Copy Link Print Information

3-TYP

105 Cited Publications
Kundenbewertung

Based on 105 publication(s) in Google Scholar

3-TYP is an inhibitor of SIRT3 (IC50of 38 μM) and an inhibitor of Methionine Adenosyltransferase (MAT) 2 and Indoleamine 2,3-Dioxygenase (IDO). There may be many off-target sites for 3-TYP that need to be examined, such as NAD-dependent enzymes, including dehydrogenases.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

  • Reinheit: 99.90%
  • CAS. Nr.: 120241-79-4
  • Formel: C7H6N4
  • Molecular Weight:146.15
  • Speicherung:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 6 months , -20°C, 1 month
  • 3-TYP Chemical Structure
    3-TYP Chemical Structure
  • Experimental Validation Results for 3-TYP
  • Experimental Validation Results for 3-TYP
  • Experimental Validation Results for 3-TYP
  • Experimental Validation Results for 3-TYP
CAS. Nr.: 120241-79-4
Größe
Preis
Verfügbarkeit
Menge
Amount: USD 0.00
Please select quantity
or
or

* Bitte wählen Sie Menge, bevor Sie Artikel hinzufügen.

To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

Data Download
Other Forms of 3-TYP:

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Finden Sie Ihren Händler vor Ort Your local distributor: Hycultec GmbHHycultec
  • Biologische Aktivität
  • Chemical Information
  • Lösungsmittel & Löslichkeit
  • Protokoll
  • Reinheit & Dokumentation
  • Verweise
  • Help & FAQs
You May Still Need
Top Publications Citing

Use of MCE Products

Publications Citing Use of MedChemExpress (MCE) 3-TYP

More
Customer Validation & Images
WBIHC
  • WB
  • IHC
  • WB
  • WB

Alle Sirtuin Isoform-spezifische Produkte anzeigen

More

Alle Indoleamine 2,3-Dioxygenase (IDO) Isoform-spezifische Produkte anzeigen

More
Keywords
MOQ
Minimum order quantity
100 mg

Angebot einholen Auf Lager

Other size
Angebot einholen
Please select quantity
Amount: USD 0.00
Sign in to MedChemExpress Einloggen
Registrieren
Sign in to MedChemExpress
Neuen Account Registrieren

At least 6 characters

Personalize your experience, you are currently not signed in. For a better experience, please create an online profile, you can:

Obtain points redemption prizes
Check out faster
Add multiple shipping locations
View orders
Assay Types
  • 3-TYP Chemical Structure
    3-TYP Chemical Structure
    1/16
  • 1/16

    3-TYP purchased from MedChemExpress. Usage Cited in: Toxicol Appl Pharmacol. 2024 Aug 9:117066. [Abstract]

    Customer Validation
     WB images of SIRT3, AcK68-MnSOD and AcK122-MnSOD expressions in DRG tissues. Quantification of SIRT3, AcK68-MnSOD and AcK122-MnSOD expressions normalized with β-actin expressions and the Saline+Saline treated samples was set to 1 (NR (Nicotinamide riboside chloride); PTX (4 mg/kg, i. p.) Group, PTX (4 mg/kg, i.p.) + NR (400 mg/kg, i.g.) Group, PTX (4 mg/kg, I.P.) + NR (400 mg/kg, i.g.) +3-TYP (50 mg/kg, i.p.) group, NR (400 mg/kg, i.p.) group, 3-TYP (50 mg/kg, i.p.) group in SIRT3 WT mice)

  • 1/16

    3-TYP purchased from MedChemExpress. Usage Cited in: Toxicol Appl Pharmacol. 2024 Aug 9:117066. [Abstract]

    Customer Validation
     The representative images depicting the expression of AcK68-MnSOD in each group were utilized for immunohistochemical detection (NR (Nicotinamide riboside chloride); PTX (4 mg/kg, i. p.) Group, PTX (4 mg/kg, i.p.) + NR (400 mg/kg, i.g.) Group, PTX (4 mg/kg, I.P.) + NR (400 mg/kg, i.g.) +3-TYP (50 mg/kg, i.p.) group, NR(400 mg/kg, i.p.) group, 3-TYP (50 mg/kg, i.p.) group in SIRT3 WT mice)

  • 1/16

    3-TYP purchased from MedChemExpress. Usage Cited in: Nat Immunol. 2023 Jan;24(1):162-173. [Abstract]

    Customer Validation
     A485 (10 μM; 24 h) leads to the downregulation of H3K9bhb and CPS1 in BHB-treated CD8+ TM cells; however, the use of 3-TYP (10 μM; 24 h) or Trichostatin A (TSA; 5 nM; 24 h) result in the increase of H3K9bhb and CPS1.

  • 1/16

    3-TYP purchased from MedChemExpress. Usage Cited in: Cell Physiol Biochem. 2017;44(6):2212-2227. [Abstract]

    Customer Validation
     MEK, ERK1/2 and IκBα phosphorylation and their total protein expression are detected by Western blot. Cardiac myocytes are stimulated by Ang II for 48h after treatment with Sesamin (10 mM) or 3-TYP (50 μM).

  • 3-TYP