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Art. -Nr.: HY-178043

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BTR2038

BTR2038 is a BTR2000-based heterobifunctional PROTAC that induces the degradation of BRD9 by recruiting the CUL3^KLHL20 E3 ubiquitin ligase. BTR2038 consists of a BRD9 bromodomain ligand derived from a BI-7273 analog, a linker, and the macrocyclic KLHL20 ligand BTR2000. BTR2038 is applicable for research related to KLHL20-recruited targeted protein degradation and BRD9 modulation.
(Pink: Target protein ligand; Blue: KLHL20 ligand (HY-172563); Black: linker).

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Formel: C₅₀H₆₃N₉O₁₁S₂
Molecular Weight:1030.22

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (279 KB)

BTR2038 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

BTR2038 is a BTR2000-based heterobifunctional PROTAC that induces the degradation of BRD9 by recruiting the CUL3^KLHL20 E3 ubiquitin ligase. BTR2038 consists of a BRD9 bromodomain ligand derived from a BI-7273 analog, a linker, and the macrocyclic KLHL20 ligand BTR2000. BTR2038 is applicable for research related to KLHL20-recruited targeted protein degradation and BRD9 modulation^[1]. (Pink: Target protein ligand; Blue: KLHL20 ligand (HY-172563); Black: linker).

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In Vitro

BTR2038 (10 μM; 4 h) reduces BRD9 protein levels in T-REx U2OS cells stably expressing V5-tagged human BRD9; the relative BRD9 gray values in two biological replicates are approximately 0.17 and 0.16, while the corresponding DMSO control values are approximately 0.85 and 1.00^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 1030.22
Formel C₅₀H₆₃N₉O₁₁S₂
SMILES

O=C(N1CCC[C@@H]1C(N[C@H](CC(O)=O)C(N[C@H](CC(C)C)C(N[C@@H](CSC2)C(N)=O)=O)=O)=O)[C@H](CSC3=CC2=CC=C3)NC(CCCNCC4=C(OC)C=C(C5=CN(C)C(C6=C5C=CN=C6)=O)C=C4OC)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (279 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Fechtmeyer PH, et al. Temporal and Spatial Characterization of CUL3-Driven Targeted Degradation of BET Family BRD Proteins by the Macrocycle-Based Degrader BTR2004. ACS chemical biology. 2025 Sep 19;20(9):2056-2062.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise

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BTR2038

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