Art. -Nr.: HY-N7674

Angoline

4 Cited Publications

Kundenbewertung

Based on 4 publication(s) in Google Scholar

Angoline is a potent and selective IL6/STAT3 signaling pathway inhibitor with an IC₅₀ of 11.56 μM. Angoline inhibits STAT3 phosphorylation and its target gene expression, and inhibits cancer cell proliferation.

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Reinheit: 99.67%
CAS. Nr.: 21080-31-9
Formel: C₂₂H₂₁NO₅
Molecular Weight:379.41

Speicherung:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Angoline Chemical Structure

CAS. Nr.: 21080-31-9

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Publications (4)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

IC50: 11.56 μM (IL6/STAT3 signaling pathway), 3.32 μM (MDA-MB-231), 4.72 μM (H4), 3.14 μM (HepG2)^[1]

Alle Interleukin Related Isoform-spezifische Produkte anzeigen :

Alle STAT Isoform-spezifische Produkte anzeigen :

In Vitro

Angoline (0-100 μM; 1 h) inhibits STAT3, STAT1 and NF-κB signaling pathways with IC₅₀ values of 11.56, ＞100 and ＞100 μM, respectively^[1].
? Angoline (0-100 μM; 2 h) affects phosphorylation of STAT3^[1].
? Angoline (0-100 μM; 72 h) inhibits MDA-MB-231, H4 and HepG2 cells proliferation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

HepG2/STAT3 cell line
Concentration:

0, 1, 10, 30 and 100 μM
Incubation Time:

2 hours
Result:

Inhibited IL-6-induced phosphorylation of STAT3 in HepG2/STAT3 cells.

Cell Proliferation Assay^[1]

Cell Line:

MDA-MB-231, H4 and HepG2 cell lines
Concentration:

0-100 μM
Incubation Time:

72 hours
Result:

Inhibited proliferation of MDA-MB-231, H4 and HepG2 cells with IC₅₀ values of 3.32, 4.72 and 3.14 μM, respectively.

Chemical Information

CAS. Nr. 21080-31-9
Appearance Solid
Molecular Weight 379.41
Formel C₂₂H₂₁NO₅
Color White to off-white
SMILES

CN1C2=C3C(C=C4OCOC4=C3)=CC=C2C5=C(C(OC)=C(OC)C=C5)C1OC
Structure Classification
- Alkaloids
- Isoquinoline Alkaloids
Initial Source
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Publications (4)

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Journal Impact Factor

Cell Res

Transient mechanical activation of the Piezo1 channel facilitates ex vivo expansion of hematopoietic stem cells. [Abstract]

2026 Jan 9. PMID: 41507440
Cytokine

TGF-beta inhibitors influence leishmania infection outcome in a susceptible host. [Abstract]

2026 Aug:204:157169. PMID: 42143915
Cell Biochem Biophys

Resolvin D1 Inhibits IL-6-Induced Epithelial-Mesenchymal Transition of Colorectal Cancer Cells by Targeting IL-6/STAT3 Signaling. [Abstract]

2024 Jun;82(2):1453-1461. PMID: 38740668
J Toxicol Sci

The mechanism of monobutyl phthalate -induced ferroptosis via TNF/IL6/STAT3 signal pathway in TM-3 cells. [Abstract]

2023;48(5):299-310. PMID: 37121744

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 20.83 mg/mL (54.90 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.6357 mL

13.1784 mL

26.3567 mL

5 mM

0.5271 mL

2.6357 mL

5.2713 mL

10 mM

0.2636 mL

1.3178 mL

2.6357 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: 2.5 mg/mL (6.59 mM); Clear solution; Need ultrasonic

This protocol yields a clear solution of 2.5 mg/mL.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: 2.5 mg/mL (6.59 mM); Suspended solution; Need ultrasonic

This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
SDS (480 KB)
- English - EN (480 KB)
- Français - FR (480 KB)
- Deutsch - DE (480 KB)
- Norwegian - NO (480 KB)
- Español - ES (480 KB)
- Swedish - SV (480 KB)
- Italian - IT (480 KB)
- Korean - KR (480 KB)
- Portuguese - PT (480 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Jiawei Liu, et al. Angoline: a selective IL-6/STAT3 signaling pathway inhibitor isolated from Zanthoxylum nitidum. Phytomedicine. Jul-Aug 2014;21(8-9):1088-91. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.6357 mL	13.1784 mL	26.3567 mL	65.8918 mL
	5 mM	0.5271 mL	2.6357 mL	5.2713 mL	13.1784 mL
	10 mM	0.2636 mL	1.3178 mL	2.6357 mL	6.5892 mL
	15 mM	0.1757 mL	0.8786 mL	1.7571 mL	4.3928 mL
	20 mM	0.1318 mL	0.6589 mL	1.3178 mL	3.2946 mL
	25 mM	0.1054 mL	0.5271 mL	1.0543 mL	2.6357 mL
	30 mM	0.0879 mL	0.4393 mL	0.8786 mL	2.1964 mL
	40 mM	0.0659 mL	0.3295 mL	0.6589 mL	1.6473 mL
	50 mM	0.0527 mL	0.2636 mL	0.5271 mL	1.3178 mL

Keywords

Angoline

4 Cited Publications

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Publications Citing Use of MedChemExpress (MCE) Angoline

Alle Interleukin Related Isoform-spezifische Produkte anzeigen

Alle STAT Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (4)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Angoline Related Classifications

HY-N7674 Related Classifications