BRD4884
Based on 1 Customer Validation
BRD4884 is a potent and brain-penetrant HDAC inhibitor with IC50 values of 29 nM, 62 nM, and 1090 nM for HDAC1, HDAC2, and HDAC3, respectively. BRD4884 can be used for the study of cognitive impairment.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 99.14%
- CAS. Nr.: 1404559-91-6
- Formel: C18H19FN2O2
- Molecular Weight:314.35
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
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HDAC1 29 nM (IC50) |
HDAC2 62 nM (IC50) |
HDAC3 1.09 μM (IC50) |
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Cell Line
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Type | Value | Description | References |
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| Sf9 | IC50 |
0.029 μM
Compound: BRD4884
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Inhibition of C-terminal His-tagged and C-terminal FLAG-tagged full length human recombinant HDAC1 expressed in baculovirus coexpressed in fall armyworm Sf9 cells using carboxyfluorescein (FAM)-labeled acetylated/ trifluoroacetylated peptide as substrate
Inhibition of C-terminal His-tagged and C-terminal FLAG-tagged full length human recombinant HDAC1 expressed in baculovirus coexpressed in fall armyworm Sf9 cells using carboxyfluorescein (FAM)-labeled acetylated/ trifluoroacetylated peptide as substrate
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[PMID: 27377864] |
| Sf9 | IC50 |
0.062 μM
Compound: BRD4884
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Inhibition full length human recombinant HDAC2 expressed in baculovirus coexpressed in fall armyworm Sf9 cells using carboxyfluorescein (FAM)-labeled acetylated/ trifluoroacetylated peptide as substrate after 60 mins by fluorescence assay
Inhibition full length human recombinant HDAC2 expressed in baculovirus coexpressed in fall armyworm Sf9 cells using carboxyfluorescein (FAM)-labeled acetylated/ trifluoroacetylated peptide as substrate after 60 mins by fluorescence assay
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[PMID: 27377864] |
BRD4884 (10 μM, 24 hours) increases H4K12 and H3K9 histone acetylation in primary mouse neuronal cell culture assays[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:CK-p25 mice (3 months) were induced for 6 weeks to obtain forebrain-specific expression of p25[1].
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Dosage:1 mg/kg, 10 mg/kg
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Administration:i.p.; daily; for 10 days
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Result:Rescued the memory defects associated with p25 induced neurodegeneration in contextual fear conditioning.
Chemical Information
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CAS. Nr. 1404559-91-6
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Appearance Solid
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Molecular Weight 314.35
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Formel C18H19FN2O2
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Color White to off-white
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SMILES
O=C(C1CCOCC1)NC2=CC(C3=CC=C(F)C=C3)=CC=C2N
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Lösungsmittel & Löslichkeit
DMSO : ≥ 100 mg/mL (318.12 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (271 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 3.1812 mL | 15.9058 mL | 31.8117 mL | 79.5292 mL |
| 5 mM | 0.6362 mL | 3.1812 mL | 6.3623 mL | 15.9058 mL | |
| 10 mM | 0.3181 mL | 1.5906 mL | 3.1812 mL | 7.9529 mL | |
| 15 mM | 0.2121 mL | 1.0604 mL | 2.1208 mL | 5.3019 mL | |
| 20 mM | 0.1591 mL | 0.7953 mL | 1.5906 mL | 3.9765 mL | |
| 25 mM | 0.1272 mL | 0.6362 mL | 1.2725 mL | 3.1812 mL | |
| 30 mM | 0.1060 mL | 0.5302 mL | 1.0604 mL | 2.6510 mL | |
| 40 mM | 0.0795 mL | 0.3976 mL | 0.7953 mL | 1.9882 mL | |
| 50 mM | 0.0636 mL | 0.3181 mL | 0.6362 mL | 1.5906 mL | |
| 60 mM | 0.0530 mL | 0.2651 mL | 0.5302 mL | 1.3255 mL | |
| 80 mM | 0.0398 mL | 0.1988 mL | 0.3976 mL | 0.9941 mL | |
| 100 mM | 0.0318 mL | 0.1591 mL | 0.3181 mL | 0.7953 mL |
BRD4884 Related Classifications
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