₀ of 4.87 μM, and its IC₅₀ values against KKU-M213, FaDu, HT29, MDA-MB-213, and A549 are 15.23, 6.74, 19.40, 22.39, and 6.02 μM, respectively^[1].

Others

Anticancer agent-373 (in silico) exhibits activity in a model of its complex with CDK2/cyclin A (PDB: 3BHT), binding tightly to its catalytic site through hydrogen bonds and hydrophobic interactions, with a binding free energy of -12.57 kcal/mol^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Subcutaneous Cell-Line-Derived Xenograft

Chemical Information

Molecular Weight 568.66
Formula C₃₁H₄₀N₂O₈
SMILES

O=C(C1=CC=CC=C1O)NN[C@H](C[C@@H]([C@@]2(C)C(CC3)[C@@](COC(C)=O)(C)[C@H](OC(C)=O)CC2)C3=C)C4=CCOC4=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (287 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Bunthawong R, et al. Stereoselective Synthesis of 12(R)‑Hydrazineyl-14-deoxy Andrographolide Analogues and Their Cytotoxic Activity. ACS Omega. 2026 Oct 12;11(42):64884-64896.

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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